Timothy A Chan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Cyclooxygenase inhibition and mechanisms of colorectal cancer prevention
    Timothy A Chan
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Curr Cancer Drug Targets 3:455-63. 2003
  2. ncbi Prostaglandins and the colon cancer connection
    Timothy A Chan
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, 401 N Broadway Street, Suite 1440, Baltimore, MD 21231, USA
    Trends Mol Med 12:240-4. 2006
  3. ncbi Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer
    Sabine C Glöckner
    Departments of Surgery, Oncology, and Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 69:4691-9. 2009
  4. ncbi Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen
    Jana Jeschke
    Department of Surgery, Johns Hopkins University, Baltimore, MD, USA
    Epigenetics 7:701-9. 2012
  5. ncbi Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation
    Timothy A Chan
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 99:8265-70. 2002
  6. ncbi Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention
    Timothy A Chan
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Lancet Oncol 3:166-74. 2002
  7. ncbi Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
    Kornel E Schuebel
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    PLoS Genet 3:1709-23. 2007
  8. ncbi Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Cyclooxygenase inhibition and mechanisms of colorectal cancer prevention
    Timothy A Chan
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Curr Cancer Drug Targets 3:455-63. 2003
    ..COX-dependent and COX-independent mechanisms are not mutually exclusive and it is likely that both are involved in the biological activity of NSAIDs...
  2. ncbi Prostaglandins and the colon cancer connection
    Timothy A Chan
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, 401 N Broadway Street, Suite 1440, Baltimore, MD 21231, USA
    Trends Mol Med 12:240-4. 2006
    ..These findings shed light on the mechanisms that underlie prostaglandin action, and provide a molecular framework for developing future treatments for colorectal cancer...
  3. ncbi Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer
    Sabine C Glöckner
    Departments of Surgery, Oncology, and Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 69:4691-9. 2009
    ..Detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of CRCs in the future...
  4. ncbi Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen
    Jana Jeschke
    Department of Surgery, Johns Hopkins University, Baltimore, MD, USA
    Epigenetics 7:701-9. 2012
    ..92) and validation cohort (HR = 2.87). Our study demonstrates an efficient method to utilize functional methylation changes in BC for the development of effective biomarkers for detection and prognosis prediction of BC...
  5. ncbi Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation
    Timothy A Chan
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 99:8265-70. 2002
    ..These findings pose several challenges to current models of APC/beta-catenin function...
  6. ncbi Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention
    Timothy A Chan
    Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Lancet Oncol 3:166-74. 2002
    ..Knowledge of how NSAIDs prevent neoplastic growth will greatly aid the design of better chemopreventive drugs and novel treatments for colorectal cancer...
  7. ncbi Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
    Kornel E Schuebel
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    PLoS Genet 3:1709-23. 2007
    ....
  8. ncbi Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
    ..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...