Timothy A Chan
Affiliation: Johns Hopkins University
- Cyclooxygenase inhibition and mechanisms of colorectal cancer preventionTimothy A Chan
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
Curr Cancer Drug Targets 3:455-63. 2003..COX-dependent and COX-independent mechanisms are not mutually exclusive and it is likely that both are involved in the biological activity of NSAIDs...
- Prostaglandins and the colon cancer connectionTimothy A Chan
Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, 401 N Broadway Street, Suite 1440, Baltimore, MD 21231, USA
Trends Mol Med 12:240-4. 2006..These findings shed light on the mechanisms that underlie prostaglandin action, and provide a molecular framework for developing future treatments for colorectal cancer...
- Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancerSabine C Glöckner
Departments of Surgery, Oncology, and Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Cancer Res 69:4691-9. 2009..Detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of CRCs in the future...
- Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screenJana Jeschke
Department of Surgery, Johns Hopkins University, Baltimore, MD, USA
Epigenetics 7:701-9. 2012..92) and validation cohort (HR = 2.87). Our study demonstrates an efficient method to utilize functional methylation changes in BC for the development of effective biomarkers for detection and prognosis prediction of BC...
- Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutationTimothy A Chan
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 99:8265-70. 2002..These findings pose several challenges to current models of APC/beta-catenin function...
- Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemopreventionTimothy A Chan
Johns Hopkins Oncology Center, Johns Hopkins University, Baltimore, MD 21231, USA
Lancet Oncol 3:166-74. 2002..Knowledge of how NSAIDs prevent neoplastic growth will greatly aid the design of better chemopreventive drugs and novel treatments for colorectal cancer...
- Comparing the DNA hypermethylome with gene mutations in human colorectal cancerKornel E Schuebel
Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
PLoS Genet 3:1709-23. 2007....
- Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosisTimothy A Chan
Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
PLoS Med 5:e114. 2008..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...