Angelo De Marzo

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Focus on prostate cancer
    William Isaacs
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Cell 2:113-6. 2002
  2. ncbi request reprint New concepts in the pathology of prostatic epithelial carcinogenesis
    A M De Marzo
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 57:103-14. 2001
  3. ncbi request reprint Human prostate cancer precursors and pathobiology
    Angelo M De Marzo
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Urology 62:55-62. 2003
  4. pmc The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
    Joseph P Garay
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 14:R27. 2012
  5. pmc Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
    Dengfeng Cao
    Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
    Breast Cancer Res 10:R91. 2008
  6. pmc Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Genomics 12:313. 2011
  7. pmc Inflammation in prostate carcinogenesis
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
    Nat Rev Cancer 7:256-69. 2007
  8. ncbi request reprint Inflammation, atrophy, and prostate carcinogenesis
    Angelo M De Marzo
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Urol Oncol 25:398-400. 2007
  9. ncbi request reprint Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatment
    Angelo M De Marzo
    Department of Oncology, The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231 1000, USA
    J Cell Biochem 91:459-77. 2004
  10. doi request reprint Prostate cancer: New answers prompt new questions regarding cell of origin
    Angelo M De Marzo
    The Brady Urological Research Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Rev Urol 7:650-2. 2010

Research Grants

  1. MOLECULAR PATHOLOGY OF STEM CELLS IN CANCER
    Angelo Demarzo; Fiscal Year: 2002
  2. INFLAMMATION AND ATROPHY IN PROSTATE CARCINOGENESIS
    Angelo Demarzo; Fiscal Year: 2003

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Focus on prostate cancer
    William Isaacs
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Cell 2:113-6. 2002
  2. ncbi request reprint New concepts in the pathology of prostatic epithelial carcinogenesis
    A M De Marzo
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 57:103-14. 2001
    ..In this review, therefore, we also present our recent immune-mediated oxidant injury and regeneration hypothesis of why and how the prostate is targeted for carcinogenesis...
  3. ncbi request reprint Human prostate cancer precursors and pathobiology
    Angelo M De Marzo
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    Urology 62:55-62. 2003
    ..Additional results show that AMACR may be an important new marker of prostate cancer, and its use in combination with p63 staining may provide the basis for an improved method for identification of prostate cancer...
  4. pmc The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
    Joseph P Garay
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 14:R27. 2012
    ..In addition, many breast cancers co-express other steroid hormone receptors that can affect AR signaling, further obfuscating the effects of androgens on breast cancer cells...
  5. pmc Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
    Dengfeng Cao
    Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
    Breast Cancer Res 10:R91. 2008
    ..Global gene expression profiling of LCIS has not been performed...
  6. pmc Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    BMC Genomics 12:313. 2011
    ..This MBD-chip approach was used to characterize DNA methylation patterns across all non-repetitive sequences of human chromosomes 21 and 22 at high-resolution in normal and malignant prostate cells...
  7. pmc Inflammation in prostate carcinogenesis
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
    Nat Rev Cancer 7:256-69. 2007
    ....
  8. ncbi request reprint Inflammation, atrophy, and prostate carcinogenesis
    Angelo M De Marzo
    Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
    Urol Oncol 25:398-400. 2007
    ..Additional epidemiological, molecular pathological, and animal model work needs to be done to determine whether inflammation and atrophy are "driving" prostate carcinogenesis...
  9. ncbi request reprint Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatment
    Angelo M De Marzo
    Department of Oncology, The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231 1000, USA
    J Cell Biochem 91:459-77. 2004
    ..We also present the implications of these changes for prostate cancer diagnosis, detection, prevention, and treatment...
  10. doi request reprint Prostate cancer: New answers prompt new questions regarding cell of origin
    Angelo M De Marzo
    The Brady Urological Research Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Nat Rev Urol 7:650-2. 2010
    ..However, these results are not mutually exclusive: there are potential solutions, and alternative views on the initiating cell derivation of prostate tumors also exist...
  11. ncbi request reprint A working group classification of focal prostate atrophy lesions
    Angelo M De Marzo
    Johns Hopkins University School of Medicine, USA
    Am J Surg Pathol 30:1281-91. 2006
    ..In conclusion, these criteria for variants of focal prostate atrophy may facilitate studies to examine the relation between various patterns of prostate atrophy and prostate cancer...
  12. pmc Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytology
    Kazutoshi Fujita
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 40:924-33. 2009
    ..1, nucleolin, and 4'-6-diamidino-2-phenylindole to detect prostate cancer cells in urine. Further refinements in marker selection and technique may increase sensitivity and applicability for prostate cancer diagnosis...
  13. ncbi request reprint Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    Anirban Maitra
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:902-12. 2003
    ....
  14. doi request reprint A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA Electronic address
    Hum Pathol 44:2494-500. 2013
    ..These and other mechanisms may contribute to the increased proliferation in malignant phyllodes relative to other fibroepithelial neoplasms. ..
  15. ncbi request reprint The diet, prostate inflammation, and the development of prostate cancer
    William G Nelson
    The Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Cancer Metastasis Rev 21:3-16. 2002
    ..The model predicts that the critical prostate carcinogens will be those that are substrates for GSTP1 detoxification and are associated with high prostate cancer risk diet and lifestyle habits...
  16. pmc Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramatically
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
    Am J Pathol 164:1523-9. 2004
    ....
  17. pmc Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation
    Srinivasan Yegnasubramanian
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 1650 Orleans Street, CRB 116, Baltimore, MD 21231, USA
    Nucleic Acids Res 34:e19. 2006
    ..This novel technology could significantly improve our ability to detect CGI hypermethylation...
  18. ncbi request reprint Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma
    Ai Ying Chuang
    Department of Pathology, Koo Foundation Sun Yat Sen Cancer Center, Taipei, Taiwan
    Am J Surg Pathol 31:1246-55. 2007
    ..1, and pPSA are useful when high-grade prostate cancer is suspected based on the morphology or clinical findings, yet shows negative or equivocal PSA staining. HMWCK and p63 are superior to the novel markers thrombomodulin and S100P...
  19. pmc Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing
    Karen Sandell Sfanos
    Department of Urology, James Buchanan Brady Urological Institute, MD, USA
    Clin Cancer Res 14:3254-61. 2008
    ..Little is known about the phenotype of these cells, despite accumulating evidence suggesting a potential role for chronic inflammation in the etiology of prostate cancer...
  20. ncbi request reprint Epithelial architectural destruction is necessary for bone marrow derived cell contribution to regenerating prostate epithelium
    Ganesh S Palapattu
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Urol 176:813-8. 2006
    ....
  21. pmc Gene expression profiling identifies clinically relevant subtypes of prostate cancer
    Jacques Lapointe
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:811-6. 2004
    ..Our results suggest that prostate tumors can be usefully classified according to their gene expression patterns, and these tumor subtypes may provide a basis for improved prognostication and treatment stratification...
  22. ncbi request reprint Pathological and molecular aspects of prostate cancer
    Angelo M DeMarzo
    Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Lancet 361:955-64. 2003
    ..Changed gene expression (eg, proliferation-related genes, changes in the androgen receptor, apoptosis and stress-response genes) have potential as biomarkers and therapeutic targets in prostate cancer...
  23. ncbi request reprint Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney
    Samson W Fine
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 30:1554-60. 2006
    ..Pathologists must be aware of the spectrum of histologic findings within MTSCs to ensure their accurate diagnosis...
  24. ncbi request reprint Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 32:321-5. 2002
    ..009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent...
  25. ncbi request reprint Immunohistochemical staining of precursor forms of prostate-specific antigen (proPSA) in metastatic prostate cancer
    Anil V Parwani
    Division of Pathology Informatics and Genito Urinary Pathology, Univeristy of Pittsburgh Medical Center Shadyside Hospital, Department of Pathology, Pittsburgh, PA 15232, USA
    Am J Surg Pathol 30:1231-6. 2006
    ..A panel of markers, including proPSA, should be performed when metastatic prostate carcinoma is in the differential diagnosis...

Research Grants4

  1. MOLECULAR PATHOLOGY OF STEM CELLS IN CANCER
    Angelo Demarzo; Fiscal Year: 2002
    ..These studies should produce new insights into altered stem cell maturation in BPH, PIN and carcinoma, and may provide new molecular targets for diagnosis, prognosis and treatment of prostate cancer. ..
  2. INFLAMMATION AND ATROPHY IN PROSTATE CARCINOGENESIS
    Angelo Demarzo; Fiscal Year: 2003
    ..Finally, new emphasis would be focused on finding the cause of chronic inflammation in the prostate with an aim towards its eradication. ..