Richard A Cone

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD 21286 USA
    BMC Infect Dis 10:331. 2010
  2. ncbi Barrier properties of mucus
    Richard A Cone
    Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
    Adv Drug Deliv Rev 61:75-85. 2009
  3. ncbi Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    Richard A Cone
    Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 6:90. 2006
  4. ncbi Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model
    Stuart S Olmsted
    Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 5:79. 2005
  5. ncbi Human monoclonal antibody stability and activity at vaginal pH
    Philip E Castle
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    J Reprod Immunol 56:61-76. 2002
  6. ncbi Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis
    Sharon L Achilles
    The Johns Hopkins University, Baltimore, Maryland, USA
    Sex Transm Dis 29:655-64. 2002
  7. ncbi Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines
    Kevin J Whaley
    Mapp Biopharmaceutical, Inc, San Diego, CA 92121, USA
    Antiviral Res 88:S55-66. 2010
  8. ncbi In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    BMC Infect Dis 11:200. 2011
  9. ncbi Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 10:120. 2010
  10. ncbi Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis
    Rebecca M Brotman
    Department of Epidemiology and Preventive Medicine, Institute for Genome Sciences, University of Maryland School of Medicine, BioPark Building II, 801 West Baltimore Street, Baltimore, MD 21201, USA
    Sex Transm Infect 86:297-302. 2010

Research Grants

  1. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2007

Detail Information

Publications13

  1. ncbi Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD 21286 USA
    BMC Infect Dis 10:331. 2010
    ..However, excipients have not previously been tested in susceptibility models...
  2. ncbi Barrier properties of mucus
    Richard A Cone
    Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
    Adv Drug Deliv Rev 61:75-85. 2009
    ..These viruses are smaller than the mucus mesh spacing, and have surfaces that do not stick to mucus. They form a useful model for developing NP for mucosal drug delivery...
  3. ncbi Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission
    Richard A Cone
    Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 6:90. 2006
    ....
  4. ncbi Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model
    Stuart S Olmsted
    Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 5:79. 2005
    ....
  5. ncbi Human monoclonal antibody stability and activity at vaginal pH
    Philip E Castle
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    J Reprod Immunol 56:61-76. 2002
    ..Taken together, our data and empirical calculations suggest that vaginally applied human MAbs are likely to remain stable and active throughout the duration they are likely to reside in the vagina...
  6. ncbi Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis
    Sharon L Achilles
    The Johns Hopkins University, Baltimore, Maryland, USA
    Sex Transm Dis 29:655-64. 2002
    ....
  7. ncbi Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccines
    Kevin J Whaley
    Mapp Biopharmaceutical, Inc, San Diego, CA 92121, USA
    Antiviral Res 88:S55-66. 2010
    ..This article forms part of a special supplement covering several presentations on novel microbicide formulations from the symposium on "Recent Trends in Microbicide Formulations" held on 25 and 26 January 2010, Arlington, VA...
  8. ncbi In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    BMC Infect Dis 11:200. 2011
    ..Here we used conditions more like those in vivo to compare the effects of physiologically plausible concentrations of H2O2 and lactic acid on a broad range of BV-associated bacteria and vaginal lactobacilli...
  9. ncbi Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli
    Deirdre E O'Hanlon
    Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
    BMC Infect Dis 10:120. 2010
    ..However, cervicovaginal fluid (CVF) and semen have significant H2O2-blocking activity...
  10. ncbi Rapid fluctuation of the vaginal microbiota measured by Gram stain analysis
    Rebecca M Brotman
    Department of Epidemiology and Preventive Medicine, Institute for Genome Sciences, University of Maryland School of Medicine, BioPark Building II, 801 West Baltimore Street, Baltimore, MD 21201, USA
    Sex Transm Infect 86:297-302. 2010
    ..The aetiology of bacterial vaginosis (BV) remains unknown...
  11. ncbi Evaluation of microbicide gel adherence monitoring methods
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD, USA
    Sex Transm Dis 39:335-40. 2012
    ....
  12. ncbi Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent
    Kristen V Khanna
    Johns Hopkins School of Hygiene and Public Health, Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 109:205-11. 2002
    ....
  13. ncbi A self-sampling method to obtain large volumes of undiluted cervicovaginal secretions
    Elizabeth R Boskey
    Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Sex Transm Dis 30:107-9. 2003
    ..It should prove suitable for a wide range of assays, including those involving sexually transmitted diseases, microbicides, vaginal physiology, immunology, and pathophysiology...

Research Grants2

  1. Duet cervical barrier device for maximizing protective efficacy of microbicides
    Richard Cone; Fiscal Year: 2007
    ..Duet" covers the cervix for maximum protection of this susceptible site for infections, and delivers microbicide gel to protect both the cervix and vagina. The reusable Duet will be low in cost and useful for low-resource areas. ..