Research Topics
Species | J CoreshSummaryAffiliation: Johns Hopkins University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Stability of haemoglobin A1c (HbA1c) measurements from frozen whole blood samples stored for over a decadeE Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
Diabet Med 22:1726-30. 2005..We undertook this study to assess the reproducibility of HbA1c measurements from whole blood samples that had been in storage at -70 degrees C for over a decade...
Uromodulin concentrations are not associated with incident CKD among persons with coronary artery diseaseMichael G Shlipak
San Francisco VA Medical Center, CA, USA
BMC Nephrol 12:2. 2011..This study within persons with known coronary artery disease (CAD) evaluated whether uromodulin concentrations could distinguish CKD risk...
Timing, causes, predictors and prognosis of switching from peritoneal dialysis to hemodialysis: a prospective studyBernard G Jaar
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
BMC Nephrol 10:3. 2009....
Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) studyCharles C Hsu
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
BMC Med Genet 12:16. 2011..Our aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP...
Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic StudyAudrey Y Chu
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
BMC Med Genet 10:108. 2009..However, few data are available in non-European ethnic groups or in a population-based cohort...
Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities StudiesAnna Kottgen
Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
BMC Med Genet 9:49. 2008..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples...
Attainment of clinical performance targets and improvement in clinical outcomes and resource use in hemodialysis care: a prospective cohort studyLaura C Plantinga
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
BMC Health Serv Res 7:5. 2007....
Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination SurveyJosef Coresh
Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
Am J Kidney Dis 41:1-12. 2003....
Prevalence of chronic kidney disease in the United StatesJosef Coresh
Department of Epidemiology, Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland 21287, USA
JAMA 298:2038-47. 2007..Whether there have been changes in the prevalence of earlier stages of chronic kidney disease (CKD) during this period is uncertain...
Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rateJosef Coresh
Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
Am J Kidney Dis 39:920-9. 2002..73 m2), but result in progressively larger differences at higher GFRs. Both clinical and research use of serum creatinine or equations to estimate GFR require knowledge of the calibration of the serum creatinine assay...
Kidney function estimating equations: where do we stand?Josef Coresh
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Curr Opin Nephrol Hypertens 15:276-84. 2006..This review summarizes recent data on the performance of equations using serum creatinine to estimate the GFR, particularly the Modification of Diet in Renal Disease (MDRD) Study equation...
Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000Josef Coresh
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Am Soc Nephrol 16:180-8. 2005..Despite a high prevalence, CKD awareness in the U.S. population is low. In contrast to the dramatic increase in treated kidney failure, overall CKD prevalence in the U.S. population has been relatively stable...
Further trends in the etiology of end-stage renal disease in African-AmericansJ Coresh
Welch Center for Prevention, Epidemiology and Clinical Research, Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, USA
Curr Opin Nephrol Hypertens 6:243-9. 1997..Studies are underway to examine ethnic differences and risk factors for the earlier stages of renal disease as well as genetic mutations for non-Mendelian forms of end-stage renal disease...
Creatinine clearance as a measure of GFR in screenees for the African-American Study of Kidney Disease and Hypertension pilot studyJ Coresh
Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Kidney Dis 32:32-42. 1998....
Prevalence of high blood pressure and elevated serum creatinine level in the United States: findings from the third National Health and Nutrition Examination Survey (1988-1994)J Coresh
2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
Arch Intern Med 161:1207-16. 2001..The prevalence and incidence of end-stage renal disease in the United States are increasing, but milder renal disease is much more common and may often go undiagnosed and undertreated...
Evidence for increased cardiovascular disease risk in patients with chronic kidney diseaseJosef Coresh
Welch Center for Prevention, Epidemiology and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Curr Opin Nephrol Hypertens 13:73-81. 2004....
Reliability of GFR formulas based on serum creatinine, with special reference to the MDRD Study equationJosef Coresh
Welch Center for Prevention, Epidemiology and Clinical Research, Department of Epidemiology, Medicine and Biostatistics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Scand J Clin Lab Invest Suppl 241:30-8. 2008..Finally, algorithms are needed to tailor clinical practice based on data from GFR estimates and other participant characteristics, including the source population and level of proteinuria...
Timing of nephrologist referral and arteriovenous access use: the CHOICE StudyB C Astor
Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, Baltimore, MD, USA
Am J Kidney Dis 38:494-501. 2001..Thus, further efforts to improve both referral patterns and preparation for dialysis after referral are needed...
Serum creatinine levels in the US population: third National Health and Nutrition Examination SurveyC A Jones
Epidemiology, Clinical Trials, and End Stage Renal Disease and Minority Health Programs, DKUHD, NIDDK, NIH, Bethesda, MD 20892 6600, USA
Am J Kidney Dis 32:992-9. 1998..Until this information is known, the use of a single cutpoint to define elevated serum creatinine values may be misleading...
Serum cystatin C in the United States: the Third National Health and Nutrition Examination Survey (NHANES III)Anna Kottgen
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Am J Kidney Dis 51:385-94. 2008..However, information for serum cystatin C levels in the general population, specifically across a wide age range and different ethnicities, is lacking...
Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the United StatesDeidra C Crews
Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Hypertension 55:1102-9. 2010..37 [95% CI: 2.00 to 2.81]). Chronic kidney disease is prevalent in undiagnosed and prehypertension. Earlier identification and treatment of both these conditions may prevent or delay morbidity and mortality from chronic kidney disease...
Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US populationBrad C Astor
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Am J Epidemiol 167:1226-34. 2008..These data support recent recommendations defining chronic kidney disease and stratifying subsequent risks based on both decreased GFR and albuminuria...
CKD surveillance using laboratory data from the population-based National Health and Nutrition Examination Survey (NHANES)Alejandro F Castro
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
Am J Kidney Dis 53:S46-55. 2009..These survey data suggest that the prevalence of CKD has increased between 1988-1994 and 1999-2004. Surveillance for early stages of CKD (stages 1 to 4) should monitor these and other trends...
Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: a longitudinal studyM L Melamed
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Kidney Int 70:351-7. 2006..Promising new interventions need to be rigorously tested in clinical trials for their ability to achieve normalization of bone mineral parameters and reduce deaths of dialysis patients...
NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) studyA Y Chu
Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, USA
Diabetologia 53:510-6. 2010....
Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21201, USA
Am J Kidney Dis 53:596-605. 2009..Inflammation and hemostasis may increase the risk of kidney function decline; however, data from prospective studies are sparse...
Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004Elizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
Am J Kidney Dis 50:918-26. 2007....
Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European AmericansJ P Chretien
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Med Genet 43:917-23. 2006....
Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injuryMorgan E Grams
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Soc Nephrol 21:1757-64. 2010..Patterns persisted within subgroups of age, race, and gender. In summary, albuminuria and eGFR have strong, independent associations with incident AKI...
Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994)Brad C Astor
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Arch Intern Med 162:1401-8. 2002..Kidney failure is known to cause anemia, which is associated with a higher risk of cardiac failure and mortality. The impact of milder decreases in kidney function on hemoglobin levels and anemia in the US population, however, is unknown...
Prevalence of kidney disease in anaemia differs by GFR-estimating method: the Third National Health and Nutrition Examination Survey (1988-94)Michelle M Estrella
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Nephrol Dial Transplant 25:2542-8. 2010..Serum cystatin C is purportedly a more sensitive marker of kidney disease and a better predictor of mortality than serum creatinine. However, studies suggest that extrarenal factors also influence cystatin C levels...
History of myocardial infarction and stroke among incident end-stage renal disease cases and population-based controls: an analysis of shared risk factorsPaul Muntner
Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Am J Kidney Dis 40:323-30. 2002..A history of myocardial infarction (MI) and stroke is more common among incident cases of treated end-stage renal disease (ESRD) than in the general US population...
Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisKunihiro Matsushita
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
Lancet 375:2073-81. 2010..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality...
Lack of benefit for intravenous thrombolysis in patients with myocardial infarction who are older than 75 yearsD R Thiemann
Division of Cardiology, Carnegie 568, Johns Hopkins Hospital, Baltimore, MD 21287 6568, USA
Circulation 101:2239-46. 2000..There are no randomized trials of thrombolytic efficacy or observational studies of clinical effectiveness that focus specifically on the elderly...
Undertreatment of hyperlipidemia in a cohort of United States kidney dialysis patientsC S Fox
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21205, USA
Clin Nephrol 61:299-307. 2004..Whether improved rates of treatment will result in decreased cardiovascular disease events needs to be tested in randomized clinical trials...
Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adultsThomas P Erlinger
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Kidney Dis 42:256-63. 2003..Atherosclerosis and chronic kidney disease (CKD) share several common antecedents. However, the association between inflammatory markers and incident CKD is unknown...
Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: results from the atherosclerosis risk in communities studyPaul Muntner
Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Avenue, SL 18, New Orleans, LA 70112, USA
J Am Soc Nephrol 16:529-38. 2005..CHD risk factors in the general population remain predictive among patients with CKD. Given the high risk for CHD among patients with CKD, control of these risk factors may have a substantial impact on their excess burden of CHD...
TCF7L2 variants associate with CKD progression and renal function in population-based cohortsAnna Kottgen
Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
J Am Soc Nephrol 19:1989-99. 2008..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes...
Area socioeconomic status and progressive CKD: the Atherosclerosis Risk in Communities (ARIC) StudySharon Stein Merkin
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Kidney Dis 46:203-13. 2005..We conducted a cohort study of 12,856 Atherosclerosis Risk in Communities Study participants to examine the independent risk for progressive CKD associated with living in a low SES area...
Blood pressure, atherosclerosis, and albuminuria in 10,113 participants in the atherosclerosis risk in communities studyCharles C Hsu
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Hypertens 27:397-409. 2009..Albuminuria predicts cardiovascular risk, but its function as a marker of endothelial damage and atherosclerosis is uncertain, as is the complex relationship with hypertension and diabetes...
Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) StudyKunihiro Matsushita
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD 21287, USA
Am J Kidney Dis 55:648-59. 2010..Although the CKD-EPI equation estimates GFR more precisely compared with the MDRD Study equation, whether this equation improves risk prediction is unknown...
Age, gender, and race effects on cystatin C levels in US adolescentsDarcy Groesbeck
Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin J Am Soc Nephrol 3:1777-85. 2008....
Risk of incident ESRD: a comprehensive look at cardiovascular risk factors and 17 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
Am J Kidney Dis 55:31-41. 2010..Previous studies suggest that other cardiovascular risk factors also may increase the risk of ESRD; however, risk associated with a comprehensive cardiovascular risk-factor assessment has not been quantified in a population-based sample...
The contribution of increased diabetes prevalence and improved myocardial infarction and stroke survival to the increase in treated end-stage renal diseasePaul Muntner
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
J Am Soc Nephrol 14:1568-77. 2003..The increasing number of treated ESRD cases in the United States is partly explained by the increase in diabetes prevalence and US population growth but only minimally by MI and stroke survival...
Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney diseaseJoseph A Eustace
Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Kidney Int 65:1031-40. 2004..Low serum albumin is a strong risk factor for mortality, but its association with low serum bicarbonate and inflammation in the setting of mild to moderately decreased kidney function is uncertain...
Kidney function estimated from serum creatinine and cystatin C and peripheral arterial disease in NHANES 1999-2002Elizabeth Selvin
Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
Eur Heart J 30:1918-25. 2009..Serum cystatin C, a novel marker of kidney function, is reported to be superior to serum creatinine as a risk factor for atherosclerotic disease, but associations may vary across vascular beds...
Lipoprotein(a) and prevalent cardiovascular disease in a dialysis population: The Choices for Healthy Outcomes in Caring for ESRD (CHOICE) studyJ Craig Longenecker
Johns Hopkins University, Baltimore, MD, USA
Am J Kidney Dis 42:108-16. 2003..We studied the association of Lp(a) level and apo(a) size with prevalent atherosclerotic cardiovascular disease (ASCVD) in 871 incident dialysis patients (261 blacks, 565 whites, 45 other)...
Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, MarylandMelanie K Haroun
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Am Soc Nephrol 14:2934-41. 2003....
Heart rate variability predicts ESRD and CKD-related hospitalizationDaniel J Brotman
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Soc Nephrol 21:1560-70. 2010..These results suggest that autonomic dysfunction may be an important risk factor for ESRD and CKD-related hospitalizations and call for further studies to define the mechanisms that underlie these associations...
Individual and neighborhood socioeconomic status and progressive chronic kidney disease in an elderly population: The Cardiovascular Health StudySharon Stein Merkin
Johns Hopkins Bloomberg School of Public Health, The Welch Center for Prevention, Epidemiology and Clinical Research, Blatimore, MD 21205, USA
Soc Sci Med 65:809-21. 2007..As such, living in a low SES area is associated with greater risk of pCKD in an elderly US population...
Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE StudyJ Craig Longenecker
Johns Hopkins University School of Medicine, Suite 2 637, 2024 E Monument Street, Baltimore, MD 21205, USA
J Am Soc Nephrol 13:1918-27. 2002..In summary, many ASCVD risk factors are more prevalent in ESRD than in the general population and may explain some, but probably not all, of the increased ASCVD risk in ESRD...
Multiple loci associated with indices of renal function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 41:712-7. 2009..Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease...
Hepatitis C virus infection and incident type 2 diabetesShruti H Mehta
Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA
Hepatology 38:50-6. 2003..05-4.40). In conclusion, pre-existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Additional larger prospective evaluations are needed to confirm these preliminary findings...
Defining incident chronic kidney disease in the research setting: The ARIC StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
Am J Epidemiol 170:414-24. 2009..3, confidence interval: 4.4, 8.9). Associations with gender differed in direction and magnitude across definitions. Case definition can impact relative risk estimates for CKD risk factors...
Apolipoprotein E and progression of chronic kidney diseaseCharles C Hsu
Department of Epidemiology, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
JAMA 293:2892-9. 2005..APOE allelic associations with chronic kidney disease beyond diabetic nephropathy are unknown, with no studies reported in high-risk African American populations...
New loci associated with kidney function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 42:376-84. 2010..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adultsElizabeth Selvin
Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
N Engl J Med 362:800-11. 2010..Fasting glucose is the standard measure used to diagnose diabetes in the United States. Recently, glycated hemoglobin was also recommended for this purpose...
Race and sex differences in the distribution of cerebral atherosclerosisR J Wityk
Department of Medicine, Sinai Hospital of Baltimore, MD 21215, USA
Stroke 27:1974-80. 1996..Noninvasive techniques such as duplex ultrasound, transcranial Doppler (TCD), and magnetic resonance angiography (MRA) allow vascular assessment of a more representative proportion of patients than does conventional angiography alone...
Glycated haemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) studyA L Christman
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
Diabetologia 54:1645-52. 2011..This study aimed to examine the association between diabetes and hyperglycaemia-assessed by HbA(1c)-and change in cognitive function in persons with and without diabetes...
Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patientsLin Zhang
Department of Epidemiology, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Am Soc Nephrol 17:2285-92. 2006..008). Variation in the STAT3 gene is associated with the risk for CVD among white dialysis patients independent of serum IL-6 and CRP levels...
Glycaemia (haemoglobin A1c) and incident ischaemic stroke: the Atherosclerosis Risk in Communities (ARIC) StudyElizabeth Selvin
Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
Lancet Neurol 4:821-6. 2005..Haemoglobin A1c (HbA(1c)), a measure of long-term glycaemia, is strongly related to retinopathy, nephropathy, and neuropathy in diabetes. We sought to assess the association between HbA(1c) and stroke in people with and without diabetes...
Phosphate levels and blood pressure in incident hemodialysis patients: a longitudinal studyCindy Xin Huang
Johns Hopkins Sinai Hospital Program in Internal Medicine, Baltimore, MD, USA
Adv Chronic Kidney Dis 15:321-31. 2008..The effect of rigorous control of serum phosphate levels on arterial stiffness and blood pressure should be studied in clinical trials...
Glycemic control, atherosclerosis, and risk factors for cardiovascular disease in individuals with diabetes: the atherosclerosis risk in communities studyElizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
Diabetes Care 28:1965-73. 2005..This study examines the relationship between A1C, carotid intima-media thickness (IMT), and traditional cardiovascular risk factors in individuals with diabetes...
The association of sudden cardiac death with inflammation and other traditional risk factorsRulan S Parekh
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Kidney Int 74:1335-42. 2008..Hence, we found that sudden cardiac death is common among patients with end stage renal disease and that inflammation and malnutrition significantly increased its occurrence independent of traditional cardiovascular risk factors...
Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis Risk in Communities (ARIC) studyRebecca F Gottesman
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Stroke 41:3-8. 2010..We hypothesized that WMH progression would be (1) strongly related to BP in blacks and whites and (2) predicted more strongly by earlier (midlife) or cumulative BP measurements than by measures at older ages...
Patient awareness of chronic kidney disease: trends and predictorsLaura C Plantinga
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Arch Intern Med 168:2268-75. 2008..The impact of recent guidelines for early detection and prevention of chronic kidney disease (CKD) on patient awareness of disease and factors that might be associated with awareness have not been well described...
Poor glycemic control in diabetes and the risk of incident chronic kidney disease even in the absence of albuminuria and retinopathy: Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Arch Intern Med 168:2440-7. 2008....
Method of glomerular filtration rate estimation affects prediction of mortality riskBrad C Astor
Department of Epidemiology, Bloomberg School of Public Health, School of Medicine, Johns Hopkins University, Welch Center for Prevention, Baltimore, Maryland 21287, USA
J Am Soc Nephrol 20:2214-22. 2009..In conclusion, despite better performance in terms of estimating GFR, equations based on both cystatin C and creatinine do not predict mortality as well as equations based on cystatin C alone...
Association of kidney function and hemoglobin with left ventricular morphology among African Americans: the Atherosclerosis Risk in Communities (ARIC) studyBrad C Astor
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Kidney Dis 43:836-45. 2004..It is unknown whether kidney function and lower hemoglobin levels are associated with LV morphological characteristics among African Americans with moderate kidney dysfunction, independent of blood pressure...
Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutritionYongmei Liu
Johns Hopkins University, Baltimore, MD 21205, USA
JAMA 291:451-9. 2004..These findings support treatment of hypercholesterolemia in this population...
Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patientsC John Sperati
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Kidney Dis 53:845-55. 2009....
Blood pressure control among persons without and with chronic kidney disease: US trends and risk factors 1999-2006Laura C Plantinga
Departments of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Hypertension 54:47-56. 2009..Although some improvement has occurred over time, uncontrolled blood pressure remains highly prevalent, especially in subjects with chronic kidney disease and in nonwhites, older persons, and women. Therapy appears suboptimal...
Chronic kidney disease is common: what do we do next?Josef Coresh
Johns Hopkins Medical Institutions, Baltimore, USA
Nephrol Dial Transplant 23:1122-5. 2008
Blood lead and chronic kidney disease in the general United States population: results from NHANES IIIPaul Muntner
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
Kidney Int 63:1044-50. 2003..High lead exposure is associated with hypertension and renal dysfunction but the effect of low-level environmental exposure is not as well studied...
Associations between genetic variants in the ACE, AGT, AGTR1 and AGTR2 genes and renal function in the Multi-ethnic Study of AtherosclerosisCatherine Y Campbell
Johns Hopkins University, Baltimore, MD, USA
Am J Nephrol 32:156-62. 2010..Some studies suggest that polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen (AGT), angiotensin II type I receptor (AGTR1) and angiotensin II type II receptor (AGTR2) genes may contribute to renal function variation...
Imprecision of urinary iothalamate clearance as a gold-standard measure of GFR decreases the diagnostic accuracy of kidney function estimating equationsYuen Ting Diana Kwong
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD
Am J Kidney Dis 56:39-49. 2010..However, the influence of imprecise measured GFRs (mGFRs) on estimates of equation error is unknown...
Novel and traditional cardiovascular risk factors for peripheral arterial disease in incident-dialysis patientsBernard G Jaar
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Adv Chronic Kidney Dis 14:304-13. 2007..This study identifies several novel risk factors (eg, Lp(a) and total homocysteine) and underscores the need for further research to reduce the burden of PAD in this high-risk group of patients...
Evaluation of a novel isotope biomarker for dietary consumption of sweetsEdwina H Yeung
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Epidemiol 172:1045-52. 2010..Within the proper framework, serum δ¹³C value could be developed into an objective biomarker promoting more reliable assessment of dietary sweets intake...
SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities StudyMichael J Garant
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
Diabetes 51:231-7. 2002..We conclude from this large prospective study that the G allele of SNP43 of CAPN10 or another allele or gene that is in linkage disequilibrium with it increases susceptibility to type 2 diabetes in African-Americans...
Risk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the atherosclerosis risk in communities studySherita Hill Golden
Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Diabetes 51:3069-76. 2002..Interventions aimed at ameliorating the IRS may produce reductions in atherosclerotic risk beyond that predicted by treatment of individual IRS-related risk factors...
Retinal microvascular abnormalities and cognitive decline: the ARIC 14-year follow-up studyS R Lesage
University of Maryland Medical Center, Department of Neurology, 22 S Greene St, Baltimore, MD 21201, USA
Neurology 73:862-8. 2009..To better understand the role of SVD in cognitive function, we investigated the relationship between retinal microvascular abnormalities and longitudinal changes in cognitive function in a community-based study...
Associations of tibia lead, DMSA-chelatable lead, and blood lead with measures of peripheral nervous system function in former organolead manufacturing workersP L Tassler
Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
Am J Ind Med 39:254-61. 2001....
Comorbidity and other factors associated with modality selection in incident dialysis patients: the CHOICE Study. Choices for Healthy Outcomes in Caring for End-Stage Renal DiseaseDana C Miskulin
Division of Nephrology, New England Medical Center, Boston, MA 02111, USA
Am J Kidney Dis 39:324-36. 2002..Adjustment for case-mix differences in patients treated with PD versus HD is essential to the assessment of the independent effect of the dialysis modality on outcomes...
Microalbuminuria in the US population: third National Health and Nutrition Examination SurveyCamille A Jones
Division of Genetics and Epidemiology, Joslin Diabetes Center, Boston, MA, 02215, USA
Am J Kidney Dis 39:445-59. 2002..MA is common, even among persons without diabetes or hypertension. Age, sex, race/ethnicity, and concomitant disease contribute to the variability of MA prevalence estimates...
National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratificationAndrew S Levey
Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
Ann Intern Med 139:137-47. 2003..Because of the high prevalence of early stages of chronic kidney disease in the general population (approximately 11% of adults), this information is particularly important for general internists and specialists...
Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the communityGuruprasad Manjunath
Division of Nephrology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Am Coll Cardiol 41:47-55. 2003..13) for ASCVD, de novo ASCVD, and recurrent ASCVD, respectively. A nonlinear model did not fit the data better than a linear model. CONCLUSIONS: The level of GFR is an independent risk factor for ASCVD and de novo ASCVD in the ARIC study...
IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohortYongmei Liu
Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Am Soc Nephrol 17:863-70. 2006..03) and higher CVD risk (hazard ratio 1.44, P=0.006) after adjustment for covariates. The IL6 gene has functional variants that affect inflammation and risk for CVD among dialysis patients, supporting a causal role for IL6 in CVD...
Level of kidney function as a risk factor for cardiovascular outcomes in the elderlyGuruprasad Manjunath
Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Kidney Int 63:1121-9. 2003..A linear model best described the relationship between GFR and CVD. CONCLUSION: The level of GFR is an independent risk factor for CVD, de novo CVD, and all-cause mortality in the elderly...
Estimating the prevalence of low glomerular filtration rate requires attention to the creatinine assay calibrationJosef Coresh
J Am Soc Nephrol 13:2811-2; author reply 2812-6. 2002
Association of kidney function with serum lipoprotein(a) level: the third National Health and Nutrition Examination Survey (1991-1994)Csaba P Kovesdy
Division of Renal Medicine, Salem Veterans Affairs Medical Center, Salem, VA 24153, USA
Am J Kidney Dis 40:899-908. 2002..Elevated lipoprotein(a) (Lp[a]) levels have been observed in patients on dialysis therapy. However, few studies explored the relationship between kidney function and Lp(a) levels in patients with mild to moderate chronic kidney disease...
Comorbidity and its change predict survival in incident dialysis patientsDana C Miskulin
Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
Am J Kidney Dis 41:149-61. 2003..Longitudinal change in the comorbid illness burden of incident dialysis patients has not been measured. Comorbidity severity and its change may serve as important prognostic markers of survival, independent of other case-mix factors...
Should the K/DOQI definition of chronic kidney disease be changed?Andrew S Levey
Division of Nephrology, Tufts University School of Medicine, Tufts New England Medical Center, Boston, MA, USA
Am J Kidney Dis 42:626-30. 2003
Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and PreventionMark J Sarnak
Circulation 108:2154-69. 2003
Cystatin C as a risk factor for outcomes in chronic kidney diseaseVandana Menon
Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Ann Intern Med 147:19-27. 2007....
Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient databaseLesley A Stevens
Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
Am J Kidney Dis 50:21-35. 2007..Variation in performance of glomerular filtration rate (GFR) estimating equations is related to variation in calibration of the creatinine assay across clinical laboratories...
Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine valuesAndrew S Levey
Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
Clin Chem 53:766-72. 2007..We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods...
Kidney function and risk of peripheral arterial disease: results from the Atherosclerosis Risk in Communities (ARIC) StudyKeattiyoat Wattanakit
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454 1015, USA
J Am Soc Nephrol 18:629-36. 2007..56 (95% CI 1.13 to 2.14). Patients with CKD are at increased risk for incident PAD. Development of strategies for screening and prevention of PAD in this high-risk population seems warranted...
Assessing kidney function--measured and estimated glomerular filtration rateLesley A Stevens
Division of Nephrology, Tufts-New England Medical Center, Boston, MA 02111, USA
N Engl J Med 354:2473-83. 2006
Cardiovascular risk among adults with chronic kidney disease, with or without prior myocardial infarctionKeattiyoat Wattanakit
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA
J Am Coll Cardiol 48:1183-9. 2006..46 [95% CI 0.24 to 0.90] for CVD mortality) than for subjects with no CKD and a prior MI. CONCLUSIONS: Stage 3 CKD confers CHD risk that is lower and not equivalent to a prior MI in this middle-aged, general, nondiabetic population...
Decreased kidney function in the elderly: clinical and preclinical, neither benignJosef Coresh
Ann Intern Med 145:299-301. 2006
International comparison of the relationship of chronic kidney disease prevalence and ESRD riskStein I Hallan
Department of Medicine, Division of Nephrology, St Olav University Hospital, N 7006 Trondheim, Norway
J Am Soc Nephrol 17:2275-84. 2006..In conclusion, CKD prevalence in Norway was similar to that in the United States, suggesting that lower progression to ESRD rather than a smaller pool of individuals at risk accounts for the lower incidence of ESRD in Norway...
