Research Topics
| Charles C Della SantinaSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
A multichannel semicircular canal neural prosthesis using electrical stimulation to restore 3-d vestibular sensationCharles C Della Santina
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA
IEEE Trans Biomed Eng 54:1016-30. 2007..Increasing stimulation selectivity via improvements in electrode design, surgical technique and stimulus protocol will likely be required to restore AVOR function over the full range of normal behavior...- Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstructionCharles C Della Santina
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
J Assoc Res Otolaryngol 6:191-206. 2005..5 +/- 5.1 degrees, and 105.6 +/- 6.6 degrees, respectively. The mean anterior SCC-contralateral posterior SCC angle was 15.3 +/- 7.2 degrees. The absolute orientations of human SCC are more nearly orthogonal than previously reported... - Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesisChenkai Dai
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
Hear Res 281:74-83. 2011.... - Vestibular function and vertigo control after intratympanic gentamicin for Ménière's diseaseKimanh D Nguyen
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
Audiol Neurootol 14:361-72. 2009.... - Hearing outcomes after surgical plugging of the superior semicircular canal by a middle cranial fossa approachBryan K Ward
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Otol Neurotol 33:1386-91. 2012..To determine postoperative hearing outcomes after surgical plugging via middle cranial fossa approach for superior semicircular canal dehiscence syndrome (SCDS)... - The effects of cochlear implantation on vestibular functionThuy Anh N Melvin
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Otol Neurotol 30:87-94. 2009..Determine the risk posed by cochlear implantation (CI) to the labyrinth... 
Objective assessment of mastoidectomy skills in the operating roomHoward W Francis
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
Otol Neurotol 31:759-65. 2010..To determine the feasibility and validity of an objective assessment tool designed to measure the development of mastoidectomy skills by resident trainees in the operating room...- Effects of vestibular prosthesis electrode implantation and stimulation on hearing in rhesus monkeysChenkai Dai
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, USA
Hear Res 277:204-10. 2011.... - Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesisChenkai Dai
Department of Otolaryngology Head and Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Brain Res 210:595-606. 2011..Similar adaptive improvements are likely to occur in other species, including humans... - Co-modulation of stimulus rate and current from elevated baselines expands head motion encoding range of the vestibular prosthesisNatan S Davidovics
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
Exp Brain Res 218:389-400. 2012..These findings can be used toward selecting optimal baseline levels for vestibular stimulation that would result in large inhibitory eye responses while maintaining a wide range of excitatory eye velocity via co-modulation... - Axis of eye rotation changes with head-pitch orientation during head impulses about earth-verticalAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Assoc Res Otolaryngol 7:140-50. 2006..Thus, even when the orientation of Listing's plane and eye position in the orbit are fixed, the axis of eye rotation during the VOR reflects a compromise between the requirements of Listing's law and a perfectly compensatory VOR... 
Responses of irregularly discharging chinchilla semicircular canal vestibular-nerve afferents during high-frequency head rotationsTimothy E Hullar
Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave 8115, Saint Louis, MO 63110, USA
J Neurophysiol 93:2777-86. 2005....- The vestibulo-ocular reflex response to head impulses rarely decreases after cochlear implantationAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Otol Neurotol 26:655-60. 2005..Measure vestibular function using the head impulse test and assess the change in function due to unilateral cochlear implantation... - Restoring the 3D vestibulo-ocular reflex via electrical stimulation: the Johns Hopkins multichannel vestibular prosthesis projectMehdi A Rahman
Departments of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Conf Proc IEEE Eng Med Biol Soc 2011:3142-5. 2011..Here we describe several parallel lines of investigation directed toward refinement of this approach toward eventual clinical application... - Variation in response dynamics of regular and irregular vestibular-nerve afferents during sinusoidal head rotations and currents in the chinchillaKyu Sung Kim
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Brain Res 210:643-9. 2011.... - Diabetes, vestibular dysfunction, and falls: analyses from the National Health and Nutrition Examination SurveyYuri Agrawal
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Otol Neurotol 31:1445-50. 2010..Our aims were 1) to further characterize the vestibular dysfunction present in patients with diabetes and 2) to evaluate for an independent effect of vestibular dysfunction on fall risk among patients with diabetes... - Effects of biphasic current pulse frequency, amplitude, duration, and interphase gap on eye movement responses to prosthetic electrical stimulation of the vestibular nerveNatan S Davidovics
Departments of Otolaryngology Head and Neck Surgery and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
IEEE Trans Neural Syst Rehabil Eng 19:84-94. 2011.... - Adaptation of the vestibulo-ocular reflex for forward-eyed foveate visionAmerico A Migliaccio
Dept of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Physiol 588:3855-67. 2010..In contrast, the lateral-eyed chinchilla faces different adaptive demands and thus enlists a different aVOR strategy... - Vestibulo-ocular reflex responses to a multichannel vestibular prosthesis incorporating a 3D coordinate transformation for correction of misalignmentGene Y Fridman
Vestibular NeuroEngineering Laboratory, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
J Assoc Res Otolaryngol 11:367-81. 2010.... - The effect of binocular eye position and head rotation plane on the human torsional vestibuloocular reflexAmerico A Migliaccio
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, MA 21205, USA
Vision Res 46:2475-86. 2006.... - Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's diseaseJohn P Carey
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
J Assoc Res Otolaryngol 3:430-43. 2002..This finding suggests that intratympanic gentamicin causes a partial vestibular lesion that may involve preservation of spontaneous discharge and/or rotational sensitivity of afferents... - Dynamic visual acuity during passive head thrusts in canal planesMichael C Schubert
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 N Caroline St, JHOC Rm 6245, Baltimore, MD 21287 0910, USA
J Assoc Res Otolaryngol 7:329-38. 2006..051 LogMAR). These findings suggest that the htDVA test, which does not require scleral coil placement, magnetic field coils, or expensive oculography equipment, can provide a useful quantitative measure of individual SCC function... - Chronic stimulation of the semicircular canals using a multichannel vestibular prosthesis: effects on locomotion and angular vestibulo-ocular reflex in chinchillasDaniel Q Sun
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Conf Proc IEEE Eng Med Biol Soc 2011:3519-23. 2011..In this study, we evaluated effects of chronic MVP stimulation on locomotion in chinchillas. Two of three animals examined exhibited significant improvements in both locomotion and aVOR... - MRI magnetic field stimulates rotational sensors of the brainDale C Roberts
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Curr Biol 21:1635-40. 2011..Such effects could confound functional MRI studies of brain behavior, including resting-state brain activity... - Inexpensive system for real-time 3-dimensional video-oculography using a fluorescent marker arrayAmerico A Migliaccio
Department of Otolaryngology-Head and Neck Surgery, Laboratory of Vestibular Neurophysiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Neurosci Methods 143:141-50. 2005..laniger). The in vivo positional difference between the two methods was <3.1% for each component of 3-D eye position... - Middle ear exploration in patients with Ménière's disease who have failed outpatient intratympanic gentamicin therapyBenjamin T Crane
Otolaryngology Head and Neck Surgery, Division of Otology, Neurotology, and Skull Base Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Otol Neurotol 30:619-24. 2009..The objective of the current study was to evaluate the option of middle ear exploration with direct application of gentamicin to the round window (MEE-G) in patients with persistent MD after transtympanic injection of gentamicin... - Incremental angular vestibulo-ocular reflex adaptation to active head rotationMichael C Schubert
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287 0910, USA
Exp Brain Res 191:435-46. 2008..This has implications for programs of vestibular rehabilitation, where active head rotation is prescribed as a means to improve gaze stability... - Time course of repeated intratympanic gentamicin for Ménière's diseaseKimanh D Nguyen
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
Laryngoscope 119:792-8. 2009..Our objective is to provide such a description with a Kaplan-Meier survival analysis, which may enable accurate predictions of the probability of recurrent vertigo after a given time or number of injections... - Progress toward development of a multichannel vestibular prosthesis for treatment of bilateral vestibular deficiencyGene Y Fridman
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Anat Rec (Hoboken) 295:2010-29. 2012.... - Multichannel Vestibular Prosthesis Employing Modulation of Pulse Rate and Current with Alignment Precompensation Elicits Improved VOR Performance in MonkeysNatan S Davidovics
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA
J Assoc Res Otolaryngol 14:233-48. 2013.... - Virtual labyrinth model of vestibular afferent excitation via implanted electrodes: validation and application to design of a multichannel vestibular prosthesisRussell Hayden
Johns Hopkins Vestibular NeuroEngineering Laboratory, Baltimore, MD 21287 0910, USA
Exp Brain Res 210:623-40. 2011..The modeling procedure is partially automated and can be readily adapted to other species, including humans... - Temporal bone characterization and cochlear implant feasibility in the common marmoset (Callithrix jacchus)Luke A Johnson
Biomedical Engineering Dept, Johns Hopkins University, 412 Traylor Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Hear Res 290:37-44. 2012..Our study provides detailed structural anatomy data for the middle and inner ear of the marmoset, and suggests the potential of the marmoset as a new non-human primate model for cochlear implant research... - Unidirectional rotations produce asymmetric changes in horizontal VOR gain before and after unilateral labyrinthectomy in macaquesMunetaka Ushio
Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Brain Res 210:651-60. 2011.... - Modification of compensatory saccades after aVOR gain recoveryMichael C Schubert
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
J Vestib Res 16:285-91. 2006..Our data suggest an inverse, dynamic relationship between the recruitment of CS and the gain of the aVOR... - Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administrationSofia Lyford Pike
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287 0910, USA
J Assoc Res Otolaryngol 8:497-508. 2007..62 (12.06-13.17) in support cells (p < 0.001, ANOVA). These results suggest that type I hair cells are more susceptible to gentamicin because they more avidly take up or retain the drug in the early period after administration... - Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004Yuri Agrawal
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 N Caroline St, Baltimore, MD 21287, USA
Arch Intern Med 169:938-44. 2009.... - Pilot testing of an assessment tool for competency in mastoidectomyKulsoom Laeeq
Department Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA
Laryngoscope 119:2402-10. 2009..This study tests the hypothesis that residents of dissimilar training levels differ in their technical performance as measured by this tool... - Comparison of head thrust test with head autorotation test reveals that the vestibulo-ocular reflex is enhanced during voluntary head movementsCharles C Della Santina
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, 601 N Caroline St, Baltimore, MD 21287-0910, USA
Arch Otolaryngol Head Neck Surg 128:1044-54. 2002.... - Effects of semicircular canal electrode implantation on hearing in chinchillasShan Tang
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Acta Otolaryngol 129:481-6. 2009..Implantation of vestibular prosthesis electrodes in chinchilla semicircular canal ampullae can be accomplished without significant loss of cochlear function; however, the risk of hearing loss with the current surgical technique is high... - Safe direct current stimulation to expand capabilities of neural prosthesesGene Y Fridman
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21208, USA
IEEE Trans Neural Syst Rehabil Eng 21:319-28. 2013..We show the SDCS's ability to both inhibit and excite neural activity to achieve improved dynamic range during prosthetic stimulation of the vestibular part of the inner ear in chinchillas...