Research Topics
Genomes and GenesSpecies | H CalkinsSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Assessment of distribution and evolution of mechanical dyssynchrony in a porcine model of myocardial infarction by cardiovascular magnetic resonanceKhaled Z Abd-Elmoniem
Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
J Cardiovasc Magn Reson 14:1. 2012..We sought to investigate the relationship between infarct and dyssynchrony post- myocardial infarct (MI), in a porcine model. Mechanical dyssynchrony post-MI is associated with left ventricular (LV) remodeling and increased mortality...
Role of cardiovascular magnetic resonance imaging in arrhythmogenic right ventricular dysplasiaAditya Jain
Russell H, Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
J Cardiovasc Magn Reson 10:32. 2008..This article reviews the genetics of ARVD, current status and role of CMR in the diagnosis of ARVD and LV involvement in ARVD...
Three dimensional mapping of atrial fibrillation: techniques and necessityHugh Calkins
The Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Interv Card Electrophysiol 13:53-9. 2005....
Is pulmonary vein antrum isolation safe and effective in valvular heart disease and open heart surgery?Hugh Calkins
John Hopkins University School of Medicine, Baltimore, MD, USA
Nat Clin Pract Cardiovasc Med 1:12-3. 2004
Catheter ablation should not be first-line therapy for atrial fibrillationHugh Calkins
The Johns Hopkins Hospital, 600 North Wolfe Street, Carnegie 530, Baltimore, MD 21287, USA
Nat Clin Pract Cardiovasc Med 4:4-5. 2007
Results of catheter ablation of typical atrial flutterHugh Calkins
Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 0409, USA
Am J Cardiol 94:437-42. 2004..Thus, the results of this study associated catheter ablation of atrial flutter with high acute efficacy, a small risk of recurrent atrial flutter, and an important risk of atrial fibrillation during follow-up...
Prospective randomized comparison of the safety and effectiveness of placement of endocardial pacemaker and defibrillator leads using the extrathoracic subclavian vein guided by contrast venography versus the cephalic approachH Calkins
Department of Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Pacing Clin Electrophysiol 24:456-64. 2001..These findings suggest that the contrast-guided approach to the extrathoracic portion of the subclavian vein should be considered as an alternative to the cephalic approach...
Arrhythmogenic right-ventricular dysplasia/cardiomyopathyHugh Calkins
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Curr Opin Cardiol 21:55-63. 2006..The purpose of this article is to review recent developments concerning the diagnosis, genetics, and management of patients with this disease...
Catheter ablation for cardiac arrhythmiasH Calkins
Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
Med Clin North Am 85:473-502, xii. 2001..Catheter ablation is considered as an alternative to pharmacologic therapy in the treatment of these cardiac arrhythmias...
Arrhythmogenic right ventricular dysplasiaHugh Calkins
Baltimore, Maryland, USA
Trans Am Clin Climatol Assoc 119:273-86; discussion 287-8. 2008..Independent LV involvement is of rare occurrence. The "accordion sign" is a promising tool for early diagnosis of ARVD. Its diagnostic utility should be confirmed in larger cohorts...
Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and meta-analysesHugh Calkins
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circ Arrhythm Electrophysiol 2:349-61. 2009....
Cooled ablationHugh Calkins
Johns Hopkins University, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 15:S12-7. 2004..The experience at Johns Hopkins suggests that cooled radiofrequency ablation has utility in a variety of situations and in some instances has come to be the ablation system of choice...
Arrhythmogenic right ventricular cardiomyopathy/dysplasia: an updateHugh Calkins
The Johns Hopkins Hospital, 600 North Wolfe Street, Carnegie 530, Baltimore, MD 21287, USA
Curr Cardiol Rep 10:367-75. 2008..Patients with ARVC/D are encouraged to avoid competitive athletics. Recent advances in the understanding of the genetic basis of ARVC/D have revealed that ARVC/D is a disease of desmosomal dysfunction...
Catheter ablation of ventricular tachycardia in patients with structural heart disease using cooled radiofrequency energy: results of a prospective multicenter study. Cooled RF Multi Center Investigators GroupH Calkins
Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Am Coll Cardiol 35:1905-14. 2000..The purpose of this multicenter study was to evaluate the safety and efficacy of a radiofrequency (RF) catheter ablation system with internal saline irrigation...
Resuscitation after prolonged ventricular fibrillation with use of monophasic and biphasic waveform pulses for external defibrillationC T Leng
Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circulation 101:2968-74. 2000..However, they have not been rigorously tested against monophasic (MP) waveforms in clinical models of external defibrillation, particularly where rescue from prolonged VF is the general rule...
Laser ablation of the pulmonary veins by using a fiberoptic balloon catheter: implications for treatment of paroxysmal atrial fibrillationN M Fried
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Lasers Surg Med 28:197-203. 2001..A new fiberoptic balloon catheter was tested as an alternative to radiofrequency catheter ablation for creation of circumferential thermal lesions at the pulmonary vein orifice...
Electrical induction of ventricular fibrillation for resuscitation from postcountershock pulseless and asystolic cardiac arrestsC T Leng
Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, The Johns Hopkins University, Baltimore, MD, USA
Circulation 104:723-8. 2001..It remains unclear, however, whether harmful effects are due primarily to initial countershock of ischemic myocardium or to resultant postdefibrillation rhythms (ie, pulseless electrical activity [PEA] or asystole)...
Predictors of recurrence following catheter ablation of atrial fibrillation using an irrigated-tip ablation catheterChandrasekhar R Vasamreddy
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0409, USA
J Cardiovasc Electrophysiol 15:692-7. 2004..The best results of this procedure are achieved in the subset of patients who are younger than 50 years and have only paroxysmal AF...
Catheter ablation of accessory pathways, atrioventricular nodal reentrant tachycardia, and the atrioventricular junction: final results of a prospective, multicenter clinical trial. The Atakr Multicenter Investigators GroupH Calkins
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 99:262-70. 1999..The purpose of this study was to evaluate the safety and efficacy of a temperature-controlled radiofrequency catheter ablation system...
Misdiagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathyChandra Bomma
Department of Cardiology Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 15:300-6. 2004..Diagnosis of ARVD/C cannot rely solely upon qualitative features on MRI...
Atrial volume reduction following catheter ablation of atrial fibrillation and relation to reduction in pulmonary vein size: an evaluation using magnetic resonance angiographyVinod K Jayam
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287-0409, USA
J Interv Card Electrophysiol 13:107-14. 2005..CONCLUSIONS: Catheter ablation of AF using a segmental PV isolation approach results in a significant reverse remodeling in the left atrium. Significant stenosis of PVs appears to be rare after the segmental isolation procedure...
Circumferential ablation with pulmonary vein isolation in permanent atrial fibrillationAamir Cheema
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 99:1425-8. 2007..In conclusion, study results suggest that circumferential ablation with PV isolation has moderate efficacy in patients with permanent AF. Efficacy is limited in those in continuous AF for >12 months...
HRS/EHRA/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on catheter and surgical ablation of Hugh Calkins
Johns Hopkins Hospital, Maryland, USA
Heart Rhythm 4:816-61. 2007
HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Hugh Calkins
Johns Hopkins Hospital, Maryland, USA
Europace 9:335-79. 2007
Modern pacemaker and implantable cardioverter/defibrillator systems can be magnetic resonance imaging safe: in vitro and in vivo assessment of safety and function at 1.5 TAriel Roguin
Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circulation 110:475-82. 2004..CONCLUSIONS: These data suggest that certain modern pacemaker and ICD systems may indeed be MRI safe. This may have major clinical implications for current imaging practices...
Radiation exposure during catheter ablation of atrial fibrillationLars Lickfett
Division of Cardiology, The Johns Hopkins Hospital, Baltimore, MD, USA
Circulation 110:3003-10. 2004..The resulting lifetime risk of fatal malignancy is within the range previously reported for standard supraventricular arrhythmias...
Arrhythmogenic right ventricular dysplasia: ex vivo and in vivo fat detection with black-blood MR imagingErnesto Castillo
Russell H. Morgan Dept of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, MRI-143 Nelson Basement, Baltimore, MD 21287, USA
Radiology 232:38-48. 2004..When fast SE imaging is applied in vivo, however, breath-holding constraints limit the spatial resolution for RV fat detection...
Regional differences in systolic and diastolic function in arrhythmogenic right ventricular dysplasia/cardiomyopathy using magnetic resonance imagingChandra Bomma
Division of Cardiology (Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Am J Cardiol 95:1507-11. 2005..In this study, we report results of quantitative evaluation of biventricular global and regional function using peak ejection rate and peak filling rate as measures of systolic and diastolic function, respectively (volumetric method)...
Real-time cardiac catheter navigation on three-dimensional CT imagesStephen B Solomon
Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Interv Card Electrophysiol 8:27-36. 2003..Because fluoroscopy provides only limited information about the relationship between catheter positions and cardiac structures, and is associated with radiation risk, other approaches to mapping may be beneficial...
Incidence and predictors of left atrial thrombus prior to catheter ablation of atrial fibrillationDaniel Scherr
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Cardiovasc Electrophysiol 20:379-84. 2009..However, the incidence and predictors of LA thrombus detected with TEE have not been systematically examined in this setting...
Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathyA Dénise den Haan
Department of Medicine Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Circ Cardiovasc Genet 2:428-35. 2009..We report comprehensive desmosome genetic analysis for 100 North Americans with clinically confirmed or suspected ARVD/C...
State-of-the-art and emerging technologies for atrial fibrillation ablationJane Dewire
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Carnegie 530, 600 North Wolfe Street, Baltimore, MD 21287, USA
Nat Rev Cardiol 7:129-38. 2010..However, technological advances are sure to result in the necessary improvements in the safety and efficacy of AF ablation procedures...
Safety and efficacy of circumferential pulmonary vein catheter ablation of atrial fibrillationChandrasekhar R Vasamreddy
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Heart Rhythm 2:42-8. 2005....
Tissue magnesium levels and the arrhythmic substrate in humansM C Haigney
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Cardiovasc Electrophysiol 8:980-6. 1997..Magnesium deficiency has been implicated in the pathogenesis of sudden death, but the investigation of arrhythmic mechanisms has been hindered by difficulties in measuring cellular tissue magnesium stores...
Catheter ablation for cardiac arrhythmiasL Lickfett
Johns Hopkins Hospital, Baltimore, Maryland, USA
Minerva Cardioangiol 50:189-207. 2002..In this article we will review the current state of knowledge about the technique, indications, and results of catheter ablation for the treatment of cardiac arrhythmias...
Lead configuration for defibrillator implantation in a patient with congenital heart disease and a mechanical prosthetic tricuspid valveC T Leng
Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Pacing Clin Electrophysiol 24:1291-2. 2001..Their lead configuration deviates substantially from existing designs in its primary use of a coronary sinus defibrillation coil and a left-sided subcutaneous array to distribute current across the ventricular myocardium...
Linear lesions in myocardium created by Nd:YAG laser using diffusing optical fibers: in vitro and in vivo resultsN M Fried
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
Lasers Surg Med 27:295-304. 2000..This study uses laser energy delivered through diffusing optical fibers as an alternative to radiofrequency energy for the creation of linear lesions in cardiac tissue in a single application...
A conservative approach to performing transseptal punctures without the use of intracardiac echocardiography: stepwise approach with real-time video clipsAlan Cheng
Department of Medicine, Division of Cardiology, Section for Cardiac Electrophysiology, The Johns Hopkins Hospital, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 18:686-9. 2007..Utilizing a series of real-time video clips, we describe our technique of double transseptal puncture and illustrate in detail ways in which to avoid common pitfalls...
Feasibility of endoscopic guidance for nonsurgical transthoracic atrial and ventricular epicardial ablationSaman Nazarian
Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Heart Rhythm 5:1115-9. 2008..The safety, efficacy, and applicability of epicardial catheter ablation likely will improve with direct visualization of the pericardial space...
Normal reference values for the adult right ventricle by magnetic resonance imagingHarikrishna Tandri
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Cardiol 98:1660-4. 2006..These values will be useful to differentiate RV health from diseases that result in abnormal RV structure and function...
Risk stratification in postmyocardial infarction patients: Is there reason to hope?Hugh Calkins
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Heart Rhythm 2:365-6. 2005
Long-term follow-up of fast pathway radiofrequency ablation in atrioventricular nodal reentrant tachycardiaLars Lickfett
Division of Cardiology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Am J Cardiol 89:1124-5. 2002
Prolonged RV endocardial activation duration: a novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathyHarikrishna Tandri
Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Heart Rhythm 6:769-75. 2009..Parietal block, defined as intra right ventricular (RV) conduction slowing, is a major diagnostic criterion for arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)...
Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathyZhao Yang
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Circ Res 99:646-55. 2006..These data suggest DSP expression in cardiomyocytes is crucial for maintaining cardiac tissue integrity, and DSP abnormalities result in ARVD/C by cardiomyocyte death, changes in lipid metabolism, and defects in cardiac development...
Characterization of acute and subacute radiofrequency ablation lesions with nonenhanced magnetic resonance imagingTimm Dickfeld
Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21201, USA
Heart Rhythm 4:208-14. 2007..However, MRI patterns after RF ablation have not been well investigated...
Effects of surgical and endoscopic electrocautery on modern-day permanent pacemaker and implantable cardioverter-defibrillator systemsAlan Cheng
Section for Cardiac Electrophysiology, Division of Cardiovascular Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Pacing Clin Electrophysiol 31:344-50. 2008..The ability of newer devices to withstand system malfunction or failure during surgery/endoscopy remains unknown...
Evidence for electrical remodeling of the native conduction system with cardiac resynchronization therapyCharles A Henrikson
Division of Cardiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
Pacing Clin Electrophysiol 30:591-5. 2007..Cardiac resynchronization therapy (CRT) improves hemodynamics and decreases heart failure symptoms. However, the potential of CRT to bring about electrical remodeling of the heart has not been investigated...
Magnetic resonance imaging findings in patients meeting task force criteria for arrhythmogenic right ventricular dysplasiaHarikrishna Tandri
Division of Cardiology, The Johns Hopkins University, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 14:476-82. 2003..Trabecular disarray is seen more frequently than wall thinning and aneurysms. RV dimensions and volumes differ significantly in ARVD compared to controls, indicating a role for quantitative evaluation in the diagnosis of ARVD...
Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trialsDavid J Bradley
Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
JAMA 289:730-40. 2003..Cardiac resynchronization, a pacemaker-based therapy for heart failure, enhances cardiac performance and quality of life, but its effect on mortality is uncertain...
Automated detection and characterization of complex fractionated atrial electrograms in human left atrium during atrial fibrillationDaniel Scherr
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Heart Rhythm 4:1013-20. 2007..Complex fractionated atrial electrograms (CFAEs) have been reported as ablative targets for the treatment of atrial fibrillation (AF). However, the process of CFAE identification is highly dependent on the operator's judgment...
Long-term efficacy of catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathyDarshan Dalal
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Coll Cardiol 50:432-40. 2007..Particular focus was placed on defining the single-procedure efficacy over long-term follow-up...
Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studiesSaman Nazarian
Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Carnegie 592C, 600 N Wolfe St, Baltimore, MD 21287, USA
Circulation 118:223-9. 2008..In this study, we sought to test the feasibility of performing electrophysiology studies with real-time MRI guidance...
Impact of heart rhythm status on registration accuracy of the left atrium for catheter ablation of atrial fibrillationJun Dong
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 18:1269-76. 2007..However, the impact of the heart rhythm change on the accuracy of left atrium (LA) registration has not been studied...
Initial experience in the use of integrated electroanatomic mapping with three-dimensional MR/CT images to guide catheter ablation of atrial fibrillationJun Dong
Department of Medicine, John Hopkins University School of Medicine, Baltimore, MD 21287 0409, USA
J Cardiovasc Electrophysiol 17:459-66. 2006..No prior studies have reported the use of integrated electroanatomic mapping with preacquired magnetic resonance/computed tomographic (MR/CT) images to guide catheter ablation of atrial fibrillation (AF) in a series of patients...
Use of a coronary sinus lead and biventricular ICD to correct a sensing abnormality in a patient with arrhythmogenic right ventricular dysplasia/cardiomyopathyKenneth C Bilchick
Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 17:317-20. 2006..We discuss how the use of a bipolar coronary sinus lead and a biventricular ICD generator with a novel header configuration solved the problem...
Anatomic stereotactic catheter ablation on three-dimensional magnetic resonance images in real timeTimm Dickfeld
Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Circulation 108:2407-13. 2003..Because fluoroscopy provides only limited information about the relationship between catheter positions and cardiac structures and is associated with radiation risk, other approaches to mapping may be beneficial...
Unusual presentation of cardiac sarcoidosisHarikrishna Tandri
Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Congest Heart Fail 13:116-8. 2007..This case illustrates the importance of complete testing, including invasive studies such as endomyocardial biopsy, in patients presenting with life-threatening ventricular arrhythmias to establish a correct diagnosis...
One method to reduce heart block risk during catheter ablation of atrioventricular nodal reentrant tachycardiaGlenn R Meininger
Department of Medicine, Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287-6568, USA
J Cardiovasc Electrophysiol 15:727-8. 2004
Changes of pulmonary vein orifice size and location throughout the cardiac cycle: dynamic analysis using magnetic resonance cine imagingLars Lickfett
Division of Cardiology, The John Hopkins University, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 16:582-8. 2005..The aim of the current study was therefore to analyze changes of PV orifice size and location throughout the cardiac cycle using cine magnetic resonance imaging (MRI)...
Beat-to-beat three-dimensional ECG variability predicts ventricular arrhythmia in ICD recipientsLarisa G Tereshchenko
Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
Heart Rhythm 7:1606-13. 2010..Methodological difficulties associated with QT measurements prompt the search for new electrocardiographic markers of repolarization heterogeneity...
Stereotactic catheter navigation using magnetic resonance image integration in the human heartTimm Dickfeld
Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Heart Rhythm 2:413-5. 2005
A new electrocardiogram marker to identify patients at low risk for ventricular tachyarrhythmias: sum magnitude of the absolute QRST integralLarisa G Tereshchenko
The Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
J Electrocardiol 44:208-16. 2011..We proposed and tested a novel electrocardiogram marker of risk of ventricular arrhythmias (VAs)...
Noninvasive detection of myocardial fibrosis in arrhythmogenic right ventricular cardiomyopathy using delayed-enhancement magnetic resonance imagingHarikrishna Tandri
Division of Cardiology, The Johns Hopkins University, Baltimore, MD 21287, USA
J Am Coll Cardiol 45:98-103. 2005....
Catheter ablation of atrial fibrillation guided by registered computed tomographic image of the atriumJun Dong
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Heart Rhythm 2:1021-2. 2005
Evaluation and course of an unusual case of arrhythmogenic right ventricular dysplasiaJan Fritz
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Int J Cardiovasc Imaging 22:269-73. 2006..In this report, we describe accurate evaluation by MR imaging confirmed by histopathologic findings as well as imaging progression of this unusual case of arrhythmogenic right ventricular dysplasia...
QRS prolongation in myotonic muscular dystrophy and diffuse fibrosis on cardiac magnetic resonanceSaman Nazarian
Department of Medicine Cardiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Magn Reson Med 64:107-14. 2010..The SNRV of the left ventricle is associated with QRS prolongation, likely due to late depolarization of tissue within islands of patchy fibrosis. The association of SNRV with future clinical events warrants further study...
The benefit of upgrading chronically right ventricle-paced heart failure patients to resynchronization therapy demonstrated by strain rate imagingZayd A Eldadah
Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Heart Rhythm 3:435-42. 2006..RV pacing induces conduction delay (CD), mechanical dyssynchrony, and increased morbidity in patients with HF. CRT improves HF symptoms and survival, but sparse data exist on its direct effect on chronically RV-paced HF patients...
Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2Darshan Dalal
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Circulation 113:1641-9. 2006..The purpose of our study was to validate the frequency of PKP2 mutations in another large series of ARVD/C patients and to examine the phenotypic characteristics associated with PKP2 mutations...
Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathyKalpana R Prakasa
Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
Am J Cardiol 97:703-9. 2006..In conclusion, 3DE measurements of RV volumes and ejection fractions closely correlate with CMR values and may be useful in the follow-up of patients with ARVD/C...
Integrated electroanatomic mapping with three-dimensional computed tomographic images for real-time guided ablationsJun Dong
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 113:186-94. 2006..This may provide significant advantages for anatomically based procedures such as ablation of atrial fibrillation and nonidiopathic ventricular tachycardia...
Characterization of radiofrequency ablation lesions with gadolinium-enhanced cardiovascular magnetic resonance imagingTimm Dickfeld
Division of Cardiology, Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
J Am Coll Cardiol 47:370-8. 2006..This study was designed to evaluate the characteristics of gadolinium-enhanced imaging of radiofrequency ablations...
Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart diseaseAlan Cheng
Section for Cardiac Electrophysiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 20:873-9. 2009..We sought to define the effects of ibutilide on the temporal lability of ventricular repolarization in patients with and without structural heart disease...
Prevalence of left ventricular regional dysfunction in arrhythmogenic right ventricular dysplasia: a tagged MRI studyAditya Jain
Department of Radiology, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Circ Cardiovasc Imaging 3:290-7. 2010..Regional left ventricular (LV) function has not been systematically studied in ARVD...
Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathySaman Nazarian
Department of Medicine Cardiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Circulation 112:2821-5. 2005..However, the substrate for ventricular arrhythmia in patients with nonischemic cardiomyopathy remains poorly understood. We hypothesized that the distribution of scar identified by MRI is predictive of inducible ventricular tachycardia...
Morphologic variants of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy a genetics-magnetic resonance imaging correlation studyDarshan Dalal
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Coll Cardiol 53:1289-99. 2009....
Ventricular pacing with premature excitation for treatment of hypertensive-cardiac hypertrophy with cavity-obliterationD A Kass
Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Circulation 100:807-12. 1999..Accordingly, we hypothesized that pacing may improve exercise tolerance long-term in this syndrome...
Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathyR D Berger
Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Circulation 96:1557-65. 1997..We sought to test the hypothesis that beat-to-beat QT interval variability is increased in DCM patients compared with control subjects...
Cost-effectiveness of catheter ablation in patients with ventricular tachycardiaH Calkins
Johns Hopkins University, Baltimore, MD, USA
Circulation 101:280-8. 2000..The analysis used a societal perspective for a hypothetical cohort of VT patients with implantable cardioverter-defibrillators, who were experiencing frequent shocks...
Sex differences in outcome after implantable cardioverter defibrillator implantation in nonischemic cardiomyopathyChristine M Albert
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
Am Heart J 156:367-72. 2008..In the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) trial, a reduction in all-cause mortality was seen in men (P = .018) but not for women (P = .76)...
Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious miceP Jumrussirikul
Department of Medicine, Department of Neurology, Department of Neuroscience, Department of Physiology, and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21287, USA
J Clin Invest 102:1279-85. 1998..Thus, neuronally derived NO and cardiac inhibitory G protein activity serve as parallel pathways to mediate autonomic slowing of heart rate in the mouse...
ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Carina Blomstrom-Lundqvist
Circulation 108:1871-909. 2003
ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary. a report of the American college of cardiology/American heart association task force on practice guidelines and the European society of cardiology Carina Blomstrom-Lundqvist
J Am Coll Cardiol 42:1493-531. 2003
Hybrid therapy with right atrial catheter ablation and previously ineffective antiarrhythmic drugs for the management of atrial fibrillationAbraham G Kocheril
Section of Cardiac Electrophysiology, Carle Heart Center and University of Illinois, Urbana, 61801, USA
J Interv Card Electrophysiol 12:189-97. 2005..Early studies suggested that linear catheter ablation in the right atrium may provide sufficient substrate modification to reestablish therapeutic efficacy of previously ineffective AADs...
Stereotactic magnetic resonance guidance for anatomically targeted ablations of the fossa ovalis and the left atriumTimm Dickfeld
Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Interv Card Electrophysiol 11:105-15. 2004....
Technique and results of pulmonary vein angiography in patients undergoing catheter ablation of atrial fibrillationChandreaekhar R Vasamreddy
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Cardiovasc Electrophysiol 15:21-6. 2004..PV angiography can be used as an alternate to MRI or computed tomographic imaging, particularly when these tests are unavailable or are contraindicated in the patient...
Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillationRiccardo Cappato
Arrhythmia and Electrophysiology Center, Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Milan, Italy
Circulation 111:1100-5. 2005..The purpose of this study was to conduct a worldwide survey investigating the methods, efficacy, and safety of catheter ablation (CA) of atrial fibrillation (AF)...
Clinical utility and safety of a protocol for noncardiac and cardiac magnetic resonance imaging of patients with permanent pacemakers and implantable-cardioverter defibrillators at 1.5 teslaSaman Nazarian
Department of Cardiology, Johns Hopkins Hospital, Carnegie 568, 600 N Wolfe St, Baltimore, MD 21287, USA
Circulation 114:1277-84. 2006..We sought to evaluate the diagnostic utility and safety of noncardiac and cardiac MRI at 1.5T using a protocol that incorporates device selection and programming and limits the estimated specific absorption rate of MRI sequences...
Prevention of esophageal injury during catheter ablation of atrial fibrillation: is intracardiac echocardiography the answer?Hugh Calkins
Heart Rhythm 3:1162-3. 2006
Long-term single procedure efficacy of catheter ablation of atrial fibrillationAamir Cheema
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Interv Card Electrophysiol 15:145-55. 2006..In order to be able to compare outcomes of various techniques in differing patient populations, we urge investigators to report long-term single procedure outcomes...
Controversial role of magnetic resonance imaging in the diagnosis of arrhythmogenic right ventricular dysplasiaHarikrishna Tandri
Am J Cardiol 92:649. 2003
Incidence and time course of early recovery of pulmonary vein conduction after catheter ablation of atrial fibrillationAamir Cheema
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0409, USA
J Cardiovasc Electrophysiol 18:387-91. 2007..Although it is well recognized that recovery of pulmonary vein (PV) conduction is common among patients who fail atrial fibrillation (AF) ablation, little is known about the precise time course of recurrence...
Long-term safety and efficacy of circumferential ablation with pulmonary vein isolationAamir Cheema
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0409, USA
J Cardiovasc Electrophysiol 17:1080-5. 2006..Repeat procedures involving re-isolation of the PVs result in a significant improvement in outcomes. Complete electrical isolation of the PVs has a significant impact on the long-term efficacy of the procedure...
Driving and implantable cardioverter-defibrillator shocks for ventricular arrhythmias: results from the TOVA studyChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine and Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02215 1204, USA
J Am Coll Cardiol 50:2233-40. 2007..This study examined the risk of implantable cardioverter-defibrillator (ICD) shocks for ventricular tachycardia (VT) or ventricular fibrillation (VF) associated with driving...
Role of magnetic resonance imaging in arrhythmogenic right ventricular dysplasia: insights from the North American arrhythmogenic right ventricular dysplasia (ARVD/C) studyHarikrishna Tandri
Department of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am Heart J 155:147-53. 2008..The aim of our study was to define the prevalence, sensitivity, and specificity of quantitative MR imaging findings in the probands of multidisciplinary study of right ventricular dysplasia...
