Research Topics
Genomes and GenesSpecies | Michael A ChotiSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancerMichael G House
Department of Surgery, the Indiana University School of Medicine, Indianapolis, USA
J Gastrointest Surg 10:138-45. 2006..Patterns of liver metastases from islet cell tumors, specifically multiple bilobar metastases that are not amenable to resection and/or ablation, predict a poor outcome despite resection of the primary pancreatic tumor...- Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trialJordan M Winter
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gastrointest Surg 10:1280-90; discussion 1290. 2006..3). Internal pancreatic duct stenting does not decrease the frequency or the severity of postoperative pancreatic fistulas... 
Colorectal liver metastases: recurrence and survival following hepatic resection, radiofrequency ablation, and combined resection-radiofrequency ablationAna L Gleisner
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
Arch Surg 143:1204-12. 2008....- Patient variability in intraoperative ultrasonographic characteristics of colorectal liver metastasesMichael A Choti
Department of Surgery, Johns Hopkins Hospital, 600 N Wolfe St, Blalock 665, Baltimore, MD 22187 6681, USA
Arch Surg 143:29-34; discussion 35. 2008..The interpatient and intrapatient variability of tumor IOUS echogenicity was assessed... 
Trends in long-term survival following liver resection for hepatic colorectal metastasesMichael A Choti
Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Ann Surg 235:759-66. 2002..To examine trends in outcomes of patients undergoing resection at a single tertiary care referral center over a 16-year period...- Chemotherapy-associated hepatotoxicity: do we need to be concerned?Michael A Choti
Department of Surgery, Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 16:2391-4. 2009..While the histologic association appears likely, the contribution of chemotherapy-associated hepatotoxicity to postoperative morbidity remains ill defined... - Surgical management of hepatocellular carcinoma: resection and ablationMichael A Choti
Department of Surgery, Johns Hopkins University School of Medicine, 1830 Monument Street, Baltimore, MD 21025, USA
J Vasc Interv Radiol 13:S197-203. 2002..Although limited controlled comparative studies exist, surgical and nonsurgical local ablative therapies, including ethanol and radiofrequency ablation, may result in survival benefit... - Patient readmission and mortality after surgery for hepato-pancreato-biliary malignanciesEric B Schneider
Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD
J Am Coll Surg 215:607-15. 2012..The objective of the current study was to compare readmission after pancreatic vs hepatobiliary surgical procedures, as well as to identify potential factors associated with higher readmission within 30 days of discharge... - Liver-directed therapy for hepatic metastases in patients undergoing pancreaticoduodenectomy: a dual-center analysisMechteld C de Jong
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg 252:142-8. 2010..To analyze the perioperative and long-term outcomes of patients undergoing liver-directed therapy after pancreaticoduodenectomy in a large dual-center cohort of patients... - The impact of portal vein resection on outcomes for hilar cholangiocarcinoma: a multi-institutional analysis of 305 casesMechteld C de Jong
Division of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer 118:4737-47. 2012..In this study, the authors sought to identify factors associated with outcome after surgical management of hilar cholangiocarcinoma and examined the impact of PVR on survival... - Conditional survival after surgical resection of colorectal liver metastasis: an international multi-institutional analysis of 949 patientsHari Nathan
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Am Coll Surg 210:755-64, 764-6. 2010..We sought to assess the comparative performance of various colorectal liver metastasis prognostic scoring systems, as well as to investigate the CS of patients who underwent resection of colorectal liver metastasis... - Incidence and management of chyle leaks following pancreatic resection: a high volume single-center institutional experienceLia Assumpcao
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gastrointest Surg 12:1915-23. 2008..We sought to identify possible risk factors associated with chyle leaks following pancreatic resection, as well as determine the natural history of this rare complication... - Therapeutic efficacy of combined intraoperative ablation and resection for colorectal liver metastases: an international, multi-institutional analysisMechteld C de Jong
Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611, 600N Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 15:336-44. 2011..By combining resection and ablation, the number of patients eligible for surgery can be expanded. We sought to determine the efficacy of combined resection and ablation for CRLM... - Trends in nontherapeutic laparotomy rates in patients undergoing surgical therapy for hepatic colorectal metastasesTimothy M Pawlik
Department of Surgery, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 22187, USA
Ann Surg Oncol 16:371-8. 2009..The reasons for this trend are probably multifactorial and may include improved preoperative assessment, such as PET imaging, as well as salvage surgical options... - Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratioBolanle Asiyanbola
Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
J Gastrointest Surg 13:752-9. 2009..There are limited data on patterns of recurrence and factors associated with local recurrence following pancreaticoduodenectomy for pancreatic adenocarcinoma and adjuvant 5-flurouracil-based chemoradiation therapy... - Patient readmission and mortality after colorectal surgery for colon cancer: impact of length of stay relative to other clinical factorsEric B Schneider
Department of Surgery and Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Am Coll Surg 214:390-8; discussion 398-9. 2012..The objective of the current study was to evaluate risk factors associated with readmission among a nationwide cohort of patients after colorectal surgery... - Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysisMark B Slidell
Department of Surgery, Georgetown University Hospital, Washington, District of Columbia, USA
Ann Surg Oncol 15:165-74. 2008..LNR has never been investigated in a large population-based study of patients with pancreatic adenocarcinoma... - MKK4 status predicts survival after resection of gastric adenocarcinomaSteven C Cunningham
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231-1000, USA
Arch Surg 141:1095-9; discussion 1100. 2006..This finding may provide a useful prognostic tool in patients with gastric adenocarcinoma... - National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysisSkye C Mayo
Department of Surgery, The Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 14:1578-91. 2010..We sought to evaluate compliance with these recommendations and to assess trends in the management and survival of patients with GBA... - Timing of multimodality therapy for resectable synchronous colorectal liver metastases: a retrospective multi-institutional analysisSrinevas K Reddy
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Ann Surg Oncol 16:1809-19. 2009..However, prospective randomized trials are needed to determine the optimal timing of chemotherapy... - Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosisJordan M Winter
Department of Surgery, Johns Hopkins Medical Institutions, Halsted 610, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 14:379-87. 2010..We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms... - Re-evaluating the impact of tumor size on survival following pancreaticoduodenectomy for pancreatic adenocarcinomaMechteld C de Jong
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Surg Oncol 103:656-62. 2011..We sought to examine the association of size with outcomes following resection of pancreatic adenocarcinoma... - The role of liver-directed surgery in patients with hepatic metastasis from a gynecologic primary carcinomaSarah I Kamel
Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
World J Surg 35:1345-54. 2011..We sought to determine the safety and efficacy of liver-directed surgery for hepatic metastasis from gynecologic primaries... - Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intentSkye C Mayo
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cancer 118:2674-81. 2012..Survival estimates, however, are dynamic and may change based on the time already survived. The authors sought to assess conditional survival among a large cohort of patients who underwent resection of PDAC... - National trends in surgical procedures for hepatocellular carcinoma: 1998-2008Hari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Cancer 118:1838-44. 2012..We quantified trends in use, mortality, and patient and hospital characteristics for 3 surgical therapies for HCC (resection, ablation, and transplantation) in the United States from 1998 to 2008... - Safety and efficacy of curative intent surgery for peri-ampullary liver metastasisMechteld C de Jong
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Surg Oncol 102:256-63. 2010..The management of patients with peri-ampullary liver metastasis remains controversial. We sought to assess the safety and efficacy of curative intent surgery for peri-ampullary liver metastasis... - Total pancreatectomy for pancreatic adenocarcinoma: evaluation of morbidity and long-term survivalSushanth Reddy
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 22187, USA
Ann Surg 250:282-7. 2009..To analyze relative perioperative and long-term outcomes of patients undergoing total pancreatectomy versus pancreaticoduodenectomy... - Impact of obesity on perioperative outcomes and survival following pancreaticoduodenectomy for pancreatic cancer: a large single-institution studySusan Tsai
Department of Surgery, Johns Hopkins Medical Institutions, 600N Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 14:1143-50. 2010..To examine the effect of body mass index (BMI) on clinicopathologic factors and long-term survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma... - Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspectiveHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Surg Oncol 99:87-92. 2009..We sought to analyze peri-operative mortality and long-term survival following TP versus PP for pancreatic adenocarcinoma... - Impact of sarcopenia on outcomes following resection of pancreatic adenocarcinomaPeter Peng
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gastrointest Surg 16:1478-86. 2012..Sarcopenia--the measurement of muscle wasting--may be a more objective and comprehensive patient-specific factor associated with long-term survival... - Duodenal adenocarcinoma: clinicopathologic analysis and implications for treatmentGeorge A Poultsides
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Ann Surg Oncol 19:1928-35. 2012..Duodenal adenocarcinoma is a rare cancer usually studied as a group with periampullary or small bowel adenocarcinoma; therefore, its natural history is poorly understood... - Early mortality risk score: identification of poor outcomes following upfront surgery for resectable pancreatic cancerCharles C Hsu
The Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 410 North Broadway Suite 1440, Baltimore, MD 21231 2410, USA
J Gastrointest Surg 16:753-61. 2012..This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS)... - Surgery versus intra-arterial therapy for neuroendocrine liver metastasis: a multicenter international analysisSkye C Mayo
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 18:3657-65. 2011..We sought to examine the relative efficacy of surgical management versus intra-arterial therapy (IAT) for NELM and determine factors predictive of survival... - Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the standard criterionSkye C Mayo
Department of Surgery, School of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
HPB (Oxford) 13:473-82. 2011..To better define perioperative mortality, trends in the risk for death during the first 90 days after hepatectomy were assessed... - Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patientsMechteld C de Jong
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg 250:440-8. 2009..To investigate rates and patterns of recurrence in patients following curative intent surgery for colorectal liver metastasis... - Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis: results from an international multi-institutional analysisMechteld C de Jong
Department of Surgery, Johns Hopkins University School of Medicine, Harvey 611 600 N Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 13:2141-51. 2009..We sought to determine safety and efficacy of repeat CIS for recurrent colorectal liver metastasis as well as determine factors predictive of survival in a large multicenter cohort of patients... - Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?Ana Luiza Gleisner
Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 22187 6681, USA
Cancer 110:2484-92. 2007..Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial... - Patterns of recurrence following liver resection for colorectal metastases: effect of primary rectal tumor siteLia Assumpcao
Department of Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Arch Surg 143:743-9; discussion 749-50. 2008..This may affect the pattern of recurrence and survival rates following hepatic resection of liver metastases from rectal adenocarcinoma... - Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancerTimothy M Pawlik
Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
Surgery 141:610-8. 2007.... - Two-stage strategy for patients with extensive bilateral colorectal liver metastasesSusan Tsai
Department of Surgery, Division of Surgical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
HPB (Oxford) 12:262-9. 2010..Two-stage hepatectomy has been proposed for patients with bilateral colorectal liver metastases. The present study assesses the feasibility and outcome of two-stage hepatectomy for the treatment of colorectal liver metastases... - Adjuvant chemoradiation therapy for adenocarcinoma of the distal pancreasKristin J Redmond
Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 17:3112-9. 2010..This study was designed to examine the effect of adjuvant 5-FU-based chemoradiation therapy (CRT) after distal pancreatectomy for adenocarcinoma of the distal pancreas... - Predicting the risk of perioperative mortality in patients undergoing pancreaticoduodenectomy: a novel scoring systemRaghunandan Venkat
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Arch Surg 146:1277-84. 2011..To develop and validate a risk score to predict the 30- and 90-day mortality after a pancreaticoduodenectomy or total pancreatectomy on the basis of preoperative risk factors in a high-volume program... - Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institutionMichelle L DeOliveira
Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
Ann Surg 245:755-62. 2007..To assess long-term survival and prognostic factors in a large series of patients with bile duct cancer... - Management of patients with pancreatic adenocarcinoma: national trends in patient selection, operative management, and use of adjuvant therapySkye C Mayo
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Am Coll Surg 214:33-45. 2012..Advances in surgical technique and perioperative care have reduced perioperative mortality; however, temporal trends in perioperative morbidity and the use of adjuvant therapy on a population basis remain ill-defined... - Palliative surgical management of patients with unresectable pancreatic adenocarcinoma: trends and lessons learned from a large, single institution experiencePeter J Kneuertz
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gastrointest Surg 15:1917-27. 2011..We examined trends in the relative use of palliative bypass over time with an emphasis on identifying changes in surgical indications, type of bypass performed, as well as perioperative outcomes associated with surgical palliation... - Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasisPeter D Peng
Departments of Surgery Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
HPB (Oxford) 13:439-46. 2011..The impact of sarcopenia on patients undergoing liver resection for colorectal liver metastasis (CRLM) was investigated... - Intrahepatic cholangiocarcinomaGeorge A Poultsides
Department of Surgery, Division of Surgical Oncology, Stanford University School of Medicine, 300 Pasteur Drive, H3680, Stanford, CA 94305 5641, USA
Surg Clin North Am 90:817-37. 2010..For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered... - Gallbladder cancer: the role of laparoscopy and radical resectionSamuel P Shih
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg 245:893-901. 2007..We assess how laparoscopy has altered the presentation of patients with gallbladder cancer and determine whether radical resection in patients with gallbladder cancer is beneficial... - A proposed staging system for intrahepatic cholangiocarcinomaHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 16:14-22. 2009..We propose a staging system specifically developed for ICC based on number of tumors, vascular invasion, lymph node status, and presence of metastatic disease... - Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging systemHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg 250:970-6. 2009..To identify predictors of survival after resection of retroperitoneal sarcoma (RPS) and to evaluate the performance of the American Joint Committee on Cancer (AJCC) staging system for RPS... - Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessmentMechteld C de Jong
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Clin Oncol 29:3140-5. 2011..To identify factors associated with outcome after surgical management of intrahepatic cholangiocarcinoma (ICC) and examine the impact of lymph node (LN) assessment on survival... - The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonographyMark G Van Vledder
Department of Surgery, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Arch Surg 145:661-7. 2010..To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM)... - Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literatureAkhil K Seth
Department of Surgery, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Carnegie 683, Baltimore, MD 21287, USA
J Gastrointest Surg 12:1061-7. 2008..Acinar cell carcinoma (ACC) is a rare, malignant neoplasm with a generally poor prognosis. We report our institutional series of 14 patients with ACC to determine current guidelines for their evaluation and treatment... - Hilar cholangiocarcinoma: tumor depth as a predictor of outcomeMechteld C de Jong
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Arch Surg 146:697-703. 2011..The American Joint Committee on Cancer staging system for hilar cholangiocarcinoma may be inaccurate because the bile duct lacks discrete tissue boundaries... - Risk factors for pancreatic leak after distal pancreatectomyHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann Surg 250:277-81. 2009..We sought to evaluate the incidence of and identify risk factors for the development of PL in patients undergoing distal pancreatectomy (DP) at a single high-volume institution... - Survival after gastric adenocarcinoma resection: eighteen-year experience at a single institutionSteven C Cunningham
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231-1000, USA
J Gastrointest Surg 9:718-25. 2005..Many of the reported differences among Western series may be due to cohort differences, such as stage of disease, extent of resection, tumor type, and tumor location... - Incidence of finding residual disease for incidental gallbladder carcinoma: implications for re-resectionTimothy M Pawlik
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 22187 6681, USA
J Gastrointest Surg 11:1478-86; discussion 1486-7. 2007.... - Effect of metabolic syndrome on perioperative outcomes after liver surgery: A National Surgical Quality Improvement Program (NSQIP) analysisNeil H Bhayani
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Surgery 152:218-26. 2012..A subset of patients with obesity will have metabolic syndrome. We sought to examine the impact of metabolic syndrome on the risk of morbidity and mortality among a large cohort of patients who underwent hepatic resection... - Understanding surgical decision making in early hepatocellular carcinomaHari Nathan
The Johns Hopkins Hospital, 600 N Wolfe St, Harvey 611, Baltimore, MD 21287, USA
J Clin Oncol 29:619-25. 2011..We sought to quantify the impact of both clinical factors and surgeon specialty on surgical decision making in early HCC by using conjoint analysis... - Racial disparity in surgical mortality after major hepatectomyHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Am Coll Surg 207:312-9. 2008..We sought to quantify and explore the nature of racial disparities in surgical mortality after major hepatectomy in a nationally representative cohort of patients... - Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysisSkye C Mayo
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 17:3129-36. 2010..We sought to define the efficacy of the surgical management of NELM in a large multicenter international cohort of patients... - Predictors of survival after resection of early hepatocellular carcinomaHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann Surg 249:799-805. 2009..To identify clinicopathologic factors that predict survival following hepatectomy in patients with early hepatocellular carcinoma (HCC)... - Primary sclerosing cholangitis: role of extrahepatic biliary resectionTimothy M Pawlik
Department of Surgery, Johns Hopkins University Hospital, Baltimore, MD 21287, USA
J Am Coll Surg 206:822-30; discussion 830-2. 2008..Management of PSC patients without cirrhosis remains controversial. We examined the results of extrahepatic biliary resection (EHBR) for PSC... - Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesionsSteven C Cunningham
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore Maryland 21231, USA
Cancer Epidemiol Biomarkers Prev 15:281-7. 2006..These findings may prove useful in the diagnosis and therapeutic targeting of gastric adenocarcinoma precursor lesions... - Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysisSrinevas K Reddy
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Ann Surg Oncol 14:3481-91. 2007..This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections... - A multi-institution analysis of outcomes of liver-directed surgery for metastatic renal cell cancerIoannis Hatzaras
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA
HPB (Oxford) 14:532-8. 2012..Few data exist on the management of hepatic metastasis from primary renal cell carcinoma (RCC). This study sought to determine the safety and efficacy of surgery for RCC LM... - Improvements in quality of life after surgery for benign hepatic tumors: Results from a dual center analysisPeter J Kneuertz
Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA
Surgery 152:193-201. 2012..Outcomes after operative management of benign hepatic lesions are ill-defined. We sought to define patient-reported quality of life (QOL) postoperatively for benign hepatic tumors... - 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experienceJordan M Winter
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Gastrointest Surg 10:1199-210; discussion 1210-1. 2006..This is the largest single-institution experience with PD for pancreatic cancer. Patients who have cancers with favorable pathological features have a statistically significant improved long-term survival... - Echogenic appearance of colorectal liver metastases on intraoperative ultrasonography is associated with survival after hepatic resectionMichelle L DeOliveira
Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
J Gastrointest Surg 11:970-6; discussion 976. 2007..4 vs isoechoic 37.4 vs hyperechoic 46.2%) (p < 0.05). Intraoperative ultrasound echogenicity should be considered a prognostic factor after hepatic resection of metastatic colorectal cancer... - Small serotonin-producing neuroendocrine tumor of the pancreas associated with pancreatic duct obstructionSatomi Kawamoto
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 601 N Caroline St, JHOC 3235A, Baltimore, MD 21287, USA
AJR Am J Roentgenol 197:W482-8. 2011..Evidence of small pancreatic neuroendocrine tumors should be sought in cases of idiopathic pancreatic duct stenosis... - The volume-outcomes effect in hepato-pancreato-biliary surgery: hospital versus surgeon contributions and specificity of the relationshipHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Am Coll Surg 208:528-38. 2009..We sought to comprehensively characterize the hospital and surgeon volume-outcomes relationships in high-risk HPB surgery... - Effect of age on survival benefit of adjuvant chemotherapy in elderly patients with Stage III colon cancerIlene H Zuckerman
Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA
J Am Geriatr Soc 57:1403-10. 2009..To estimate the modifying effect of age on the survival benefit associated with adjuvant chemotherapy receipt in elderly patients with a diagnosis of Stage III colon cancer... - Single-center phase II trial of transarterial chemoembolization with drug-eluting beads for patients with unresectable hepatocellular carcinoma: initial experience in the United StatesDiane K Reyes
Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA
Cancer J 15:526-32. 2009..This prospective phase II pilot study evaluated safety and efficacy of transarterial chemoembolization (TACE) with drug-eluting beads (DEBs) loaded with doxorubicin in patients with unresectable hepatocellular carcinoma (HCC)... - Disappearing colorectal liver metastases after chemotherapy: should we be concerned?Mark G Van Vledder
Department of Surgery and Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Gastrointest Surg 14:1691-700. 2010..With increasing efficacy of preoperative chemotherapy for colorectal cancer, more patients will present with one or more disappearing liver metastases (DLM) on preoperative cross-sectional imaging... - Factors determining the sensitivity of intraoperative ultrasonography in detecting colorectal liver metastases in the modern eraMark G Van Vledder
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 17:2756-63. 2010..The purpose of the current study was to determine the association of clinical parameters and tumor echogenicity with the ability of IOUS to detect occult CRLM... - Palliation of hepatic tumorsSteven C Cunningham
Department of Surgery, University of Maryland Medical Center, Baltimore, MD 21201, USA
Surg Oncol 16:277-91. 2007..We herein provide a review of the therapeutic approaches to palliate hepatic tumors, as well as how such therapies are designed to alleviate the symptoms of patients with end-stage liver tumors... - Trends in survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysisHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Room 442, Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
J Gastrointest Surg 11:1488-96; discussion 1496-7. 2007..We suggest that these trends are largely caused by developments in imaging technology, improvements in patient selection, and advances in surgical techniques... - Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastasesTimothy M Pawlik
Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 22187 6681, USA
Curr Oncol Rep 9:193-201. 2007..Moreover, tumor response to preoperative chemotherapy may also prove to be a useful predictor of outcome following liver resection for colorectal metastases... - Operative mortality after hepatic resection: are literature-based rates broadly applicable?Bolanle Asiyanbola
Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
J Gastrointest Surg 12:842-51. 2008..The objective of the current study was to compare published vs public, nationally available mortality rates after hepatic resection... - Periampullary and pancreatic incidentaloma: a single institution's experience with an increasingly common diagnosisJordan M Winter
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Ann Surg 243:673-80; discussion 680-3. 2006.... - Chemoembolization of hepatocellular carcinoma: results of a metaanalysisJean-Francois H Geschwind
Departments of Cardiovascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Am J Clin Oncol 26:344-9. 2003.... - Efficacy of preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography for assessing primary rectal cancer response to neoadjuvant therapyGenevieve B Melton
Department of Surgery, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 11:961-9; discussion 969. 2007..We sought to evaluate serial FDG-PET/CT for assessing tumor down-staging, percentage residual tumor, and complete response or microscopic disease with rectal cancer neoadjuvant therapy... - Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject reviewSusanna L Matsen
Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Gastrointest Surg 9:270-9. 2005..We then review the literature of previous cases and delve into the pathophysiology of this peptide... - Expanding criteria for resectability of colorectal liver metastasesTimothy M Pawlik
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 22187 6681, USA
Oncologist 13:51-64. 2008..A therapeutic approach that includes all aspects of multidisciplinary and multimodality care is required to select and treat this complex group of patients... - Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitisJeffrey M Hardacre
Department of Surgery, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287-4688, USA
Ann Surg 237:853-8; discussion 858-9. 2003..Nevertheless, differentiation from pancreatic neoplasia remains difficult. Patients undergoing pancreaticoduodenectomy for LPSP have durable relief of symptoms and a subjectively improved quality of life... - Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancyJEREMIAH L DENEVE
Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Ann Surg Oncol 16:640-8. 2009..Liver cell adenoma (LCA) is a benign hepatic tumor with poorly characterized risk for spontaneous rupture and malignant transformation... - Surgically staged focal liver lesions: accuracy and reproducibility of dual-phase helical CT for detection and characterizationIhab R Kamel
Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 600 N Wolfe St, Rm 100, Baltimore, MD 21287, USA
Radiology 227:752-7. 2003..To assess the accuracy and reproducibility of dual-phase helical computed tomography (CT) in enabling preoperative detection and characterization of surgically staged focal liver lesions... - Influence of a new prophylactic antibiotic therapy on the incidence of liver abscesses after chemoembolization treatment of liver tumorsJean Francois H Geschwind
Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
J Vasc Interv Radiol 13:1163-6. 2002..Aggressive antibiotic prophylaxis with bowel preparation may provide protection against intrahepatic abscesses after chemoembolization in patients who have a history of biliary reconstructive surgery... - The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancerOlga Kovbasnjuk
Division of Gastroenterology, Department of Medicine, and Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:19087-92. 2005..These data demonstrate the appearance of a subpopulation of Gb(3) containing epithelial cells in the metastatic stage of human colon cancer and suggest their possible role in colon cancer invasiveness... - Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysisTimothy M Pawlik
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 14:2807-16. 2007..The role of hepatic resection for metastatic squamous cell carcinoma (SCC) remains unknown. The current study evaluates the role of hepatic resection in patients with metastatic SCC to the liver... - Multidisciplinary management of metastatic sarcomaKatherine Thornton
Department of Medical Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Surg Clin North Am 88:661-72, viii. 2008.... - Preoperative assessment of hepatocellular carcinoma tumor grade using needle biopsy: implications for transplant eligibilityTimothy M Pawlik
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
Ann Surg 245:435-42. 2007..To examine the diagnostic agreement of preoperative needle core biopsy (NCB) grading of hepatocellular carcinoma (HCC) compared with the final surgical pathologic tumor grade... - Transcatheter arterial chemoembolization of liver tumors: effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patencyJean-Francois H Geschwind
The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA
Cardiovasc Intervent Radiol 26:111-7. 2003..6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE... - Palliative therapy for pancreatic/biliary cancerMichael G House
Department of Surgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Surg Oncol Clin N Am 13:491-503, ix. 2004..As with all treatment planning, palliative therapy should be planned using a multidisciplinary approach, including input from the surgeon, gastroenterologist,radiologist, and medical and radiation oncologist... - Counting alleles to predict recurrence of early-stage colorectal cancersWei Zhou
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Lancet 359:219-25. 2002..002). INTERPRETATION: In patients without metastasis, allelic imbalance is a better predictor of prognosis than histopathological stage... - Surgical therapy for colorectal metastases to the liverTimothy M Pawlik
Division of Surgical Oncology, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
J Gastrointest Surg 11:1057-77. 2007..Modern treatment of colorectal liver metastasis requires a multidisciplinary approach in an effort to increase the number of patients who may benefit from surgical treatment of colorectal cancer liver metastasis... - Malignant transformation of hepatic adenomasShien T L Micchelli
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Mod Pathol 21:491-7. 2008..No common molecular pathway of hepatocellular carcinogenesis was observed by examining AFP, beta-catenin, and p53 immunostains and no beta-catenin mutations or deletions were found... - Differences in characteristics of patients with and without known risk factors for hepatocellular carcinoma in the United StatesJon D Dorfman
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
World J Gastroenterol 13:781-4. 2007..To examine the clinical characteristics of a subgroup of patients with hepatocellular carcinoma (HCC) and compare them to those with known risk factors... - Controversies in the surgical management of cholangiocarcinoma and gallbladder cancerJason K Sicklick
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Semin Oncol 32:S112-7. 2005..This review examines available information and controversies in the areas of preoperative evaluation and surgical treatment of cholangiocarcinoma and gallbladder cancer... - Urgent need for a new staging system in advanced colorectal cancerGraeme J Poston
Department of Surgery, University Hospital Aintree, Liverpool, L9 7AL, United Kingdom
J Clin Oncol 26:4828-33. 2008.... - Racial and geographic disparities in the utilization of surgical therapy for hepatocellular carcinomaChristopher J Sonnenday
The Department of Surgery, The University of Michigan, Ann Arbor, MI, USA
J Gastrointest Surg 11:1636-46; discussion 1646. 2007..001). Further investigation to understand the etiology of these profound racial and geographic disparities is essential to ensure equitable provision of surgical therapies, which provide the only potentially curative treatments for HCC...
Research Grants
- Robot-Aided Liver Ablation Under 3D Ultrasound GuidanceMichael Choti; Fiscal Year: 2003..In contrast to those, a specific goal of this project is to demonstrate full functional capability with a simple, lightweight and inexpensive system. ..