M J CaterinaSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytesMan Kyo Chung
Department of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
J Biol Chem 279:21569-75. 2004..Together, these findings demonstrate that keratinocytes can indeed act as thermosensory cells and that they do so via at least two distinct transduction mechanisms...
Molecular pain, a new era of pain research and medicineJianguo Gu
Mol Pain 1:1. 2005..Molecular Pain, an Open Access, peer-reviewed, online journal, will provide a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field...- The vanilloid receptor: a molecular gateway to the pain pathwayM J Caterina
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Annu Rev Neurosci 24:487-517. 2001..At the same time, these studies demonstrate the existence of redundant mechanisms for the sensation of heat-evoked pain... - Transient receptor potential ion channels as participants in thermosensation and thermoregulationMichael J Caterina
Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
Am J Physiol Regul Integr Comp Physiol 292:R64-76. 2007..Moreover, the identification of invertebrate TRP channels, whose genetic ablation alters thermally driven behaviors, makes it clear that thermosensation represents an evolutionarily conserved role of this ion channel family... - TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensationSusan M Huang
Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Mol Pain 7:37. 2011..Additionally, we assessed the contributions of TRPV3 and TRPV4 to acute heat nociception and inflammatory heat hyperalgesia during inhibition of TRPV1... - Vanilloid receptors take a TRP beyond the sensory afferentMichael J Caterina
Departments of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
Pain 105:5-9. 2003 - Thermoregulation: channels that are cool to the coreCraig Montell
Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Curr Biol 17:R885-7. 2007..Recent studies have provided strong evidence that at least one TRP channel, TRPV1, is also essential for the maintenance of internal body temperature... - 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3Man Kyo Chung
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 24:5177-82. 2004..Together, these findings identify 2-APB as the first known chemical activator of TRPV3 and enhance the notion that TRPV3 participates in the detection of heat by keratinocytes... - Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4Hyosang Lee
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 25:1304-10. 2005..Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo... - Enhanced thermal avoidance in mice lacking the ATP receptor P2X3Isao Shimizu
Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
Pain 116:96-108. 2005..Regardless, this study illustrates the utility of thermal preference assays as part of a comprehensive approach to the analysis of mouse thermosensation... - TRP channel knockout mice lose their coolMan Kyo Chung
Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Neuron 54:345-7. 2007..In this issue of Neuron, Dhaka et al. and Colburn et al. report that mice lacking the cold- and menthol-gated ion channel TRPM8 exhibit deficient behavioral responses to cold temperatures... - TRPV2 has a pivotal role in macrophage particle binding and phagocytosisTiffany M Link
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Nat Immunol 11:232-9. 2010..Our data demonstrate the participation of TRPV2 in early phagocytosis and its fundamental importance in innate immunity... - Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2Susan M Huang
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA
J Neurosci 28:13727-37. 2008..Our results reveal a previously undescribed mechanism for keratinocyte participation in thermal pain transduction through keratinocyte TRPV3 ion channels and the intercellular messenger PGE(2)... - Shear stress regulates aquaporin-5 and airway epithelial barrier functionVenkataramana K Sidhaye
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 105:3345-50. 2008..These findings have direct relevance to the regulation of epithelial barrier function, membrane permeability, and water homeostasis in the respiratory epithelia... - Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditionsVenkataramana K Sidhaye
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 103:4747-52. 2006..These findings have direct relevance to regulation of membrane water permeability and water homeostasis in epithelia of the lung and other organs... - TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from ratMichele L Nealen
Department of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Neurophysiol 90:515-20. 2003..Together with previous findings, our data support the notion that cold responsive neurons are functionally heterogeneous... - TRPV channels as thermosensory receptors in epithelial cellsHyosang Lee
Departments of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
Pflugers Arch 451:160-7. 2005..Here, we review these studies and speculate on possible communication mechanisms from cutaneous epithelial cells to sensory neurons... - Take a TRP to beat the heatMichael J Caterina
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genes Dev 19:415-8. 2005 - On the thermoregulatory perils of TRPV1 antagonismMichael J Caterina
Pain 136:3-4. 2008 - Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brainArieh Moussaieff
Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University of Jerusalem, 91120, Jerusalem, Israel
FASEB J 22:3024-34. 2008..Furthermore, the biochemical and pharmacological effects of IA may provide a biological basis for deeply rooted cultural and religious traditions... - Nociceptors lacking TRPV1 and TRPV2 have normal heat responsesC Jeffery Woodbury
Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 24:6410-5. 2004..Moreover, in TRPV1(-/-) mice, 82% of heat-responsive neurons did not express immunoreactivity for TRPV2, another putative noxious heat channel... - Mechanisms of sensory transduction in the skinEllen A Lumpkin
Departments of Neuroscience, Molecular Physiology and Biophysics and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nature 445:858-65. 2007..To break the code underlying somatosensation, we must therefore understand how the skin's sensory functions are divided among signalling molecules and cell types...
Research Grants
- Role of TRPV channels in pain and temperature sensationMichael Caterina; Fiscal Year: 2009..Finally, biochemical electrophysiological, fluorescent calcium imaging, and behavioral methods will be used to identify molecules through which heat-exposed keratinocytes communicate with nearby sensory neurons. ..
- Agonist-evoked changes in TRPV ion channel selectivityMichael Caterina; Fiscal Year: 2007....
- Agonist-evoked changes in TRPV ion channel selectivityMichael J Caterina; Fiscal Year: 2011..abstract_text> ..