Charles C Della Santina

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstruction
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 6:191-206. 2005
  2. pmc A multichannel semicircular canal neural prosthesis using electrical stimulation to restore 3-d vestibular sensation
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA
    IEEE Trans Biomed Eng 54:1016-30. 2007
  3. pmc Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis
    Chenkai Dai
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Hear Res 281:74-83. 2011
  4. pmc Vestibular function and vertigo control after intratympanic gentamicin for Ménière's disease
    Kimanh D Nguyen
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
    Audiol Neurootol 14:361-72. 2009
  5. pmc Multichannel vestibular prosthesis employing modulation of pulse rate and current with alignment precompensation elicits improved VOR performance in monkeys
    Natan S Davidovics
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    J Assoc Res Otolaryngol 14:233-48. 2013
  6. pmc Hearing outcomes after surgical plugging of the superior semicircular canal by a middle cranial fossa approach
    Bryan K Ward
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 33:1386-91. 2012
  7. pmc The effects of cochlear implantation on vestibular function
    Thuy Anh N Melvin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Otol Neurotol 30:87-94. 2009
  8. pmc Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis
    Chenkai Dai
    Department of Otolaryngology Head and Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Brain Res 210:595-606. 2011
  9. doi request reprint Objective assessment of mastoidectomy skills in the operating room
    Howard W Francis
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Otol Neurotol 31:759-65. 2010
  10. pmc Effects of vestibular prosthesis electrode implantation and stimulation on hearing in rhesus monkeys
    Chenkai Dai
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, USA
    Hear Res 277:204-10. 2011

Collaborators

Detail Information

Publications43

  1. pmc Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstruction
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 6:191-206. 2005
    ..5 +/- 5.1 degrees, and 105.6 +/- 6.6 degrees, respectively. The mean anterior SCC-contralateral posterior SCC angle was 15.3 +/- 7.2 degrees. The absolute orientations of human SCC are more nearly orthogonal than previously reported...
  2. pmc A multichannel semicircular canal neural prosthesis using electrical stimulation to restore 3-d vestibular sensation
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA
    IEEE Trans Biomed Eng 54:1016-30. 2007
    ..Increasing stimulation selectivity via improvements in electrode design, surgical technique and stimulus protocol will likely be required to restore AVOR function over the full range of normal behavior...
  3. pmc Restoration of 3D vestibular sensation in rhesus monkeys using a multichannel vestibular prosthesis
    Chenkai Dai
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Hear Res 281:74-83. 2011
    ....
  4. pmc Vestibular function and vertigo control after intratympanic gentamicin for Ménière's disease
    Kimanh D Nguyen
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
    Audiol Neurootol 14:361-72. 2009
    ....
  5. pmc Multichannel vestibular prosthesis employing modulation of pulse rate and current with alignment precompensation elicits improved VOR performance in monkeys
    Natan S Davidovics
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    J Assoc Res Otolaryngol 14:233-48. 2013
    ....
  6. pmc Hearing outcomes after surgical plugging of the superior semicircular canal by a middle cranial fossa approach
    Bryan K Ward
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 33:1386-91. 2012
    ..To determine postoperative hearing outcomes after surgical plugging via middle cranial fossa approach for superior semicircular canal dehiscence syndrome (SCDS)...
  7. pmc The effects of cochlear implantation on vestibular function
    Thuy Anh N Melvin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Otol Neurotol 30:87-94. 2009
    ..Determine the risk posed by cochlear implantation (CI) to the labyrinth...
  8. pmc Cross-axis adaptation improves 3D vestibulo-ocular reflex alignment during chronic stimulation via a head-mounted multichannel vestibular prosthesis
    Chenkai Dai
    Department of Otolaryngology Head and Neck Surgery and Biomedical Engineering, Vestibular NeuroEngineering Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Brain Res 210:595-606. 2011
    ..Similar adaptive improvements are likely to occur in other species, including humans...
  9. doi request reprint Objective assessment of mastoidectomy skills in the operating room
    Howard W Francis
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Otol Neurotol 31:759-65. 2010
    ..To determine the feasibility and validity of an objective assessment tool designed to measure the development of mastoidectomy skills by resident trainees in the operating room...
  10. pmc Effects of vestibular prosthesis electrode implantation and stimulation on hearing in rhesus monkeys
    Chenkai Dai
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, USA
    Hear Res 277:204-10. 2011
    ....
  11. doi request reprint Co-modulation of stimulus rate and current from elevated baselines expands head motion encoding range of the vestibular prosthesis
    Natan S Davidovics
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
    Exp Brain Res 218:389-400. 2012
    ..These findings can be used toward selecting optimal baseline levels for vestibular stimulation that would result in large inhibitory eye responses while maintaining a wide range of excitatory eye velocity via co-modulation...
  12. ncbi request reprint The vestibulo-ocular reflex response to head impulses rarely decreases after cochlear implantation
    Americo A Migliaccio
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Otol Neurotol 26:655-60. 2005
    ..Measure vestibular function using the head impulse test and assess the change in function due to unilateral cochlear implantation...
  13. ncbi request reprint Responses of irregularly discharging chinchilla semicircular canal vestibular-nerve afferents during high-frequency head rotations
    Timothy E Hullar
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave 8115, Saint Louis, MO 63110, USA
    J Neurophysiol 93:2777-86. 2005
    ....
  14. pmc Axis of eye rotation changes with head-pitch orientation during head impulses about earth-vertical
    Americo A Migliaccio
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Assoc Res Otolaryngol 7:140-50. 2006
    ..Thus, even when the orientation of Listing's plane and eye position in the orbit are fixed, the axis of eye rotation during the VOR reflects a compromise between the requirements of Listing's law and a perfectly compensatory VOR...
  15. doi request reprint Safe direct current stimulation to expand capabilities of neural prostheses
    Gene Y Fridman
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21208, USA
    IEEE Trans Neural Syst Rehabil Eng 21:319-28. 2013
    ..We show the SDCS's ability to both inhibit and excite neural activity to achieve improved dynamic range during prosthetic stimulation of the vestibular part of the inner ear in chinchillas...
  16. pmc Restoring the 3D vestibulo-ocular reflex via electrical stimulation: the Johns Hopkins multichannel vestibular prosthesis project
    Mehdi A Rahman
    Departments of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3142-5. 2011
    ..Here we describe several parallel lines of investigation directed toward refinement of this approach toward eventual clinical application...
  17. doi request reprint Variation in response dynamics of regular and irregular vestibular-nerve afferents during sinusoidal head rotations and currents in the chinchilla
    Kyu Sung Kim
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Brain Res 210:643-9. 2011
    ....
  18. pmc Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's disease
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 3:430-43. 2002
    ..This finding suggests that intratympanic gentamicin causes a partial vestibular lesion that may involve preservation of spontaneous discharge and/or rotational sensitivity of afferents...
  19. pmc Dynamic visual acuity during passive head thrusts in canal planes
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 N Caroline St, JHOC Rm 6245, Baltimore, MD 21287 0910, USA
    J Assoc Res Otolaryngol 7:329-38. 2006
    ..051 LogMAR). These findings suggest that the htDVA test, which does not require scleral coil placement, magnetic field coils, or expensive oculography equipment, can provide a useful quantitative measure of individual SCC function...
  20. ncbi request reprint The effect of binocular eye position and head rotation plane on the human torsional vestibuloocular reflex
    Americo A Migliaccio
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, MA 21205, USA
    Vision Res 46:2475-86. 2006
    ....
  21. pmc Vestibulo-ocular reflex responses to a multichannel vestibular prosthesis incorporating a 3D coordinate transformation for correction of misalignment
    Gene Y Fridman
    Vestibular NeuroEngineering Laboratory, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Assoc Res Otolaryngol 11:367-81. 2010
    ....
  22. doi request reprint Diabetes, vestibular dysfunction, and falls: analyses from the National Health and Nutrition Examination Survey
    Yuri Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 31:1445-50. 2010
    ..Our aims were 1) to further characterize the vestibular dysfunction present in patients with diabetes and 2) to evaluate for an independent effect of vestibular dysfunction on fall risk among patients with diabetes...
  23. pmc Adaptation of the vestibulo-ocular reflex for forward-eyed foveate vision
    Americo A Migliaccio
    Dept of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Physiol 588:3855-67. 2010
    ..In contrast, the lateral-eyed chinchilla faces different adaptive demands and thus enlists a different aVOR strategy...
  24. pmc Effects of biphasic current pulse frequency, amplitude, duration, and interphase gap on eye movement responses to prosthetic electrical stimulation of the vestibular nerve
    Natan S Davidovics
    Departments of Otolaryngology Head and Neck Surgery and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    IEEE Trans Neural Syst Rehabil Eng 19:84-94. 2011
    ....
  25. pmc Chronic stimulation of the semicircular canals using a multichannel vestibular prosthesis: effects on locomotion and angular vestibulo-ocular reflex in chinchillas
    Daniel Q Sun
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3519-23. 2011
    ..In this study, we evaluated effects of chronic MVP stimulation on locomotion in chinchillas. Two of three animals examined exhibited significant improvements in both locomotion and aVOR...
  26. pmc MRI magnetic field stimulates rotational sensors of the brain
    Dale C Roberts
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Curr Biol 21:1635-40. 2011
    ..Such effects could confound functional MRI studies of brain behavior, including resting-state brain activity...
  27. doi request reprint Middle ear exploration in patients with Ménière's disease who have failed outpatient intratympanic gentamicin therapy
    Benjamin T Crane
    Otolaryngology Head and Neck Surgery, Division of Otology, Neurotology, and Skull Base Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 30:619-24. 2009
    ..The objective of the current study was to evaluate the option of middle ear exploration with direct application of gentamicin to the round window (MEE-G) in patients with persistent MD after transtympanic injection of gentamicin...
  28. pmc Inexpensive system for real-time 3-dimensional video-oculography using a fluorescent marker array
    Americo A Migliaccio
    Department of Otolaryngology Head and Neck Surgery, Laboratory of Vestibular Neurophysiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci Methods 143:141-50. 2005
    ..laniger). The in vivo positional difference between the two methods was <3.1% for each component of 3-D eye position...
  29. pmc Incremental angular vestibulo-ocular reflex adaptation to active head rotation
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287 0910, USA
    Exp Brain Res 191:435-46. 2008
    ..This has implications for programs of vestibular rehabilitation, where active head rotation is prescribed as a means to improve gaze stability...
  30. doi request reprint Time course of repeated intratympanic gentamicin for Ménière's disease
    Kimanh D Nguyen
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Laryngoscope 119:792-8. 2009
    ..Our objective is to provide such a description with a Kaplan-Meier survival analysis, which may enable accurate predictions of the probability of recurrent vertigo after a given time or number of injections...
  31. doi request reprint Progress toward development of a multichannel vestibular prosthesis for treatment of bilateral vestibular deficiency
    Gene Y Fridman
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Anat Rec (Hoboken) 295:2010-29. 2012
    ....
  32. pmc Virtual labyrinth model of vestibular afferent excitation via implanted electrodes: validation and application to design of a multichannel vestibular prosthesis
    Russell Hayden
    Johns Hopkins Vestibular NeuroEngineering Laboratory, Baltimore, MD 21287 0910, USA
    Exp Brain Res 210:623-40. 2011
    ..The modeling procedure is partially automated and can be readily adapted to other species, including humans...
  33. pmc Temporal bone characterization and cochlear implant feasibility in the common marmoset (Callithrix jacchus)
    Luke A Johnson
    Biomedical Engineering Dept, Johns Hopkins University, 412 Traylor Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Hear Res 290:37-44. 2012
    ..Our study provides detailed structural anatomy data for the middle and inner ear of the marmoset, and suggests the potential of the marmoset as a new non-human primate model for cochlear implant research...
  34. pmc Unidirectional rotations produce asymmetric changes in horizontal VOR gain before and after unilateral labyrinthectomy in macaques
    Munetaka Ushio
    Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Brain Res 210:651-60. 2011
    ....
  35. doi request reprint Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004
    Yuri Agrawal
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 N Caroline St, Baltimore, MD 21287, USA
    Arch Intern Med 169:938-44. 2009
    ....
  36. doi request reprint Pilot testing of an assessment tool for competency in mastoidectomy
    Kulsoom Laeeq
    Department Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA
    Laryngoscope 119:2402-10. 2009
    ..This study tests the hypothesis that residents of dissimilar training levels differ in their technical performance as measured by this tool...
  37. pmc Modification of compensatory saccades after aVOR gain recovery
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
    J Vestib Res 16:285-91. 2006
    ..Our data suggest an inverse, dynamic relationship between the recruitment of CS and the gain of the aVOR...
  38. pmc Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administration
    Sofia Lyford-Pike
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287 0910, USA
    J Assoc Res Otolaryngol 8:497-508. 2007
    ..62 (12.06-13.17) in support cells (p < 0.001, ANOVA). These results suggest that type I hair cells are more susceptible to gentamicin because they more avidly take up or retain the drug in the early period after administration...
  39. pmc Near-dehiscence: clinical findings in patients with thin bone over the superior semicircular canal
    Bryan K Ward
    Department of Otolaryngology Head and Neck Surgery, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, U S A
    Otol Neurotol 34:1421-8. 2013
    ..To determine whether patients with thin bone over the superior semicircular canal can develop signs or symptoms of superior canal dehiscence syndrome (SCDS)...
  40. doi request reprint Prevalence and Impact of Bilateral Vestibular Hypofunction: Results From the 2008 US National Health Interview Survey
    Bryan K Ward
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland2Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland
    JAMA Otolaryngol Head Neck Surg 139:803-10. 2013
    ..These data support the need for new therapeutic strategies for BVH, including vestibular rehabilitation and implantable vestibular prostheses. ..
  41. ncbi request reprint Comparison of head thrust test with head autorotation test reveals that the vestibulo-ocular reflex is enhanced during voluntary head movements
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, 601 N Caroline St, Baltimore, MD 21287 0910, USA
    Arch Otolaryngol Head Neck Surg 128:1044-54. 2002
    ....
  42. pmc Effects of semicircular canal electrode implantation on hearing in chinchillas
    Shan Tang
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Acta Otolaryngol 129:481-6. 2009
    ..Implantation of vestibular prosthesis electrodes in chinchilla semicircular canal ampullae can be accomplished without significant loss of cochlear function; however, the risk of hearing loss with the current surgical technique is high...
  43. doi request reprint Skin grafting facilitates the maintenance of head recording chambers for neurophysiological recording
    Joong Ho Ahn
    Vestibular NeuroEngineering Laboratory, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, United States
    J Neurosci Methods 215:161-3. 2013
    ..We recommend this technique to reduce the potential for infection, to prevent cerebral spinal fluid leakage or bleeding in experiment and to minimise animal anxiety that might otherwise result from frequent chamber cleanings...