Valeria Culotta

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Analysis of hypoxia and hypoxia-like states through metabolite profiling
    Julie E Gleason
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e24741. 2011
  2. pmc Manganese complexes: diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast
    Valeria C Culotta
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Antioxid Redox Signal 19:933-44. 2013
  3. ncbi request reprint Speaking from the heart: systemic copper signaling
    Valeria Culotta
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, E7626, Baltimore, MD 21205, USA
    Cell Metab 11:343-4. 2010
  4. pmc Activation of superoxide dismutases: putting the metal to the pedal
    Valeria Cizewski Culotta
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1763:747-58. 2006
  5. pmc Manganese transport and trafficking: lessons learned from Saccharomyces cerevisiae
    Valeria Cizewski Culotta
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Room E7626, Baltimore, MD 21205, USA
    Eukaryot Cell 4:1159-65. 2005
  6. ncbi request reprint Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron
    Laran T Jensen
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Mol Biol 318:251-60. 2002
  7. ncbi request reprint Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria
    Lori Sturtz Field
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 278:28052-9. 2003
  8. ncbi request reprint Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae
    Edward Luk
    Environmental Health Sciences and Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 280:22715-20. 2005
  9. pmc Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone
    Mark C Carroll
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 101:5964-9. 2004
  10. pmc Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family
    Edward Luk
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:10353-7. 2003

Research Grants

  1. Gordon Conferecnce on Oxidative Stress and Disease
    Valeria Culotta; Fiscal Year: 2003
  2. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 2004
  3. 2005 Oxidative Stress and Disease
    Valeria Culotta; Fiscal Year: 2005
  4. Intracellular Pathways of Manganese Trafficking
    Valeria Culotta; Fiscal Year: 2007
  5. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 2007
  6. Intracellular Pathways of Manganese Trafficking
    Valeria Culotta; Fiscal Year: 2009
  7. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 1993
  8. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 2000
  9. INTRACELLULAR PATHWAYS OF COPPER TRAFFICKING
    Valeria Culotta; Fiscal Year: 2001
  10. Intracellular Pathways of Manganese Trafficking
    Valeria C Culotta; Fiscal Year: 2010

Collaborators

  • Laran T Jensen
  • Michael J Daly
  • JOAN VALENTINE
  • Edward Luk
  • Lori Sturtz Field
  • Julie E Gleason
  • Mark C Carroll
  • Rajaa El Meskini
  • Matthew E Portnoy
  • Lori A Sturtz
  • Amit R Reddi
  • Lauren A McGinnis
  • David J Corrigan
  • James E Cox
  • Mei Yang
  • Yves Bourbonnais
  • Phillip C Wong
  • Janella L Ulloa
  • Jamuna R Subramaniam
  • Jody B Girouard
  • Yoshiaki Furukawa
  • Michelle Baker
  • THOMAS V O'HALLORAN
  • Betty A Eipper
  • Mark Carroll
  • Richard E Mains

Detail Information

Publications17

  1. pmc Analysis of hypoxia and hypoxia-like states through metabolite profiling
    Julie E Gleason
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e24741. 2011
    ..Although much is known about the transcriptional response to hypoxia and cobalt, little is known about the all-important cell metabolism effects that trigger these responses...
  2. pmc Manganese complexes: diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast
    Valeria C Culotta
    Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Antioxid Redox Signal 19:933-44. 2013
    ..Accumulated metabolites can direct reactivity of Mn²⁺ with superoxide and specifically shield proteins from oxidative damage...
  3. ncbi request reprint Speaking from the heart: systemic copper signaling
    Valeria Culotta
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, E7626, Baltimore, MD 21205, USA
    Cell Metab 11:343-4. 2010
    ..In a mouse model for cardiac copper deficiency, a serum-carried signal mobilized liver and intestinal copper by inducing ATP7A, a copper-exporting ATPase...
  4. pmc Activation of superoxide dismutases: putting the metal to the pedal
    Valeria Cizewski Culotta
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1763:747-58. 2006
    ..Accurate and regulated metallation of copper and manganese SOD molecules is vital to cell survival in an oxygenated environment...
  5. pmc Manganese transport and trafficking: lessons learned from Saccharomyces cerevisiae
    Valeria Cizewski Culotta
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Room E7626, Baltimore, MD 21205, USA
    Eukaryot Cell 4:1159-65. 2005
  6. ncbi request reprint Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron
    Laran T Jensen
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Mol Biol 318:251-60. 2002
    ..cerevisiae SMF3, proposed to function in vacuolar iron transport. This oxygen control of iron transporter gene expression is part of an adaptation response to changes in the redox state of transition metals...
  7. ncbi request reprint Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria
    Lori Sturtz Field
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 278:28052-9. 2003
    ..A model for how CCS-mediated post-translational modification of SOD1 controls its partitioning between the mitochondria and cytosol will be presented...
  8. ncbi request reprint Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae
    Edward Luk
    Environmental Health Sciences and Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 280:22715-20. 2005
    ..We propose a model in which the insertion of manganese into eukaryotic SOD2 molecules is driven by the protein unfolding process associated with mitochondrial import...
  9. pmc Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone
    Mark C Carroll
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 101:5964-9. 2004
    ..The possible implications of multiple pathways for SOD1 activation are discussed in the context of SOD1 evolutionary biology and familial amyotrophic lateral sclerosis...
  10. pmc Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family
    Edward Luk
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:10353-7. 2003
    ..We propose that Mtm1p functions in the mitochondrial activation of SOD2 by specifically facilitating insertion of the essential manganese cofactor...
  11. ncbi request reprint Copper chaperones: personal escorts for metal ions
    Lori Sturtz Field
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Bioenerg Biomembr 34:373-9. 2002
    ..In particular, emphasis will be placed on the ATX1 and CCS copper chaperones that act to deliver copper to the secretory pathway and to Cu/Zn superoxide dismutase in the cytosol, respectively...
  12. ncbi request reprint Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes and oxidative stress relevant to Cu,Zn superoxide dismutase
    Laran T Jensen
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 279:29938-43. 2004
    ..By comparison, the sod1Delta lysine auxotrophy appears to be reversed in the seo mutants by increased expression of genes in the lysine biosynthetic pathway, perhaps through sensing of mitochondrial damage by the retrograde response...
  13. ncbi request reprint The Saccharomyces cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis
    Laran T Jensen
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe Street, Rm 7032, Baltimore, MD 21205, USA
    J Biol Chem 278:42036-40. 2003
    ..We conclude that Pho84p plays a role in manganese homeostasis predominantly under manganese surplus conditions and appears to be functioning as a low affinity metal transporter...
  14. ncbi request reprint Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS
    Laran T Jensen
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 280:41373-9. 2005
    ..Overall, these studies demonstrate that the CuZn-SODs of C. elegans have uniquely evolved to acquire copper without the copper chaperone and this may reflect the lifestyle of this organism...
  15. ncbi request reprint Superoxide dismutase null mutants of baker's yeast, Saccharomyces cerevisiae
    Lori A Sturtz
    Division of Toxicological Sciences, Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Methods Enzymol 349:167-72. 2002
  16. pmc The distinct methods by which manganese and iron regulate the Nramp transporters in yeast
    Matthew E Portnoy
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, U S A
    Biochem J 362:119-24. 2002
    ..Together with the promoter mapping studies, these results suggest that both Aft-dependent and Aft-independent pathways may contribute to iron regulation of SMF3...
  17. ncbi request reprint Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase
    Rajaa El Meskini
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    J Biol Chem 278:12278-84. 2003
    ..Similarly, production of active PHM in mouse fibroblasts is impaired in the presence of a mutant ATP7A gene. Although delivery of copper to lumenal cuproproteins like PAM involves ATP7A, lumenal chaperones may not be required...

Research Grants29

  1. Gordon Conferecnce on Oxidative Stress and Disease
    Valeria Culotta; Fiscal Year: 2003
    ..Funds are requested to support the travel and meeting expenses of the invited speakers and discussion leaders as well as 10 junior investigators that apply to the meeting. ..
  2. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 2004
    ..We will now test whether this pathway occurs in mitochondria and will employ yeast genetics to identify factor(s) other than CCS that activate mammalian SOD1 with copper. ..
  3. 2005 Oxidative Stress and Disease
    Valeria Culotta; Fiscal Year: 2005
    ..The detailed program and rationale presented within this project description supports the objective of this proposal being to obtain funds sufficient to cover this important international scientific meeting. ..
  4. Intracellular Pathways of Manganese Trafficking
    Valeria Culotta; Fiscal Year: 2007
    ..Overall, these studies will combine diverse disciplines of yeast molecular genetics, biochemistry and cell biology to provide new insight into the homeostasis of essential, but potentially toxic manganese ions. ..
  5. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 2007
    ..Together, these studies in both yeast and mammalian cells promise to shed new light into the biology of SOD1 and its metallochaperone CCS with important implications to disease. ..
  6. Intracellular Pathways of Manganese Trafficking
    Valeria Culotta; Fiscal Year: 2009
    ..Overall, this multi-disciplinary approach to understanding manganese ion biology should provide novel insight into the homeostasis of a toxic nutrient. ..
  7. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 1993
    ..Conceivably, these findings could ultimately foster the development of new pharmacological methods for treating the various disorders attributed to oxygen free radicals...
  8. GENETIC DETERMINANTS OF OXYGEN TOXICITY
    Valeria Culotta; Fiscal Year: 2000
    ..Overall, these studies promise to provide new information regarding the natural role of Sod1 in cell metabolism, and the findings obtained with yeast should be readily extrapolated to more complex organisms, including man. ..
  9. INTRACELLULAR PATHWAYS OF COPPER TRAFFICKING
    Valeria Culotta; Fiscal Year: 2001
    ..Overall, we believe that these studies in yeast will provide new important information regarding the complex pathways of copper trafficking in eukaryotes that serve to control the homeostasis of this important redox active metal. ..
  10. Intracellular Pathways of Manganese Trafficking
    Valeria C Culotta; Fiscal Year: 2010
    ..Overall, this multi-disciplinary approach to understanding manganese ion biology should provide novel insight into the homeostasis of a toxic nutrient. ..