Raul Chavez-Valdez

Summary

Affiliation: Johns Hopkins University
Location: Baltimore, United States
URL: http://www.hopkinschildrens.org/Raul-Chavez-Valdez/
Publications:
1. Bierman AM, Tankersley CG, Wilson CG, Chavez-Valdez R, Gauda EB. Perinatal hyperoxic exposure reconfigures the central respiratory network contributing to intolerance to anoxia in newborn rat pups. J Appl Physiol (1985). 2014 Jan;116(1):47-53. PMID: .

2. Chavez-Valdez R, Martin LJ, Razdan S, Gauda EB, Northington FJ. Sexual dimorphism in BDNF signaling after neonatal hypoxia-ischemia and treatment with necrostatin-1. Neuroscience. 2013 Dec 17. PMID: .

3. Stridh L, Mottahedin A, Johansson ME, Valdez RC, Northington F, Wang X, Mallard C. Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia. J Neurosci. 2013 Jul 17;33(29):12041-51. PMID:

4. Chavez-Valdez R, Kovell L, Ahlawat R, McLemore GL, Wills-Karp M, Gauda EB. Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells. J Perinatol. 2013 May;33(5):374-82. PubMed PMID:

5. Gauda EB, Shirahata M, Mason A, Pichard LE, Kostuk EW, Chavez-Valdez R. Inflammation in the carotid body during development and its contribution to apnea of prematurity. Respir Physiol Neurobiol. 2013 Jan 1;185(1):120-31. PubMed PMID: .

6. Chavez-Valdez R, Martin LJ, Flock DL, Northington FJ. Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia. Neuroscience. 2012 Sep 6;219:192-203. PMID: .

7. Chavez-Valdez R, Mason A, Nunes AR, Northington FJ, Tankersley C, Ahlawat R, Johnson SM, Gauda EB. Effect of hyperoxic exposure during early development on neurotrophin expression in the carotid body and nucleus tractus solitarii. J Appl Physiol (1985). 2012 May;112(10):1762-72. PubMed PMID:

8. Robertson NJ, Tan S, Groenendaal F, van Bel F, Juul SE, Bennet L, Derrick M, Back SA, Valdez RC, Northington F, Gunn AJ, Mallard C. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? J Pediatr. 2012 Apr;160(4):544-552.e4. PMID: .

9. Nunes AR, Chavez-Valdez R, Ezell T, Donnelly DF, Glover JC, Gauda EB. Effect of development on [Ca2+]i transients to ATP in petrosal ganglion neurons: a pharmacological approach using optical recording. J Appl Physiol (1985). 2012 Apr;112(8):1393-402. PubMed PMID:

10. Chavez-Valdez R, Martin LJ, Northington FJ. Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury. Neurol Res Int. 2012;2012:257563. PMID:

11. Chavez-Valdez R, McGowan J, Cannon E, Lehmann CU. Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants. J Perinatol. 2011 Dec;31(12):749-56. PMID: .

12. Northington FJ, Chavez-Valdez R, Martin LJ. Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol. 2011 May;69(5):743-58. PMID: .

13. Martinez EA, Chavez-Valdez R, Holt NF, Grogan KL, Khalifeh KW, Slater T, Winner LE, Moyer J, Lehmann CU. Successful implementation of a perioperative glycemic control protocol in cardiac surgery: barrier analysis and intervention using lean six sigma. Anesthesiol Res Pract. 2011;2011:565069. PMID:

14. Chavez Valdez R, Ahlawat R, Wills-Karp M, Nathan A, Ezell T, Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Pediatr. 2011 Jan;158(1):57-64, 64.e1. PMID: .

15. Northington FJ, Chavez-Valdez R, Graham EM, Razdan S, Gauda EB, Martin LJ. Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. J Cereb Blood Flow Metab. 2011 Jan;31(1):178-89. PMID:

16. Agthe AG, Kim GR, Mathias KB, Hendrix CW, Chavez-Valdez R, Jansson L, Lewis TR, Yaster M, Gauda EB. Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. Pediatrics. 2009 May;123(5):e849-56. PMID:

17. Chavez-Valdez R, Wills-Karp M, Ahlawat R, Cristofalo EA, Nathan A, Gauda EB. Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors. Pediatr Res. 2009 Feb;65(2):203-8. PubMed PMID: .

18. Cama VA, Ross JM, Crawford S, Kawai V, Chavez-Valdez R, Vargas D, Vivar A, Ticona E, Navincopa M, Williamson J, Ortega Y, Gilman RH, Bern C, Xiao L. Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons. J Infect Dis. 2007 Sep 1;196(5):684-91. PMID: .

19. Bern C, Kawai V, Vargas D, Rabke-Verani J, Williamson J, Chavez-Valdez R, Xiao L, Sulaiman I, Vivar A, Ticona E, Navincopa M, Cama V, Moura H, Secor WE, Visvesvara G, Gilman RH. The epidemiology of intestinal microsporidiosis in patients with HIV/AIDS in Lima, Peru. J Infect Dis. 2005 May 15;191(10):1658-64. PubMed PMID: .

Publications

  1. ncbi request reprint The epidemiology of intestinal microsporidiosis in patients with HIV/AIDS in Lima, Peru
    Caryn Bern
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Infect Dis 191:1658-64. 2005
  2. pmc Perinatal hyperoxic exposure reconfigures the central respiratory network contributing to intolerance to anoxia in newborn rat pups
    Alexis M Bierman
    Department of Pediatrics, Neonatology Research Laboratories, Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Appl Physiol (1985) 116:47-53. 2014
  3. pmc Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia
    Linnea Stridh
    Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, S 40530 Gothenburg, Sweden
    J Neurosci 33:12041-51. 2013
  4. pmc Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells
    R Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Perinatol 33:374-82. 2013
  5. doi request reprint Inflammation in the carotid body during development and its contribution to apnea of prematurity
    Estelle B Gauda
    Department of Pediatrics, Division of Neonatology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Respir Physiol Neurobiol 185:120-31. 2013
  6. pmc Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury
    Raul Chavez-Valdez
    Neonatal Research Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3200, USA
    Neurol Res Int 2012:257563. 2012
  7. pmc Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia
    R Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins Medical Institutions, Johns Hopkins Hospital, 600 N Wolfe Street, CMSC 6 104, Baltimore, MD 21287, USA
    Neuroscience 219:192-203. 2012
  8. pmc Effect of hyperoxic exposure during early development on neurotrophin expression in the carotid body and nucleus tractus solitarii
    Raul Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3200, USA
    J Appl Physiol (1985) 112:1762-72. 2012
  9. pmc Effect of development on [Ca2+]i transients to ATP in petrosal ganglion neurons: a pharmacological approach using optical recording
    Ana R Nunes
    Dept of Pediatrics, Division of Neonatology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287 3200, USA
    J Appl Physiol (1985) 112:1393-402. 2012
  10. pmc Successful implementation of a perioperative glycemic control protocol in cardiac surgery: barrier analysis and intervention using lean six sigma
    Elizabeth A Martinez
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 4 44, Boston, MA 02114, USA
    Anesthesiol Res Pract 2011:565069. 2011

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The epidemiology of intestinal microsporidiosis in patients with HIV/AIDS in Lima, Peru
    Caryn Bern
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Infect Dis 191:1658-64. 2005
    ..0001), no ART (P<.0001), and cryptosporidiosis (P=.004) but not with microsporidiosis (P=.48). Our data suggest the possibility of zoonotic E. bieneusi transmission and an association with poor sanitary conditions...
  2. pmc Perinatal hyperoxic exposure reconfigures the central respiratory network contributing to intolerance to anoxia in newborn rat pups
    Alexis M Bierman
    Department of Pediatrics, Neonatology Research Laboratories, Johns Hopkins Medical Institutions, Baltimore, Maryland
    J Appl Physiol (1985) 116:47-53. 2014
    ..Importantly, our data suggest that perinatal hyperoxia alters ventilation and the response to anoxia at P5 in part by altering the frequency of phrenic bursts generated by the central respiratory network. ..
  3. pmc Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia
    Linnea Stridh
    Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, S 40530 Gothenburg, Sweden
    J Neurosci 33:12041-51. 2013
    ..Because TLR-3 is activated via double-stranded RNA during most viral infections, the present study provides evidence that viral infections during pregnancy or in the neonate could have great impact on subsequent HI brain injury...
  4. pmc Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells
    R Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Perinatol 33:374-82. 2013
    ..Therefore, our objective is to study how clinically relevant concentrations of different opioids and clonidine change cytokine levels in cultured whole blood from preterm and full-term infants...
  5. doi request reprint Inflammation in the carotid body during development and its contribution to apnea of prematurity
    Estelle B Gauda
    Department of Pediatrics, Division of Neonatology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Respir Physiol Neurobiol 185:120-31. 2013
    ....
  6. pmc Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury
    Raul Chavez-Valdez
    Neonatal Research Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3200, USA
    Neurol Res Int 2012:257563. 2012
    ..There are still more questions than answers, yet the fascinating new perspectives provided by the understanding of programmed necrosis in the developing brain may lay the foundation for new therapies for neonatal HI...
  7. pmc Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia
    R Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins Medical Institutions, Johns Hopkins Hospital, 600 N Wolfe Street, CMSC 6 104, Baltimore, MD 21287, USA
    Neuroscience 219:192-203. 2012
    ..We conclude that Nec-1 immediately after HI, is strongly mitoprotective and prevents secondary energy failure by blocking early NO• accumulation, glutathione oxidation and attenuating mitochondrial dysfunction...
  8. pmc Effect of hyperoxic exposure during early development on neurotrophin expression in the carotid body and nucleus tractus solitarii
    Raul Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3200, USA
    J Appl Physiol (1985) 112:1762-72. 2012
    ....
  9. pmc Effect of development on [Ca2+]i transients to ATP in petrosal ganglion neurons: a pharmacological approach using optical recording
    Ana R Nunes
    Dept of Pediatrics, Division of Neonatology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287 3200, USA
    J Appl Physiol (1985) 112:1393-402. 2012
    ..We speculate that these changes may participate in the postnatal maturation of chemosensitivity...
  10. pmc Successful implementation of a perioperative glycemic control protocol in cardiac surgery: barrier analysis and intervention using lean six sigma
    Elizabeth A Martinez
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 4 44, Boston, MA 02114, USA
    Anesthesiol Res Pract 2011:565069. 2011
    ..Key elements to success include barrier analysis and intervention, provider education, and broadening the project scope to address the intraoperative period...
  11. pmc Neuronal cell death in neonatal hypoxia-ischemia
    Frances J Northington
    Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 69:743-58. 2011
    ..The accurate identification of the various cell death chreodes and their mechanisms unfolding within the immature brain matrix could provide fresh insight for developing meaningful therapies for neonatal and pediatric HIE...
  12. doi request reprint Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants
    R Chavez-Valdez
    Department of Pediatrics, Texas Tech University Health Sciences Center, Odessa, TX 79763, USA
    J Perinatol 31:749-56. 2011
    ..The objective of this study is to investigate the relationship between glycemic status and severe retinopathy of prematurity (ROP).Study..
  13. pmc Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants
    Raul Chavez Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pediatr 158:57-64, 64.e1. 2011
    ..To determine changes in cytokine levels associated with caffeine treatment in a cohort of preterm infants...
  14. pmc Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI
    Frances J Northington
    Neonatal Research Laboratory, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 31:178-89. 2011
    ..The effects of necrostatin treatment after HI reflect the importance of necrosis in the delayed phases of neonatal brain injury and represent a new direction for therapy of neonatal HI...
  15. pmc Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial
    Alexander G Agthe
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pediatrics 123:e849-56. 2009
    ..To determine if oral clonidine would reduce the duration of opioid detoxification for neonatal abstinence syndrome...
  16. doi request reprint Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors
    Raul Chavez-Valdez
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Res 65:203-8. 2009
    ..Our findings also suggest that caffeine, via A1R blockade, increases cAMP production and inhibits pretranscriptional TNF-alpha production by CBM...
  17. ncbi request reprint Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons
    Vitaliano A Cama
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, US Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Infect Dis 196:684-91. 2007
    ..parvum was associated with chronic diarrhea and vomiting. These results demonstrate that different Cryptosporidium genotypes and subtype families are linked to different clinical manifestations...
  18. pmc Sexual dimorphism in BDNF signaling after neonatal hypoxia-ischemia and treatment with necrostatin-1
    R Chavez-Valdez
    Department of Pediatrics, Neonatal Research Laboratory, Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 6 104, Baltimore, MD 21287, USA Electronic address
    Neuroscience 260:106-19. 2014
    ..The biological significance of ERα predominance and its correlation with BDNF levels is still unclear. ..