Richard A Cone
Affiliation: Johns Hopkins University
- Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouseThomas R Moench
ReProtect, Inc, Baltimore, MD 21286 USA
BMC Infect Dis 10:331. 2010..However, excipients have not previously been tested in susceptibility models...
- Barrier properties of mucusRichard A Cone
Biophysics Department, Johns Hopkins University, and ReProtect, Inc, Baltimore MD, USA
Adv Drug Deliv Rev 61:75-85. 2009..These viruses are smaller than the mucus mesh spacing, and have surfaces that do not stick to mucus. They form a useful model for developing NP for mucosal drug delivery...
- Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmissionRichard A Cone
Mucosal Protection Laboratory, Dept of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 6:90. 2006....
- Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse modelStuart S Olmsted
Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 5:79. 2005....
- Human monoclonal antibody stability and activity at vaginal pHPhilip E Castle
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
J Reprod Immunol 56:61-76. 2002..Taken together, our data and empirical calculations suggest that vaginally applied human MAbs are likely to remain stable and active throughout the duration they are likely to reside in the vagina...
- Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatisSharon L Achilles
The Johns Hopkins University, Baltimore, Maryland, USA
Sex Transm Dis 29:655-64. 2002....
- Novel approaches to vaginal delivery and safety of microbicides: biopharmaceuticals, nanoparticles, and vaccinesKevin J Whaley
Mapp Biopharmaceutical, Inc, San Diego, CA 92121, USA
Antiviral Res 88:S55-66. 2010..This article forms part of a special supplement covering several presentations on novel microbicide formulations from the symposium on "Recent Trends in Microbicide Formulations" held on 25 and 26 January 2010, Arlington, VA...
- In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxideDeirdre E O'Hanlon
Mucosal Protection Laboratory, Thomas C Jenkins Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
BMC Infect Dis 11:200. 2011..Here we used conditions more like those in vivo to compare the effects of physiologically plausible concentrations of H2O2 and lactic acid on a broad range of BV-associated bacteria and vaginal lactobacilli...
- Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilliDeirdre E O'Hanlon
Mucosal Protection Laboratory, Thomas C, Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA
BMC Infect Dis 10:120. 2010..However, cervicovaginal fluid (CVF) and semen have significant H2O2-blocking activity...
- Rapid fluctuation of the vaginal microbiota measured by Gram stain analysisRebecca M Brotman
Department of Epidemiology and Preventive Medicine, Institute for Genome Sciences, University of Maryland School of Medicine, BioPark Building II, 801 West Baltimore Street, Baltimore, MD 21201, USA
Sex Transm Infect 86:297-302. 2010..The aetiology of bacterial vaginosis (BV) remains unknown...
- Evaluation of microbicide gel adherence monitoring methodsThomas R Moench
ReProtect, Inc, Baltimore, MD, USA
Sex Transm Dis 39:335-40. 2012....
- Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agentKristen V Khanna
Johns Hopkins School of Hygiene and Public Health, Department of Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Clin Invest 109:205-11. 2002....
- A self-sampling method to obtain large volumes of undiluted cervicovaginal secretionsElizabeth R Boskey
Thomas C Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA
Sex Transm Dis 30:107-9. 2003..It should prove suitable for a wide range of assays, including those involving sexually transmitted diseases, microbicides, vaginal physiology, immunology, and pathophysiology...
- Duet cervical barrier device for maximizing protective efficacy of microbicidesRichard Cone; Fiscal Year: 2007..Duet" covers the cervix for maximum protection of this susceptible site for infections, and delivers microbicide gel to protect both the cervix and vagina. The reusable Duet will be low in cost and useful for low-resource areas. ..