Ibolja Cernak

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Recent advances in neuroprotection for treating traumatic brain injury
    Ibolja Cernak
    Johns Hopkins University Applied Physics Laboratory, Biomedicine Business Area, 11100 Johns Hopkins Road, Laurel, MD 20723 6099, USA
    Expert Opin Investig Drugs 15:1371-81. 2006
  2. pmc Traumatic brain injury: an overview of pathobiology with emphasis on military populations
    Ibolja Cernak
    National Security Technology Department, Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland 20723, USA
    J Cereb Blood Flow Metab 30:255-66. 2010
  3. pmc The importance of systemic response in the pathobiology of blast-induced neurotrauma
    Ibolja Cernak
    Biomedicine Business Area, National Security Technology Department, Johns Hopkins University Applied Physics Laboratory Laurel, MD, USA
    Front Neurol 1:151. 2010
  4. doi The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice
    Ibolja Cernak
    Biomedicine Business Area, National Security Technology Department, Johns Hopkins University Applied Physics Laboratory JHU APL, Laurel, MD 20723, USA
    Neurobiol Dis 41:538-51. 2011
  5. pmc Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 102:8333-8. 2005
  6. ncbi Novel neuroprotective tripeptides and dipeptides
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, Room EP04, Washington, District of Columbia 20057, USA
    Ann N Y Acad Sci 1053:472-81. 2005
  7. ncbi Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Department of Pathology, University of Adelaide, Adelaide, Australia
    Brain Res 1062:171-4. 2005
  8. pmc Animal models of head trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    NeuroRx 2:410-22. 2005
  9. ncbi Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Discipline of Pathology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Exp Neurol 205:145-53. 2007
  10. ncbi Neuroprotective effects of novel small peptides in vitro and after brain injury
    Alan I Faden
    Laboratory for the Study of CNS Injury, Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Research Bld, Room EP04, Washington, DC 20057, USA
    Neuropharmacology 49:410-24. 2005

Collaborators

Detail Information

Publications21

  1. ncbi Recent advances in neuroprotection for treating traumatic brain injury
    Ibolja Cernak
    Johns Hopkins University Applied Physics Laboratory, Biomedicine Business Area, 11100 Johns Hopkins Road, Laurel, MD 20723 6099, USA
    Expert Opin Investig Drugs 15:1371-81. 2006
    ..In addition, new neurobiological findings and their consequence for novel neuroprotective approaches are discussed...
  2. pmc Traumatic brain injury: an overview of pathobiology with emphasis on military populations
    Ibolja Cernak
    National Security Technology Department, Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland 20723, USA
    J Cereb Blood Flow Metab 30:255-66. 2010
    ....
  3. pmc The importance of systemic response in the pathobiology of blast-induced neurotrauma
    Ibolja Cernak
    Biomedicine Business Area, National Security Technology Department, Johns Hopkins University Applied Physics Laboratory Laurel, MD, USA
    Front Neurol 1:151. 2010
    ....
  4. doi The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice
    Ibolja Cernak
    Biomedicine Business Area, National Security Technology Department, Johns Hopkins University Applied Physics Laboratory JHU APL, Laurel, MD 20723, USA
    Neurobiol Dis 41:538-51. 2011
    ....
  5. pmc Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 102:8333-8. 2005
    ..The ability of cell cycle inhibition to decrease both neuronal cell death and reactive gliosis after experimental TBI suggests that this treatment approach may be useful clinically...
  6. ncbi Novel neuroprotective tripeptides and dipeptides
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Research Building, Room EP04, Washington, District of Columbia 20057, USA
    Ann N Y Acad Sci 1053:472-81. 2005
    ..Here, we review these novel tripeptide and dipeptide compounds...
  7. ncbi Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Department of Pathology, University of Adelaide, Adelaide, Australia
    Brain Res 1062:171-4. 2005
    ..We conclude that both hormones may contribute to reduce edema in females after brain injury...
  8. pmc Animal models of head trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    NeuroRx 2:410-22. 2005
    ..Thus, a search continues for new animal models, which would more closely mimic the highly heterogeneous nature of human TBI, and address key factors in treatment optimization...
  9. ncbi Effects of progesterone on neurologic and morphologic outcome following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Discipline of Pathology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Exp Neurol 205:145-53. 2007
    ..We conclude that physiological concentrations of progesterone administered after diffuse TBI confers beneficial effects on morphologic and functional outcome in both ovariectomized female and male animals...
  10. ncbi Neuroprotective effects of novel small peptides in vitro and after brain injury
    Alan I Faden
    Laboratory for the Study of CNS Injury, Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Rd, NW, Research Bld, Room EP04, Washington, DC 20057, USA
    Neuropharmacology 49:410-24. 2005
    ....
  11. ncbi Novel small peptides with neuroprotective and nootropic properties
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Alzheimers Dis 6:S93-7. 2004
    ..Thus, these novel dipeptides have multipotential actions that make them candidates for the treatment of both acute and chronic neurodegeneration...
  12. ncbi Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury
    Susan M Knoblach
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 24:1119-32. 2004
    ..These data suggest that neuroprotection by z-DEVD-fmk may, in part, reflect inhibition of calpain-related necrotic cell death...
  13. ncbi Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington DC, USA
    Exp Brain Res 147:193-9. 2002
    ..We conclude that COX-2 is involved in the development of functional deficits following diffuse TBI, particularly cognitive deficits, and that these can be improved by administration of COX-2 inhibitors...
  14. ncbi Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP 12, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 23:342-54. 2003
    ..Thus, 35b shows none of the typical physiologic actions associated with TRH, but possesses neuroprotective actions in vivo and in vitro, and appears to attenuate both necrotic and apoptotic cell death...
  15. ncbi Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice
    Alan I Faden
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Room EP 12, Washington, DC 20057, USA
    J Cereb Blood Flow Metab 23:355-63. 2003
    ..In addition, they show that 35b has a relatively wide therapeutic window and improves cognitive function after both acute and chronic injury...
  16. ncbi Interaction between anesthesia, gender, and functional outcome task following diffuse traumatic brain injury in rats
    Christine A O'Connor
    Department of Pathology, University of Adelaide, Adelaide SA, Australia
    J Neurotrauma 20:533-41. 2003
    ..Isoflurane is particularly protective in females, pentobarbital is deleterious to female outcome, while halothane anesthesia has the least influence on gender-related outcome...
  17. ncbi Gene expression profile changes are commonly modulated across models and species after traumatic brain injury
    Joanne E Natale
    Research Centers for Genetic Medicine and Neuroscience, Children s National Medical Center, Washington, D C, USA
    J Neurotrauma 20:907-27. 2003
    ..Gene expression profiling across species and models may help identify candidate molecular pathways induced by brain injury, some of which may provide novel targets for therapeutic intervention...
  18. ncbi Effects of daily versus weekly testing and pre-training on the assessment of neurologic impairment following diffuse traumatic brain injury in rats
    Christine O'Connor
    Department of Pathology, University of Adelaide, Adelaide SA, Australia
    J Neurotrauma 20:985-93. 2003
    ..These studies demonstrate that the functional assessment paradigm needs to be considered when quantifying functional deficits following diffuse TBI in rats...
  19. ncbi The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington, DC 20057 1464, USA
    Neurobiol Dis 17:29-43. 2004
    ..These results show that this model is capable of reproducing major biochemical and neurological changes of diffuse clinical TBI...
  20. ncbi A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats
    Robert Vink
    Department of Pathology, University of Adelaide, Adelaide, SA, Australia
    J Am Coll Nutr 23:538S-540S. 2004
    ..We therefore examined whether a substance P antagonist restores brain intracellular free magnesium concentration following TBI...
  21. ncbi Temporal characterisation of pro- and anti-apoptotic mechanisms following diffuse traumatic brain injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington, DC, USA
    J Clin Neurosci 9:565-72. 2002
    ..Pharmacological manipulation of this balance may offer a therapeutic approach for preventing cell death and improving outcome after diffuse traumatic brain injury...