Peter Calabresi

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis
    Stephanie B Syc
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain 135:521-33. 2012
  2. doi request reprint Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography
    Shiv Saidha
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain 134:518-33. 2011
  3. ncbi request reprint The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL
    P A Calabresi
    Johns Hopkins Multiple Sclerosis Center, Baltimore, MD, USA
    Neurology 69:1391-403. 2007
  4. pmc Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosis
    Daniel S Reich
    Department of Neurology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Neuroimage 38:271-9. 2007
  5. pmc Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease
    Katharine A Whartenby
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 102:16741-6. 2005
  6. pmc Axonal protective effects of the myelin-associated glycoprotein
    Thien Nguyen
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci 29:630-7. 2009
  7. pmc Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy
    Jiangyang Zhang
    Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:3160-71. 2009
  8. ncbi request reprint FLT3 inhibitors for the treatment of autoimmune disease
    Katharine A Whartenby
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Expert Opin Investig Drugs 17:1685-92. 2008
  9. pmc Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability
    Daniel S Reich
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Phipps Bldg, Room B 112, Baltimore, MD 21287, USA
    Arch Neurol 66:998-1006. 2009
  10. ncbi request reprint High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord
    Cynthia A Deboy
    Department of Neurology, Johns Hopkins University, School of Medicine, USA
    Brain 130:2199-210. 2007

Research Grants

  1. CHEMOKINE RECEPTOR EXPRESSION ON MBP REACTIVE T CELLS
    Peter Calabresi; Fiscal Year: 2002
  2. Potassium Channel Expression on Myelin Reactive Effector T Cells
    Peter Calabresi; Fiscal Year: 2006
  3. The Role of KV1.3 in Effector T cells
    Peter A Calabresi; Fiscal Year: 2010

Detail Information

Publications58

  1. pmc Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis
    Stephanie B Syc
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain 135:521-33. 2012
    ....
  2. doi request reprint Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography
    Shiv Saidha
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain 134:518-33. 2011
    ..Patients with inner and outer nuclear layer pathology have more rapid disability progression and thus retinal neuronal pathology may be a harbinger of a more aggressive form of multiple sclerosis...
  3. ncbi request reprint The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL
    P A Calabresi
    Johns Hopkins Multiple Sclerosis Center, Baltimore, MD, USA
    Neurology 69:1391-403. 2007
    ..To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab...
  4. pmc Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosis
    Daniel S Reich
    Department of Neurology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Neuroimage 38:271-9. 2007
    ..To do so, we develop an intuitive method for creating and displaying spatially normalized tract-specific imaging data...
  5. pmc Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease
    Katharine A Whartenby
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 102:16741-6. 2005
    ....
  6. pmc Axonal protective effects of the myelin-associated glycoprotein
    Thien Nguyen
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci 29:630-7. 2009
    ..Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss...
  7. pmc Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy
    Jiangyang Zhang
    Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:3160-71. 2009
    ..These data suggest that there is an early imaging signature associated with axon transections that could be used in a variety of neurological disease processes...
  8. ncbi request reprint FLT3 inhibitors for the treatment of autoimmune disease
    Katharine A Whartenby
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Expert Opin Investig Drugs 17:1685-92. 2008
    ..This review will outline the science behind the development of the therapy, the roles of dendritic cells in generating autoimmune disease, and the function of the FLT3 receptor in this process...
  9. pmc Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability
    Daniel S Reich
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Phipps Bldg, Room B 112, Baltimore, MD 21287, USA
    Arch Neurol 66:998-1006. 2009
    ..To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS) is associated with optic nerve injury and visual dysfunction...
  10. ncbi request reprint High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord
    Cynthia A Deboy
    Department of Neurology, Johns Hopkins University, School of Medicine, USA
    Brain 130:2199-210. 2007
    ..These data suggest that high resolution DTI may be a more sensitive method than conventional imaging for detecting axonal damage at sites distant from inflammation...
  11. doi request reprint Retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis
    Maulik S Zaveri
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Neurol 65:924-8. 2008
    ....
  12. pmc Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
    Lauren S Talman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 67:749-60. 2010
    ..We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON)...
  13. doi request reprint Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    J Neurol Sci 282:96-105. 2009
    ..Measurement of retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) is gaining increasing attention...
  14. pmc q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy
    Jonathan A D Farrell
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 63:1323-35. 2010
    ..When compared to histology, the increase in perpendicular diffusion was not specific to demyelination, whereas combined reduced parallel diffusion and increased perpendicular diffusion was associated with axon damage...
  15. pmc A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions
    Navid Shiee
    Laboratory of Medical Image Computing, Neuroradiology Division, Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Neuroimage 49:1524-35. 2010
    ..Evaluation with both simulated and real data sets demonstrates that the method has an accuracy competitive with state-of-the-art MS lesion segmentation methods, while simultaneously segmenting the whole brain...
  16. pmc High b-value q-space diffusion-weighted MRI of the human cervical spinal cord in vivo: feasibility and application to multiple sclerosis
    Jonathan A D Farrell
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Magn Reson Med 59:1079-89. 2008
    ..Thus, q-space DWI can be used to study water diffusion in the human spinal cord in vivo and is well suited to assess white matter damage...
  17. doi request reprint Low serum vitamin D levels and recurrent inflammatory spinal cord disease
    Maureen A Mealy
    Department of Neurology, Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Neurol 69:352-6. 2012
    ..As a sterol hormone involved in multiple immunologic pathways, vitamin D may play a role in preventing monophasic immune-mediated central nervous system attacks from developing into recurrent disease...
  18. pmc FLT-3 expression and function on microglia in multiple sclerosis
    Cynthia A Deboy
    Neurology, Johns Hopkins University, Pathology 627, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Exp Mol Pathol 89:109-16. 2010
    ..Furthermore these data suggest that FLT-3 may be a therapeutic target on microglia to mitigate CNS inflammation...
  19. pmc Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord
    Kathleen M Zackowski
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Brain 132:1200-9. 2009
    ..30, P < 0.001). These results help to understand the anatomic basis of sensorimotor disability in multiple sclerosis and have implications for testing the effects of neuroprotective and reparative interventions...
  20. ncbi request reprint Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells
    Peter A Calabresi
    Department of Neurology, School of Medicine, University of Maryland, Room 12 027, 655 W Baltimore St, Baltimore, MD 21201, USA
    J Neuroimmunol 127:96-105. 2002
    ..CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS)...
  21. pmc Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification
    Kegang Hua
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 39:336-47. 2008
    ..Excellent correlation was found between the automated and the individual tractography-based results. This tool allows efficient initial screening of the status of multiple white matter tracts...
  22. doi request reprint Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  23. pmc Optical coherence tomography: a window into the mechanisms of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Nat Clin Pract Neurol 4:664-75. 2008
    ....
  24. doi request reprint Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial
    Kathleen Hawker
    Department of Neurology, The Ohio State University Medical Center, Columbus, USA
    Ann Neurol 66:460-71. 2009
    ..We evaluated rituximab in adults with primary progressive MS (PPMS) through 96 weeks and safety through 122 weeks...
  25. pmc Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis
    Cornelia Cudrici
    Department of Neurology, University of Maryland, Baltimore, MD 21201, USA
    Exp Mol Pathol 83:198-206. 2007
    ..Since injury to the NLGM is one of the key factors associated with disability accumulation, targeting DCs may represent a possible new therapeutic approach in MS to prevent disease progression...
  26. ncbi request reprint Kinetics of CCR7 expression differ between primary activation and effector memory states of T(H)1 and T(H)2 cells
    Peter A Calabresi
    Department of Neurology, BRB 12 027, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
    J Neuroimmunol 139:58-65. 2003
    ....
  27. pmc Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers
    Tongguang Wang
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 30:5020-7. 2010
    ..We have thus identified a novel pathway in neurogenesis. The increased expression of Kv1.3 in pathological conditions makes it a novel target for promoting neurorestoration...
  28. pmc IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis
    Adam I Kaplin
    Department of Psychiatry and Behavioral Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Clin Invest 115:2731-41. 2005
    ..The elucidation of this pathway identifies specific therapeutic targets in the management of CNS autoimmune conditions...
  29. doi request reprint Reproducibility of high-resolution optical coherence tomography in multiple sclerosis
    Stephanie B Syc
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mult Scler 16:829-39. 2010
    ..Specific procedures for OCT acquisition and analysis of retinal imaging metrics using SD-OCT technology may improve the application of this novel technology in multiple sclerosis...
  30. doi request reprint Reproducibility of optical coherence tomography in multiple sclerosis
    Deanna Cettomai
    Pathology Bldg, Ste 627, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 65:1218-22. 2008
    ..Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers...
  31. ncbi request reprint Granzyme B mediates neurotoxicity through a G-protein-coupled receptor
    Tongguang Wang
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA
    FASEB J 20:1209-11. 2006
    ..GrB-induced neurotoxicity could also be blocked by vitamin E and a neuroimmunophilin ligand. In conclusion, GrB may be an important mediator of neuronal injury in T cell-mediated neuroinflammatory disorders...
  32. pmc Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis
    Mario Skarica
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore MD 21231, USA
    J Immunol 182:4192-9. 2009
    ..Thus, use of this class of signal transduction inhibitors may represent a novel method to treat autoimmunity by dampening the autoreactive polarizing condition driven by DCs...
  33. ncbi request reprint Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes
    Lina Hu
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Immunol 179:4563-70. 2007
    ..Specific Kv1.3 blockers may be beneficial in autoimmune diseases such as multiple sclerosis in which T(EM) are found in the target organ...
  34. doi request reprint Future research directions in multiple sclerosis therapies
    Benjamin M Greenberg
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Semin Neurol 28:121-7. 2008
    ..Neuroprotective drugs that were once only considered for classical degenerative diseases, such as amyotrophic lateral sclerosis and Parkinson's disease, are now being considered in MS...
  35. doi request reprint Interleukin-17 in transverse myelitis and multiple sclerosis
    Jerome J Graber
    The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD 21287 6965, United States
    J Neuroimmunol 196:124-32. 2008
    ..We conclude that IL-17 and IL-6 production from PBMC in TM and early MS are increased and induce astrocyte IL-6 production through IL-6...
  36. pmc Complex geometric models of diffusion and relaxation in healthy and damaged white matter
    Bennett A Landman
    Department of Biomedical Engineering, John Hopkins University, Baltimore, MD 21218, USA
    NMR Biomed 23:152-62. 2010
    ..g. mesh-based) geometries. Three-dimensional diffusion displacement probability functions are mapped with high reproducibility, and thus can be readily used to assess reproducibility of diffusion-derived contrasts...
  37. ncbi request reprint Diagnosis and management of multiple sclerosis
    Peter A Calabresi
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am Fam Physician 70:1935-44. 2004
    ..Five disease-modifying treatments for multiple sclerosis have been approved by the U.S. Food and Drug Administration. These treatments are partially effective in reducing exacerbations and may slow progression of disability...
  38. ncbi request reprint 2004 Pathogenesis of rare neuroimmunologic disorders, Hyatt Regency Inner Harbor, Baltimore, MD, August 19th 2004-August 20th 2004
    Douglas A Kerr
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neuroimmunol 159:3-11. 2005
  39. ncbi request reprint Unmasking of autoimmune hepatitis in a patient with MS following interferon beta therapy
    Mathew Pulicken
    Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Neurology 66:1954-5. 2006
  40. ncbi request reprint Bystander modulation of chemokine receptor expression on peripheral blood T lymphocytes mediated by glatiramer therapy
    Rameeza Allie
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Neurol 62:889-94. 2005
    ..Determining the site of action and effect of glatiramer on cell trafficking is of major importance in designing rational combination therapy clinical trials...
  41. pmc The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain
    Horea Rus
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11094-9. 2005
    ..3(high)/CCR7(-) T(EM), suggesting that a subset of cerebrospinal fluid cells existed in a primed state ready to become T(EM). These studies provide further rationale for the use of specific Kv1.3 antagonists in MS...
  42. pmc Automated vs. conventional tractography in multiple sclerosis: variability and correlation with disability
    Daniel S Reich
    Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Neuroimage 49:3047-56. 2010
    ..In the optic tract, the automated method failed. With judicious application, therefore, the automated method may be useful for studies that investigate the relationship between imaging findings and clinical outcomes in disease...
  43. ncbi request reprint Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis
    David N Irani
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 59:237-47. 2006
    ..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis...
  44. pmc Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 tesla
    Seth A Smith
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
    NMR Biomed 23:207-17. 2010
    ..These column-specific MR measurements are expected to enhance understanding of the intimate structure-function relationship in the cervical spinal cord and may be useful for the assessment of disease progression...
  45. pmc A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
    David Wheeler
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain 131:3092-102. 2008
    ..Modelling the biophysical consequence of this change in lipid composition of NAWM indicated an increase in the repulsive force between opposing bilayers that could explain decompaction and disruption of myelin structure...
  46. pmc Reduction of disease activity and disability with high-dose cyclophosphamide in patients with aggressive multiple sclerosis
    Chitra Krishnan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5371, USA
    Arch Neurol 65:1044-51. 2008
    ..To explore the safety and effectiveness of high-dose cyclophosphamide (HiCy) without bone marrow transplantation in patients with aggressive multiple sclerosis (MS)...
  47. ncbi request reprint Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system
    Katherine M Mullen
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 60:118-27. 2006
    ..We examined K(+) channels on dendritic cells (DCs), which infiltrate the brain in MS and may impact disease course...
  48. ncbi request reprint Health-related quality of life in multiple sclerosis: effects of natalizumab
    Richard A Rudick
    Department of Neurology, Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Neurol 62:335-46. 2007
    ..To report the relationship between disease activity and health-related quality of life (HRQoL) in relapsing multiple sclerosis, and the impact of natalizumab...
  49. ncbi request reprint Considerations in the treatment of relapsing-remitting multiple sclerosis
    Peter A Calabresi
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neurology 58:S10-22. 2002
    ..Investigational compounds, including oral formulations of glatiramer acetate and interferon, are in various stages of development...
  50. pmc The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS
    Heike Wulff
    Department of Physiology and Biophysics, University of California Irvine, College of Medicine, Irvine, California 92697, USA
    J Clin Invest 111:1703-13. 2003
    ..Selective targeting of Kv1.3 in T(EM) cells may therefore hold therapeutic promise for MS and other T cell-mediated autoimmune diseases...
  51. ncbi request reprint Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    Richard A Rudick
    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:911-23. 2006
    ..Despite interferon beta therapy, many patients have relapses. Natalizumab, an alpha4 integrin antagonist, appeared to be safe and effective alone and when added to interferon beta-1a in preliminary studies...
  52. ncbi request reprint Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, 291 Irvine Hall, Medical School, University of California Irvine, Irvine, CA 92697 4561, USA
    Mol Pharmacol 67:1369-81. 2005
    ..ShK(L5) prevents and treats experimental autoimmune encephalomyelitis and suppresses delayed type hypersensitivity in rats. ShK(L5) might prove useful for therapy of autoimmune disorders...
  53. ncbi request reprint Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis
    Jennifer B Fisher
    Division of Neuro ophthalmology, Departments of Neurology, Ophthalmology, and Biostatistics, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania, USA
    Ophthalmology 113:324-32. 2006
    ....
  54. ncbi request reprint Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale
    George P A Rice
    Department of Clinical Neurologic Sciences, University of Western Ontario, London Health Sciences Centre, University Campus, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    Neurology 64:1336-42. 2005
    ..The authors discuss the mechanisms by which alpha4 integrins alter lymphocyte function as a rationale for anti-alpha4 integrin use in MS...
  55. ncbi request reprint Pulsed magnetization transfer imaging with body coil transmission at 3 Tesla: feasibility and application
    Seth A Smith
    F M Kirby Research Center for Functional Brain Imaging, Johns Hopkins University, Baltimore, Maryland, USA
    Magn Reson Med 56:866-75. 2006
    ..The method is demonstrated in nine normal volunteers and five patients with relapsing remitting MS (RRMS), and the results show a clear delineation of heterogeneous lesions...
  56. pmc Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 103:17414-9. 2006
    ..Repeated dosing with Kv1.3 inhibitors in rats has not revealed systemic toxicity. Further development of Kv1.3 blockers for autoimmune disease therapy is warranted...
  57. pmc Cleavage of myelin associated glycoprotein by matrix metalloproteinases
    Elizabeth Milward
    School of Biomedical Sciences, The University of Newcastle and the Hunter Medical Research Institute, Callaghan, New South Wales 2308, Australia
    J Neuroimmunol 193:140-8. 2008
    ..We conclude that MMPs may have the potential both to disrupt MAG dependent axon-glia communication and to generate bioactive fragments that can inhibit neurite growth...
  58. doi request reprint The diagnosis of MS: white spots and red flags
    John N Ratchford
    Neurology 70:1071-2. 2008

Research Grants10

  1. CHEMOKINE RECEPTOR EXPRESSION ON MBP REACTIVE T CELLS
    Peter Calabresi; Fiscal Year: 2002
    ..The results from these aims will enhance our understanding of MBP reactive T cells as a model for the pathogenic events in MS. ..
  2. Potassium Channel Expression on Myelin Reactive Effector T Cells
    Peter Calabresi; Fiscal Year: 2006
    ..abstract_text> ..
  3. The Role of KV1.3 in Effector T cells
    Peter A Calabresi; Fiscal Year: 2010
    ..Further, understanding basic mechanisms of T cell function will enhance our knowledge of how the immune system causes disease and allow us to develop novel strategies for correcting abnormal immune responses in diseases like MS. ..