Kejing Chen

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells
    Kejing Chen
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, 613 Traylor Building, Baltimore, MD 21205, USA
    Free Radic Biol Med 41:668-80. 2006
  2. pmc Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3)
    Kejing Chen
    Department of Biomedical Engineering, 613 Traylor Building, 720 Rutland Avenue, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Free Radic Biol Med 42:811-22. 2007
  3. ncbi request reprint Vascular smooth muscle NO exposure from intraerythrocytic SNOHb: a mathematical model
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:1097-110. 2007
  4. pmc Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 613 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Nitric Oxide 18:47-60. 2008
  5. pmc Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 10:1185-98. 2008
  6. pmc Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: a quantitative analysis
    Kejing Chen
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Microvasc Res 78:107-18. 2009
  7. pmc Nitric oxide production pathways in erythrocytes and plasma
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biorheology 46:107-19. 2009
  8. ncbi request reprint Effects of iron nitrosylation on sickle cell hemoglobin solubility
    Xiuli Xu
    Department of Physics, Wake Forest University, Winston Salem, North Carolina 27109, USA
    J Biol Chem 277:36787-92. 2002

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells
    Kejing Chen
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, 613 Traylor Building, Baltimore, MD 21205, USA
    Free Radic Biol Med 41:668-80. 2006
    ..The results indicated that the predicted low level of NO production can be attributed primarily to a low expression of eNOS in the microvascular endothelial cells...
  2. pmc Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3)
    Kejing Chen
    Department of Biomedical Engineering, 613 Traylor Building, 720 Rutland Avenue, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Free Radic Biol Med 42:811-22. 2007
    ....
  3. ncbi request reprint Vascular smooth muscle NO exposure from intraerythrocytic SNOHb: a mathematical model
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:1097-110. 2007
    ..In conclusion, our mathematical model predicts that picomolar amounts of NO can be delivered to the vascular smooth muscle by intraerythrocytic SNOHb; this amount of NO alone appears not sufficient to induce the hypoxic vasodilation...
  4. pmc Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 613 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Nitric Oxide 18:47-60. 2008
    ..mM in erythrocyte); (3) intraerythrocytic hemoglobin encapsulated by a NO-resistant membrane is the major source of NO from nitrite reduction, and cell-free hemoglobin is a significant scavenger of both paracrine and endocrine NO...
  5. pmc Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 10:1185-98. 2008
    ..Resolving these issues is highly relevant to improving our understanding of vascular biology and to developing pharmaceutical agents that target NO pathways, such as vasodilating drugs...
  6. pmc Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: a quantitative analysis
    Kejing Chen
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 613 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Microvasc Res 78:107-18. 2009
    ..This study provides a basis for detailed studies to characterize the impairment of NO release pathways during hemorrhage and yield important insights for the development of resuscitation methods...
  7. pmc Nitric oxide production pathways in erythrocytes and plasma
    Kejing Chen
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biorheology 46:107-19. 2009
    ..Here we review the hypotheses that have been put forward concerning blood-borne NO and its contribution to hemorheological properties and the regulation of vascular tone, with an emphasis on the quantitative aspects of these processes...
  8. ncbi request reprint Effects of iron nitrosylation on sickle cell hemoglobin solubility
    Xiuli Xu
    Department of Physics, Wake Forest University, Winston Salem, North Carolina 27109, USA
    J Biol Chem 277:36787-92. 2002
    ..Given the small amounts of NO-ligated hemoglobin achievable through any kind of NO therapy, we conclude that NO therapy does not benefit patients through any direct solubilizing effect...