Michael A Choti

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancer
    Michael G House
    Department of Surgery, the Indiana University School of Medicine, Indianapolis, USA
    J Gastrointest Surg 10:138-45. 2006
  2. ncbi request reprint Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gastrointest Surg 10:1280-90; discussion 1290. 2006
  3. ncbi request reprint Colorectal liver metastases: recurrence and survival following hepatic resection, radiofrequency ablation, and combined resection-radiofrequency ablation
    Ana L Gleisner
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
    Arch Surg 143:1204-12. 2008
  4. ncbi request reprint Conditional survival after surgical resection of colorectal liver metastasis: an international multi-institutional analysis of 949 patients
    Hari Nathan
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Coll Surg 210:755-64, 764-6. 2010
  5. ncbi request reprint Surgical management of hepatocellular carcinoma: resection and ablation
    Michael A Choti
    Department of Surgery, Johns Hopkins University School of Medicine, 1830 Monument Street, Baltimore, MD 21025, USA
    J Vasc Interv Radiol 13:S197-203. 2002
  6. pmc Trends in long-term survival following liver resection for hepatic colorectal metastases
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Surg 235:759-66. 2002
  7. doi request reprint Patient variability in intraoperative ultrasonographic characteristics of colorectal liver metastases
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, 600 N Wolfe St, Blalock 665, Baltimore, MD 22187 6681, USA
    Arch Surg 143:29-34; discussion 35. 2008
  8. doi request reprint Chemotherapy-associated hepatotoxicity: do we need to be concerned?
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 16:2391-4. 2009
  9. pmc Patient readmission and mortality after surgery for hepato-pancreato-biliary malignancies
    Eric B Schneider
    Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 215:607-15. 2012
  10. pmc Influence of patient, physician, and hospital factors on 30-day readmission following pancreatoduodenectomy in the United States
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    JAMA Surg 148:1095-102. 2013

Research Grants

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancer
    Michael G House
    Department of Surgery, the Indiana University School of Medicine, Indianapolis, USA
    J Gastrointest Surg 10:138-45. 2006
    ..Patterns of liver metastases from islet cell tumors, specifically multiple bilobar metastases that are not amenable to resection and/or ablation, predict a poor outcome despite resection of the primary pancreatic tumor...
  2. ncbi request reprint Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gastrointest Surg 10:1280-90; discussion 1290. 2006
    ..3). Internal pancreatic duct stenting does not decrease the frequency or the severity of postoperative pancreatic fistulas...
  3. ncbi request reprint Colorectal liver metastases: recurrence and survival following hepatic resection, radiofrequency ablation, and combined resection-radiofrequency ablation
    Ana L Gleisner
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
    Arch Surg 143:1204-12. 2008
    ....
  4. ncbi request reprint Conditional survival after surgical resection of colorectal liver metastasis: an international multi-institutional analysis of 949 patients
    Hari Nathan
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Coll Surg 210:755-64, 764-6. 2010
    ..We sought to assess the comparative performance of various colorectal liver metastasis prognostic scoring systems, as well as to investigate the CS of patients who underwent resection of colorectal liver metastasis...
  5. ncbi request reprint Surgical management of hepatocellular carcinoma: resection and ablation
    Michael A Choti
    Department of Surgery, Johns Hopkins University School of Medicine, 1830 Monument Street, Baltimore, MD 21025, USA
    J Vasc Interv Radiol 13:S197-203. 2002
    ..Although limited controlled comparative studies exist, surgical and nonsurgical local ablative therapies, including ethanol and radiofrequency ablation, may result in survival benefit...
  6. pmc Trends in long-term survival following liver resection for hepatic colorectal metastases
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Surg 235:759-66. 2002
    ..To examine trends in outcomes of patients undergoing resection at a single tertiary care referral center over a 16-year period...
  7. doi request reprint Patient variability in intraoperative ultrasonographic characteristics of colorectal liver metastases
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, 600 N Wolfe St, Blalock 665, Baltimore, MD 22187 6681, USA
    Arch Surg 143:29-34; discussion 35. 2008
    ..The interpatient and intrapatient variability of tumor IOUS echogenicity was assessed...
  8. doi request reprint Chemotherapy-associated hepatotoxicity: do we need to be concerned?
    Michael A Choti
    Department of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 16:2391-4. 2009
    ..While the histologic association appears likely, the contribution of chemotherapy-associated hepatotoxicity to postoperative morbidity remains ill defined...
  9. pmc Patient readmission and mortality after surgery for hepato-pancreato-biliary malignancies
    Eric B Schneider
    Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 215:607-15. 2012
    ..The objective of the current study was to compare readmission after pancreatic vs hepatobiliary surgical procedures, as well as to identify potential factors associated with higher readmission within 30 days of discharge...
  10. pmc Influence of patient, physician, and hospital factors on 30-day readmission following pancreatoduodenectomy in the United States
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    JAMA Surg 148:1095-102. 2013
    ..IMPORTANCE It is not known whether hospital and surgeon volumes have an association with readmission among patients undergoing pancreatoduodenectomy...
  11. doi request reprint Liver-directed therapy for hepatic metastases in patients undergoing pancreaticoduodenectomy: a dual-center analysis
    Mechteld C de Jong
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 252:142-8. 2010
    ..To analyze the perioperative and long-term outcomes of patients undergoing liver-directed therapy after pancreaticoduodenectomy in a large dual-center cohort of patients...
  12. doi request reprint The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: a multi-institutional analysis of 305 cases
    Mechteld C de Jong
    Division of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 118:4737-47. 2012
    ..In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival...
  13. doi request reprint Trends in nontherapeutic laparotomy rates in patients undergoing surgical therapy for hepatic colorectal metastases
    Timothy M Pawlik
    Department of Surgery, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 22187, USA
    Ann Surg Oncol 16:371-8. 2009
    ..The reasons for this trend are probably multifactorial and may include improved preoperative assessment, such as PET imaging, as well as salvage surgical options...
  14. doi request reprint Therapeutic efficacy of combined intraoperative ablation and resection for colorectal liver metastases: an international, multi-institutional analysis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 15:336-44. 2011
    ..By combining resection and ablation, the number of patients eligible for surgery can be expanded. We sought to determine the efficacy of combined resection and ablation for CRLM...
  15. doi request reprint Incidence and management of chyle leaks following pancreatic resection: a high volume single-center institutional experience
    Lia Assumpcao
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 12:1915-23. 2008
    ..We sought to identify possible risk factors associated with chyle leaks following pancreatic resection, as well as determine the natural history of this rare complication...
  16. doi request reprint Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratio
    Bolanle Asiyanbola
    Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 13:752-9. 2009
    ..There are limited data on patterns of recurrence and factors associated with local recurrence following pancreaticoduodenectomy for pancreatic adenocarcinoma and adjuvant 5-flurouracil-based chemoradiation therapy...
  17. doi request reprint Timing of multimodality therapy for resectable synchronous colorectal liver metastases: a retrospective multi-institutional analysis
    Srinevas K Reddy
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg Oncol 16:1809-19. 2009
    ..However, prospective randomized trials are needed to determine the optimal timing of chemotherapy...
  18. doi request reprint Patient readmission and mortality after colorectal surgery for colon cancer: impact of length of stay relative to other clinical factors
    Eric B Schneider
    Department of Surgery and Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Coll Surg 214:390-8; discussion 398-9. 2012
    ..The objective of the current study was to evaluate risk factors associated with readmission among a nationwide cohort of patients after colorectal surgery...
  19. ncbi request reprint Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases
    Epameinondas Dogeas
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD
    J Am Coll Surg 218:628-35. 2014
    ..In this study, we aimed to evaluate the use of ALT as a biomarker in patients with NELM, in particular to predict the site of origin of metastases...
  20. pmc Recurrence after operative management of intrahepatic cholangiocarcinoma
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Surgery 153:811-8. 2013
    ..Data on recurrence after operation for intrahepatic cholangiocarcinoma (ICC) are limited. We sought to investigate rates and patterns of recurrence in patients after operative intervention for ICC...
  21. pmc A risk model to predict 90-day mortality among patients undergoing hepatic resection
    Omar Hyder
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 216:1049-56. 2013
    ..In addition, we propose a novel integer-based score for 90-day mortality using a large cohort of patients...
  22. ncbi request reprint Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis
    Mark B Slidell
    Department of Surgery, Georgetown University Hospital, Washington, District of Columbia, USA
    Ann Surg Oncol 15:165-74. 2008
    ..LNR has never been investigated in a large population-based study of patients with pancreatic adenocarcinoma...
  23. ncbi request reprint National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis
    Skye C Mayo
    Department of Surgery, The Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:1578-91. 2010
    ..We sought to evaluate compliance with these recommendations and to assess trends in the management and survival of patients with GBA...
  24. doi request reprint Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Halsted 610, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:379-87. 2010
    ..We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms...
  25. ncbi request reprint MKK4 status predicts survival after resection of gastric adenocarcinoma
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Arch Surg 141:1095-9; discussion 1100. 2006
    ..Lack of expression of the tumor-suppressor gene MKK4 is significantly correlated with poor survival after resection of gastric adenocarcinoma...
  26. pmc Re-evaluating the impact of tumor size on survival following pancreaticoduodenectomy for pancreatic adenocarcinoma
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Surg Oncol 103:656-62. 2011
    ..We sought to examine the association of size with outcomes following resection of pancreatic adenocarcinoma...
  27. pmc The role of liver-directed surgery in patients with hepatic metastasis from a gynecologic primary carcinoma
    Sarah I Kamel
    Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
    World J Surg 35:1345-54. 2011
    ..We sought to determine the safety and efficacy of liver-directed surgery for hepatic metastasis from gynecologic primaries...
  28. pmc Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases
    Georgios Karagkounis
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Cancer 119:4137-44. 2013
    ..In this study, the incidence and prognostic significance of KRAS and BRAF mutations were determined in patients undergoing surgical therapy of colorectal liver metastases (CRLM)...
  29. pmc Treating patients with colon cancer liver metastasis: a nationwide analysis of therapeutic decision making
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 19:3668-76. 2012
    ..Criteria for resectability of colon cancer liver metastases (CLM) are evolving, yet little is known about how physicians choose a therapeutic strategy for potentially resectable CLM...
  30. doi request reprint National trends in surgical procedures for hepatocellular carcinoma: 1998-2008
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 118:1838-44. 2012
    ..We quantified trends in use, mortality, and patient and hospital characteristics for 3 surgical therapies for HCC (resection, ablation, and transplantation) in the United States from 1998 to 2008...
  31. pmc Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer 118:2674-81. 2012
    ..Survival estimates, however, are dynamic and may change based on the time already survived. The authors sought to assess conditional survival among a large cohort of patients who underwent resection of PDAC...
  32. ncbi request reprint Impact of obesity on perioperative outcomes and survival following pancreaticoduodenectomy for pancreatic cancer: a large single-institution study
    Susan Tsai
    Department of Surgery, Johns Hopkins Medical Institutions, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:1143-50. 2010
    ..To examine the effect of body mass index (BMI) on clinicopathologic factors and long-term survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma...
  33. doi request reprint Safety and efficacy of curative intent surgery for peri-ampullary liver metastasis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Surg Oncol 102:256-63. 2010
    ..The management of patients with peri-ampullary liver metastasis remains controversial. We sought to assess the safety and efficacy of curative intent surgery for peri-ampullary liver metastasis...
  34. doi request reprint Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspective
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Surg Oncol 99:87-92. 2009
    ..We sought to analyze peri-operative mortality and long-term survival following TP versus PP for pancreatic adenocarcinoma...
  35. ncbi request reprint Total pancreatectomy for pancreatic adenocarcinoma: evaluation of morbidity and long-term survival
    Sushanth Reddy
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 22187, USA
    Ann Surg 250:282-7. 2009
    ..To analyze relative perioperative and long-term outcomes of patients undergoing total pancreatectomy versus pancreaticoduodenectomy...
  36. doi request reprint Influence of nonclinical factors on choice of therapy for early hepatocellular carcinoma
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 20:448-56. 2013
    ..While we previously reported on the effect of clinical factors and surgeon specialty on choice of therapy for early HCC, other nonclinical factors also may impact decision-making...
  37. pmc Impact of sarcopenia on outcomes following resection of pancreatic adenocarcinoma
    Peter Peng
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 16:1478-86. 2012
    ..Sarcopenia--the measurement of muscle wasting--may be a more objective and comprehensive patient-specific factor associated with long-term survival...
  38. pmc Duodenal adenocarcinoma: clinicopathologic analysis and implications for treatment
    George A Poultsides
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg Oncol 19:1928-35. 2012
    ..Duodenal adenocarcinoma is a rare cancer usually studied as a group with periampullary or small bowel adenocarcinoma; therefore, its natural history is poorly understood...
  39. pmc Early mortality risk score: identification of poor outcomes following upfront surgery for resectable pancreatic cancer
    Charles C Hsu
    The Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 410 North Broadway Suite 1440, Baltimore, MD 21231 2410, USA
    J Gastrointest Surg 16:753-61. 2012
    ..This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS)...
  40. doi request reprint Surgery versus intra-arterial therapy for neuroendocrine liver metastasis: a multicenter international analysis
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 18:3657-65. 2011
    ..We sought to examine the relative efficacy of surgical management versus intra-arterial therapy (IAT) for NELM and determine factors predictive of survival...
  41. pmc Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the standard criterion
    Skye C Mayo
    Department of Surgery, School of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    HPB (Oxford) 13:473-82. 2011
    ..To better define perioperative mortality, trends in the risk for death during the first 90 days after hepatectomy were assessed...
  42. ncbi request reprint Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?
    Ana Luiza Gleisner
    Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 22187 6681, USA
    Cancer 110:2484-92. 2007
    ..Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial...
  43. pmc Patterns of recurrence following liver resection for colorectal metastases: effect of primary rectal tumor site
    Lia Assumpcao
    Department of Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Arch Surg 143:743-9; discussion 749-50. 2008
    ..This may affect the pattern of recurrence and survival rates following hepatic resection of liver metastases from rectal adenocarcinoma...
  44. pmc Adjuvant chemoradiation therapy for adenocarcinoma of the distal pancreas
    Kristin J Redmond
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 17:3112-9. 2010
    ..This study was designed to examine the effect of adjuvant 5-FU-based chemoradiation therapy (CRT) after distal pancreatectomy for adenocarcinoma of the distal pancreas...
  45. doi request reprint Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 250:440-8. 2009
    ..To investigate rates and patterns of recurrence in patients following curative intent surgery for colorectal liver metastasis...
  46. pmc Two-stage strategy for patients with extensive bilateral colorectal liver metastases
    Susan Tsai
    Department of Surgery, Division of Surgical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    HPB (Oxford) 12:262-9. 2010
    ..Two-stage hepatectomy has been proposed for patients with bilateral colorectal liver metastases. The present study assesses the feasibility and outcome of two-stage hepatectomy for the treatment of colorectal liver metastases...
  47. doi request reprint Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis: results from an international multi-institutional analysis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 13:2141-51. 2009
    ..We sought to determine safety and efficacy of repeat CIS for recurrent colorectal liver metastasis as well as determine factors predictive of survival in a large multicenter cohort of patients...
  48. ncbi request reprint Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer
    Timothy M Pawlik
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Surgery 141:610-8. 2007
    ....
  49. pmc Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate
    Chad M McCall
    Departments of Pathology Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO
    Am J Surg Pathol 37:1671-7. 2013
    ..These data strongly suggest that Ki67 labeling be performed on all PanNETs in addition to mitotic rate determination to define more accurately tumor grade and prognosis...
  50. pmc Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm?
    Jin He
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Am Coll Surg 216:657-65; discussion 665-7. 2013
    ..Little is known about the risk of subsequently developing a new or progressive intraductal papillary mucinous neoplasm (IPMN) after partial pancreatic resection of a noninvasive IPMN...
  51. doi request reprint Predicting the risk of perioperative mortality in patients undergoing pancreaticoduodenectomy: a novel scoring system
    Raghunandan Venkat
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arch Surg 146:1277-84. 2011
    ..To develop and validate a risk score to predict the 30- and 90-day mortality after a pancreaticoduodenectomy or total pancreatectomy on the basis of preoperative risk factors in a high-volume program...
  52. pmc Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution
    Michelle L DeOliveira
    Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Ann Surg 245:755-62. 2007
    ..To assess long-term survival and prognostic factors in a large series of patients with bile duct cancer...
  53. pmc Palliative surgical management of patients with unresectable pancreatic adenocarcinoma: trends and lessons learned from a large, single institution experience
    Peter J Kneuertz
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 15:1917-27. 2011
    ..We examined trends in the relative use of palliative bypass over time with an emphasis on identifying changes in surgical indications, type of bypass performed, as well as perioperative outcomes associated with surgical palliation...
  54. pmc Management of patients with pancreatic adenocarcinoma: national trends in patient selection, operative management, and use of adjuvant therapy
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Coll Surg 214:33-45. 2012
    ..Advances in surgical technique and perioperative care have reduced perioperative mortality; however, temporal trends in perioperative morbidity and the use of adjuvant therapy on a population basis remain ill-defined...
  55. pmc Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis
    Peter D Peng
    Departments of Surgery Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    HPB (Oxford) 13:439-46. 2011
    ..The impact of sarcopenia on patients undergoing liver resection for colorectal liver metastasis (CRLM) was investigated...
  56. pmc Gallbladder cancer: the role of laparoscopy and radical resection
    Samuel P Shih
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 245:893-901. 2007
    ..We assess how laparoscopy has altered the presentation of patients with gallbladder cancer and determine whether radical resection in patients with gallbladder cancer is beneficial...
  57. ncbi request reprint Survival after gastric adenocarcinoma resection: eighteen-year experience at a single institution
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 1000, USA
    J Gastrointest Surg 9:718-25. 2005
    ..Many of the reported differences among Western series may be due to cohort differences, such as stage of disease, extent of resection, tumor type, and tumor location...
  58. doi request reprint A proposed staging system for intrahepatic cholangiocarcinoma
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 16:14-22. 2009
    ..We propose a staging system specifically developed for ICC based on number of tumors, vascular invasion, lymph node status, and presence of metastatic disease...
  59. ncbi request reprint The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography
    Mark G Van Vledder
    Department of Surgery, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Surg 145:661-7. 2010
    ..To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM)...
  60. ncbi request reprint Intrahepatic cholangiocarcinoma
    George A Poultsides
    Department of Surgery, Division of Surgical Oncology, Stanford University School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305 5641, USA
    Surg Clin North Am 90:817-37. 2010
    ..For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered...
  61. ncbi request reprint Risk factors for pancreatic leak after distal pancreatectomy
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Surg 250:277-81. 2009
    ..We sought to evaluate the incidence of and identify risk factors for the development of PL in patients undergoing distal pancreatectomy (DP) at a single high-volume institution...
  62. pmc Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging system
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 250:970-6. 2009
    ..To identify predictors of survival after resection of retroperitoneal sarcoma (RPS) and to evaluate the performance of the American Joint Committee on Cancer (AJCC) staging system for RPS...
  63. pmc Hilar cholangiocarcinoma: tumor depth as a predictor of outcome
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Surg 146:697-703. 2011
    ..The American Joint Committee on Cancer staging system for hilar cholangiocarcinoma may be inaccurate because the bile duct lacks discrete tissue boundaries...
  64. ncbi request reprint Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment
    Mechteld C de Jong
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Clin Oncol 29:3140-5. 2011
    ..To identify factors associated with outcome after surgical management of intrahepatic cholangiocarcinoma (ICC) and examine the impact of lymph node (LN) assessment on survival...
  65. ncbi request reprint Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literature
    Akhil K Seth
    Department of Surgery, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Carnegie 683, Baltimore, MD 21287, USA
    J Gastrointest Surg 12:1061-7. 2008
    ..Acinar cell carcinoma (ACC) is a rare, malignant neoplasm with a generally poor prognosis. We report our institutional series of 14 patients with ACC to determine current guidelines for their evaluation and treatment...
  66. ncbi request reprint Incidence of finding residual disease for incidental gallbladder carcinoma: implications for re-resection
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 11:1478-86; discussion 1486-7. 2007
    ....
  67. pmc Effect of metabolic syndrome on perioperative outcomes after liver surgery: A National Surgical Quality Improvement Program (NSQIP) analysis
    Neil H Bhayani
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Surgery 152:218-26. 2012
    ..A subset of patients with obesity will have metabolic syndrome. We sought to examine the impact of metabolic syndrome on the risk of morbidity and mortality among a large cohort of patients who underwent hepatic resection...
  68. ncbi request reprint Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis
    Srinevas K Reddy
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg Oncol 14:3481-91. 2007
    ..This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections...
  69. ncbi request reprint Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore Maryland 21231, USA
    Cancer Epidemiol Biomarkers Prev 15:281-7. 2006
    ..These findings may prove useful in the diagnosis and therapeutic targeting of gastric adenocarcinoma precursor lesions...
  70. ncbi request reprint Racial disparity in surgical mortality after major hepatectomy
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Coll Surg 207:312-9. 2008
    ..We sought to quantify and explore the nature of racial disparities in surgical mortality after major hepatectomy in a nationally representative cohort of patients...
  71. ncbi request reprint Understanding surgical decision making in early hepatocellular carcinoma
    Hari Nathan
    The Johns Hopkins Hospital, 600 N Wolfe St, Harvey 611, Baltimore, MD 21287, USA
    J Clin Oncol 29:619-25. 2011
    ..We sought to quantify the impact of both clinical factors and surgeon specialty on surgical decision making in early HCC by using conjoint analysis...
  72. doi request reprint Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysis
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 17:3129-36. 2010
    ..We sought to define the efficacy of the surgical management of NELM in a large multicenter international cohort of patients...
  73. doi request reprint Primary sclerosing cholangitis: role of extrahepatic biliary resection
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 206:822-30; discussion 830-2. 2008
    ..Management of PSC patients without cirrhosis remains controversial. We examined the results of extrahepatic biliary resection (EHBR) for PSC...
  74. doi request reprint Predictors of survival after resection of early hepatocellular carcinoma
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann Surg 249:799-805. 2009
    ..To identify clinicopathologic factors that predict survival following hepatectomy in patients with early hepatocellular carcinoma (HCC)...
  75. pmc A multi-institution analysis of outcomes of liver-directed surgery for metastatic renal cell cancer
    Ioannis Hatzaras
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA
    HPB (Oxford) 14:532-8. 2012
    ..Few data exist on the management of hepatic metastasis from primary renal cell carcinoma (RCC). This study sought to determine the safety and efficacy of surgery for RCC LM...
  76. doi request reprint Improvements in quality of life after surgery for benign hepatic tumors: Results from a dual center analysis
    Peter J Kneuertz
    Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA
    Surgery 152:193-201. 2012
    ..Outcomes after operative management of benign hepatic lesions are ill-defined. We sought to define patient-reported quality of life (QOL) postoperatively for benign hepatic tumors...
  77. ncbi request reprint Echogenic appearance of colorectal liver metastases on intraoperative ultrasonography is associated with survival after hepatic resection
    Michelle L DeOliveira
    Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 11:970-6; discussion 976. 2007
    ..4 vs isoechoic 37.4 vs hyperechoic 46.2%) (p < 0.05). Intraoperative ultrasound echogenicity should be considered a prognostic factor after hepatic resection of metastatic colorectal cancer...
  78. doi request reprint The volume-outcomes effect in hepato-pancreato-biliary surgery: hospital versus surgeon contributions and specificity of the relationship
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Am Coll Surg 208:528-38. 2009
    ..We sought to comprehensively characterize the hospital and surgeon volume-outcomes relationships in high-risk HPB surgery...
  79. doi request reprint Small serotonin-producing neuroendocrine tumor of the pancreas associated with pancreatic duct obstruction
    Satomi Kawamoto
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 601 N Caroline St, JHOC 3235A, Baltimore, MD 21287, USA
    AJR Am J Roentgenol 197:W482-8. 2011
    ..The purpose of this study was to describe cases of small serotonin-producing pancreatic neuroendocrine tumors associated with pancreatic duct obstruction...
  80. ncbi request reprint 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gastrointest Surg 10:1199-210; discussion 1210-1. 2006
    ..This is the largest single-institution experience with PD for pancreatic cancer. Patients who have cancers with favorable pathological features have a statistically significant improved long-term survival...
  81. ncbi request reprint Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Room 442, Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    J Gastrointest Surg 11:1488-96; discussion 1496-7. 2007
    ..We suggest that these trends are largely caused by developments in imaging technology, improvements in patient selection, and advances in surgical techniques...
  82. doi request reprint Factors determining the sensitivity of intraoperative ultrasonography in detecting colorectal liver metastases in the modern era
    Mark G Van Vledder
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 17:2756-63. 2010
    ..The purpose of the current study was to determine the association of clinical parameters and tumor echogenicity with the ability of IOUS to detect occult CRLM...
  83. doi request reprint Disappearing colorectal liver metastases after chemotherapy: should we be concerned?
    Mark G Van Vledder
    Department of Surgery and Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Gastrointest Surg 14:1691-700. 2010
    ..With increasing efficacy of preoperative chemotherapy for colorectal cancer, more patients will present with one or more disappearing liver metastases (DLM) on preoperative cross-sectional imaging...
  84. doi request reprint Single-center phase II trial of transarterial chemoembolization with drug-eluting beads for patients with unresectable hepatocellular carcinoma: initial experience in the United States
    Diane K Reyes
    Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA
    Cancer J 15:526-32. 2009
    ..This prospective phase II pilot study evaluated safety and efficacy of transarterial chemoembolization (TACE) with drug-eluting beads (DEBs) loaded with doxorubicin in patients with unresectable hepatocellular carcinoma (HCC)...
  85. ncbi request reprint Palliation of hepatic tumors
    Steven C Cunningham
    Department of Surgery, University of Maryland Medical Center, Baltimore, MD 21201, USA
    Surg Oncol 16:277-91. 2007
    ..We herein provide a review of the therapeutic approaches to palliate hepatic tumors, as well as how such therapies are designed to alleviate the symptoms of patients with end-stage liver tumors...
  86. doi request reprint Effect of age on survival benefit of adjuvant chemotherapy in elderly patients with Stage III colon cancer
    Ilene H Zuckerman
    Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA
    J Am Geriatr Soc 57:1403-10. 2009
    ..To estimate the modifying effect of age on the survival benefit associated with adjuvant chemotherapy receipt in elderly patients with a diagnosis of Stage III colon cancer...
  87. doi request reprint Operative mortality after hepatic resection: are literature-based rates broadly applicable?
    Bolanle Asiyanbola
    Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 12:842-51. 2008
    ..The objective of the current study was to compare published vs public, nationally available mortality rates after hepatic resection...
  88. doi request reprint Expanding criteria for resectability of colorectal liver metastases
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
    Oncologist 13:51-64. 2008
    ..A therapeutic approach that includes all aspects of multidisciplinary and multimodality care is required to select and treat this complex group of patients...
  89. ncbi request reprint Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review
    Susanna L Matsen
    Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Gastrointest Surg 9:270-9. 2005
    ..We then review the literature of previous cases and delve into the pathophysiology of this peptide...
  90. ncbi request reprint Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastases
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 22187 6681, USA
    Curr Oncol Rep 9:193-201. 2007
    ..Moreover, tumor response to preoperative chemotherapy may also prove to be a useful predictor of outcome following liver resection for colorectal metastases...
  91. ncbi request reprint Efficacy of preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography for assessing primary rectal cancer response to neoadjuvant therapy
    Genevieve B Melton
    Department of Surgery, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 11:961-9; discussion 969. 2007
    ..We sought to evaluate serial FDG-PET/CT for assessing tumor down-staging, percentage residual tumor, and complete response or microscopic disease with rectal cancer neoadjuvant therapy...
  92. ncbi request reprint Chemoembolization of hepatocellular carcinoma: results of a metaanalysis
    Jean Francois H Geschwind
    Departments of Cardiovascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Am J Clin Oncol 26:344-9. 2003
    ....
  93. doi request reprint Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy
    JEREMIAH L DENEVE
    Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Ann Surg Oncol 16:640-8. 2009
    ..Liver cell adenoma (LCA) is a benign hepatic tumor with poorly characterized risk for spontaneous rupture and malignant transformation...
  94. pmc Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis
    Jeffrey M Hardacre
    Department of Surgery, The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287 4688, USA
    Ann Surg 237:853-8; discussion 858-9. 2003
    ....
  95. pmc Periampullary and pancreatic incidentaloma: a single institution's experience with an increasingly common diagnosis
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg 243:673-80; discussion 680-3. 2006
    ..While incidental masses in certain organs have received particular attention, periampullary and pancreatic incidentalomas (PIs) remain poorly characterized...
  96. ncbi request reprint Influence of a new prophylactic antibiotic therapy on the incidence of liver abscesses after chemoembolization treatment of liver tumors
    Jean Francois H Geschwind
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
    J Vasc Interv Radiol 13:1163-6. 2002
    ..Aggressive antibiotic prophylaxis with bowel preparation may provide protection against intrahepatic abscesses after chemoembolization in patients who have a history of biliary reconstructive surgery...
  97. doi request reprint Multidisciplinary management of metastatic sarcoma
    Katherine Thornton
    Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Surg Clin North Am 88:661-72, viii. 2008
    ....
  98. pmc The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer
    Olga Kovbasnjuk
    Division of Gastroenterology, Department of Medicine, and Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:19087-92. 2005
    ..These data demonstrate the appearance of a subpopulation of Gb(3) containing epithelial cells in the metastatic stage of human colon cancer and suggest their possible role in colon cancer invasiveness...
  99. ncbi request reprint Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 14:2807-16. 2007
    ..The role of hepatic resection for metastatic squamous cell carcinoma (SCC) remains unknown. The current study evaluates the role of hepatic resection in patients with metastatic SCC to the liver...
  100. pmc Preoperative assessment of hepatocellular carcinoma tumor grade using needle biopsy: implications for transplant eligibility
    Timothy M Pawlik
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Ann Surg 245:435-42. 2007
    ..To examine the diagnostic agreement of preoperative needle core biopsy (NCB) grading of hepatocellular carcinoma (HCC) compared with the final surgical pathologic tumor grade...
  101. ncbi request reprint Surgically staged focal liver lesions: accuracy and reproducibility of dual-phase helical CT for detection and characterization
    Ihab R Kamel
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 600 N Wolfe St, Rm 100, Baltimore, MD 21287, USA
    Radiology 227:752-7. 2003
    ..To assess the accuracy and reproducibility of dual-phase helical computed tomography (CT) in enabling preoperative detection and characterization of surgically staged focal liver lesions...

Research Grants1

  1. Robot-Aided Liver Ablation Under 3D Ultrasound Guidance
    Michael Choti; Fiscal Year: 2003
    ..In contrast to those, a specific goal of this project is to demonstrate full functional capability with a simple, lightweight and inexpensive system. ..