Research Topics
| P H ChavesSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Detail Information
Publications
Subclinical cardiovascular disease in older adults: insights from the Cardiovascular Health StudyPaulo H M Chaves
Departments of Medicine and Epidemiology, The Johns Hopkins University, Baltimore, MD 21205, USA
Am J Geriatr Cardiol 13:137-51. 2004..Ongoing research will address the potential use of SCVD for clinical decision making in older adults...- Functional outcomes of anemia in older adultsPaulo H M Chaves
Center on Aging and Health, Division of Geriatric Medicine and Gerontology, Departments of Medicine and Epidemiology, Johns Hopkins University, 2024 E Monument Street, Baltimore, MD, USA
Semin Hematol 45:255-60. 2008..Randomized clinical trial data assessing the impact of anemia correction on functional outcomes are lacking at this time... - Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women's Health and Aging Studies I and IIPaulo H M Chaves
The Johns Hopkins Center on Aging and Health, 2024 East Monument Street, Suite 2 700, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 60:729-35. 2005..We examined the cross-sectional relationship between hemoglobin (Hb) and a recently-validated measure of frailty in community-dwelling older women, and whether this relationship was modified by cardiovascular disease (CVD) status... - Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older womenPaulo H M Chaves
Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 56:1698-703. 2008..For supporting validity, relationships between frailty and traditional linear indices of heart rate variability (HRV) were also assessed... - What constitutes normal hemoglobin concentration in community-dwelling disabled older women?Paulo H M Chaves
Johns Hopkins Center on Aging and Health, 2024 E Monument Street, Baltimore, MD 21205, USA
J Am Geriatr Soc 52:1811-6. 2004.... - Association between mild anemia and executive function impairment in community-dwelling older women: The Women's Health and Aging Study IIPaulo H M Chaves
Center on Aging and Health and Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Am Geriatr Soc 54:1429-35. 2006..To evaluate the relationship between mild anemia and executive function in community-dwelling older women... - Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated?Paulo H M Chaves
Division of Internal Medicine, Department of Medicine, School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
J Am Geriatr Soc 50:1257-64. 2002..To explore their clinical appropriateness, we evaluated the relationship between hemoglobin (Hb) concentration, prevalent mobility difficulty, and the Summary Performance Score (SPS)... - Predicting the risk of mobility difficulty in older women with screening nomograms: the Women's Health and Aging Study IIP H Chaves
Center on Aging and Health, The Johns Hopkins University School of Medicine, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205 2223, USA
Arch Intern Med 160:2525-33. 2000..The goal of this study was to develop easy-to-use clinical nomograms for estimation of the probability of incident mobility difficulty... - Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars StudyJorge R Kizer
Department of Medicine, Weill Cornell Medical College, New York, USA
J Gerontol A Biol Sci Med Sci 65:1208-14. 2010.... - Frailty and impaired cardiac autonomic control: new insights from principal components aggregation of traditional heart rate variability indicesRavi Varadhan
The Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland, USA
J Gerontol A Biol Sci Med Sci 64:682-7. 2009..We propose a new measure of heart rate variability (HRV) to capture the impairment in cardiac autonomic control associated with frailty... - Preclinical mobility disability predicts incident mobility disability in older womenL P Fried
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Gerontol A Biol Sci Med Sci 55:M43-52. 2000..The objective of this study was to determine preclinical functional predictors of incident mobility difficulty and provide evidence for a preclinical stage of disability... - Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study IQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Am J Epidemiol 167:240-8. 2008..Together, these data suggest that a slightly constricted life space may be a marker and/or risk factor for the development of frailty that may prove useful as a screening tool or a target of intervention... - Association between reduced heart rate variability and cognitive impairment in older disabled women in the community: Women's Health and Aging Study IDae Hyun Kim
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
J Am Geriatr Soc 54:1751-7. 2006..To examine the independent association between heart rate variability (HRV), a marker of cardiac autonomic function, and cognitive impairment... - Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women's Health and Aging Study IIJennifer A Deal
Department of Epidemiology, Center on Aging and Health, The Johns Hopkin Medical Institutions, 2024 E Monument St, Suite 2 700, Baltimore, MD 21205, USA
J Am Geriatr Soc 57:1604-11. 2009..To test the hypothesis that anemia (hemoglobin <12 g/dL) is associated with a faster rate of cognitive decline over 9 years in a community-dwelling sample of women aged 70 to 80 at baseline... - Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the Women's Health and Aging Study IIQian Li Xue
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
J Am Geriatr Soc 58:2076-84. 2010..To assess the relationship between rate of change in muscle strength and all-cause mortality... - A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health StudyNeil A Zakai
Department of Medicine, University of Vermont College of Medicine and Fletcher Allen Health Care, Burlington, USA
Arch Intern Med 165:2214-20. 2005..Additional study is needed on the clinically valid definition for and causes of anemia in the elderly and on the increased mortality at the extremes of hemoglobin concentrations... - Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study IIMichelle M Mielke
Johns Hopkins University School of Medicine, Center on Aging and Health and Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, 550 N Broadway, Suite 308, Baltimore, MD 21205, USA
J Gerontol A Biol Sci Med Sci 63:619-24. 2008..We examined serum total and high-density lipoprotein (HDL) cholesterol, total-to-HDL ratio, and trajectories across cognitive domains... - Kidney function as a predictor of noncardiovascular mortalityLinda F Fried
VA Pittsburgh Healthcare System and Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15240, USA
J Am Soc Nephrol 16:3728-35. 2005..Kidney function predicts noncardiovascular mortality from multiple causes in the elderly. Further research is needed to understand the mechanisms and evaluate interventions to reduce the high mortality rate in chronic kidney disease... - Hormone replacement therapy and the risk of incident congestive heart failure: the Cardiovascular Health StudyThomas D Rea
Cardiovascular Health Research Unit, University of Washington, Metropolitan Park, East Tower, 1730 Minor Avenue, Seattle, WA 98101, USA
J Womens Health (Larchmt) 12:341-50. 2003..Hormone replacement therapy (HRT) affects several of the pathways that may be important in the development of CHF. We hypothesized that HRT would be associated with a decreased risk of incident CHF... - C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health StudyJie J Cao
Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
Circulation 108:166-70. 2003..We investigated whether elevated CRP is a risk factor for ischemic stroke independent of carotid IMT and studied the interaction between CRP and IMT... - Relation of heart rate at rest and mortality in the Women's Health and Aging StudyMilan Chang
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Am J Cardiol 92:1294-9. 2003..In patients with and without heart disease, further investigation of cardiovascular status may be warranted if their HR is >/=90 beats/min... - Beta2-microglobulin for risk stratification of total mortality in the elderly population: comparison with cystatin C and C-reactive proteinShoji Shinkai
Department of Community Health, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
Arch Intern Med 168:200-6. 2008..The clinicoepidemiologic relevance of moderately elevated concentrations of circulating beta(2)-microglobulin (beta(2)-M) has not been established... - Arterial pulse wave velocity as a marker of poor cognitive function in an elderly community-dwelling populationYoshinori Fujiwara
Community Health Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
J Gerontol A Biol Sci Med Sci 60:607-12. 2005..The aim of this study was to determine the cross-sectional relationship between a low level of cognitive function and brachial-ankle pulse wave velocity (baPWV) in a community-dwelling elderly population... - The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: a double-blind, randomized, placebo-controlled clinical trialAlberto Frisoli
Gastric and Gerontology Division, Department of Medicine, Federal University of Sao Paulo, Brazil
J Gerontol A Biol Sci Med Sci 60:648-53. 2005..Sixty-five osteoporotic women older than 70 years were studied. Thirty-two patients received injections of 50 mg ND, and 33 received placebos every 3 weeks. All patients received 500 mg calcium tablets daily... - Proinflammatory state and circulating erythropoietin in persons with and without anemiaLuigi Ferrucci
Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
Am J Med 118:1288. 2005..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin... - Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health StudyPhyllis K Stein
Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Am Geriatr Soc 56:315-21. 2008..To explore the relationship between (1) insulin resistance and inflammation factors with (2) higher heart rate (HR) and lower heart rate variability (HRV) in normoglycemic older adults... - Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonistsChris L Bryson
VA Puget Sound Health Services Research and Development, VAMC, Seattle, Washington 98108, USA
J Am Geriatr Soc 52:1648-54. 2004.... - Frequency of going outdoors as a good predictors for incident disability of physical function as well as disability recovery in community-dwelling older adults in rural JapanKoji Fujita
Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo
J Epidemiol 16:261-70. 2006..Public health nurses and clinicians should pay more attention how often their senior clients usually go outdoors... - Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)Eddy Barasch
Department of Research and Education, St Francis Hospital, Roslyn, New York, USA
Am J Cardiol 97:1281-6. 2006..Elderly patients with these findings represent a high-risk group and may require close medical attention... - Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The Cardiovascular Health Study (CHS)Eddy Barasch
Department of Research and Education, St Francis Hospital, SUNY at Stony Brook, Roslyn, NY, USA
Am Heart J 151:39-47. 2006..CONCLUSIONS: In free-living elderly, MAC, AAC, and AVS are highly prevalent and are associated with CVD. Mitral annular calcification in particular has strong association with CVD, and with an adverse biomedical profile... - The association between time since last meal and blood pressure in older adults: the cardiovascular health studyNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, Washington, USA
J Am Geriatr Soc 51:824-8. 2003..To demonstrate a postprandial hypotensive (PPH) phenomenon in older adults...