P Caturegli

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Anatabine ameliorates experimental autoimmune thyroiditis
    Patrizio Caturegli
    Department of Pathology, Johns Hopkins University School of Medicine, Ross 656, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocrinology 153:4580-7. 2012
  2. pmc Hürthle cells predict hypothyroidism in interferon-γ transgenic mice of different genetic backgrounds
    Shintaro Iwama
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 153:4059-66. 2012
  3. pmc Pituitary and systemic autoimmunity in a case of intrasellar germinoma
    Angelika Gutenberg
    Department for Neurosurgery, Georg August University Gottingen, Gottingen, Germany
    Pituitary 14:388-94. 2011
  4. ncbi request reprint Karl Hürthle! Now, who was he?
    Patrizio Caturegli
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Thyroid 15:121-3. 2005
  5. ncbi request reprint Autoimmune thyroid diseases
    Patrizio Caturegli
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Rheumatol 19:44-8. 2007
  6. pmc Pituitary autoimmunity: 30 years later
    Patrizio Caturegli
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
    Autoimmun Rev 7:631-7. 2008
  7. ncbi request reprint Studies on murine thyroiditis: new insights from organ flow cytometry
    Patrizio Caturegli
    The Johns Hopkins Medical Institutions, Department of Pathology, Baltimore, Maryland, USA
    Thyroid 13:419-26. 2003
  8. pmc Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid
    P Caturegli
    Department of Pathology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:1719-24. 2000
  9. ncbi request reprint Autoimmune hypophysitis
    Patrizio Caturegli
    Johns Hopkins Pathology, Ross 656, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Endocr Rev 26:599-614. 2005
  10. doi request reprint Growth hormone and proopiomelanocortin are targeted by autoantibodies in a patient with biopsy-proven IgG4-related hypophysitis
    M A Landek-Salgado
    Department of Pathology, The Johns Hopkins University School of Medicine, Ross 656, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Pituitary 15:412-9. 2012

Research Grants

  1. ROLE OF INTERFERON GAMMA IN THYROIDITIS
    Patrizio Caturegli; Fiscal Year: 2003
  2. Interferon gamma in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2007

Collaborators

Detail Information

Publications41

  1. doi request reprint Anatabine ameliorates experimental autoimmune thyroiditis
    Patrizio Caturegli
    Department of Pathology, Johns Hopkins University School of Medicine, Ross 656, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocrinology 153:4580-7. 2012
    ..Anatabine ameliorates disease in a model of autoimmune thyroiditis, making the delineation of its mechanisms of action and potential clinical utility worthwhile...
  2. pmc Hürthle cells predict hypothyroidism in interferon-γ transgenic mice of different genetic backgrounds
    Shintaro Iwama
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 153:4059-66. 2012
    ..This study reports a novel association of Hürhtle cells and brown adipocytes on thyroid function that should prompt a reconsideration of their significance and role in pathogenesis of autoimmune thyroiditis...
  3. pmc Pituitary and systemic autoimmunity in a case of intrasellar germinoma
    Angelika Gutenberg
    Department for Neurosurgery, Georg August University Gottingen, Gottingen, Germany
    Pituitary 14:388-94. 2011
    ....
  4. ncbi request reprint Karl Hürthle! Now, who was he?
    Patrizio Caturegli
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Thyroid 15:121-3. 2005
    ..This article describes the life of Karl Hürthle (1860-1945) and the experiments he performed in the early 1890s to explore the morphology and function of the thyroid gland...
  5. ncbi request reprint Autoimmune thyroid diseases
    Patrizio Caturegli
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Rheumatol 19:44-8. 2007
    ..The review is organized into four main areas: genetics, environment, adaptive immune system, and innate immune system...
  6. pmc Pituitary autoimmunity: 30 years later
    Patrizio Caturegli
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
    Autoimmun Rev 7:631-7. 2008
    ..This review summarizes the advances made in the field since the publication of the first review on pituitary autoimmunity, and the challenges that await clarification...
  7. ncbi request reprint Studies on murine thyroiditis: new insights from organ flow cytometry
    Patrizio Caturegli
    The Johns Hopkins Medical Institutions, Department of Pathology, Baltimore, Maryland, USA
    Thyroid 13:419-26. 2003
    ..These methods should also be applicable to other organ systems targeted by autoimmune attack, such as heart, exocrine, and other endocrine glands...
  8. pmc Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroid
    P Caturegli
    Department of Pathology, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:1719-24. 2000
    ..Taken together, these results indicate a direct role of IFN-gamma in the thyroid dysfunction that occurs in autoimmune thyroiditis...
  9. ncbi request reprint Autoimmune hypophysitis
    Patrizio Caturegli
    Johns Hopkins Pathology, Ross 656, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Endocr Rev 26:599-614. 2005
    ..The present review synthesizes the clinical and research data reported in this body of scientific literature...
  10. doi request reprint Growth hormone and proopiomelanocortin are targeted by autoantibodies in a patient with biopsy-proven IgG4-related hypophysitis
    M A Landek-Salgado
    Department of Pathology, The Johns Hopkins University School of Medicine, Ross 656, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Pituitary 15:412-9. 2012
    ..In addition, the work supports previous suggestions of growth hormone as a pituitary autoantigen. Further studies are needed to prove the pathogenicity and diagnostic utility of these two pituitary proteins...
  11. ncbi request reprint Thyroid uptake of radioactive iodine and scintigraphy in mice
    R Rocchi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Thyroid 16:705-6. 2006
  12. pmc Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older women
    George C Wang
    Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 95:1161-8. 2010
    ..These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women...
  13. pmc Autoimmune hypophysitis of SJL mice: clinical insights from a new animal model
    Shey Cherng Tzou
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Endocrinology 149:3461-9. 2008
    ..These findings provide new insights into the pathogenesis of AH, and establish a platform for developing novel diagnostic biomarkers and therapeutics...
  14. ncbi request reprint Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization
    Hiroaki Kimura
    Department of Pathology, Johns Hopkins Medical Institutions, Ross Building, Room 656, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocrinology 146:1154-62. 2005
    ..These findings suggest that expression of class II MHC molecules on epithelial cells is not sufficient to initiate autoimmunity but mildly modulates an already established autoimmune attack against the target organ...
  15. ncbi request reprint Modulation of thyroidal radioiodine uptake by theophylline
    J M Lee
    Department of Pathology, The Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Exp Mol Pathol 77:116-20. 2004
    ..These studies suggest that theophylline modulates the radioiodine uptake in a dose-dependent fashion, although the modulation is mild and probably not applicable to the clinical setting...
  16. pmc Regenerative potentials of the murine thyroid in experimental autoimmune thyroiditis: role of CD24
    Cindy Y Chen
    Department of Pathology, The Johns Hopkins Medical Institutions, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Endocrinology 150:492-9. 2009
    ..Regeneration was faster in the absence of CD24, likely a consequence of the effect of CD24 on the infiltrating lymphocytes. The study suggests that the EAT model can also be used as a tool to investigate adult thyroid stem cells...
  17. doi request reprint A radiologic score to distinguish autoimmune hypophysitis from nonsecreting pituitary adenoma preoperatively
    A Gutenberg
    Department of Neurosurgery, Georg August University Gottingen, Gottingen, Germany
    AJNR Am J Neuroradiol 30:1766-72. 2009
    ..The purpose of this study was to develop a scoring system that summarizes numerous MR imaging signs to increase the probability of diagnosing AH before surgery...
  18. ncbi request reprint Cloning and characterization of murine thyroglobulin cDNA
    P Caturegli
    School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Clin Immunol Immunopathol 85:221-6. 1997
    ..EpiMer analysis showed seven murine-specific T cell epitopes in thyroglobulin. The availability of the complete murine thyroglobulin sequence should promote the understanding of the pathogenesis and immunoregulation of EAT...
  19. doi request reprint Novel autoantigens in autoimmune hypophysitis
    Isabella Lupi
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Clin Endocrinol (Oxf) 69:269-78. 2008
    ..The methods used for their detection lack adequate sensitivity and specificity, mainly because the pathogenic pituitary autoantigen(s) are not known and therefore antigen-based immunoassays have not been developed...
  20. ncbi request reprint Chemokine orchestration of autoimmune thyroiditis
    Hiroaki Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Thyroid 17:1005-11. 2007
    ..The goal is to emphasize how a better understanding of chemokine biology has advanced our knowledge of the pathogenesis of autoimmune thyroiditis...
  21. ncbi request reprint Early chemokine expression induced by interferon-gamma in a murine model of Hashimoto's thyroiditis
    Hiroaki Kimura
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Exp Mol Pathol 77:161-7. 2004
    ..Our findings indicate that the isolated expression of IFNgamma is capable of recruiting mononuclear cells but they do not progress to full lymphoid transformation of the thyroid...
  22. ncbi request reprint Thyroid-specific expression of IFN-gamma limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes
    Jobert G Barin
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 170:5523-9. 2003
    ..The study supports a disease-limiting role of IFN-gamma in autoimmune thyroiditis. Furthermore, it provides the first evidence that local IFN-gamma activity in the thyroid is sufficient for disease suppression...
  23. pmc Pregnancy, postpartum autoimmune thyroiditis, and autoimmune hypophysitis: intimate relationships
    Melissa A Landek-Salgado
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
    Autoimmun Rev 9:153-7. 2010
    ..This article will review the current state of knowledge of the immunological changes that occur during normal pregnancy, and will explore the striking temporal association with pregnancy observed in thyroiditis and hypophysitis...
  24. ncbi request reprint Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes
    Rajni B Sharma
    Department of Pathology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 174:7740-5. 2005
    ..These findings suggest that iodine and IFN-gamma cooperate to promote thyroidal expression of ICAM-1 in this mouse model of thyroiditis, highlighting the complex interplay present in the pathogenesis of Hashimoto's thyroiditis...
  25. ncbi request reprint Adhesion molecules as susceptibility factors in spontaneous autoimmune thyroiditis in the NOD-H2h4 mouse
    Raphael E Bonita
    Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Exp Mol Pathol 73:155-63. 2002
    ..ICAM-1 was not detected on the thyrocytes of other untreated strains of mice, implicating expression of this adhesion molecule as a critical event in the recruitment of inflammatory mononuclear cells to the thyroid...
  26. pmc Increased thyroidal fat and goitrous hypothyroidism induced by interferon-gamma
    Hiroaki Kimura
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Exp Pathol 86:97-106. 2005
    ....
  27. ncbi request reprint Application of innate immune molecules for a new class of drugs: infection, inflammation and beyond
    H J Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Endocr Metab Immune Disord Drug Targets 11:68-75. 2011
    ....
  28. pmc Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness
    Roberto Rocchi
    Department of Pathology and Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:6019-24. 2007
    ..The study demonstrates a link between Toll-like and Fc receptor signaling and thyroid gland function, uncovering a role of mast cells in murine NTI...
  29. ncbi request reprint Novel model of constrictive pericarditis associated with autoimmune heart disease in interferon-gamma-knockout mice
    Marina Afanasyeva
    Department of Pathology, Johns Hopkins Medical Intitutions, Baltimore, MD, USA
    Circulation 110:2910-7. 2004
    ..Constrictive pericarditis represents a serious hemodynamic syndrome that may lead to heart failure. Studies of its pathophysiological mechanisms have been impeded by the lack of an animal model...
  30. pmc Immunoproteasome overexpression underlies the pathogenesis of thyroid oncocytes and primary hypothyroidism: studies in humans and mice
    Hiroaki J Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 4:e7857. 2009
    ..They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown...
  31. pmc From pituitary expansion to empty sella: disease progression in a mouse model of autoimmune hypophysitis
    Isabella Lupi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Endocrinology 152:4190-8. 2011
    ..No radiological or pathological changes were observed in controls. Overall, these findings indicate that the evolution of hypophysitis is complex but can lead, through different routes, to the development of empty sella...
  32. pmc IgG4-related hypophysitis: a new addition to the hypophysitis spectrum
    Paola Leporati
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 96:1971-80. 2011
    ..Within this spectrum, lymphocytic and granulomatous hypophysitis are the most common forms, but newer variants have recently been reported...
  33. ncbi request reprint IL-12 overexpression in mice as a model for Sjögren lung disease
    Sharon McGrath-Morrow
    Department of Pediatrics, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 291:L837-46. 2006
    ..This new mouse model highlights the role of IL-12 in the initiation of Sjögren syndrome...
  34. pmc Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome
    Jelle L Vosters
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 60:3633-41. 2009
    ..Our secondary objective was to further characterize this animal model and to determine if the changes observed in these mice are representative of those observed in patients with SS overall...
  35. ncbi request reprint Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease
    Scott J Cameron
    Clinical Chemistry Division, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0003, USA
    Clin Chem 51:1065-9. 2005
    ..These findings indicate that hypothyroidism can be masked by coexisting euthyroid dysprealbuminemic hyperthyroxinemia...
  36. pmc Influence of signal transducer and activator of transcription-1 signaling on thyroid morphology and function
    Hiroaki J Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 150:3409-16. 2009
    ..These results indicate that STAT1 is required to mediate some but not all of the phenotypic changes induced by IFN gamma and that it also regulates iodine accumulation via TGFbeta signaling...
  37. pmc Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:180-5. 2005
    ..An exaggerated inflammatory response in IFN-gamma KO mice causes cardiac dysfunction, leading to dilated cardiomyopathy and heart failure...
  38. ncbi request reprint Kinetics of mononuclear cell infiltration and cytokine expression in iodine-induced thyroiditis in the NOD-H2h4 mouse
    Raphael E Bonita
    MCP Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Exp Mol Pathol 74:1-12. 2003
    ..Thyrocytes clearly expressed I-Ak after 4 weeks of iodine treatment near the location of mononuclear cell infiltration...
  39. ncbi request reprint Interleukin (IL)-12-driven primary hypothyroidism: the contrasting roles of two Th1 cytokines (IL-12 and interferon-gamma)
    Hiroaki Kimura
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 146:3642-51. 2005
    ..These findings highlight the contrasting roles of two T helper 1 cytokines and report a novel role of IL-12 on thyroid hormonogenesis...
  40. ncbi request reprint Primary hypophysitis: clinical-pathological correlations
    Angelika Gutenberg
    Department of Neurosurgery, Georg August University Gottingen, Gottingen, Germany
    Eur J Endocrinol 155:101-7. 2006
    ..Primary hypophysitis comprises of three distinct histomorphological entities: lymphocytic, granulomatous and xanthomatous. Clinical features of the three subtypes for diagnostic and treatment strategies have yet not been well characterized...
  41. pmc Theophylline increases the uptake of radioiodine by mouse thyroid
    Jong Min Lee
    Department of Internal Medicine, The Catholic University of Korea, Medical College, Seoul, Korea
    J Korean Med Sci 19:704-9. 2004
    ..The in vitro effects of theophylline on both radioiodine uptake and cAMP production in a dose-dependent manner are consistent with an action mediated by phosphodiesterase inhibition...

Research Grants7

  1. ROLE OF INTERFERON GAMMA IN THYROIDITIS
    Patrizio Caturegli; Fiscal Year: 2003
    ..Furthermore, the understanding of the pathogenesis can open new avenues for diagnosis, prognosis, and treatment of these and other organ-specific autoimmune diseases. ..
  2. Interferon gamma in autoimmune thyroiditis & thyroid function
    Patrizio Caturegli; Fiscal Year: 2007
    ..We also hypothesize that augmented TSH signaling is required to induce the adipocyte-rich phenotype, and cross thyr-IFNg transgenics to TSH receptor knockout mice. ..