J P Carey

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Acoustic responses of vestibular afferents in a model of superior canal dehiscence
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Otol Neurotol 25:345-52. 2004
  2. pmc Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's disease
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 3:430-43. 2002
  3. ncbi request reprint Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo
    John Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 601 North Caroline St, Baltimore, MD 21287, USA
    Otolaryngol Clin North Am 37:1075-90. 2004
  4. ncbi request reprint Changes in the angular vestibulo-ocular reflex after a single dose of intratympanic gentamicin for Ménière's disease
    J P Carey
    Department of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 956:581-4. 2002
  5. ncbi request reprint Evolutionary changes in the cochlea and labyrinth: Solving the problem of sound transmission to the balance organs of the inner ear
    John Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:482-9. 2006
  6. ncbi request reprint Semicircular canal function before and after surgery for superior canal dehiscence
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 28:356-64. 2007
  7. ncbi request reprint Superior canal dehiscence: mechanisms of pressure sensitivity in a chinchilla model
    T P Hirvonen
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Otolaryngol Head Neck Surg 127:1331-6. 2001
  8. ncbi request reprint Vestibular-evoked myogenic potentials in the diagnosis of superior canal dehiscence syndrome
    S O Streubel
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Acta Otolaryngol Suppl 545:41-9. 2001
  9. ncbi request reprint Symptoms and signs in superior canal dehiscence syndrome
    L B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 942:259-73. 2001
  10. ncbi request reprint Differential central projections of physiologically characterized horizontal semicircular canal vestibular nerve afferents in the toadfish, Opsanus tau
    A F Mensinger
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 384:71-85. 1997

Detail Information

Publications38

  1. ncbi request reprint Acoustic responses of vestibular afferents in a model of superior canal dehiscence
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Otol Neurotol 25:345-52. 2004
    ..Afferents innervating the superior semicircular canal are rendered especially sensitive to acoustic stimulation when there is a dehiscence of the superior canal. Other vestibular end organs are also more sensitive to acoustic stimulation...
  2. pmc Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's disease
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 3:430-43. 2002
    ..This finding suggests that intratympanic gentamicin causes a partial vestibular lesion that may involve preservation of spontaneous discharge and/or rotational sensitivity of afferents...
  3. ncbi request reprint Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo
    John Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 601 North Caroline St, Baltimore, MD 21287, USA
    Otolaryngol Clin North Am 37:1075-90. 2004
    ..The salient effect of intratympanic gentamicin is probably the reduction of vestibular function through damage to hair cells, but a complete ablation of function does not seem to be necessary for vertigo control...
  4. ncbi request reprint Changes in the angular vestibulo-ocular reflex after a single dose of intratympanic gentamicin for Ménière's disease
    J P Carey
    Department of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 956:581-4. 2002
  5. ncbi request reprint Evolutionary changes in the cochlea and labyrinth: Solving the problem of sound transmission to the balance organs of the inner ear
    John Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:482-9. 2006
    ..Even in normal human ears, acoustic sensitivity of the labyrinth to loud clicks or tones is retained enough to be measured in a standard clinical test, the vestibular-evoked myogenic potential test...
  6. ncbi request reprint Semicircular canal function before and after surgery for superior canal dehiscence
    John P Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Otol Neurotol 28:356-64. 2007
    ..To characterize semicircular canal function before and after surgery for superior semicircular canal dehiscence (SCD) syndrome...
  7. ncbi request reprint Superior canal dehiscence: mechanisms of pressure sensitivity in a chinchilla model
    T P Hirvonen
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Otolaryngol Head Neck Surg 127:1331-6. 2001
    ..A rigid seal applied to the fenestra abolished pressure sensitivity while maintaining physiologic rotational sensitivity...
  8. ncbi request reprint Vestibular-evoked myogenic potentials in the diagnosis of superior canal dehiscence syndrome
    S O Streubel
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Acta Otolaryngol Suppl 545:41-9. 2001
    ..Rather than being based upon a single test, the diagnosis of SCD syndrome is best established when the characteristic symptoms, signs, VEMP response, and CT imaging all indicate SCD...
  9. ncbi request reprint Symptoms and signs in superior canal dehiscence syndrome
    L B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 942:259-73. 2001
    ....
  10. ncbi request reprint Differential central projections of physiologically characterized horizontal semicircular canal vestibular nerve afferents in the toadfish, Opsanus tau
    A F Mensinger
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 384:71-85. 1997
    ..Thus, there are anatomically demonstrable differential central projections of canal afferents with different response dynamics within the vestibular complex of the fish...
  11. doi request reprint Technical assessment of a cone-beam CT scanner for otolaryngology imaging: image quality, dose, and technique protocols
    J Xu
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Med Phys 39:4932-42. 2012
    ..The results guided evaluation of technique protocols to minimize radiation dose in a manner sufficient for OHNS imaging tasks...
  12. ncbi request reprint Ototoxicity of carboplatin delivered locally in a monkey brainstem
    J P Carey
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins School of Medicine, 600 N Wolfe Street, Suite 811 Harvey, Baltimore, MD 21287 8811, USA
    Int J Toxicol 24:443-9. 2005
    ..In this single study of eight monkeys, a dose-dependent reduction of vestibular hair cells or support cells was not observed in animals infused with brainstem infusions of 0.025 to 0.25 mg/kg of carboplatin...
  13. ncbi request reprint The effect of binocular eye position and head rotation plane on the human torsional vestibuloocular reflex
    Americo A Migliaccio
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, MA 21205, USA
    Vision Res 46:2475-86. 2006
    ....
  14. pmc Axis of eye rotation changes with head-pitch orientation during head impulses about earth-vertical
    Americo A Migliaccio
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Assoc Res Otolaryngol 7:140-50. 2006
    ..Thus, even when the orientation of Listing's plane and eye position in the orbit are fixed, the axis of eye rotation during the VOR reflects a compromise between the requirements of Listing's law and a perfectly compensatory VOR...
  15. ncbi request reprint Vergence-mediated modulation of the human horizontal angular VOR provides evidence of pathway-specific changes in VOR dynamics
    David M Lasker
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 956:324-37. 2002
    ..The response asymmetries arise because the near-viewing pathway is more susceptible to inhibitory cutoff than is the far-viewing pathway...
  16. ncbi request reprint Auditory function in patients with surgically treated superior semicircular canal dehiscence
    Charles J Limb
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Otol Neurotol 27:969-80. 2006
    ..To characterize preoperative and postoperative audiologic findings in patients with superior semicircular canal dehiscence syndrome...
  17. pmc [Vestibulo-oculomotor reflex recording using the scleral search coil technique. Review of peripheral vestibular disorders]
    Marisol Boleas-Aguirre
    Clinica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Espana
    Acta Otorrinolaringol Esp 58:321-6. 2007
    ..Ideally, eye rotation axis is aligned with head rotation axis and VOR gain (eye velocity/head velocity) for horizontal and vertical head rotations is almost 1. The VOR gain, however, for torsional head rotations is smaller and about 0.7...
  18. pmc Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administration
    Sofia Lyford-Pike
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287 0910, USA
    J Assoc Res Otolaryngol 8:497-508. 2007
    ..62 (12.06-13.17) in support cells (p < 0.001, ANOVA). These results suggest that type I hair cells are more susceptible to gentamicin because they more avidly take up or retain the drug in the early period after administration...
  19. doi request reprint Vergence-mediated modulation of the human angular vestibulo-ocular reflex is unaffected by canal plugging
    Americo A Migliaccio
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 710, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Exp Brain Res 186:581-7. 2008
    ..We hypothesize that canal plugging, unlike gentamicin or galvanic ablation, has no effect on vergence-mediated modulation of the AVOR because plugging does not preferentially affect irregular afferents...
  20. pmc Longitudinal results with intratympanic dexamethasone in the treatment of Ménière's disease
    Maria Soledad Boleas-Aguirre
    Clinica Universitaria de Navarra, School of Medicine, University of Navarra, Pamplona, Spain
    Otol Neurotol 29:33-8. 2008
    ..To assess patient satisfaction with vertigo control using intratympanic (IT) dexamethasone (12 mg/mL) for medically refractory unilateral Ménière's disease...
  21. doi request reprint Vestibular-evoked myogenic potential thresholds normalize on plugging superior canal dehiscence
    Miriam S Welgampola
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 70:464-72. 2008
    ..Lowered thresholds for eliciting vestibular-evoked myogenic potentials (VEMPs) provide additional conformation...
  22. pmc Mechanism of dynamic visual acuity recovery with vestibular rehabilitation
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287 0910, USA
    Arch Phys Med Rehabil 89:500-7. 2008
    ..To determine why dynamic visual acuity (DVA) improves after vestibular rehabilitation in people with vestibular hypofunction...
  23. doi request reprint Superior canal dehiscence plugging reduces dizziness handicap
    Benjamin T Crane
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0910, USA
    Laryngoscope 118:1809-13. 2008
    ..The size of the dehiscence as measured during surgery, subject age, vestibular-evoked myogenic potentials threshold, and degree of conductive hearing loss (CHL) were also considered...
  24. ncbi request reprint Dehiscence of bone overlying the superior semicircular canal as a cause of an air-bone gap on audiometry: a case study
    Kenneth M Cox
    Department of Communication Sciences and Disorders, Radford University, Radford, VA 24142, USA
    Am J Audiol 12:11-6. 2003
    ..Normal acoustic immittance findings in the presence of conductive hearing loss should alert clinicians to the possibility of inner ear cause of an air-bone gap due to superior canal dehiscence...
  25. ncbi request reprint Angular vestibulo-ocular reflex gains correlate with vertigo control after intratympanic gentamicin treatment for Meniere's disease
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Otol Rhinol Laryngol 114:777-85. 2005
    ..The objective of our study was to determine whether angular vestibulo-ocular reflex (aVOR) gains correlated with vertigo control after intratympanic gentamicin treatment for Meniere's disease...
  26. ncbi request reprint Ménière's disease
    Lloyd B Minor
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Curr Opin Neurol 17:9-16. 2004
    ..The pathologic process involves distortion of the membranous labyrinth with the formation of endolymphatic hydrops. This review describes the pathogenesis and etiology as well as the diagnosis and treatment of Ménière's disease...
  27. ncbi request reprint Dehiscence of bone overlying the superior canal as a cause of apparent conductive hearing loss
    Lloyd B Minor
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Otol Neurotol 24:270-8. 2003
    ..To identify patients with superior semicircular canal dehiscence and apparent conductive hearing loss and to define the cause of the air-bone gap...
  28. ncbi request reprint Vergence-mediated modulation of the human horizontal vestibulo-ocular reflex is eliminated by a partial peripheral gentamicin lesion
    Americo A Migliaccio
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Ross Building, Room 710, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Exp Brain Res 159:92-8. 2004
    ..Our findings are consistent with the hypothesis that irregular afferents provide the necessary signal for vergence-mediated modulation of the VOR...
  29. ncbi request reprint Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla
    Timo P Hirvonen
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline St, 6th Floor, Baltimore, MD 21287 0910, USA
    J Neurophysiol 93:643-55. 2005
    ....
  30. ncbi request reprint Comparison of head thrust test with head autorotation test reveals that the vestibulo-ocular reflex is enhanced during voluntary head movements
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, 601 N Caroline St, Baltimore, MD 21287 0910, USA
    Arch Otolaryngol Head Neck Surg 128:1044-54. 2002
    ....
  31. ncbi request reprint Responses of irregularly discharging chinchilla semicircular canal vestibular-nerve afferents during high-frequency head rotations
    Timothy E Hullar
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave 8115, Saint Louis, MO 63110, USA
    J Neurophysiol 93:2777-86. 2005
    ....
  32. ncbi request reprint Superior canal dehiscence is not due to cephalic displacement of the labyrinth
    Valeria L Potyagaylo
    The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann N Y Acad Sci 1039:498-502. 2005
    ..Results showed that neither was the case. Instead, the defect may be in the process of ossification above the superior canal...
  33. pmc Functional recovery of anterior semicircular canal afferents following hair cell regeneration in birds
    Richard Boyle
    Ames Research Center, National Aeronautics and Space Administration, Moffett Field, CA 94035, USA
    J Assoc Res Otolaryngol 3:149-66. 2002
    ....
  34. pmc Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstruction
    Charles C Della Santina
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
    J Assoc Res Otolaryngol 6:191-206. 2005
    ..5 +/- 5.1 degrees, and 105.6 +/- 6.6 degrees, respectively. The mean anterior SCC-contralateral posterior SCC angle was 15.3 +/- 7.2 degrees. The absolute orientations of human SCC are more nearly orthogonal than previously reported...
  35. ncbi request reprint Search-coil head-thrust and caloric tests in Ménière's disease
    Hong Ju Park
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Acta Otolaryngol 125:852-7. 2005
    ..In these subjects, the head-thrust test (HTT) may not be as sensitive to canal dysfunction as traditional caloric testing. MD may differentially affect the low-frequency sensitivity of the canals...
  36. ncbi request reprint The vestibulo-ocular reflex response to head impulses rarely decreases after cochlear implantation
    Americo A Migliaccio
    Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Otol Neurotol 26:655-60. 2005
    ..Measure vestibular function using the head impulse test and assess the change in function due to unilateral cochlear implantation...
  37. ncbi request reprint Hemangioma of the external auditory canal
    Charles J Limb
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
    Otolaryngol Head Neck Surg 126:74-5. 2002
  38. ncbi request reprint Images in clinical medicine. Abnormal eye movements associated with unilateral loss of vestibular function
    Richard F Lewis
    Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 355:e26. 2006

Research Grants7

  1. Vestibular Recovery after Intratympanic Gentamicin
    John Carey; Fiscal Year: 2004
    ..Furthermore, the mechanisms of vestibular recovery may help us understand the potential for the inner ear to recover from a variety of injuries. ..
  2. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
  3. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2007
    ..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
  4. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..