T O Crawford
Affiliation: Johns Hopkins University
- Evaluation of SMN protein, transcript, and copy number in the biomarkers for spinal muscular atrophy (BforSMA) clinical studyThomas O Crawford
Departments of Neurology and Pediatrics, The Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS ONE 7:e33572. 2012..Early disappointments from putative SMN-enhancing agent clinical trials have increased interest in improving the assessment of SMN expression in blood as an early "biomarker" of treatment effect...
- Safety and caregiver satisfaction with gastrostomy in patients with Ataxia TelangiectasiaMaureen A Lefton-Greif
The Ataxia Telangiectasia Clinical Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Orphanet J Rare Dis 6:23. 2011..The primary purposes of this study were to determine whether GT placement in patients with A-T would be tolerated and associated with caregiver satisfaction...
- Prevalence and distribution of regional scar in dysfunctional myocardial segments in Duchenne muscular dystrophyKenneth C Bilchick
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
J Cardiovasc Magn Reson 13:20. 2011....
- Extrapyramidal signs in normal pressure hydrocephalus: an objective assessmentAllen S Mandir
Johns Hopkins University, Department of Neurology and Neurosurgery, Baltimore, MD 21287, USA
Cerebrospinal Fluid Res 4:7. 2007..Concentrated evaluation of these profound, yet underappreciated movement disorders of NPH before and after techniques of therapeutic intervention may lead to improved diagnosis, insight into pathophysiology, and targeted treatment...
- Survival probability in ataxia telangiectasiaT O Crawford
Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Arch Dis Child 91:610-1. 2006..Median survival in two large cohorts of patients with this disease, one prospective and one retrospective, is 25 and 19 years, with a wide range. Life expectancy does not correlate well with severity of neurological impairment...
- Quantitative proton MR spectroscopic imaging in acute disseminated encephalomyelitisA Bizzi
Russell C. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, Maryland 21287, USA
AJNR Am J Neuroradiol 22:1125-30. 2001..This case demonstrates that reduced levels of NAA are not always associated with neuronal loss, irreversible tissue damage, or poor neurologic outcome...
- Toxic neuropathy in patients with pre-existing neuropathyV Chaudhry
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurology 60:337-40. 2003..The authors conclude that functionally disabling toxic neuropathy can occur in patients with pre-existing neuropathy at standard doses...
- Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disordersE L Finanger Hedderick
Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway BRB 529, Baltimore, MD 21205, USA
Neurology 76:960-7. 2011..Our objectives were to characterize further the range of patients manifesting aberrant nNOS sarcolemmal immunolocalization and to study nNOS localization in animal models of nondystrophic myopathy...
- Stimulation single-fiber EMG in infant botulismV Chaudhry
Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 6 119, Baltimore, Maryland 21287, USA
Muscle Nerve 22:1698-703. 1999..Compared to baseline study at 2 Hz (100%), the mean percent changes in jitter at 5, 10, and 20 Hz were 109, 60, and 47, respectively. This is the first report of the usefulness of S-SFEMG in the diagnosis of infant botulism...
- Proton MR spectroscopic imaging in ataxia-telangiectasiaD D M Lin
Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neuropediatrics 37:241-6. 2006....
- Gaze fixation deficits and their implication in ataxia-telangiectasiaA G Shaikh
Department of Neurology, The Johns Hopkins University, Baltimore, Maryland, USA
J Neurol Neurosurg Psychiatry 80:858-64. 2009..Unstable fixation often leads to difficulty reading and blurred vision. Here we characterise the disturbance of visual fixation in A-T...