Andrea L Cox

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection
    Alleluiah Rutebemberwa
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 181:8215-25. 2008
  2. pmc Hepatitis C virus vaccines among people who inject drugs
    Andrea L Cox
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Clin Infect Dis 57:S46-50. 2013
  3. doi request reprint Making sense of HIV innate sensing
    Andrea L Cox
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Immunity 39:998-1000. 2013
  4. ncbi request reprint Prospective evaluation of community-acquired acute-phase hepatitis C virus infection
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Infect Dis 40:951-8. 2005
  5. pmc Cellular immune selection with hepatitis C virus persistence in humans
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Exp Med 201:1741-52. 2005
  6. pmc Immunogenicity and cross-reactivity of a representative ancestral sequence in hepatitis C virus infection
    Kelly P Burke
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Immunol 188:5177-88. 2012
  7. pmc Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection
    Lin Liu
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, 855 N Wolfe St, Suite 530, Baltimore, MD 21205, USA
    J Virol 84:5067-77. 2010
  8. pmc Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection
    William O Osburn
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Gastroenterology 138:315-24. 2010
  9. pmc Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses
    William O Osburn
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD
    Hepatology 59:2140-51. 2014
  10. pmc Spontaneous clearance of primary acute hepatitis C virus infection correlated with high initial viral RNA level and rapid HVR1 evolution
    Lin Liu
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Hepatology 55:1684-91. 2012

Collaborators

Detail Information

Publications23

  1. pmc High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection
    Alleluiah Rutebemberwa
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 181:8215-25. 2008
    ..These results support the idea that PD-1 expression on T cells specific for nonescaped epitopes contributes to viral persistence and suggest that PD-1 blockade may alter the outcome of HCV infection...
  2. pmc Hepatitis C virus vaccines among people who inject drugs
    Andrea L Cox
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Clin Infect Dis 57:S46-50. 2013
    ..However, the first HCV vaccine trial in at-risk HCV-uninfected PWID was initiated in 2012. The results will likely guide future vaccine development and strategies for vaccination of this and other high-risk populations. ..
  3. doi request reprint Making sense of HIV innate sensing
    Andrea L Cox
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Electronic address
    Immunity 39:998-1000. 2013
    ..In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by the DNA sensor cCAS and contribute to differential pathogenesis of HIV-1 and HIV-2...
  4. ncbi request reprint Prospective evaluation of community-acquired acute-phase hepatitis C virus infection
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Infect Dis 40:951-8. 2005
    ....
  5. pmc Cellular immune selection with hepatitis C virus persistence in humans
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Exp Med 201:1741-52. 2005
    ..015). These findings reveal two distinct mechanisms of sequence evolution involved in HCV persistence: viral escape from CD8+ T cell responses and optimization of replicative capacity...
  6. pmc Immunogenicity and cross-reactivity of a representative ancestral sequence in hepatitis C virus infection
    Kelly P Burke
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Immunol 188:5177-88. 2012
    ..These data support the use of representative sequence in HCV vaccine design...
  7. pmc Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection
    Lin Liu
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, 855 N Wolfe St, Suite 530, Baltimore, MD 21205, USA
    J Virol 84:5067-77. 2010
    ..These data provide the first systematic estimates of HCV evolutionary rates in multiple genes during early infection in vivo and provide additional evidence for deterministic, rather than random, evolution of HCV...
  8. pmc Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection
    William O Osburn
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Gastroenterology 138:315-24. 2010
    ..We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections...
  9. pmc Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses
    William O Osburn
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD
    Hepatology 59:2140-51. 2014
    ..Also, individual library HCVpp neutralization sensitivity was not associated with any known E2 sequence determinants. Interestingly, two single nucleotide polymorphisms in the HLA-DQ locus were associated with nAb breadth...
  10. pmc Spontaneous clearance of primary acute hepatitis C virus infection correlated with high initial viral RNA level and rapid HVR1 evolution
    Lin Liu
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Hepatology 55:1684-91. 2012
    ..All major substitutions in HVR1 in persistence subjects were convergent changes, whereas over the same time interval clearance subjects displayed divergent evolution, indicating different immune responses between the two groups...
  11. pmc Computational reconstruction of Bole1a, a representative synthetic hepatitis C virus subtype 1a genome
    Supriya Munshaw
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Virol 86:5915-21. 2012
    ..In this study, we demonstrate that a rationally designed, fully synthetic HCV genome contains representative epitopes and envelope genes that assemble properly and mediate entry into target cells...
  12. pmc Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus
    Kimberly A Dowd
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 136:2377-86. 2009
    ....
  13. pmc Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C
    Andrea L Cox
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hepatology 42:104-12. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  14. pmc High plasma interleukin-18 levels mark the acute phase of hepatitis C virus infection
    Michael A Chattergoon
    Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 204:1730-40. 2011
    ..Large-scale genome studies have found correlations between single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 18 promoter and spontaneous control of hepatitis C virus (HCV), suggesting a role in clearance...
  15. ncbi request reprint CD4+ T cell-dependent reduction in hepatitis C virus-specific humoral immune responses after HIV infection
    Dale M Netski
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, 21231, USA
    J Infect Dis 195:857-63. 2007
    ..These disease interactions may result in part from impairment of B cell function, which is CD4(+) T cell dependent...
  16. pmc Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts
    Priya Duggal
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 158:235-45. 2013
    ..Chinese translation..
  17. pmc Immunity and hepatitis C: a review
    Rebecca R Terilli
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Rangos Building, Suite 536, 855 N Wolfe St, Baltimore, MD 21205, USA
    Curr HIV/AIDS Rep 10:51-8. 2013
    ..Further defining the interaction between hepatitis C and the host immune system will potentially reveal insights into HCV pathogenesis and the host's ability to prevent persistent infection, as well as direct the development of vaccines...
  18. pmc Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
    Ashwin Balagopal
    Division of Infectious Diseases, Viral Hepatitis Center, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Gastroenterology 135:226-33. 2008
    ..We hypothesized that HIV promotes liver disease by enhancing microbial translocation...
  19. pmc Hepatitis C virus evasion of adaptive immune responses: a model for viral persistence
    Kelly P Burke
    Johns Hopkins University School of Medicine, Rangos Building, Suite 536, Baltimore, MD 21205, USA
    Immunol Res 47:216-27. 2010
    ..Understanding what constitutes an effective immune response in the control of HCV may enable the development of prophylactic and therapeutic vaccines for HCV and other chronic viral infections...
  20. pmc HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon
    Michael A Chattergoon
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Pathog 10:e1004082. 2014
    ..inflammasome pathways of inflammation. ..
  21. pmc Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro
    Lucy Golden-Mason
    Department of Medicine, Division of GI Hepatology, University of Colorado Denver, Aurora, CO, USA
    Hepatology 52:1581-9. 2010
    ..Using the JFH-1 infection system, we demonstrated that NKp30(high) cells in the absence of exogenous stimulation significantly reduce infection of hepatocytes...
  22. pmc Cohort Profile: The International Collaboration of Incident HIV and Hepatitis C in Injecting Cohorts (InC3) Study
    Jason Grebely
    The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, New South Wales, Australia, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA, CRCHUM, Universite de Montreal, Montreal, Quebec, Canada, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA, Harvard Medical School, Boston, MA, USA, Tufts Medical School, Boston, MA, USA, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia, Burnet Institute, Melbourne, Victoria, Australia, Cluster Infectious Diseases, Public Health Service, Amsterdam, Netherlands and Department of Internal Medicine, Academic Medical Center, Center for Infection and Immunity, Amsterdam, Netherlands
    Int J Epidemiol 42:1649-59. 2013
    ..Potential collaborators should contact the InC(3) PI Dr Kimberley Page (kPage@psg.ucsf.edu) for further information. ..
  23. ncbi request reprint Pillars article: Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992. 255: 1261-1263
    Donald F Hunt
    J Immunol 179:2669-71. 2007

Research Grants4

  1. Incident HIV Infection and Immune Response to Hepatitis C Virus
    Andrea Cox; Fiscal Year: 2007
    ..This, along with excellent mentorship and the supportive and rich environment at JHU, will provide Dr. Cox with the skills she needs to develop into an independent researcher studying HIV/HCV coinfection immunology. ..
  2. Mechanisms of Immune Evasion by Hepatitis C Virus
    Andrea Cox; Fiscal Year: 2009
    ....
  3. Mechanisms of Immune Evasion by Hepatitis C Virus
    Andrea L Cox; Fiscal Year: 2010
    ....
  4. Mechanisms of Immune Evasion by Hepatitis C Virus
    Andrea L Cox; Fiscal Year: 2010
    ....