Haitao Chu

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Estimating biomarker-based HIV incidence using prevalence data in high risk groups with missing outcomes
    Haitao Chu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biom J 48:772-9. 2006
  2. ncbi request reprint Estimating heterogeneous transmission with multiple infectives using MCMC methods
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:35-49. 2004
  3. ncbi request reprint Estimating vaccine efficacy using auxiliary outcome data and a small validation sample
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:2697-711. 2004
  4. ncbi request reprint Assessing the effect of interventions in the context of mixture distributions with detection limits
    Haitao Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, U S A
    Stat Med 24:2053-67. 2005
  5. ncbi request reprint Individual variation in CD4 cell count trajectory among human immunodeficiency virus-infected men and women on long-term highly active antiretroviral therapy: an application using a Bayesian random change-point model
    Haitao Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 162:787-97. 2005
  6. ncbi request reprint Bayesian estimation of vaccine efficacy
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Clin Trials 1:306-14. 2004
  7. ncbi request reprint A note on comparing exposure data to a regulatory limit in the presence of unexposed and a limit of detection
    Haitao Chu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biom J 47:880-7. 2005
  8. ncbi request reprint Sample size and statistical power assessing the effect of interventions in the context of mixture distributions with detection limits
    Haitao Chu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Stat Med 25:2647-57. 2006
  9. pmc Bayesian posterior distributions without Markov chains
    Stephen R Cole
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 27599 7435, USA
    Am J Epidemiol 175:368-75. 2012
  10. ncbi request reprint Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 21:1731-8. 2007

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Estimating biomarker-based HIV incidence using prevalence data in high risk groups with missing outcomes
    Haitao Chu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biom J 48:772-9. 2006
    ..Our methods can be applied to estimate the incidence of other diseases from prevalence data using similar testing algorithms when missing data is present...
  2. ncbi request reprint Estimating heterogeneous transmission with multiple infectives using MCMC methods
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:35-49. 2004
    ..Parameters are estimated using Markov chain Monte Carlo methods...
  3. ncbi request reprint Estimating vaccine efficacy using auxiliary outcome data and a small validation sample
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:2697-711. 2004
    ..Comparing the performance of these approaches using data from a field study of influenza vaccine and simulations, we recommend to use the Bayesian method in this situation...
  4. ncbi request reprint Assessing the effect of interventions in the context of mixture distributions with detection limits
    Haitao Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, U S A
    Stat Med 24:2053-67. 2005
    ..We illustrate our methods using data from a randomized clinical trial conducted in Qidong, People's Republic of China...
  5. ncbi request reprint Individual variation in CD4 cell count trajectory among human immunodeficiency virus-infected men and women on long-term highly active antiretroviral therapy: an application using a Bayesian random change-point model
    Haitao Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 162:787-97. 2005
    ..At the individual level, 35% of men in the Multicenter AIDS Cohort Study versus 25% of women in the Women's Interagency HIV Study had a statistically significant change in CD4 cell count trajectory within 7 years after HAART initiation...
  6. ncbi request reprint Bayesian estimation of vaccine efficacy
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Clin Trials 1:306-14. 2004
    ..We illustrate the methods using the data from two pertussis vaccine studies and the H. influenza Type B preventive trial...
  7. ncbi request reprint A note on comparing exposure data to a regulatory limit in the presence of unexposed and a limit of detection
    Haitao Chu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biom J 47:880-7. 2005
    ..A simulation study is conducted to investigate the performance of the proposed sample size calculation methods...
  8. ncbi request reprint Sample size and statistical power assessing the effect of interventions in the context of mixture distributions with detection limits
    Haitao Chu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Stat Med 25:2647-57. 2006
    ..A Monte Carlo simulation study is conducted to investigate the performance of the proposed methods...
  9. pmc Bayesian posterior distributions without Markov chains
    Stephen R Cole
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 27599 7435, USA
    Am J Epidemiol 175:368-75. 2012
    ..The transparency of the proposed approach comes at a price of being less broadly applicable than MCMC...
  10. ncbi request reprint Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 21:1731-8. 2007
    ..The relative contributions of the different classes of antiretroviral therapy (ART), HIV infection per se, and aging to body shape changes in HIV-infected patients have not been clearly defined in longitudinal studies...
  11. ncbi request reprint Confidence intervals for biomarker-based human immunodeficiency virus incidence estimates and differences using prevalent data
    Stephen R Cole
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 165:94-100. 2007
    ..The Monte Carlo-based CI may be preferable to competing methods because of the ease of extension to the incidence difference or to exploration of departures from assumptions...
  12. pmc Bimodal virological response to antiretroviral therapy for HIV infection: an application using a mixture model with left censoring
    Xiuhong Li
    Room E7648, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Epidemiol Community Health 60:811-8. 2006
    ..To assess whether HIV RNA levels (log(10) scale) in highly active antiretroviral therapy (HAART) treated population have a bimodal distribution, suggesting optimal or suboptimal response to HAART...
  13. pmc Survival attributable to an exposure
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Stat Med 28:3276-93. 2009
    ..We apply these methods to assess the effect of introducing highly active antiretroviral therapy for the treatment of clinical AIDS at the population level...
  14. ncbi request reprint A general approach for sample size and statistical power calculations assessing of interventions using a mixture model in the presence of detection limits
    Lei Nie
    Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University, 4000 Reservoir Road, Washington, DC 20057, USA
    Contemp Clin Trials 27:483-91. 2006
    ..The simulation results illustrate that the proposed methods provide adequate sample size estimates. However, when the aforementioned irregularity occurs, our methods are restricted and further research is needed...
  15. pmc Sample size and power determination in joint modeling of longitudinal and survival data
    Liddy M Chen
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, U S A
    Stat Med 30:2295-309. 2011
    ..Optimal frequency of repeated measurements also depends on the nature of the trajectory with higher polynomial trajectories and larger measurement error requiring more frequent measurements...
  16. pmc Illustrating bias due to conditioning on a collider
    Stephen R Cole
    Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA
    Int J Epidemiol 39:417-20. 2010
    ..In both examples, conditioning on the common effect imparts an association between two otherwise independent variables; we call this selection bias...
  17. doi request reprint Estimation of risk ratios in cohort studies with common outcomes: a Bayesian approach
    Haitao Chu
    Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Epidemiology 21:855-62. 2010
    ..We propose a novel Bayesian approach for the estimation of the risk ratio from the log binomial model that addresses drawbacks of existing approaches. Posterior computation can be accomplished easily using the WinBUGs code provided...
  18. ncbi request reprint Combined analysis of retrospective and prospective occurrences in cohort studies: HIV-1 serostatus and incident pneumonia
    Stephen R Cole
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Epidemiol 35:1442-6. 2006
    ..The authors show how information collected on retrospective occurrence times may be combined with prospective occurrence times in the analysis of recurrent events from cohort studies...
  19. pmc Bayesian methods in clinical trials: a Bayesian analysis of ECOG trials E1684 and E1690
    Joseph G Ibrahim
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Med Res Methodol 12:183. 2012
    ..The analyses of E1684 and E1690 were carried out separately when the results were published, and there were no further analyses trying to perform a single analysis of the combined trials...
  20. pmc On the estimation of disease prevalence by latent class models for screening studies using two screening tests with categorical disease status verified in test positives only
    Haitao Chu
    Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stat Med 29:1206-18. 2010
    ..In summary, further research is needed to reduce the impact of model misspecification on the estimation of disease prevalence in such settings...
  21. ncbi request reprint Multiple-imputation for measurement-error correction
    Stephen R Cole
    Department of Epidemiology, 615 Norht Wolfe Street, E7640, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Epidemiol 35:1074-81. 2006
    ..There are many methods for measurement-error correction. These methods remain rarely used despite the ubiquity of measurement error...
  22. doi request reprint Random effects regression models for trends in standardised mortality ratios
    David B Richardson
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Occup Environ Med 70:133-9. 2013
    ..However, because the distribution of people with respect to age usually changes as calendar time advances, comparisons of SMRs across calendar periods can produce misleading results...
  23. doi request reprint Basic concepts and methods for joint models of longitudinal and survival data
    Joseph G Ibrahim
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Clin Oncol 28:2796-801. 2010
    ..To demonstrate our points throughout, we present an analysis from the Eastern Cooperative Oncology Group trial E1193, as well as examine some operating characteristics of joint models through simulation studies...
  24. doi request reprint Meta-analysis of randomized trials on the association of prophylactic acyclovir and HIV-1 viral load in individuals coinfected with herpes simplex virus-2
    Christina Ludema
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    AIDS 25:1265-9. 2011
    ..To summarize the randomized evidence regarding the association between acyclovir use and HIV-1 replication as measured by plasma HIV-1 RNA viral load among individuals coinfected with herpes simplex virus (HSV)-2...
  25. ncbi request reprint Longitudinal anthropometric changes in HIV-infected and HIV-uninfected men
    Todd Brown
    Johns Hopkins University, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 43:356-62. 2006
    ....
  26. pmc On estimation of vaccine efficacy using validation samples with selection bias
    Daniel O Scharfstein
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biostatistics 7:615-29. 2006
    ..Our approach is generally applicable to studies with missing binary outcomes with categorical covariates...
  27. ncbi request reprint Parametric survival analysis and taxonomy of hazard functions for the generalized gamma distribution
    Christopher Cox
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Stat Med 26:4352-74. 2007
    ..Description of standard statistical software (Stata, SAS and S-Plus) for the computations is included and available at http://statepi.jhsph.edu/software...
  28. ncbi request reprint Effect of acyclovir on herpetic ocular recurrence using a structural nested model
    Stephen R Cole
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street Room E7640, Baltimore, MD 21205, United States
    Contemp Clin Trials 26:300-10. 2005
    ..41 times that of the non-exposed (test-based 95% CI: 0.28, 0.72), or 34% larger than the intent-to-treat estimate. Notwithstanding excellent compliance, intent-to-treat estimates may notably undervalue the causal effect of a treatment...
  29. ncbi request reprint Sensitivity analysis of misclassification: a graphical and a Bayesian approach
    Haitao Chu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Ann Epidemiol 16:834-41. 2006
    ..Misclassification can produce bias in measures of association. Sensitivity analyses have been suggested to explore the impact of such bias, but do not supply formally justified interval estimates...
  30. doi request reprint Meta-analysis of diagnostic accuracy studies accounting for disease prevalence: alternative parameterizations and model selection
    Haitao Chu
    Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stat Med 28:2384-99. 2009
    ..In summary, the proposed trivariate random effects models are novel and can be very useful in practice for meta-analysis of diagnostic accuracy studies...
  31. pmc Lagging exposure information in cumulative exposure-response analyses
    David B Richardson
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, NC 27599, USA
    Am J Epidemiol 174:1416-22. 2011
    ..Lagging exposure assignment by a constant will lead to bias toward the null if the distribution of latency periods is not a fixed constant. Direct estimation of latency periods can minimize bias and improve confidence interval coverage...
  32. ncbi request reprint An intervention to decrease catheter-related bloodstream infections in the ICU
    Peter Pronovost
    School of Medicine, Johns Hopkins University, Baltimore, USA
    N Engl J Med 355:2725-32. 2006
    ..Catheter-related bloodstream infections occurring in the intensive care unit (ICU) are common, costly, and potentially lethal...
  33. doi request reprint Missing data in clinical studies: issues and methods
    Joseph G Ibrahim
    Department of Biostatistics, University of North Carolina, CB 7420, Chapel Hill, NC 27599, USA
    J Clin Oncol 30:3297-303. 2012
    ..Although the main area of application discussed here is cancer, the issues and methods we discuss apply to any type of study...
  34. ncbi request reprint Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 158:305-11. 2003
    ..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...
  35. ncbi request reprint Re: "Confidence intervals for biomarker-based human immunodeficiency virus incidence estimates and differences using prevalent data"
    Stephen R Cole
    Am J Epidemiol 166:861-2. 2007
  36. ncbi request reprint Prospective study of attitudinal and relationship predictors of sexual risk in the multicenter AIDS cohort study
    David G Ostrow
    David Ostrow and Associates, Chicago MACS Howard Brown Health Center and Northwestern University School of Medicine, 5455 N Sheridan Rd, Suite 1207, Chicago, IL 60640, USA
    AIDS Behav 12:127-38. 2008
    ..We conclude that HIV prevention efforts should target modifiable attitudes (reduced concern about HIV and safer sex fatigue) and increases in sexual risk-taking of MSM, particularly among HIV+ men having sex with serodiscordant partners...
  37. doi request reprint A Bayesian approach estimating treatment effects on biomarkers containing zeros with detection limits
    Haitao Chu
    Department of Biostatistics and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stat Med 27:2497-508. 2008
    ..Stat. Med. 2005; 24:2053-2067) through simulation studies and a randomized chemoprevention trial conducted in Qidong, People's Republic of China...
  38. pmc Association of rear seat safety belt use with death in a traffic crash: a matched cohort study
    Motao Zhu
    Bureau of Injury Prevention, New York State Department of Health, Albany, New York 12204, USA
    Inj Prev 13:183-5. 2007
    ..To estimate the association of rear seat safety belt use with death in a traffic crash...
  39. ncbi request reprint Sample size calculation using exact methods in diagnostic test studies
    Haitao Chu
    J Clin Epidemiol 60:1201-2; author reply 1202. 2007
  40. ncbi request reprint Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach
    Haitao Chu
    J Clin Epidemiol 59:1331-2; author reply 1332-3. 2006