Genomes and Genes
Angelo De Marzo
Affiliation: Johns Hopkins University
- Focus on prostate cancerWilliam Isaacs
Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Cell 2:113-6. 2002
- New concepts in the pathology of prostatic epithelial carcinogenesisA M De Marzo
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Urology 57:103-14. 2001..In this review, therefore, we also present our recent immune-mediated oxidant injury and regeneration hypothesis of why and how the prostate is targeted for carcinogenesis...
- Human prostate cancer precursors and pathobiologyAngelo M De Marzo
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
Urology 62:55-62. 2003..Additional results show that AMACR may be an important new marker of prostate cancer, and its use in combination with p63 staining may provide the basis for an improved method for identification of prostate cancer...
- Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanismsCheryl M Koh
Departments of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
Oncotarget 2:669-83. 2011..Further, the results implicate EZH2-driven mechanisms by which Myc may stimulate prostate tumor initiation and disease progression...
- Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylationM Uemura
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Oncogene 31:1254-63. 2012..Rather, rRNA levels and nucleolar size and number relate more closely to MYC overexpression...
- MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cellsTsuyoshi Iwata
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e9427. 2010..We also identified a novel histopathologically identifiable intermediate step prior to invasion that should facilitate studies of molecular pathway alterations occurring during early progression of prostatic adenocarcinomas...
- The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activationJoseph P Garay
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Breast Cancer Res 14:R27. 2012..In addition, many breast cancers co-express other steroid hormone receptors that can affect AR signaling, further obfuscating the effects of androgens on breast cancer cells...
- Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9Dengfeng Cao
Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
Breast Cancer Res 10:R91. 2008..Global gene expression profiling of LCIS has not been performed...
- Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequencesSrinivasan Yegnasubramanian
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
BMC Genomics 12:313. 2011..This MBD-chip approach was used to characterize DNA methylation patterns across all non-repetitive sequences of human chromosomes 21 and 22 at high-resolution in normal and malignant prostate cells...
- Inflammation, atrophy, and prostate carcinogenesisAngelo M De Marzo
Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA
Urol Oncol 25:398-400. 2007..Additional epidemiological, molecular pathological, and animal model work needs to be done to determine whether inflammation and atrophy are "driving" prostate carcinogenesis...
- A working group classification of focal prostate atrophy lesionsAngelo M De Marzo
Johns Hopkins University School of Medicine, USA
Am J Surg Pathol 30:1281-91. 2006..In conclusion, these criteria for variants of focal prostate atrophy may facilitate studies to examine the relation between various patterns of prostate atrophy and prostate cancer...
- Prostate cancer: New answers prompt new questions regarding cell of originAngelo M De Marzo
The Brady Urological Research Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Nat Rev Urol 7:650-2. 2010..However, these results are not mutually exclusive: there are potential solutions, and alternative views on the initiating cell derivation of prostate tumors also exist...
- Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatmentAngelo M De Marzo
Department of Oncology, The Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231 1000, USA
J Cell Biochem 91:459-77. 2004..We also present the implications of these changes for prostate cancer diagnosis, detection, prevention, and treatment...
- Inflammation in prostate carcinogenesisAngelo M De Marzo
Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA
Nat Rev Cancer 7:256-69. 2007....
- Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytologyKazutoshi Fujita
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Hum Pathol 40:924-33. 2009..1, nucleolin, and 4'-6-diamidino-2-phenylindole to detect prostate cancer cells in urine. Further refinements in marker selection and technique may increase sensitivity and applicability for prostate cancer diagnosis...
- Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarrayAnirban Maitra
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mod Pathol 16:902-12. 2003....
- A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathwayAshley Cimino-Mathews
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA Electronic address
Hum Pathol 44:2494-500. 2013..These and other mechanisms may contribute to the increased proliferation in malignant phyllodes relative to other fibroepithelial neoplasms. ..
- Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramaticallyElizabeth Montgomery
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
Am J Pathol 164:1523-9. 2004....
- The diet, prostate inflammation, and the development of prostate cancerWilliam G Nelson
The Sidney Kimmel Cancer Center at Johns Hopkins, Baltimore, MD, USA
Cancer Metastasis Rev 21:3-16. 2002..The model predicts that the critical prostate carcinogens will be those that are substrates for GSTP1 detoxification and are associated with high prostate cancer risk diet and lifestyle habits...
- Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylationSrinivasan Yegnasubramanian
Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine 1650 Orleans Street, CRB 116, Baltimore, MD 21231, USA
Nucleic Acids Res 34:e19. 2006..This novel technology could significantly improve our ability to detect CGI hypermethylation...
- Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer riskJianfeng Xu
Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Nat Genet 32:321-5. 2002..009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent...
- Pathological and molecular aspects of prostate cancerAngelo M DeMarzo
Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Lancet 361:955-64. 2003..Changed gene expression (eg, proliferation-related genes, changes in the androgen receptor, apoptosis and stress-response genes) have potential as biomarkers and therapeutic targets in prostate cancer...
- Gene expression profiling identifies clinically relevant subtypes of prostate cancerJacques Lapointe
Department of Pathology, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 101:811-6. 2004..Our results suggest that prostate tumors can be usefully classified according to their gene expression patterns, and these tumor subtypes may provide a basis for improved prognostication and treatment stratification...
- Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinomaAi Ying Chuang
Department of Pathology, Koo Foundation Sun Yat Sen Cancer Center, Taipei, Taiwan
Am J Surg Pathol 31:1246-55. 2007..1, and pPSA are useful when high-grade prostate cancer is suspected based on the morphology or clinical findings, yet shows negative or equivocal PSA staining. HMWCK and p63 are superior to the novel markers thrombomodulin and S100P...
- Epithelial architectural destruction is necessary for bone marrow derived cell contribution to regenerating prostate epitheliumGanesh S Palapattu
Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
J Urol 176:813-8. 2006....
- Immunohistochemical staining of precursor forms of prostate-specific antigen (proPSA) in metastatic prostate cancerAnil V Parwani
Division of Pathology Informatics and Genito Urinary Pathology, Univeristy of Pittsburgh Medical Center Shadyside Hospital, Department of Pathology, Pittsburgh, PA 15232, USA
Am J Surg Pathol 30:1231-6. 2006..A panel of markers, including proPSA, should be performed when metastatic prostate carcinoma is in the differential diagnosis...
- Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewingKaren Sandell Sfanos
Department of Urology, James Buchanan Brady Urological Institute, MD, USA
Clin Cancer Res 14:3254-61. 2008..Little is known about the phenotype of these cells, despite accumulating evidence suggesting a potential role for chronic inflammation in the etiology of prostate cancer...
- Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidneySamson W Fine
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Am J Surg Pathol 30:1554-60. 2006..Pathologists must be aware of the spectrum of histologic findings within MTSCs to ensure their accurate diagnosis...
- MOLECULAR PATHOLOGY OF STEM CELLS IN CANCERAngelo Demarzo; Fiscal Year: 2002..These studies should produce new insights into altered stem cell maturation in BPH, PIN and carcinoma, and may provide new molecular targets for diagnosis, prognosis and treatment of prostate cancer. ..
- INFLAMMATION AND ATROPHY IN PROSTATE CARCINOGENESISAngelo Demarzo; Fiscal Year: 2003..Finally, new emphasis would be focused on finding the cause of chronic inflammation in the prostate with an aim towards its eradication. ..