Affiliation: Johns Hopkins University
- Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cellsMatam Vijay Kumar
Department of Pathology, 600 N Wolfe Street, Meyer B 125A, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neuroimmunol 153:7-15. 2004..The presence of TLRs on RPE cells and the resultant TLR signaling in RPE cells suggest that these molecules may play an important role in innate and adaptive immune responses within the retina...
- Immune regulation in the retinaBarbara Detrick
Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
Immunol Res 47:153-61. 2010..Herein, we summarize the varied interactions of the RPE cell with the immune response and highlight how the RPE cell survives and participates in this dynamic environment...
- Experimental coronavirus retinopathy (ECOR): retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infectionBarbara Detrick
Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21287 7065, USA
J Neuroimmunol 193:28-37. 2008..These augmented innate responses observed correlated with the development of autoimmune reactivity and retinal degeneration and thus may contribute to the pathogenic processes...
- Vitamin D deficiency is associated with coronary artery calcification in cardiovascularly asymptomatic African Americans with HIV infectionShenghan Lai
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA Department of Epidemiology, John Hopkins University, Johns Hopkins Bloomberg School of Public Heath, Baltimore, MD, USA
Vasc Health Risk Manag 9:493-500. 2013..However, the relationship between vitamin D deficiency and coronary artery calcification (CAC), a sensitive marker for subclinical CAD, in those with HIV infection is not well investigated...
- Beta interferon suppresses the development of experimental cerebral malariaCraig N Morrell
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Infect Immun 79:1750-8. 2011..berghei-infected mice also had fewer brain T-cell infiltrates, further demonstrating its protective effects. Hence, IFN-β has important anti-inflammatory properties that ameliorate the severity of ECM and prolong mouse survival...
- Preoperative recipient cytokine levels are associated with early lung allograft dysfunctionJeremiah G Allen
Department of Surgery, Division of Cardiac Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann Thorac Surg 93:1843-9. 2012..Primary graft dysfunction (PGD) is a morbid complication after lung transplant (LTx). Recipient before and after cytokine and chemokine profiles may be associated with a recipient's propensity to have PGD...
- γ/IgG ratio: role in distinguishing monoclonal spikes from fibrinogenMaria Teresa Lee
Immunology Laboratory, Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
J Clin Lab Anal 25:332-6. 2011..Using the γ/IgG ratio improves the screening power of SPEP and offers a simple and reliable diagnostic tool for distinguishing fibrinogen spikes from true monoclonal spikes...
- Detection of type-specific antibodies to HSV-1 and HSV-2: comparative analysis of a chemiluminescence immunoassay with a conventional ELISAAmelia W Maters
Immunology Laboratory, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Diagn Microbiol Infect Dis 73:273-4. 2012..The overall agreement of the chemiluminescence immunoassay versus the ELISA assay was 99.6% (HSV-1) and 100% (HSV-2). The LIAISON® methodology has several advantages...
- Vitamin D deficiency is associated with significant coronary stenoses in asymptomatic African American chronic cocaine usersHong Lai
Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States
Int J Cardiol 158:211-6. 2012..Chronic cocaine use may lead to premature atherosclerosis, however, the prevalence of and risk factors for coronary artery disease in asymptomatic cocaine users have not been reported...
- Naturally occurring interference in Luminex assays for HLA-specific antibodies: characteristics and resolutionAndrea A Zachary
Departments of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Hum Immunol 70:496-501. 2009..Because interference is frequently observed in sera from highly sensitized patients, it is important to recognize and eliminate interference in Luminex antibody assays for accurate and meaningful test interpretation...
- Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathyKarl H Schuleri
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Eur Heart J 30:2722-32. 2009..Here we tested the hypothesis that autologous MSCs can be safely injected into a chronic myocardial infarct scar, reduce its size, and improve ventricular function...
- Gamma heavy chain disease in a patient with diabetes and chronic renal insufficiency: diagnostic assessment of the heavy chain fragmentMaria Teresa Lee
Immunology Laboratory, Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
J Clin Lab Anal 22:146-50. 2008..The evaluation of IgG subclasses in the context of a HCD may be limited by the capability of the test to recognize the particular IgG fragment...
- Origin of a false positive urine pregnancy test in a patient with membranoproliferative glomerulonephritis type IMark A Marzinke
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, United States
Clin Chim Acta 413:361-3. 2012..Discrepant qualitative urine and quantitative serum hCG results were observed in a patient with a history of membranoproliferative glomerulonephritis. Further studies were performed to investigate this discrepancy...
- Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort studyGeorge C Wang
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Epidemiol 171:1144-52. 2010..79, 95% confidence interval: 1.22, 6.40). Better understanding of the long-term clinical consequences of CMV infection in immunocompetent humans is needed to guide public health efforts for this widely prevalent infection...
- Retinal degeneration in experimental coronavirus retinopathy (ECOR) is associated with increased TNF-alpha, soluble TNFR2 and altered TNF-alpha signalingLaura C Hooper
Laboratory of Immunology, Immunology and Virology Section, National Eye Institute, National Institutes of Health, NIH Bldg 10, Rm 6N228, 10 Center Drive, Bethesda, MD 20892, USA
J Neuroimmunol 166:65-74. 2005..Furthermore they suggest that these molecules are involved in alterations in immune response leading to autoimmune reactivity...
- Autoantibodies to p75/LEDGF, a cell survival factor, found in patients with atypical retinal degenerationMarian S Chin
Immunology and Virology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N248, Bethesda, MD 20892, USA
J Autoimmun 27:17-27. 2006..Finally, identification of specific anti-retinal antibodies may have applications in the diagnosis and management of retinal degeneration...
- The critical role of IFN-gamma in experimental coronavirus retinopathyJohn J Hooks
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
Invest Ophthalmol Vis Sci 44:3402-8. 2003..In retinal degeneration-resistant CD-1 mice, only the acute infection is seen. In the present study, interferon (IFN)-gamma production during ECOR was studied and its role evaluated in the clearance of infectious virus from the retina...