A L Burnett

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism
    Arthur L Burnett
    Johns Hopkins University Urology, Baltimore, MD, USA
    J Sex Med 3:1077-84. 2006
  2. ncbi request reprint Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism
    Gwen Lagoda
    1Department of Urology, The Johns Hopkins Hospital, 600 N Wolfe St, Marburg 407, Baltimore, MD 21287 2411, USA
    FASEB J 28:76-84. 2014
  3. doi request reprint Management of erectile dysfunction: great progress, greater promise
    Arthur L Burnett
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Androl 33:1107-10. 2012
  4. doi request reprint Sexual health outcomes improvement in sickle cell disease: a matter of health policy?
    Arthur L Burnett
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    J Sex Med 9:104-13. 2012
  5. doi request reprint Surgical management of ischemic priapism
    Arthur L Burnett
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287 2101, USA
    J Sex Med 9:114-20. 2012
  6. ncbi request reprint Benign prostatic hyperplasia in primary care: what you need to know
    Arthur L Burnett
    Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 175:S19-24. 2006
  7. ncbi request reprint Erectile function outcome reporting after clinically localized prostate cancer treatment
    Arthur L Burnett
    The Johns Hopkins Hospital, 600 North Wolfe St, Marburg 407, Baltimore, Maryland 21287 2411, USA
    J Urol 178:597-601. 2007
  8. ncbi request reprint Novel nitric oxide signaling mechanisms regulate the erectile response
    A L Burnett
    Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    Int J Impot Res 16:S15-9. 2004
  9. ncbi request reprint The impact of sildenafil on molecular science and sexual health
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
    Eur Urol 46:9-14. 2004
  10. ncbi request reprint Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health
    Arthur L Burnett
    Department of Urology, Johns Hopkins Hospital, 600 N Wolfe St Marburg 407, Baltimore, MD 21287 2411, USA
    J Androl 29:3-14. 2008

Research Grants

  1. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism
    Arthur L Burnett
    Johns Hopkins University Urology, Baltimore, MD, USA
    J Sex Med 3:1077-84. 2006
    ..Recurrent ischemic priapism is an enigmatic erectile disorder in need of improved clinical interventions to avert its known, potentially serious complications...
  2. ncbi request reprint Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism
    Gwen Lagoda
    1Department of Urology, The Johns Hopkins Hospital, 600 N Wolfe St, Marburg 407, Baltimore, MD 21287 2411, USA
    FASEB J 28:76-84. 2014
    ..Exogenous sustained NO release from C6' corrects pathological erectile signaling in mouse models of priapism and suggests novel approaches to human therapy...
  3. doi request reprint Management of erectile dysfunction: great progress, greater promise
    Arthur L Burnett
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Androl 33:1107-10. 2012
    ..The field continues to evolve as a legitimate discipline in medicine and is worthy of ongoing scientific support and activity...
  4. doi request reprint Sexual health outcomes improvement in sickle cell disease: a matter of health policy?
    Arthur L Burnett
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
    J Sex Med 9:104-13. 2012
    ..Males with sickle cell disease (SCD) are commonly affected. Given the adverse health consequences of this condition coupled with its specific population extent, health policy considerations are warranted...
  5. doi request reprint Surgical management of ischemic priapism
    Arthur L Burnett
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287 2101, USA
    J Sex Med 9:114-20. 2012
    ..Surgery is a mainstay in the management of ischemic priapism. The surgical armamentarium for this condition has recently been expanded with the introduction of several innovative procedures...
  6. ncbi request reprint Benign prostatic hyperplasia in primary care: what you need to know
    Arthur L Burnett
    Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 175:S19-24. 2006
    ..We reviewed recent literature and treatment guidelines regarding the prevalence, pathophysiology, and management of BPO related to BPH; and management of lower urinary tract symptoms secondary to BPH...
  7. ncbi request reprint Erectile function outcome reporting after clinically localized prostate cancer treatment
    Arthur L Burnett
    The Johns Hopkins Hospital, 600 North Wolfe St, Marburg 407, Baltimore, Maryland 21287 2411, USA
    J Urol 178:597-601. 2007
    ....
  8. ncbi request reprint Novel nitric oxide signaling mechanisms regulate the erectile response
    A L Burnett
    Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    Int J Impot Res 16:S15-9. 2004
    ..Thus, nNOS may initiate cavernosal tissue relaxation, while activated eNOS may facilitate attainment and maintenance of full erection...
  9. ncbi request reprint The impact of sildenafil on molecular science and sexual health
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
    Eur Urol 46:9-14. 2004
    ....
  10. ncbi request reprint Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health
    Arthur L Burnett
    Department of Urology, Johns Hopkins Hospital, 600 N Wolfe St Marburg 407, Baltimore, MD 21287 2411, USA
    J Androl 29:3-14. 2008
    ..This review provides a critical examination of the multifaceted role of the PDE5 regulatory system in the penis and its relevance for applying existing and emerging therapeutic strategies for erectile disorders...
  11. ncbi request reprint Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2411, USA
    J Urol 171:495-500. 2004
    ..We investigated the long-term effect of immunophilin ligands on erection physiology and cavernous tissue histology using rat models of unilateral and bilateral cavernous nerve (CN) injury...
  12. ncbi request reprint Neurophysiology of erectile function: androgenic effects
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    J Androl 24:S2-5. 2003
  13. ncbi request reprint Priapism pathophysiology: clues to prevention
    A L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    Int J Impot Res 15:S80-5. 2003
    ..New ideas for prevention may emerge from targeting molecular mechanisms involved in regulating erectile tissue function...
  14. ncbi request reprint Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism?
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Sex Med 5:237-40. 2008
    ..Efforts to identify the health risk associations for priapism may reveal pathophysiologic mechanisms for the disorder and suggest a scientifically rational approach for correcting it...
  15. ncbi request reprint Vasoactive pharmacotherapy to cure erectile dysfunction: fact or fiction?
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 65:224-30. 2005
  16. ncbi request reprint Nonimmunosuppressant immunophilin ligand GPI-1046 does not promote in vitro growth of prostate cancer cells
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2411, USA
    Urology 65:1003-7. 2005
    ..Before establishing their clinical roles, however, it would be useful to evaluate whether they exert mitogenic effects on malignant prostate cells...
  17. ncbi request reprint Erectile dysfunction following radical prostatectomy
    Arthur L Burnett
    Johns Hopkins University School of Medicine, Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
    JAMA 293:2648-53. 2005
    ..Corrective, cause-specific advances such as neuromodulatory therapy offer valuable adjuncts to this surgery...
  18. ncbi request reprint Therapy insight: Priapism associated with hematologic dyscrasias
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Baltimore, MD, USA
    Nat Clin Pract Urol 2:449-56. 2005
    ..Here, the current knowledge of priapism as it relates to hematologic and coagulative diseases is discussed, with a focus on the diagnosis and treatment of the disorder...
  19. ncbi request reprint Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Urology 67:1043-8. 2006
    ..We explored the use of PDE5 inhibitors to treat recurrent priapism, based on the hypothesis that the erection regulatory function of PDE5 would be regularized by this treatment and protect against further episodes...
  20. ncbi request reprint Phosphodiesterase 5 mechanisms and therapeutic applications
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    Am J Cardiol 96:29M-31M. 2005
    ..They have shown excellent clinical efficacy and safety. This presentation affirms the value of PDE5 inhibition as a therapeutic strategy for ED...
  21. ncbi request reprint Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: association and management
    Arthur L Burnett
    The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
    Curr Urol Rep 6:470-5. 2005
    ....
  22. ncbi request reprint Nitric oxide/redox-based signalling as a therapeutic target for penile disorders
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
    Expert Opin Ther Targets 10:445-57. 2006
    ..The next line of pharmaceuticals for disorders of the penis, in general, may well spawn from an integrative understanding of the complex regulatory interactions influenced by, as well as influencing nitric oxide signalling in this organ...
  23. ncbi request reprint Nitric oxide in the penis--science and therapeutic implications from erectile dysfunction to priapism
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD 21287 2101, USA
    J Sex Med 3:578-82. 2006
  24. ncbi request reprint Neuromodulatory therapy to improve erectile function recovery outcomes after pelvic surgery
    Arthur L Burnett
    Department of Urology, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Urol 176:882-7. 2006
    ....
  25. ncbi request reprint The role of nitric oxide in erectile dysfunction: implications for medical therapy
    Arthur L Burnett
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Clin Hypertens (Greenwich) 8:53-62. 2006
    ..Because not all patients respond to PDE-5 inhibitors, additional therapies are being investigated, such as soluble guanylyl cyclase activators and NO donors, which act on NO-independent and NO-dependent pathways, respectively...
  26. ncbi request reprint Priapism: current principles and practice
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Instituitions, Baltimore, MD, USA
    Urol Clin North Am 34:631-42, viii. 2007
    ..All health care professionals should appreciate the importance of the disorder and be prepared to follow current principles of diagnosis and treatment to reduce or avert its complications...
  27. doi request reprint Environmental erectile dysfunction: can the environment really be hazardous to your erectile health?
    Arthur L Burnett
    Department of Urology, The Johns Hopkins Hospital, 600 N Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
    J Androl 29:229-36. 2008
    ..More scientific work is needed to identify specific environmental agents that may harm erectile function and define their exact mechanisms of action in this regard...
  28. ncbi request reprint The nitric oxide signaling pathway in the penis
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
    Curr Pharm Des 11:3987-94. 2005
    ..The purpose of this review is to highlight the latest areas of investigation related to the science of nitric oxide in the penis, as a gateway for considering novel therapeutic strategies for erectile disorders now and in the future...
  29. ncbi request reprint Novel pharmacological approaches in the treatment of erectile dysfunction
    A L Burnett
    Marburg 407, The Johns Hopkins Hospital, Baltimore, MD 21287 2411, USA
    World J Urol 19:57-66. 2001
    ..The purpose of this report is to review the current trends and new directions in the pharmacotherapy of erectile dysfunction...
  30. doi request reprint Priapism: new concepts in medical and surgical management
    Arthur L Burnett
    Division of Sexual Medicine, Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Johns Hopkins Hospital, Marburg 407, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Urol Clin North Am 38:185-94. 2011
    ..All successes in these arenas ensure that afflicted individuals avoid the health burdens of priapism and preserve sexual function...
  31. ncbi request reprint Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthase
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2411, USA
    J Androl 23:92-7. 2002
    ..We concluded that eNOS-/- mice preserve erectile function on the basis of a noncholinergic but NO-dependent mechanism and that eNOS physiologically mediates penile erection under cholinergic stimulation...
  32. ncbi request reprint Erectile dysfunction
    Arthur L Burnett
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Urol 175:S25-31. 2006
    ..An overview of the latest concepts advanced with regard to the epidemiology, pathophysiology, and management of male ED is provided...
  33. doi request reprint Anxiety disorders in patients with idiopathic priapism: risk factor and pathophysiologic link?
    Arthur L Burnett
    Johns Hopkins Medical Institutions, The James Buchanan Brady Urological Institute, Department of Urology, Baltimore, MD 21287, USA
    J Sex Med 6:1712-8. 2009
    ..A scientific explanation remains elusive for many presentations of recurrent ischemic priapism...
  34. ncbi request reprint Mediators of the female sexual response: pharmacotherapeutic implications
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 2411, USA
    World J Urol 20:101-5. 2002
    ....
  35. ncbi request reprint Nitric oxide regulation of penile erection: biology and therapeutic implications
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Androl 23:S20-6. 2002
  36. doi request reprint Future sexual medicine physiological treatment targets
    Arthur L Burnett
    The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    J Sex Med 7:3269-304. 2010
    ..There is need for state-of-the-art information as there is an evolving research understanding of the underlying molecular biological factors and mechanisms governing sexual physiologic functions...
  37. ncbi request reprint Strategies to promote recovery of cavernous nerve function after radical prostatectomy
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Marburg 407, Baltimore, Maryland 21287 2411, USA
    World J Urol 20:337-42. 2003
    ..The purpose of this report is to review strategies under development to promote post-prostatectomy erectile function, particularly with respect to preserving penile innervation involved in this function...
  38. doi request reprint Intraoperative assessment of an implantable electrode array for cavernous nerve stimulation
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
    J Sex Med 5:1949-54. 2008
    ..Erectile dysfunction remains a major functional complication of radical prostatectomy in the modern era despite surgical techniques to preserve the penile autonomic nerve supply...
  39. doi request reprint Erythropoietin promotes erection recovery after nerve-sparing radical retropubic prostatectomy: a retrospective analysis
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Sex Med 5:2392-8. 2008
    ..Erectile dysfunction persists as a major functional complication of nerve-sparing radical prostatectomy...
  40. doi request reprint Resolution of recurrent ischemic priapism after celiac plexus block: case report evidence for its neurogenic origin?
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Sex Med 6:886-9. 2009
    ..Recurrent ischemic priapism likely has a neurogenic basis for some clinical presentations...
  41. doi request reprint Corporal "snake" maneuver: corporoglanular shunt surgical modification for ischemic priapism
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
    J Sex Med 6:1171-6. 2009
    ..Current surgical shunting procedures for major ischemic priapism do not always effectively resolve acute presentations of this disorder...
  42. ncbi request reprint Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2
    A L Burnett
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 4:84-7. 1998
    ..Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-)...
  43. ncbi request reprint Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans
    A L Burnett
    Department of Urology, College of Arts and Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Med 3:571-4. 1997
    ..The mice possess hypertrophic dilated bladders and dysfunctional urinary outlets which do not relax in response to electrical field stimulation or L-arginine. The mice also display increased urinary frequency...
  44. ncbi request reprint FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms
    Gwen Lagoda
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 N Wolfe Street Marburg 407, Baltimore, MD 21287, USA
    J Sex Med 4:908-16. 2007
    ..Immunophilin ligands and phosphodiesterase type 5 (PDE5) inhibitors are touted to promote erectile function recovery after cavernous nerve (CN) injury. However, the mechanisms for their effects remain unclear...
  45. pmc Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection
    K Joseph Hurt
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:4061-6. 2002
    ..Our findings support a model in which rapid, brief activation of neuronal NOS initiates the erectile process, whereas PI3-kinase/Akt-dependent phosphorylation and activation of eNOS leads to sustained NO production and maximal erection...
  46. ncbi request reprint Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves
    N F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Biol Reprod 63:704-14. 2000
    ....
  47. ncbi request reprint Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase
    D L Drazen
    Departments of Psychology and Neuroscience, The Johns Hopkins University, Baltimore, Maryland, 21218, USA
    Nitric Oxide 3:366-74. 1999
    ..These data suggest that NO from endothelial sources might play a role in mediating rodent ovulation and may be involved in regulation of the timing of the estrous cycle...
  48. pmc Impaired ovulation in mice with targeted deletion of the neuronal isoform of nitric oxide synthase
    S L Klein
    Department of Psychology, Johns Hopkins University, Baltimore, Maryland, USA
    Mol Med 4:658-64. 1998
    ..The purpose of this study was to determine the specific role of neuronal NOS (nNOS) in the regulation of ovulation in female mice lacking the gene that encodes for nNOS (nNOS-/-)...
  49. pmc Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: new experimental paradigms
    Heather Valentine
    Department of Research, Guilford Pharmaceuticals Inc now MGI Pharma, Baltimore, Maryland 21287, United States
    Eur Urol 51:1724-31. 2007
    ....
  50. ncbi request reprint Rationale for cavernous nerve restorative therapy to preserve erectile function after radical prostatectomy
    Arthur L Burnett
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD 21287 2411, USA
    Urology 61:491-7. 2003
  51. ncbi request reprint Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Sex Med 6:2494-504. 2009
    ..Priapism is a poorly understood disease process with little information on the etiology and pathophysiology of this erectile disorder. One group of patients with a high prevalence of priapism is men with sickle-cell disease...
  52. ncbi request reprint Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction
    Liming Jin
    Department of Urology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    FASEB J 20:536-8. 2006
    ..05). Taken together, these data suggest that impaired erectile function during the aging process involves increased RhoA/Rho-kinase signaling, and this pathway may be exploited for the treatment of age-associated ED...
  53. pmc Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase
    A L Burnett
    Department of Urology, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Mol Med 2:288-96. 1996
    ..To clarify the source of NO in penile function, we have examined mice with targeted deletion of the nNOS gene (nNOS- mice)...
  54. ncbi request reprint Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-)
    L J Kriegsfeld
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Physiol Behav 67:561-6. 1999
    ..003) and intromissions (p < 0.001) to ejaculate compared to WT mice. Taken together, these results suggest that NO synthesized by eNOS may be involved in ejaculatory physiology, but not sexual motivation...
  55. ncbi request reprint eNOS function and dysfunction in the penis
    Biljana Musicki
    Johns Hopkins Hospital, Department of Urology, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Exp Biol Med (Maywood) 231:154-65. 2006
    ....
  56. ncbi request reprint FK506-binding protein localizations in human penile innervation
    Gwen Lagoda
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
    BJU Int 101:604-9. 2008
    ....
  57. ncbi request reprint A castrated mouse model of erectile dysfunction
    Michael A Palese
    Department of Surgery Division of Urology, University of Maryland Medical System, Baltimore, Maryland, USA
    J Androl 24:699-703. 2003
    ..This study defines an androgen-dependent mechanism of veno-occlusive erectile function in the mouse. The castrated mouse model can be applied in future studies of veno-occlusive erectile dysfunction...
  58. pmc Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism
    Hunter C Champion
    Department of Cardiology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:1661-6. 2005
    ..Coupled with the observation that sickle cell disease mice (which show a priapism phenotype) evince dysregulated PDE5A expression/activity, these data suggest that PDE5A dysregulation is a fundamental mechanism for priapism...
  59. pmc Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis
    Trinity J Bivalacqua
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Hospital, Baltimore, MD 21287, United States
    Eur Urol 51:1732-40. 2007
    ....
  60. doi request reprint Increased expression of nestin in the major pelvic ganglion following cavernous nerve injury
    O Kutlu
    The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Impot Res 24:84-90. 2012
    ..In conclusion, CNI induces nestin in the MPG. These data suggest that nestin may be involved in the regenerative process of the cavernous nerve following crush injury...
  61. pmc eNOS-uncoupling in age-related erectile dysfunction
    J M Johnson
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Impot Res 23:43-8. 2011
    ..These findings suggest that aging induces eNOS uncoupling in the penis, resulting in increased oxidative stress and ED...
  62. ncbi request reprint Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 292:H1340-51. 2007
    ..Inhibition of the arginase pathway improves endothelial function in the aging penile circulation, suggesting that the arginase pathway may be exploited to improve erectile dysfunction associated with aging...
  63. doi request reprint FK506 and rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injury
    Gwen Lagoda
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 2411, USA
    J Sex Med 6:1914-23. 2009
    ..Immunophilin ligands function by binding to receptor proteins such as FK506 binding proteins (FKBPs). FKBPs are studied for their roles in neuroprotection...
  64. doi request reprint Serum biomarker measurements of endothelial function and oxidative stress after daily dosing of sildenafil in type 2 diabetic men with erectile dysfunction
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 181:245-51. 2009
    ..We investigated changes in serum biomarkers of vascular function after short-term, continuous sildenafil dosing in men with type 2 diabetes with erectile dysfunction...
  65. ncbi request reprint Neuroprotection and nerve grafts in the treatment of neurogenic erectile dysfunction
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    J Urol 170:S31-4; discussion S34. 2003
    ..Novel directions in the management of neurogenic erectile dysfunction that pertain specifically to sustaining penile neuronal function are described...
  66. ncbi request reprint Protein inhibitor of nitric oxide synthase (NOS) and the N-methyl-D-aspartate receptor are expressed in the rat and mouse penile nerves and colocalize with penile neuronal NOS
    T R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 68:478-88. 2003
    ..In conclusion, PIN and NMDAR colocalize with PnNOS in penile nerves, but the functional significance of these protein interactions for penile erection remains to be elucidated...
  67. ncbi request reprint Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism
    K K Meldrum
    Departments of Urology and Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Physiol Regul Integr Comp Physiol 281:R359-64. 2001
    ..These data demonstrate that thermal stress protects renal tubular cells from simulated ischemia-induced apoptosis through a PKC-dependent mechanism...
  68. pmc Alternatively spliced neuronal nitric oxide synthase mediates penile erection
    K Joseph Hurt
    Department of Urology, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:3440-3. 2006
    ..Thus, alternatively spliced forms of nNOS are major mediators of penile erection and so may be targets for therapeutic intervention...
  69. ncbi request reprint Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penis
    Tongyun Liu
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    BJU Int 100:1103-6. 2007
    ....
  70. ncbi request reprint Imaging the cavernous nerves in the rat prostate using optical coherence tomography
    Nathaniel M Fried
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Lasers Surg Med 39:36-41. 2007
    ..The rat prostate serves as an excellent model for studying the use of OCT for imaging the CNs, as the rat CN is a large, visible, and distinct bundle allowing for easy identification with OCT in addition to histologic confirmation...
  71. ncbi request reprint Endothelial dysfunction in diabetic erectile dysfunction
    B Musicki
    Department of Urology, Johns Hopkins University, SOM, Baltimore, MD 21287, USA
    Int J Impot Res 19:129-38. 2007
    ..Considering recent advances in the field of vascular biology and diabetes, the emphasis in this review is placed on the mechanisms of hyperglycemia-induced endothelial dysfunction in the pathophysiology of diabetes-associated ED...
  72. doi request reprint Stem and endothelial progenitor cells in erection biology
    T D Strong
    Department of Urology, The Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Int J Impot Res 20:243-54. 2008
    ..In this paper, erection physiology and stem cell biology is reviewed, and the potential application of novel cell-based therapies for the treatment of ED is discussed...
  73. ncbi request reprint Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
    Lili A Barouch
    Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Nature 416:337-9. 2002
    ..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function...
  74. pmc Post-translational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vagina
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:1768-77. 2010
    ..Although vascular effects of estrogens are attributed to an increase in endothelial NO production, the mechanisms of endothelial NO synthase (eNOS) regulation by estrogens in the vagina are largely unknown...
  75. pmc Role of immunophilins in recovery of erectile function after cavernous nerve injury
    Sena F Sezen
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Department of Urology, Baltimore, MD 21287, USA
    J Sex Med 6:340-6. 2009
    ..Immunophilin ligands provide potentially new alternatives for the treatment of erectile dysfunction (ED), which occurs after injury of the cavernous nerves (CNs)...
  76. ncbi request reprint RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights
    Liming Jin
    Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
    Clin Sci (Lond) 110:153-65. 2006
    ..Understanding the RhoA/Rho-kinase signalling pathway in the regulation of erection is important for the development of therapeutic interventions for erectile dysfunction...
  77. doi request reprint Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivo
    Trinity J Bivalacqua
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 72:1169-73. 2008
    ..To evaluate the effect of the fibrin sealant, Evicel, on the neuroregulatory control of penile erections in an experimental rat model...
  78. pmc Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase
    Biljana Musicki
    Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:3023-32. 2010
    ....
  79. ncbi request reprint Erythropoietin promotes the recovery of erectile function following cavernous nerve injury
    Mohamad E Allaf
    The James Buchanan Brady Urological Institute, Baltimore, Maryland, USA
    J Urol 174:2060-4. 2005
    ..We investigated the effects of recombinant human (rh) erythropoietin (EPO) on erectile function recovery in a rat model of cavernous nerve (CN) injury...
  80. ncbi request reprint Time from dosing to sexual intercourse attempts in men taking tadalafil in clinical trials
    Ridwan Shabsigh
    Department of Urology, Columbia University, New York, NY 10032, USA
    BJU Int 96:857-63. 2005
    ....
  81. ncbi request reprint Erection capability is potentiated by long-term sildenafil treatment: role of blood flow-induced endothelial nitric-oxide synthase phosphorylation
    Biljana Musicki
    Department of Urology, Johns Hopkins Hospital, Marburg 405, 600 North Wolfe St, Baltimore, MD 21287, USA
    Mol Pharmacol 68:226-32. 2005
    ....
  82. ncbi request reprint In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: no tachyphylaxis effect
    Biljana Musicki
    Department of Urology and Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Urol 174:1493-6. 2005
    ....
  83. pmc Endothelial nitric oxide synthase regulation in female genital tract structures
    Biljana Musicki
    Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 6:247-53. 2009
    ..However, the role of endothelial NO synthase (eNOS) and the mechanisms that regulate eNOS in female genital tract structures are largely unknown...
  84. doi request reprint Penile rehabilitation and neuromodulation
    Fernando Facio
    Department of Urology, The Johns Hopkins Hospital, Baltimore, MD, USA
    ScientificWorldJournal 9:652-64. 2009
    ....
  85. doi request reprint Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, The Johns Hopkins Medical Institution, The James Buchanan Brady Urological Institute, Baltimore, Maryland 21287, USA
    J Urol 181:899-906. 2009
    ....
  86. ncbi request reprint Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penis
    Biljana Musicki
    Johns Hopkins Hospital, Brady Urological Institute, Baltimore, MD 21287, USA
    J Sex Med 2:347-55; discussion 355-7. 2005
    ....
  87. pmc Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction
    Biljana Musicki
    Department of Urology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 102:11870-5. 2005
    ..In vivo penile erection paradigm supports the physiologic relevance of O-GlcNAc modification in vascular disorders associated with diabetes...
  88. doi request reprint Erectile dysfunction management for the future
    Arthur L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2411, USA
    J Androl 30:391-6. 2009
    ..The purpose of this review is to present the foundations for future therapies in ED management...
  89. pmc Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell mice
    Trinity J Bivalacqua
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Urology 76:510.e7-12. 2010
    ..Therefore, the objective of the present study was to evaluate the molecular changes in RhoA and ROCK in an established transgenic sickle cell mouse model of priapism...
  90. ncbi request reprint Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erection
    Biljana Musicki
    Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Biol Reprod 70:282-9. 2004
    ..The data provide a molecular explanation for VEGF stimulatory effect on penile erection, which involves phosphorylated eNOS (Serine 1177) mediation...
  91. pmc Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysis
    Biljana Musicki
    Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA
    J Sex Med 5:552-61. 2008
    ..Diet and exercise affect endothelial function in the penis, but the molecular mechanisms underlying their effects are not understood...
  92. doi request reprint The effect of 5 alpha-reductase inhibitors on erectile function
    Onder Canguven
    The Johns Hopkins Hospital, The James Buchanan Brady Urological Institute, Department of Urology, Marburg 414, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Androl 29:514-23. 2008
    ..We conclude that 5 alpha-reductase inhibitors do not lead to erectile dysfunction to a significant degree, and we support the position that dihydrotestosterone is less relevant than testosterone in erectile function...
  93. ncbi request reprint Corporoplasty using pericardium allograft (tutoplast) with complex penile prosthesis surgery
    M A Palese
    Department of Surgery, Division of Urology, University of Maryland Medical System, Baltimore, Maryland, USA
    Urology 58:1049-52. 2001
    ..We offer a new role for Tutoplast processed pericardial allograft for complex corporoplasty during penile prosthesis surgery...
  94. ncbi request reprint FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury
    S F Sezen
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    Int J Impot Res 14:506-12. 2002
    ..Whether FK506 affords neuroprotection that preserves penile erection through FKBP 12 upregulation is unclear...
  95. ncbi request reprint Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat
    A G Akingba
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-2411, USA
    Mol Urol 5:189-97. 2001
    ..These eNOS effects apparently preceded nNOS effects. Full elucidation of the possible mechanisms affecting eNOS function in the diabetic rat penis requires further investigation...
  96. ncbi request reprint General use of animal models for investigation of the physiology of erection
    A L Burnett
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD 21287-2411, USA
    Int J Impot Res 13:135-9. 2001
    ..The promise of advancing therapies in this field indicates the additional prominent role for animals for the purposes of drug development...
  97. pmc Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells
    J Y Chung
    Department of Biochemistry and Molecular Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 154:2156-65. 2013
    ..We suggest that this approach might serve as a therapeutic means to increase steroid levels in vivo in cases of primary hypogonadism...
  98. doi request reprint Avanafil for the treatment of erectile dysfunction
    R Segal
    Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Drugs Today (Barc) 48:7-15. 2012
    ..It was recently approved and launched in Korea, and is currently under review by the U.S. Food and Drug Administration. Its efficacy and purported role in the treatment for erectile dysfunction are reviewed here...
  99. doi request reprint Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablation
    Phillip M Pierorazio
    James Buchanan Brady Urological Institute, Johns Hopkins Hospital, 600 N Wolfe Ave, Marburg 407, Baltimore, MD 21287, USA
    J Androl 32:371-4. 2011
    ..Our treatment of recurrent priapism implicates androgens and both biochemical and neurovascular control mechanisms in the penis...
  100. ncbi request reprint Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice
    Lili A Barouch
    Department of Medicine, Division of Cardiology, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, MD 21287, Baltimore, USA
    J Mol Cell Cardiol 35:637-44. 2003
    ..These findings suggest that cardiac NO signals may play an essential role in successful cardiac aging...
  101. ncbi request reprint The efficacy of sildenafil citrate (Viagra) in clinical populations: an update
    Culley C Carson
    Department of Surgery, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7235, USA
    Urology 60:12-27. 2002
    ..Findings from published accounts of sildenafil use in the clinical practice setting further demonstrated that sildenafil is an effective treatment for a wide range of patients with ED...

Research Grants3

  1. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002
    ....