M J Caterina

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes
    Man Kyo Chung
    Department of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 279:21569-75. 2004
  2. pmc TRPV2 has a pivotal role in macrophage particle binding and phagocytosis
    Tiffany M Link
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Nat Immunol 11:232-9. 2010
  3. pmc Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
  4. ncbi request reprint The vanilloid receptor: a molecular gateway to the pain pathway
    M J Caterina
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Neurosci 24:487-517. 2001
  5. ncbi request reprint Transient receptor potential ion channels as participants in thermosensation and thermoregulation
    Michael J Caterina
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 292:R64-76. 2007
  6. pmc TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
    Susan M Huang
    Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Mol Pain 7:37. 2011
  7. ncbi request reprint Vanilloid receptors take a TRP beyond the sensory afferent
    Michael J Caterina
    Departments of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Pain 105:5-9. 2003
  8. ncbi request reprint Thermoregulation: channels that are cool to the core
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 17:R885-7. 2007
  9. ncbi request reprint Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4
    Hyosang Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:1304-10. 2005
  10. ncbi request reprint 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3
    Man Kyo Chung
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:5177-82. 2004

Research Grants

Collaborators

  • J M Walker
  • Makoto Suzuki
  • D Julius
  • P A Coulombe
  • Yun Guan
  • Michael F Jarvis
  • C Montell
  • R Mechoulam
  • Alex Straiker
  • D A Cockayne
  • MICHEAL S GOLD
  • E Fride
  • Hyosang Lee
  • Man Kyo Chung
  • Susan M Huang
  • Venkataramana K Sidhaye
  • Atsuko Mizuno
  • Tiffany M Link
  • Una Park
  • Arieh Moussaieff
  • Landon S King
  • Kelly S Schweitzer
  • Ellen A Lumpkin
  • Jianguo Gu
  • Tohko Iida
  • Isao Shimizu
  • C Jeffery Woodbury
  • Michele L Nealen
  • Juan Wang
  • Yinyin Yu
  • Xiaoxin Li
  • Mark J Soloski
  • Becky M Vonakis
  • Daniel M Raben
  • Larissa Shimoda
  • Yoel Kashman
  • Esther Shohami
  • Neta Rimmerman
  • Christian C Felder
  • Tatiana Bregman
  • Shai Shoham
  • Ken Mackie
  • Heather B Bradshaw
  • Yin Yin Yu
  • Ali D Guler
  • Franco D'Alessio
  • Megumu Yoshimura
  • Min Zhuo
  • Srinivasa N Raja
  • Amy B Macdermott
  • Annika Malmberg
  • Volker Neugebauer
  • Chengshui Zhao
  • H Richard Koerber
  • Shuying Wang
  • Kathryn M Albers
  • Jeffrey J Lawson
  • Melissa Zwick
  • Brian M Davis
  • Martin Koltzenburg
  • Paul D Thut

Detail Information

Publications22

  1. ncbi request reprint TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes
    Man Kyo Chung
    Department of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 279:21569-75. 2004
    ..Together, these findings demonstrate that keratinocytes can indeed act as thermosensory cells and that they do so via at least two distinct transduction mechanisms...
  2. pmc TRPV2 has a pivotal role in macrophage particle binding and phagocytosis
    Tiffany M Link
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Nat Immunol 11:232-9. 2010
    ..Our data demonstrate the participation of TRPV2 in early phagocytosis and its fundamental importance in innate immunity...
  3. pmc Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
    ..Molecular Pain, an Open Access, peer-reviewed, online journal, will provide a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field...
  4. ncbi request reprint The vanilloid receptor: a molecular gateway to the pain pathway
    M J Caterina
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Neurosci 24:487-517. 2001
    ..At the same time, these studies demonstrate the existence of redundant mechanisms for the sensation of heat-evoked pain...
  5. ncbi request reprint Transient receptor potential ion channels as participants in thermosensation and thermoregulation
    Michael J Caterina
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 292:R64-76. 2007
    ..Moreover, the identification of invertebrate TRP channels, whose genetic ablation alters thermally driven behaviors, makes it clear that thermosensation represents an evolutionarily conserved role of this ion channel family...
  6. pmc TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
    Susan M Huang
    Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Mol Pain 7:37. 2011
    ..Additionally, we assessed the contributions of TRPV3 and TRPV4 to acute heat nociception and inflammatory heat hyperalgesia during inhibition of TRPV1...
  7. ncbi request reprint Vanilloid receptors take a TRP beyond the sensory afferent
    Michael J Caterina
    Departments of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Pain 105:5-9. 2003
  8. ncbi request reprint Thermoregulation: channels that are cool to the core
    Craig Montell
    Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 17:R885-7. 2007
    ..Recent studies have provided strong evidence that at least one TRP channel, TRPV1, is also essential for the maintenance of internal body temperature...
  9. ncbi request reprint Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4
    Hyosang Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:1304-10. 2005
    ..Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo...
  10. ncbi request reprint 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3
    Man Kyo Chung
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:5177-82. 2004
    ..Together, these findings identify 2-APB as the first known chemical activator of TRPV3 and enhance the notion that TRPV3 participates in the detection of heat by keratinocytes...
  11. ncbi request reprint Enhanced thermal avoidance in mice lacking the ATP receptor P2X3
    Isao Shimizu
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 408 Biophysics Building, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Pain 116:96-108. 2005
    ..Regardless, this study illustrates the utility of thermal preference assays as part of a comprehensive approach to the analysis of mouse thermosensation...
  12. ncbi request reprint TRP channel knockout mice lose their cool
    Man Kyo Chung
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Neuron 54:345-7. 2007
    ..In this issue of Neuron, Dhaka et al. and Colburn et al. report that mice lacking the cold- and menthol-gated ion channel TRPM8 exhibit deficient behavioral responses to cold temperatures...
  13. pmc Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions
    Venkataramana K Sidhaye
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 103:4747-52. 2006
    ..These findings have direct relevance to regulation of membrane water permeability and water homeostasis in epithelia of the lung and other organs...
  14. pmc Shear stress regulates aquaporin-5 and airway epithelial barrier function
    Venkataramana K Sidhaye
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:3345-50. 2008
    ..These findings have direct relevance to the regulation of epithelial barrier function, membrane permeability, and water homeostasis in the respiratory epithelia...
  15. ncbi request reprint TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat
    Michele L Nealen
    Department of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurophysiol 90:515-20. 2003
    ..Together with previous findings, our data support the notion that cold responsive neurons are functionally heterogeneous...
  16. ncbi request reprint TRPV channels as thermosensory receptors in epithelial cells
    Hyosang Lee
    Departments of Biological Chemistry and Neuroscience, Johns Hopkins School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Pflugers Arch 451:160-7. 2005
    ..Here, we review these studies and speculate on possible communication mechanisms from cutaneous epithelial cells to sensory neurons...
  17. ncbi request reprint Take a TRP to beat the heat
    Michael J Caterina
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genes Dev 19:415-8. 2005
  18. pmc Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2
    Susan M Huang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21025, USA
    J Neurosci 28:13727-37. 2008
    ..Our results reveal a previously undescribed mechanism for keratinocyte participation in thermal pain transduction through keratinocyte TRPV3 ion channels and the intercellular messenger PGE(2)...
  19. pmc Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University of Jerusalem, 91120, Jerusalem, Israel
    FASEB J 22:3024-34. 2008
    ..Furthermore, the biochemical and pharmacological effects of IA may provide a biological basis for deeply rooted cultural and religious traditions...
  20. doi request reprint On the thermoregulatory perils of TRPV1 antagonism
    Michael J Caterina
    Pain 136:3-4. 2008
  21. ncbi request reprint Mechanisms of sensory transduction in the skin
    Ellen A Lumpkin
    Departments of Neuroscience, Molecular Physiology and Biophysics and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 445:858-65. 2007
    ..To break the code underlying somatosensation, we must therefore understand how the skin's sensory functions are divided among signalling molecules and cell types...
  22. ncbi request reprint Nociceptors lacking TRPV1 and TRPV2 have normal heat responses
    C Jeffery Woodbury
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 24:6410-5. 2004
    ..Moreover, in TRPV1(-/-) mice, 82% of heat-responsive neurons did not express immunoreactivity for TRPV2, another putative noxious heat channel...

Research Grants10

  1. Role of TRPV channels in pain and temperature sensation
    Michael Caterina; Fiscal Year: 2009
    ..Finally, biochemical electrophysiological, fluorescent calcium imaging, and behavioral methods will be used to identify molecules through which heat-exposed keratinocytes communicate with nearby sensory neurons. ..
  2. Agonist-evoked changes in TRPV ion channel selectivity
    Michael J Caterina; Fiscal Year: 2011
    ..abstract_text> ..
  3. Agonist-evoked changes in TRPV ion channel selectivity
    Michael Caterina; Fiscal Year: 2007
    ....