Candice E Coombes

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function
    Darren J Moore
    Neurobiology Programme, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    Brain Res Mol Brain Res 118:10-23. 2003
  2. ncbi Molecular pathophysiology of Parkinson's disease
    Darren J Moore
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:57-87. 2005
  3. ncbi Lessons from Drosophila models of DJ-1 deficiency
    Darren J Moore
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Aging Knowledge Environ 2006:pe2. 2006
  4. ncbi Parkin: a multifaceted ubiquitin ligase
    D J Moore
    Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Broadway Research Building, Suite 731, Baltimore, MD 21205, USA
    Biochem Soc Trans 34:749-53. 2006
  5. ncbi GTPase activity plays a key role in the pathobiology of LRRK2
    Yulan Xiong
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Genet 6:e1000902. 2010
  6. ncbi Dynamic and redundant regulation of LRRK2 and LRRK1 expression
    Saskia Biskup
    Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Neurosci 8:102. 2007
  7. ncbi Synthetic chromosome arms function in yeast and generate phenotypic diversity by design
    Jessica S Dymond
    High Throughput Biology Center, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
    Nature 477:471-6. 2011

Research Grants

  1. Alpha-Synuclein Conditional Knock-in Mice as Novel Models of Parkinson's Disease
    Darren Moore; Fiscal Year: 2007

Collaborators

Detail Information

Publications7

  1. ncbi GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function
    Darren J Moore
    Neurobiology Programme, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    Brain Res Mol Brain Res 118:10-23. 2003
    ..Based on these observations, we propose that G(i/o)-coupled GPR105 might play an important role in peripheral and neuroimmune function in response to extracellular UDP-sugars...
  2. ncbi Molecular pathophysiology of Parkinson's disease
    Darren J Moore
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:57-87. 2005
    ....
  3. ncbi Lessons from Drosophila models of DJ-1 deficiency
    Darren J Moore
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Aging Knowledge Environ 2006:pe2. 2006
    ..DJ-1-deficient fly models further highlight the utility of Drosophila as an important tool for elucidating protein function and for modeling neurodegenerative disease...
  4. ncbi Parkin: a multifaceted ubiquitin ligase
    D J Moore
    Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Broadway Research Building, Suite 731, Baltimore, MD 21205, USA
    Biochem Soc Trans 34:749-53. 2006
    ..Parkin therefore represents a unique multifaceted ubiquitin ligase consistent with an important housekeeping role in maintaining the integrity or survival of dopaminergic neurons...
  5. ncbi GTPase activity plays a key role in the pathobiology of LRRK2
    Yulan Xiong
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Genet 6:e1000902. 2010
    ..These findings may guide future therapeutic strategies aimed at attenuating LRRK2-mediated neurodegeneration...
  6. ncbi Dynamic and redundant regulation of LRRK2 and LRRK1 expression
    Saskia Biskup
    Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Neurosci 8:102. 2007
    ..The expression profiles of the murine LRRK proteins have not been fully described and insufficiently characterized antibodies have produced conflicting results in the literature...
  7. ncbi Synthetic chromosome arms function in yeast and generate phenotypic diversity by design
    Jessica S Dymond
    High Throughput Biology Center, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21205, USA
    Nature 477:471-6. 2011
    ..When complete, the fully synthetic genome will allow massive restructuring of the yeast genome, and may open the door to a new type of combinatorial genetics based entirely on variations in gene content and copy number...

Research Grants2

  1. Alpha-Synuclein Conditional Knock-in Mice as Novel Models of Parkinson's Disease
    Darren Moore; Fiscal Year: 2007
    ....