R D Cohn

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint The genetics revolution and primary care pediatrics
    Tina L Cheng
    Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 299:451-3. 2008
  2. pmc Role of TGF-β signaling in inherited and acquired myopathies
    Tyesha N Burks
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Skelet Muscle 1:19. 2011
  3. pmc Myostatin does not regulate cardiac hypertrophy or fibrosis
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuromuscul Disord 17:290-6. 2007
  4. ncbi request reprint Intracranial hemorrhage as the initial manifestation of a congenital disorder of glycosylation
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins Hospital, Children s Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 1008, Baltimore, Maryland 21205, USA
    Pediatrics 118:e514-21. 2006
  5. ncbi request reprint Dystroglycan: important player in skeletal muscle and beyond
    Ronald D Cohn
    Johns Hopkins Hospital, Children s Center, McKusick Nathans Institute of Genetic Medicine, 600 N Wolfe Street, Blalock 1008, Baltimore, MD 21287, USA
    Neuromuscul Disord 15:207-17. 2005
  6. pmc Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders
    E L Finanger Hedderick
    Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway BRB 529, Baltimore, MD 21205, USA
    Neurology 76:960-7. 2011
  7. pmc Regulation of muscle mass by follistatin and activins
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Endocrinol 24:1998-2008. 2010
  8. pmc Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland 21205, USA
    Nat Med 13:204-10. 2007
  9. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
  10. doi request reprint SP-litting the satellite niche to repopulate muscle
    Stefani Fontana
    Department of Pediatrics and Neurology, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 529 Baltimore, MD 21205, USA
    Cell Stem Cell 4:194-5. 2009

Collaborators

Detail Information

Publications15

  1. doi request reprint The genetics revolution and primary care pediatrics
    Tina L Cheng
    Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21287, USA
    JAMA 299:451-3. 2008
  2. pmc Role of TGF-β signaling in inherited and acquired myopathies
    Tyesha N Burks
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Skelet Muscle 1:19. 2011
    ..We also discuss how the inhibition of several members of the TGF-β signaling pathway has been implicated in ameliorating disease phenotypes, opening up novel therapeutic avenues for a large group of neuromuscular disorders...
  3. pmc Myostatin does not regulate cardiac hypertrophy or fibrosis
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuromuscul Disord 17:290-6. 2007
    ..2% vs. 12%). The physiological role of myostatin in cardiac muscle appears significantly different than that in skeletal muscle as it does not induce cardiac hypertrophy and does not modulate cardiac fibrosis in mdx mice...
  4. ncbi request reprint Intracranial hemorrhage as the initial manifestation of a congenital disorder of glycosylation
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins Hospital, Children s Center, Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 1008, Baltimore, Maryland 21205, USA
    Pediatrics 118:e514-21. 2006
    ..Intracranial hemorrhage in a term neonate without a potential precipitating factor represents yet another clinical feature that should raise the suspicion for a congenital disorder of glycosylation...
  5. ncbi request reprint Dystroglycan: important player in skeletal muscle and beyond
    Ronald D Cohn
    Johns Hopkins Hospital, Children s Center, McKusick Nathans Institute of Genetic Medicine, 600 N Wolfe Street, Blalock 1008, Baltimore, MD 21287, USA
    Neuromuscul Disord 15:207-17. 2005
    ..The current review summarizes the recent scientific achievements as they relate to the function of dystroglycan under normal and pathophysiological conditions...
  6. pmc Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders
    E L Finanger Hedderick
    Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway BRB 529, Baltimore, MD 21205, USA
    Neurology 76:960-7. 2011
    ..Our objectives were to characterize further the range of patients manifesting aberrant nNOS sarcolemmal immunolocalization and to study nNOS localization in animal models of nondystrophic myopathy...
  7. pmc Regulation of muscle mass by follistatin and activins
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Endocrinol 24:1998-2008. 2010
    ....
  8. pmc Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states
    Ronald D Cohn
    McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland 21205, USA
    Nat Med 13:204-10. 2007
    ..Moreover, we show TGF-beta-induced failure of muscle regeneration and a similar therapeutic response in a dystrophin-deficient mouse model of Duchenne muscular dystrophy...
  9. pmc Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Jennifer P Habashi
    Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 312:117-21. 2006
    ....
  10. doi request reprint SP-litting the satellite niche to repopulate muscle
    Stefani Fontana
    Department of Pediatrics and Neurology, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 North Broadway, BRB 529 Baltimore, MD 21205, USA
    Cell Stem Cell 4:194-5. 2009
    ..2009) advance our understanding of the cells that contribute to muscle regeneration by identifying an ABCG2-expressing population that exhibits excellent engraftment potential, particularly within the satellite cell niche...
  11. ncbi request reprint Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
    Daniel E Michele
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Nature 418:417-22. 2002
    ....
  12. ncbi request reprint Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy
    Steven A Moore
    Department of Pathology, The University of Iowa, Iowa City, Iowa 52242 1101, USA
    Nature 418:422-5. 2002
    ..Our data strongly support the hypothesis that defects in dystroglycan are central to the pathogenesis of structural and functional brain abnormalities seen in CMD...
  13. ncbi request reprint Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration
    Ronald D Cohn
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, Department of Neurology, Iowa City, IA 52242, USA
    Cell 110:639-48. 2002
    ..Therefore, inadequate repair of skeletal muscle by satellite cells represents an important mechanism affecting the pathogenesis of muscular dystrophy...
  14. ncbi request reprint Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization
    Fumiaki Saito
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Neuron 38:747-58. 2003
    ..Dystroglycan may be required for the normal maintenance of voltage-gated sodium channels at nodes of Ranvier, possibly by mediating trans interactions between Schwann cell microvilli and the nodal axolemma...
  15. ncbi request reprint LARGE can functionally bypass alpha-dystroglycan glycosylation defects in distinct congenital muscular dystrophies
    Rita Barresi
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Nat Med 10:696-703. 2004
    ..Our findings indicate that modulation of LARGE expression or activity is a viable therapeutic strategy for glycosyltransferase-deficient congenital muscular dystrophies...

Research Grants2

  1. Role of TGFB signaling in muscle regeneration and various myopathic states
    RONALD COHN; Fiscal Year: 2007
    ..Moreover, improvement of muscle regeneration may have potential benefit for other conditions such as disease, disuse or age related decrease in muscle mass. ..