Eric M Cooper

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1
    Eric M Cooper
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    EMBO J 28:621-31. 2009
  2. pmc Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin
    Eric M Cooper
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 285:10344-52. 2010
  3. doi request reprint The Build-a-Genome course
    Eric M Cooper
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 852:273-83. 2012
  4. pmc Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1
    Tao Wang
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Mol Biol 386:1011-23. 2009
  5. pmc Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling
    Joshua J Sims
    Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Nat Methods 9:303-9. 2012
  6. doi request reprint Assembling large DNA segments in yeast
    Héloïse Muller
    Department of Environmental Health Sciences, Johns Hopkins University School of Public Health, Baltimore, MD, USA
    Methods Mol Biol 852:133-50. 2012

Research Grants

Collaborators

Detail Information

Publications6

  1. pmc K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1
    Eric M Cooper
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    EMBO J 28:621-31. 2009
    ..Our results suggest that specificity for K63-linked polyubiquitin is a common property of the JAMM/MPN+ family of DUBs...
  2. pmc Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin
    Eric M Cooper
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 285:10344-52. 2010
    ..Finally, we also show that Abro1, another BRISC subunit, binds directly to Brcc36 and that the Brcc36-Abro1 heterodimer includes a minimal complex with Lys(63)-specific DUB activity...
  3. doi request reprint The Build-a-Genome course
    Eric M Cooper
    High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 852:273-83. 2012
    ..In this chapter, we describe the organization of the course and provide advice for anyone interested in starting a similar course at their own institution...
  4. pmc Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1
    Tao Wang
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Mol Biol 386:1011-23. 2009
    ..Bidentate binding may be a general strategy used to achieve linkage-specific deubiquitination...
  5. pmc Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling
    Joshua J Sims
    Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Nat Methods 9:303-9. 2012
    ..We anticipate live-cell imaging, proteomic and biochemical applications for these tools and extension of the design strategy to other polymeric ubiquitin-like protein modifications...
  6. doi request reprint Assembling large DNA segments in yeast
    Héloïse Muller
    Department of Environmental Health Sciences, Johns Hopkins University School of Public Health, Baltimore, MD, USA
    Methods Mol Biol 852:133-50. 2012
    ..In this chapter, we describe the assembly of 3-kb fragments with an overlap of one building block (∼750 base pairs) into a 40-kb DNA piece...

Research Grants2

  1. Regulation and Proteomics of Polyubiquitin Signaling
    ERIC COOPER; Fiscal Year: 2007
    ..Specifically, the goal is to establish a paradigm for how these chains are recognized, what factors bind to them, and how such signals are ultimately turned off. ..