Ashley Cimino-Mathews

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287 Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD 21287 Electronic address
    Hum Pathol 47:52-63. 2016
  2. pmc A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA Electronic address
    Hum Pathol 44:2494-500. 2013
  3. pmc Neural crest transcription factor Sox10 is preferentially expressed in triple-negative and metaplastic breast carcinomas
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 44:959-65. 2013
  4. pmc GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 44:1341-9. 2013
  5. pmc Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA Electronic address
    Hum Pathol 44:2055-63. 2013
  6. doi request reprint The immune microenvironment of breast ductal carcinoma in situ
    Elizabeth Thompson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Mod Pathol 29:249-58. 2016
  7. pmc Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 43:1003-11. 2012
  8. doi request reprint Clinicopathologic features of ductal carcinoma in situ in young women with an emphasis on molecular subtype
    Christopher J Vandenbussche
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA Electronic address
    Hum Pathol 44:2487-93. 2013
  9. doi request reprint Detection of human papillomavirus in small cell carcinomas of the anus and rectum
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 36:1087-92. 2012
  10. pmc A subset of malignant phyllodes tumors express p63 and p40: a diagnostic pitfall in breast core needle biopsies
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD
    Am J Surg Pathol 38:1689-96. 2014

Collaborators

Detail Information

Publications23

  1. doi request reprint PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287 Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD 21287 Electronic address
    Hum Pathol 47:52-63. 2016
    ..Our data support PD-L1 expression by tumor cells as a biomarker of active breast tumor immunity and programmed death 1 blockade as a therapeutic strategy for breast cancer. ..
  2. pmc A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA Electronic address
    Hum Pathol 44:2494-500. 2013
    ..These and other mechanisms may contribute to the increased proliferation in malignant phyllodes relative to other fibroepithelial neoplasms. ..
  3. pmc Neural crest transcription factor Sox10 is preferentially expressed in triple-negative and metaplastic breast carcinomas
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 44:959-65. 2013
    ..Sox10 expression in the basal-like, unclassified triple-negative, and metaplastic carcinomas types supports the concept that these neoplasms show myoepithelial differentiation...
  4. pmc GATA3 expression in breast carcinoma: utility in triple-negative, sarcomatoid, and metastatic carcinomas
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 44:1341-9. 2013
    ..Finally, GATA3 labeling may help distinguish metaplastic carcinoma from malignant phyllodes tumors...
  5. pmc Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA Electronic address
    Hum Pathol 44:2055-63. 2013
    ..These findings suggest that evaluating the immunologic microenvironment of both PBCs and MBCs may yield important clinical information to guide breast cancer prognosis and therapy. ..
  6. doi request reprint The immune microenvironment of breast ductal carcinoma in situ
    Elizabeth Thompson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Mod Pathol 29:249-58. 2016
    ..01). Further characterization of the DCIS immune microenvironment may identify useful targets for immune-based therapy and breast cancer prevention. ..
  7. pmc Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 43:1003-11. 2012
    ..This suggests an opportunity for targeted antiandrogen therapy at an earlier stage of disease progression...
  8. doi request reprint Clinicopathologic features of ductal carcinoma in situ in young women with an emphasis on molecular subtype
    Christopher J Vandenbussche
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA Electronic address
    Hum Pathol 44:2487-93. 2013
    ..A larger series is necessary to confirm the impact that the molecular subtypes of ductal carcinoma in situ in younger patients might have on outcome. ..
  9. doi request reprint Detection of human papillomavirus in small cell carcinomas of the anus and rectum
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 36:1087-92. 2012
    ..High-risk HPV can be detected using in situ hybridization in the majority of anorectal small cell carcinomas, which are uniformly p16 positive by IHC. HPV-targeted therapy could result in better control of these aggressive neoplasms...
  10. pmc A subset of malignant phyllodes tumors express p63 and p40: a diagnostic pitfall in breast core needle biopsies
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD
    Am J Surg Pathol 38:1689-96. 2014
    ..These results are consistent with the sarcoma literature in which p63 labeling has been increasingly reported and suggest caution in classifying malignant spindle cell tumors of the breast on core biopsy. ..
  11. pmc HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression
    Nilay Shah
    Departments of Oncology, Surgery, and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Cancer Res 73:5449-58. 2013
    ..Taken together, our results establish a function for HOXB13 in TAM resistance through direct suppression of ERα and they identify the IL-6 pathways as mediator of disease progression and recurrence...
  12. doi request reprint GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder
    Carla L Ellis
    Department of Pathology, The Johns Hopkins Hospital and School of Medicine, Baltimore, MD Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX
    Am J Surg Pathol 37:1756-60. 2013
    ..GATA-3 is rarely positive in bladder adenocarcinomas that lack signet ring features and in SRCs displaying extracellular mucin production...
  13. pmc MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors
    Aatur D Singhi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 25:378-87. 2012
    ..These observations underscore the importance of MYC in breast cancer progression/metastasis, as well as its relevance as a potential therapeutic target in otherwise incurable metastatic disease...
  14. pmc A PIK3CA mutation detected in plasma from a patient with synchronous primary breast and lung cancers
    Danijela Jelovac
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA
    Hum Pathol 45:880-3. 2014
    ..This case report highlights potential applications and concerns that can arise with the use of ptDNA in clinical oncology practice. ..
  15. pmc EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis
    Heather M Moore
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res Treat 138:741-52. 2013
    ..Together our findings reveal a new mechanism by which EZH2 functions in breast cancer, and provide direct evidence that EZH2 inhibition reduces breast cancer metastasis in vivo...
  16. pmc Borderline atypical ductal hyperplasia/low-grade ductal carcinoma in situ on breast needle core biopsy should be managed conservatively
    Christopher J Vandenbussche
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 37:913-23. 2013
    ..In conclusion, our study provides preliminary data that justify a conservative approach to borderline ADH/DCIS lesions on CNB: that is, diagnose as MADH and treat by conservative excision...
  17. doi request reprint Ki-67 is required for maintenance of cancer stem cells but not cell proliferation
    Justin Cidado
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 7:6281-93. 2016
    ..These results elucidate Ki-67's role in maintaining the cancer stem cell niche, which has potential diagnostic and therapeutic implications for human malignancies. ..
  18. doi request reprint Metastatic metaplastic breast carcinoma mimicking pulmonary squamous cell carcinoma on fine-needle aspiration
    Doreen N Nguyen
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Diagn Cytopathol 43:844-9. 2015
    ..This suggests that immunoreactivity for ER and GATA-3 may support a diagnosis of metastatic SCC in the context of a prior metaplastic SCC of the breast...
  19. pmc Frozen section evaluation of breast carcinoma sentinel lymph nodes: a retrospective review of 1,940 cases
    Justin S Poling
    Department of Pathology, The Johns Hopkins Hospital, 401 North Broadway Street, Weinberg 2242, Baltimore, MD, 21231, USA
    Breast Cancer Res Treat 148:355-61. 2014
    ..The trend of fewer patients getting additional AD after a discrepant frozen SLNB suggests that clinicians may be using this information differently recently...
  20. doi request reprint Benign and low-grade fibroepithelial neoplasms of the breast have low recurrence rate after positive surgical margins
    Morgan L Cowan
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Mod Pathol 29:259-65. 2016
    ....
  21. doi request reprint The role of GATA3 in breast carcinomas: a review
    Rebecca Asch-Kendrick
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231
    Hum Pathol 48:37-47. 2016
    ....
  22. doi request reprint Telomere length alterations unique to invasive lobular carcinoma
    Christopher M Heaphy
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231 Department of Oncology, The Johns Hopkins Hospital, Baltimore, MD 21231
    Hum Pathol 46:1197-203. 2015
    ..Additional studies are needed to further evaluate the significance of the unique bright telomere spot phenotype and the potential utility of telomere length as a prognostic marker in ILC. ..
  23. doi request reprint Cytologic and histologic findings of iron pill-induced injury of the lower respiratory tract
    Ashley Cimino-Mathews
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland
    Diagn Cytopathol 41:901-3. 2013
    ..The presence of extracellular and intracellular crystalline iron in the airway lumen and/or mucosa with associated varying degrees of ulceration and inflammation confirms the diagnosis...