Research Topics
| J P CareySummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Acoustic responses of vestibular afferents in a model of superior canal dehiscenceJohn P Carey
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
Otol Neurotol 25:345-52. 2004..Afferents innervating the superior semicircular canal are rendered especially sensitive to acoustic stimulation when there is a dehiscence of the superior canal. Other vestibular end organs are also more sensitive to acoustic stimulation...
Changes in the three-dimensional angular vestibulo-ocular reflex following intratympanic gentamicin for Ménière's diseaseJohn P Carey
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
J Assoc Res Otolaryngol 3:430-43. 2002..This finding suggests that intratympanic gentamicin causes a partial vestibular lesion that may involve preservation of spontaneous discharge and/or rotational sensitivity of afferents...- Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigoJohn Carey
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 601 North Caroline St, Baltimore, MD 21287, USA
Otolaryngol Clin North Am 37:1075-90. 2004..The salient effect of intratympanic gentamicin is probably the reduction of vestibular function through damage to hair cells, but a complete ablation of function does not seem to be necessary for vertigo control... - Changes in the angular vestibulo-ocular reflex after a single dose of intratympanic gentamicin for Ménière's diseaseJ P Carey
Department of Otolaryngology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 956:581-4. 2002 - Evolutionary changes in the cochlea and labyrinth: Solving the problem of sound transmission to the balance organs of the inner earJohn Carey
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Anat Rec A Discov Mol Cell Evol Biol 288:482-9. 2006..Even in normal human ears, acoustic sensitivity of the labyrinth to loud clicks or tones is retained enough to be measured in a standard clinical test, the vestibular-evoked myogenic potential test... - Semicircular canal function before and after surgery for superior canal dehiscenceJohn P Carey
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Otol Neurotol 28:356-64. 2007..To characterize semicircular canal function before and after surgery for superior semicircular canal dehiscence (SCD) syndrome... - Superior canal dehiscence: mechanisms of pressure sensitivity in a chinchilla modelT P Hirvonen
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Otolaryngol Head Neck Surg 127:1331-6. 2001..A rigid seal applied to the fenestra abolished pressure sensitivity while maintaining physiologic rotational sensitivity... - Vestibular-evoked myogenic potentials in the diagnosis of superior canal dehiscence syndromeS O Streubel
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Acta Otolaryngol Suppl 545:41-9. 2001..Rather than being based upon a single test, the diagnosis of SCD syndrome is best established when the characteristic symptoms, signs, VEMP response, and CT imaging all indicate SCD... - Symptoms and signs in superior canal dehiscence syndromeL B Minor
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 942:259-73. 2001.... - Differential central projections of physiologically characterized horizontal semicircular canal vestibular nerve afferents in the toadfish, Opsanus tauA F Mensinger
Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Comp Neurol 384:71-85. 1997..Thus, there are anatomically demonstrable differential central projections of canal afferents with different response dynamics within the vestibular complex of the fish... 
Technical assessment of a cone-beam CT scanner for otolaryngology imaging: image quality, dose, and technique protocolsJ Xu
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
Med Phys 39:4932-42. 2012..The results guided evaluation of technique protocols to minimize radiation dose in a manner sufficient for OHNS imaging tasks...- Ototoxicity of carboplatin delivered locally in a monkey brainstemJ P Carey
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Suite 811 Harvey, Baltimore, MD 21287-8811, USA
Int J Toxicol 24:443-9. 2005..In this single study of eight monkeys, a dose-dependent reduction of vestibular hair cells or support cells was not observed in animals infused with brainstem infusions of 0.025 to 0.25 mg/kg of carboplatin... - The effect of binocular eye position and head rotation plane on the human torsional vestibuloocular reflexAmerico A Migliaccio
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, MA 21205, USA
Vision Res 46:2475-86. 2006.... - Axis of eye rotation changes with head-pitch orientation during head impulses about earth-verticalAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Assoc Res Otolaryngol 7:140-50. 2006..Thus, even when the orientation of Listing's plane and eye position in the orbit are fixed, the axis of eye rotation during the VOR reflects a compromise between the requirements of Listing's law and a perfectly compensatory VOR... - Vergence-mediated modulation of the human horizontal angular VOR provides evidence of pathway-specific changes in VOR dynamicsDavid M Lasker
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ann N Y Acad Sci 956:324-37. 2002..The response asymmetries arise because the near-viewing pathway is more susceptible to inhibitory cutoff than is the far-viewing pathway... - Auditory function in patients with surgically treated superior semicircular canal dehiscenceCharles J Limb
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Otol Neurotol 27:969-80. 2006..To characterize preoperative and postoperative audiologic findings in patients with superior semicircular canal dehiscence syndrome... - [Vestibulo-oculomotor reflex recording using the scleral search coil technique. Review of peripheral vestibular disorders]Marisol Boleas-Aguirre
Clinica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Espana
Acta Otorrinolaringol Esp 58:321-6. 2007..Ideally, eye rotation axis is aligned with head rotation axis and VOR gain (eye velocity/head velocity) for horizontal and vertical head rotations is almost 1. The VOR gain, however, for torsional head rotations is smaller and about 0.7... - Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administrationSofia Lyford Pike
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287 0910, USA
J Assoc Res Otolaryngol 8:497-508. 2007..62 (12.06-13.17) in support cells (p < 0.001, ANOVA). These results suggest that type I hair cells are more susceptible to gentamicin because they more avidly take up or retain the drug in the early period after administration... - Vergence-mediated modulation of the human angular vestibulo-ocular reflex is unaffected by canal pluggingAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Ross Building, Room 710, 720 Rutland Avenue, Baltimore, MD 21205, USA
Exp Brain Res 186:581-7. 2008..We hypothesize that canal plugging, unlike gentamicin or galvanic ablation, has no effect on vergence-mediated modulation of the AVOR because plugging does not preferentially affect irregular afferents... - Longitudinal results with intratympanic dexamethasone in the treatment of Ménière's diseaseMaria Soledad Boleas-Aguirre
Clinica Universitaria de Navarra, School of Medicine, University of Navarra, Pamplona, Spain
Otol Neurotol 29:33-8. 2008..To assess patient satisfaction with vertigo control using intratympanic (IT) dexamethasone (12 mg/mL) for medically refractory unilateral Ménière's disease... - Vestibular-evoked myogenic potential thresholds normalize on plugging superior canal dehiscenceMiriam S Welgampola
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neurology 70:464-72. 2008..Lowered thresholds for eliciting vestibular-evoked myogenic potentials (VEMPs) provide additional conformation... - Mechanism of dynamic visual acuity recovery with vestibular rehabilitationMichael C Schubert
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287 0910, USA
Arch Phys Med Rehabil 89:500-7. 2008..To determine why dynamic visual acuity (DVA) improves after vestibular rehabilitation in people with vestibular hypofunction... - Superior canal dehiscence plugging reduces dizziness handicapBenjamin T Crane
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0910, USA
Laryngoscope 118:1809-13. 2008..The size of the dehiscence as measured during surgery, subject age, vestibular-evoked myogenic potentials threshold, and degree of conductive hearing loss (CHL) were also considered... - Dehiscence of bone overlying the superior semicircular canal as a cause of an air-bone gap on audiometry: a case studyKenneth M Cox
Department of Communication Sciences and Disorders, Radford University, Radford, VA 24142, USA
Am J Audiol 12:11-6. 2003..Normal acoustic immittance findings in the presence of conductive hearing loss should alert clinicians to the possibility of inner ear cause of an air-bone gap due to superior canal dehiscence... - Angular vestibulo-ocular reflex gains correlate with vertigo control after intratympanic gentamicin treatment for Meniere's diseaseFrank R Lin
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ann Otol Rhinol Laryngol 114:777-85. 2005..CONCLUSIONS: Our results suggest that successful treatment of Meniere's disease is closely related to attenuation of semicircular canal function as measured by horizontal canal aVOR gains... - Ménière's diseaseLloyd B Minor
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
Curr Opin Neurol 17:9-16. 2004..The pathologic process involves distortion of the membranous labyrinth with the formation of endolymphatic hydrops. This review describes the pathogenesis and etiology as well as the diagnosis and treatment of Ménière's disease... - Dehiscence of bone overlying the superior canal as a cause of apparent conductive hearing lossLloyd B Minor
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Otol Neurotol 24:270-8. 2003..To identify patients with superior semicircular canal dehiscence and apparent conductive hearing loss and to define the cause of the air-bone gap... - Vergence-mediated modulation of the human horizontal vestibulo-ocular reflex is eliminated by a partial peripheral gentamicin lesionAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Ross Building, Room 710, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
Exp Brain Res 159:92-8. 2004..Our findings are consistent with the hypothesis that irregular afferents provide the necessary signal for vergence-mediated modulation of the VOR... - Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchillaTimo P Hirvonen
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, 601 North Caroline St, 6th Floor, Baltimore, MD 21287-0910, USA
J Neurophysiol 93:643-55. 2005.... - Comparison of head thrust test with head autorotation test reveals that the vestibulo-ocular reflex is enhanced during voluntary head movementsCharles C Della Santina
Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, 601 N Caroline St, Baltimore, MD 21287-0910, USA
Arch Otolaryngol Head Neck Surg 128:1044-54. 2002.... - Responses of irregularly discharging chinchilla semicircular canal vestibular-nerve afferents during high-frequency head rotationsTimothy E Hullar
Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave 8115, Saint Louis, MO 63110, USA
J Neurophysiol 93:2777-86. 2005.... - Superior canal dehiscence is not due to cephalic displacement of the labyrinthValeria L Potyagaylo
The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Ann N Y Acad Sci 1039:498-502. 2005..Results showed that neither was the case. Instead, the defect may be in the process of ossification above the superior canal... - Functional recovery of anterior semicircular canal afferents following hair cell regeneration in birdsRichard Boyle
Ames Research Center, National Aeronautics and Space Administration, Moffett Field, CA 94035, USA
J Assoc Res Otolaryngol 3:149-66. 2002.... - Orientation of human semicircular canals measured by three-dimensional multiplanar CT reconstructionCharles C Della Santina
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Rm JHOC 6253, Baltimore, MD 21287, USA
J Assoc Res Otolaryngol 6:191-206. 2005..5 +/- 5.1 degrees, and 105.6 +/- 6.6 degrees, respectively. The mean anterior SCC-contralateral posterior SCC angle was 15.3 +/- 7.2 degrees. The absolute orientations of human SCC are more nearly orthogonal than previously reported... - Search-coil head-thrust and caloric tests in Ménière's diseaseHong Ju Park
Department of Otolaryngology--Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
Acta Otolaryngol 125:852-7. 2005..Two subjects with unilateral MD had 100% UW, but none had >30% asymmetry on HTTs... - The vestibulo-ocular reflex response to head impulses rarely decreases after cochlear implantationAmerico A Migliaccio
Laboratory of Vestibular Neurophysiology, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Otol Neurotol 26:655-60. 2005..Measure vestibular function using the head impulse test and assess the change in function due to unilateral cochlear implantation... - Hemangioma of the external auditory canalCharles J Limb
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0910, USA
Otolaryngol Head Neck Surg 126:74-5. 2002 - Images in clinical medicine. Abnormal eye movements associated with unilateral loss of vestibular functionRichard F Lewis
Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 355:e26. 2006
Research Grants
- Vestibular Recovery after Intratympanic GentamicinJohn Carey; Fiscal Year: 2004..Furthermore, the mechanisms of vestibular recovery may help us understand the potential for the inner ear to recover from a variety of injuries. ..
- VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICINJohn Carey; Fiscal Year: 2005..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
- Evalution of Vestibular Function in Meniere's DiseaseJohn Carey; Fiscal Year: 2007..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
- Evalution of Vestibular Function in Meniere's DiseaseJohn Carey; Fiscal Year: 2009..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..