ROBERT CASERO

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner
    Lihua Jin
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Biochem J 449:459-68. 2013
  2. pmc Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes
    Yu Wu
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Biochem J 442:693-701. 2012
  3. pmc Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism
    Tracy Murray-Stewart
    Corresponding Author Robert A Casero, Jr, CRB 1 Room 551, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Bunting Blaustein Building, Baltimore, MD 21287
    Mol Cancer Ther 12:2088-99. 2013
  4. pmc Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
    Manuela Cervelli
    Dipartimento di Biologia, Universita Roma Tre, Rome, Italy
    BMC Cancer 10:555. 2010
  5. ncbi request reprint The role of polyamine catabolism in anti-tumour drug response
    R A Casero
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, U S A
    Biochem Soc Trans 31:361-5. 2003
  6. ncbi request reprint Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues
    Robert A Casero
    Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
    Proc West Pharmacol Soc 48:24-30. 2005
  7. ncbi request reprint Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
    Robert A Casero
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nat Rev Drug Discov 6:373-90. 2007
  8. pmc Polyamine catabolism and disease
    Robert A Casero
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Biochem J 421:323-38. 2009
  9. pmc Polyamine analogues targeting epigenetic gene regulation
    Yi Huang
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Essays Biochem 46:95-110. 2009
  10. ncbi request reprint Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines
    Allison Pledgie
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Biol Chem 280:39843-51. 2005

Collaborators

Detail Information

Publications56

  1. pmc Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner
    Lihua Jin
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Biochem J 449:459-68. 2013
    ..The results of the present study suggested that LSD1 is critical in the regulation of cell proliferation, but also indicated that LSD1 is not an absolute requirement for the stabilization of either p53 or DNMT1...
  2. pmc Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes
    Yu Wu
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Biochem J 442:693-701. 2012
    ..The treatment-induced re-expression of SFRP2 is associated with increased H3K4me2 (di-methyl H3K4) in the gene promoter. The combination of LSD1-inhibiting oligoamines and DFMO represents a novel approach to epigenetic therapy of cancer...
  3. pmc Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism
    Tracy Murray-Stewart
    Corresponding Author Robert A Casero, Jr, CRB 1 Room 551, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Bunting Blaustein Building, Baltimore, MD 21287
    Mol Cancer Ther 12:2088-99. 2013
    ..Furthermore, the individual agents used in this study have been investigated clinically; therefore, translation of these combinations into the clinical setting holds promise...
  4. pmc Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
    Manuela Cervelli
    Dipartimento di Biologia, Universita Roma Tre, Rome, Italy
    BMC Cancer 10:555. 2010
    ..Biochemical analysis of Spm analogues BENSpm and CPENSpm, utilized in anticancer therapy, was also carried out to test their property in silico and in vitro on the recombinant SMO enzyme...
  5. ncbi request reprint The role of polyamine catabolism in anti-tumour drug response
    R A Casero
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, U S A
    Biochem Soc Trans 31:361-5. 2003
    ..The current understanding of the role and regulation of these two important polyamine catabolic enzymes are discussed...
  6. ncbi request reprint Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues
    Robert A Casero
    Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
    Proc West Pharmacol Soc 48:24-30. 2005
    ..These results are particularly significant in that the products of polyamine catabolism, including H2O2, have been demonstrated to participate in the tumoricidal activity of specific analogues...
  7. ncbi request reprint Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
    Robert A Casero
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nat Rev Drug Discov 6:373-90. 2007
    ....
  8. pmc Polyamine catabolism and disease
    Robert A Casero
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Biochem J 421:323-38. 2009
    ..The goal of the present review is to cover those aspects of polyamine catabolism that have an impact on disease aetiology or treatment and to provide a solid background in this ever more exciting aspect of polyamine biology...
  9. pmc Polyamine analogues targeting epigenetic gene regulation
    Yi Huang
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Essays Biochem 46:95-110. 2009
    ..The use of these novel polyamine-based HDAC or LSD1 inhibitors represents a highly promising and novel approach to cancer prevention and therapy...
  10. ncbi request reprint Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines
    Allison Pledgie
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Biol Chem 280:39843-51. 2005
    ..These data suggested that SSAT and SMO(PAOh1) activities are the major mediators of the cellular response of breast tumor cells to BENSpm and that PAO plays little or no role in this response...
  11. ncbi request reprint A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer
    Antonio C Wolff
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 9:5922-8. 2003
    ..This study evaluated the activity of the first-generation analog DENSpm in women with metastatic breast cancer...
  12. pmc Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells
    Naveen Babbar
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Biochem J 394:317-24. 2006
    ..These results suggest that activation of SSAT by aspirin and different NSAIDs may be a common property of NSAIDs that plays an important role in their chemopreventive actions in colorectal cancer...
  13. ncbi request reprint Tumor necrosis factor alpha induces spermidine/spermine N1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells
    Naveen Babbar
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 281:24182-92. 2006
    ..The results of these studies indicate that a common mediator of inflammation can lead to the induction of SSAT expression by activating the NFkappaB signaling pathway in non-small cell lung cancer cells...
  14. ncbi request reprint Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine
    Edward Gabrielson
    Department of Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231 1000, USA
    Cancer Chemother Pharmacol 54:122-6. 2004
    ..Therefore, to estimate the response of breast cancers to DENSpm, we measured induction of SSAT in breast cancer explants treated in vitro with this polyamine analogue...
  15. pmc A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells
    Yi Huang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 9:2769-77. 2003
    ....
  16. ncbi request reprint Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer
    Hillary A Hahm
    The Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Clin Cancer Res 8:684-90. 2002
    ..Diethylnorspermine (DENSPM) is one such agent. A focused Phase I clinical trial in patients with advanced non-small cell lung cancer was undertaken...
  17. ncbi request reprint Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein
    Mi Kyoung Kwak
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 305:662-70. 2003
    ..These results indicate that spermidine and spermine increase the expression of phase 2 genes in cells grown in culture through activation of the Nrf2-ARE pathway by generating the sulfhydryl reactive aldehyde, acrolein...
  18. ncbi request reprint Protective role of arginase in a mouse model of colitis
    Alain P Gobert
    Department of Medicine, Division of Gastroenterology, School of Medicine, University of Maryland, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    J Immunol 173:2109-17. 2004
    ..Modulation of the balance of iNOS and arginase, and of the arginase-ODC metabolic pathway may represent a new strategy for regulating intestinal inflammation...
  19. ncbi request reprint Molecular mechanisms of polyamine analogs in cancer cells
    Yi Huang
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Anticancer Drugs 16:229-41. 2005
    ..The development and use of these analogs have provided valuable information for understanding the molecular mechanisms of targeting the polyamine pathway as a means of cancer therapy...
  20. pmc Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region
    Lan Liu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 398:257-67. 2006
    ..These findings confirm that p21Cip1 is one of the direct mediators of induced c-Myc following increased polyamines and that p21Cip1 repression by c-Myc is implicated in stimulation of normal IEC proliferation...
  21. ncbi request reprint Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis
    Naveen Babbar
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 66:11125-30. 2006
    ..Further, these results suggest a common mechanism by which inflammation from multiple sources can lead to the mutagenic changes necessary for the development and progression of epithelial cancers...
  22. pmc Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
    Yi Huang
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 104:8023-8. 2007
    ..We thus define important new agents for reversing aberrant repression of gene transcription...
  23. ncbi request reprint Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis
    Hangxiu Xu
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 64:8521-5. 2004
    ..These results identify a pathway for oxidative stress-induced epithelial cell apoptosis and DNA damage due to SMO(PAOh1) activation by H. pylori that may contribute to the pathogenesis of the infection and development of gastric cancer...
  24. pmc Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics
    Tracy Murray-Stewart
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting Blaustein Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231, USA
    Biochem J 368:673-7. 2002
    ....
  25. ncbi request reprint Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells
    Wendy Devereux
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 52:383-90. 2003
    ..The induction of PAOh1/SMO in response to multiple polyamine analogues was examined in representative lung tumor cell lines...
  26. pmc Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells
    Yi Huang
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 281:19055-63. 2006
    ..Taken together, these results suggest a novel antiestrogenic mechanism for specific polyamine analogues in human breast cancer cells...
  27. ncbi request reprint Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?
    Yanlin Wang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, 21231, USA
    J Biochem 139:17-25. 2006
    ..The most recent data suggest that the two polyamine catabolic pathways exhibit distinct properties and understanding these properties should aid in their exploitation for therapeutic and/or chemopreventive strategies...
  28. ncbi request reprint Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc
    Yulan Cheng
    Department of Medicine, Division of Gastroenterology, and Greenebaum Cancer Center, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    J Biol Chem 280:22492-6. 2005
    ..These studies indicate that c-Myc is an important mediator of macrophage activation and may contribute to the mucosal inflammatory response to pathogens such as H. pylori by its effect on ODC...
  29. pmc Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology
    Tracy Murray-Stewart
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    FEBS J 275:2795-806. 2008
    ....
  30. ncbi request reprint Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells
    Yi Huang
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD and SLIL Biomedical Corp, Madison, WI, USA
    Mol Cancer Res 2:81-8. 2004
    ....
  31. pmc Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells
    Yi Huang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 4:1006-13. 2005
    ..Understanding the mechanism of p53-mediated cellular responses to polyamine analogue may help to improve the therapeutic efficacy of polyamine analogues in human breast cancer...
  32. ncbi request reprint Properties of purified recombinant human polyamine oxidase, PAOh1/SMO
    Yanlin Wang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Biochem Biophys Res Commun 304:605-11. 2003
    ..The results of these studies are consistent with the hypothesis that PAOh1/SMO represents a new addition to the polyamine metabolic pathway that may represent a new target for antineoplastic drug development...
  33. pmc Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression
    Yanlin Wang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231, U S A
    Biochem J 366:79-86. 2002
    ..Since CSN 7 does not contain a DNA-binding domain, its effects on transcription must occur in conjunction with binding to other proteins. The results presented here demonstrate that PMF-1 and Nrf-2 can act as protein partners of CSN 7...
  34. ncbi request reprint Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity
    Yanlin Wang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 56:83-90. 2005
    ..The results of these studies demonstrate how changes in polyamine catabolism may affect drug response...
  35. ncbi request reprint Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization
    Rupesh Chaturvedi
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:40161-73. 2004
    ..pylori infection...
  36. pmc Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct
    Tracy Murray-Stewart
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting Blaustein Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231, USA
    Biochem J 373:629-34. 2003
    ..Furthermore, this is the first production of a cell line capable of SSAT protein induction from a generally unresponsive parent line...
  37. pmc Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein
    Yanlin Wang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Biochem J 386:543-7. 2005
    ..These data indicate that the major level of control of SMO(PAOh1) expression in response to polyamine analogues exposure is at the level of mRNA...
  38. ncbi request reprint Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation
    Francoise I Bussiere
    Department of Medicine, Division of Gastroenterology, and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA
    J Biol Chem 280:2409-12. 2005
    ..pylori in which stimulated spermine synthesis by the arginase-ODC pathway inhibits iNOS translation and NO production, leading to persistence of the bacterium and risk for peptic ulcer disease and gastric cancer...
  39. pmc Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis
    Francis M Giardiello
    Department of Medicine, and Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Gastroenterology 126:425-31. 2004
    ..The usefulness of colorectal mucosal compounds to predict the effect on adenoma development of primary chemoprevention with the nonsteroidal anti-inflammatory drug sulindac was evaluated...
  40. pmc Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes
    Yi Huang
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 15:7217-28. 2009
    ..We hypothesized that a novel class of oligoamine analogues would effectively inhibit LSD1 and thus cause the reexpression of aberrantly silenced genes...
  41. ncbi request reprint Growth status significantly affects the response of human lung cancer cells to antitumor polyamine-analogue exposure
    Diane L Carlisle
    The Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Clin Cancer Res 8:2684-9. 2002
    ....
  42. ncbi request reprint Helicobacter pylori induces macrophage apoptosis by activation of arginase II
    Alain P Gobert
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    J Immunol 168:4692-700. 2002
    ..pylori gastritis tissues, indicating the likely in vivo relevance of our findings. Therefore, we describe arginase- and ODC-dependent macrophage apoptosis, which implicates polyamines in the pathophysiology of H. pylori infection...
  43. pmc In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells
    Amy Hacker
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Chemother Pharmacol 63:45-53. 2008
    ..Therefore, studies were designed to gain a better understanding of its effects on cellular polyamine biochemistry and efficacy in the treatment of human lung cancer models in vitro and in vivo...
  44. pmc The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib
    Jennifer S Carew
    Departments of Biochemistry, Oncology, and Pathology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer Res 68:4783-90. 2008
    ..These findings support the study of the use of the combination of bortezomib and CGC-11093 in MM patients that fail to respond to frontline therapy...
  45. ncbi request reprint The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells
    Wendy L Allen
    Department of Oncology, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast City Hospital, University Floor, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, Northern Ireland
    Mol Cancer Ther 6:128-37. 2007
    ..Furthermore, DENSpm sensitizes both sensitive and resistant cells to chemotherapeutic agents. Taken together, these results suggest that SSAT may be an important target for therapeutic intervention in colorectal cancer...
  46. ncbi request reprint Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer
    Naveen Babbar
    Arizona Cancer Center, and Biochemistry, Molecular and Cellular Biology Graduate Program, The University of Arizona, Tucson, 85724, USA
    J Biol Chem 278:47762-75. 2003
    ..These data suggest that apoptosis induced by sulindac sulfone is mediated, in part, by the COX-independent, PPAR-dependent transcriptional activation of SSAT, leading to reduced tissue polyamine contents in human colon cancer cells...
  47. ncbi request reprint Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells
    Natalia A Ignatenko
    Department of Cell Biology, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Mol Carcinog 39:91-102. 2004
    ..We concluded that mutated Ki-ras suppressed SSAT via a transcriptional mechanism involving the PPARgamma signaling pathway...
  48. ncbi request reprint Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury
    Zhaohui Wang
    Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    J Am Soc Nephrol 15:1844-52. 2004
    ..These data point to the inhibition of polyamine catabolism as a therapeutic approach for the prevention of tissue injury in kidney IRI...
  49. ncbi request reprint Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    Yujiang Shi
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 119:941-53. 2004
    ..The results thus identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histone methylases and demethylases...
  50. ncbi request reprint Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase
    Kathryn R Lawson
    Department of Radiation Oncology and Biochemistry, The University of Arizona, Arizona Cancer Center, Tucson 85724, USA
    Clin Cancer Res 8:1241-7. 2002
    ....
  51. ncbi request reprint Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia-reperfusion injury
    Sharon Barone
    Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati, Ohio 45267 0585, USA
    Am J Physiol Cell Physiol 289:C826-35. 2005
    ..The data further suggest that SSAT may play a role in the initiation of injury, whereas p21 and stathmin may be involved in the resolution and recovery after liver IRI...
  52. pmc Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors
    Sheeba Varghese
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48202, USA
    J Med Chem 48:6350-65. 2005
    ..On the basis of these results, PAHAs 6-21 represent an important new chemical class of HDAC inhibitors...
  53. ncbi request reprint Implication of SSAT by gene expression and genetic variation in suicide and major depression
    Adolfo Sequeira
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Arch Gen Psychiatry 63:35-48. 2006
    ..A large body of evidence suggests that predisposition to suicide, an important public health problem, is mediated to a certain extent by neurobiological factors...
  54. pmc Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors
    Sheeba Varghese
    Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Avenue, Detroit, Michigan 48202, USA
    J Med Chem 51:2447-56. 2008
    ..None of these compounds were cytotoxic at 100 microM. PAHAs and PABAs exhibit strikingly different cellular effects from SAHA and have the potential for use in combination antitumor therapies with reduced toxicity...
  55. ncbi request reprint Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury
    Kamyar Zahedi
    Division of Nephrology and Hypertension, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45267, USA
    Am J Physiol Renal Physiol 284:F1046-55. 2003
    ..Our results suggest that SSAT is likely a new marker of tubular cell injury that distinguishes acute prerenal from intrarenal failure...
  56. ncbi request reprint Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma
    Rongcai Jiang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 31:431-40. 2007
    ..Taken together, our studies indicate that DENSPM kills GBM cells through induction of SSAT coupled with H2O2 production, which is a potential target for GBM therapy...

Research Grants26

  1. Spermine N1-Acetylase Induction in Lung Cancers
    ROBERT CASERO; Fiscal Year: 2005
    ..abstract_text> ..
  2. The role of polyamine oxidase in antitumor drug response
    ROBERT CASERO; Fiscal Year: 2006
    ....
  3. Spermine N1-Acetylase Induction in Lung Cancers
    ROBERT CASERO; Fiscal Year: 2006
    ..abstract_text> ..
  4. The role of polyamine oxidase in antitumor drug response
    ROBERT CASERO; Fiscal Year: 2003
    ....
  5. SPERMIDINE N1-ACETYLASE INDUCTION IN LUNG CANCERS
    ROBERT CASERO; Fiscal Year: 2002
    ..abstract_text> ..
  6. SPERMIDINE N1-ACETYLASE INDUCTION IN LUNG CANCERS
    ROBERT CASERO; Fiscal Year: 2001
    ..abstract_text> ..
  7. SPERMIDINE N1-ACETYLASE INDUCTION IN LUNG CANCERS
    ROBERT CASERO; Fiscal Year: 2000
    ..abstract_text> ..
  8. SPERMIDINE N1-ACETYLASE INDUCTION IN LUNG CANCERS
    ROBERT CASERO; Fiscal Year: 1993
    ....
  9. Re-expression of Aberrantly Silenced Genes Induced by Polyamine Analogues
    ROBERT CASERO; Fiscal Year: 2009
    ..Therefore, developing our inhibitors of LSD1 and understanding the molecular mechanisms by which they reactivate silenced genes will improve our ability to target aberrant gene silencing for the treatment of cancer. ..
  10. SPERMIDINE N1-ACETYLASE INDUCTION IN LUNG CANCERS
    ROBERT CASERO; Fiscal Year: 1999
    ..abstract_text> ..
  11. The role of polyamine oxidase in antitumor drug response
    ROBERT CASERO; Fiscal Year: 2009
    ..A better understanding of the role of SMO in inflammation-induced cancers should aid in treatment strategies to prevent cancer. ..
  12. The role of polyamine oxidase in antitumor drug response
    ROBERT CASERO; Fiscal Year: 2005
    ....
  13. Spermine N1-Acetylase Induction in Lung Cancers
    ROBERT CASERO; Fiscal Year: 2007
    ..abstract_text> ..
  14. Re-expression of Aberrantly Silenced Genes Induced by Polyamine Analogues
    Robert A Casero; Fiscal Year: 2010
    ..Therefore, developing our inhibitors of LSD1 and understanding the molecular mechanisms by which they reactivate silenced genes will improve our ability to target aberrant gene silencing for the treatment of cancer. ..
  15. The role of polyamine oxidase in antitumor drug response
    Robert A Casero; Fiscal Year: 2010
    ..A better understanding of the role of SMO in inflammation-induced cancers should aid in treatment strategies to prevent cancer. ..
  16. Spermine N1-Acetylase Induction in Lung Cancers
    ROBERT CASERO; Fiscal Year: 2004
    ..abstract_text> ..
  17. The role of polyamine oxidase in antitumor drug response
    ROBERT CASERO; Fiscal Year: 2004
    ....
  18. Spermine N1-Acetylase Induction in Lung Cancers
    ROBERT CASERO; Fiscal Year: 2003
    ..abstract_text> ..
  19. SPERMIDINE N1-ACETYLASE INDUCTION IN LUNG CANCERS
    ROBERT CASERO; Fiscal Year: 1992
    ....
  20. SPERMIDINE N1-ACETYLASE INDUCTION IN LUNG CANCERS
    ROBERT CASERO; Fiscal Year: 1991
    ....
  21. Re-expression of Aberrantly Silenced Genes Induced by Polyamine Analogues
    Robert A Casero; Fiscal Year: 2011
    ..Therefore, developing our inhibitors of LSD1 and understanding the molecular mechanisms by which they reactivate silenced genes will improve our ability to target aberrant gene silencing for the treatment of cancer. ..