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Genomes and Genes | A L BurnettSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Management of erectile dysfunction: great progress, greater promiseArthur L Burnett
Department of Urology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Marburg 407, Baltimore, MD 21287
J Androl 33:1107-10. 2012..The field continues to evolve as a legitimate discipline in medicine and is worthy of ongoing scientific support and activity...- Sexual health outcomes improvement in sickle cell disease: a matter of health policy?Arthur L Burnett
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2101, USA
J Sex Med 9:104-13. 2012..Males with sickle cell disease (SCD) are commonly affected. Given the adverse health consequences of this condition coupled with its specific population extent, health policy considerations are warranted... - Surgical management of ischemic priapismArthur L Burnett
Department of Urology, The Johns Hopkins University, Baltimore, MD 21287 2101, USA
J Sex Med 9:114-20. 2012..Surgery is a mainstay in the management of ischemic priapism. The surgical armamentarium for this condition has recently been expanded with the introduction of several innovative procedures... 
Novel nitric oxide signaling mechanisms regulate the erectile responseA L Burnett
Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
Int J Impot Res 16:S15-9. 2004..Thus, nNOS may initiate cavernosal tissue relaxation, while activated eNOS may facilitate attainment and maintenance of full erection...- Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapismArthur L Burnett
Johns Hopkins University Urology, Baltimore, MD, USA
J Sex Med 3:1077-84. 2006..Recurrent ischemic priapism is an enigmatic erectile disorder in need of improved clinical interventions to avert its known, potentially serious complications... - The impact of sildenafil on molecular science and sexual healthArthur L Burnett
Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
Eur Urol 46:9-14. 2004.... - Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injuryArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2411, USA
J Urol 171:495-500. 2004..We investigated the long-term effect of immunophilin ligands on erection physiology and cavernous tissue histology using rat models of unilateral and bilateral cavernous nerve (CN) injury... - Neurophysiology of erectile function: androgenic effectsArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287-2411, USA
J Androl 24:S2-5. 2003 - Priapism pathophysiology: clues to preventionA L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
Int J Impot Res 15:S80-5. 2003..New ideas for prevention may emerge from targeting molecular mechanisms involved in regulating erectile tissue function... - The role of nitric oxide in erectile dysfunction: implications for medical therapyArthur L Burnett
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Clin Hypertens (Greenwich) 8:53-62. 2006..Because not all patients respond to PDE-5 inhibitors, additional therapies are being investigated, such as soluble guanylyl cyclase activators and NO donors, which act on NO-independent and NO-dependent pathways, respectively... - Erectile function outcome reporting after clinically localized prostate cancer treatmentArthur L Burnett
The Johns Hopkins Hospital, 600 North Wolfe St, Marburg 407, Baltimore, Maryland 21287 2411, USA
J Urol 178:597-601. 2007.... - Neuromodulatory therapy to improve erectile function recovery outcomes after pelvic surgeryArthur L Burnett
Department of Urology, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Urol 176:882-7. 2006.... - Vasoactive pharmacotherapy to cure erectile dysfunction: fact or fiction?Arthur L Burnett
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Urology 65:224-30. 2005 - Nitric oxide in the penis--science and therapeutic implications from erectile dysfunction to priapismArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD 21287-2101, USA
J Sex Med 3:578-82. 2006 - Phosphodiesterase 5 mechanisms and therapeutic applicationsArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
Am J Cardiol 96:29M-31M. 2005..They have shown excellent clinical efficacy and safety. This presentation affirms the value of PDE5 inhibition as a therapeutic strategy for ED... - The nitric oxide signaling pathway in the penisArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
Curr Pharm Des 11:3987-94. 2005..The purpose of this review is to highlight the latest areas of investigation related to the science of nitric oxide in the penis, as a gateway for considering novel therapeutic strategies for erectile disorders now and in the future... - Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: association and managementArthur L Burnett
The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
Curr Urol Rep 6:470-5. 2005.... - Erectile dysfunctionArthur L Burnett
Johns Hopkins University, Baltimore, Maryland 21287, USA
J Urol 175:S25-31. 2006..An overview of the latest concepts advanced with regard to the epidemiology, pathophysiology, and management of male ED is provided... - Therapy insight: Priapism associated with hematologic dyscrasiasArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Baltimore, MD, USA
Nat Clin Pract Urol 2:449-56. 2005..Here, the current knowledge of priapism as it relates to hematologic and coagulative diseases is discussed, with a focus on the diagnosis and treatment of the disorder... - Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapismArthur L Burnett
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Urology 67:1043-8. 2006..We explored the use of PDE5 inhibitors to treat recurrent priapism, based on the hypothesis that the erection regulatory function of PDE5 would be regularized by this treatment and protect against further episodes... - Nitric oxide/redox-based signalling as a therapeutic target for penile disordersArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2411, USA
Expert Opin Ther Targets 10:445-57. 2006..The next line of pharmaceuticals for disorders of the penis, in general, may well spawn from an integrative understanding of the complex regulatory interactions influenced by, as well as influencing nitric oxide signalling in this organ... - Erectile dysfunction following radical prostatectomyArthur L Burnett
Johns Hopkins University School of Medicine, Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
JAMA 293:2648-53. 2005..Corrective, cause-specific advances such as neuromodulatory therapy offer valuable adjuncts to this surgery... - Nonimmunosuppressant immunophilin ligand GPI-1046 does not promote in vitro growth of prostate cancer cellsArthur L Burnett
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2411, USA
Urology 65:1003-7. 2005..Before establishing their clinical roles, however, it would be useful to evaluate whether they exert mitogenic effects on malignant prostate cells... - Strategies to promote recovery of cavernous nerve function after radical prostatectomyArthur L Burnett
Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Marburg 407, Baltimore, Maryland 21287 2411, USA
World J Urol 20:337-42. 2003..The purpose of this report is to review strategies under development to promote post-prostatectomy erectile function, particularly with respect to preserving penile innervation involved in this function... - Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile healthArthur L Burnett
Department of Urology, Johns Hopkins Hospital, 600 N Wolfe St Marburg 407, Baltimore, MD 21287 2411, USA
J Androl 29:3-14. 2008..This review provides a critical examination of the multifaceted role of the PDE5 regulatory system in the penis and its relevance for applying existing and emerging therapeutic strategies for erectile disorders... - Future sexual medicine physiological treatment targetsArthur L Burnett
The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
J Sex Med 7:3269-304. 2010..There is need for state-of-the-art information as there is an evolving research understanding of the underlying molecular biological factors and mechanisms governing sexual physiologic functions... - Anxiety disorders in patients with idiopathic priapism: risk factor and pathophysiologic link?Arthur L Burnett
Johns Hopkins Medical Institutions, The James Buchanan Brady Urological Institute, Department of Urology, Baltimore, MD 21287, USA
J Sex Med 6:1712-8. 2009..A scientific explanation remains elusive for many presentations of recurrent ischemic priapism... - Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthaseArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2411, USA
J Androl 23:92-7. 2002..We concluded that eNOS-/- mice preserve erectile function on the basis of a noncholinergic but NO-dependent mechanism and that eNOS physiologically mediates penile erection under cholinergic stimulation... - Novel pharmacological approaches in the treatment of erectile dysfunctionA L Burnett
Marburg 407, The Johns Hopkins Hospital, Baltimore, MD 21287 2411, USA
World J Urol 19:57-66. 2001..The purpose of this report is to review the current trends and new directions in the pharmacotherapy of erectile dysfunction... - Benign prostatic hyperplasia in primary care: what you need to knowArthur L Burnett
Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Urol 175:S19-24. 2006..We reviewed recent literature and treatment guidelines regarding the prevalence, pathophysiology, and management of BPO related to BPH; and management of lower urinary tract symptoms secondary to BPH... - Resolution of recurrent ischemic priapism after celiac plexus block: case report evidence for its neurogenic origin?Arthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Sex Med 6:886-9. 2009..Recurrent ischemic priapism likely has a neurogenic basis for some clinical presentations... - Erythropoietin promotes erection recovery after nerve-sparing radical retropubic prostatectomy: a retrospective analysisArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Sex Med 5:2392-8. 2008..Erectile dysfunction persists as a major functional complication of nerve-sparing radical prostatectomy... - Mediators of the female sexual response: pharmacotherapeutic implicationsArthur L Burnett
Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287 2411, USA
World J Urol 20:101-5. 2002.... - Corporal "snake" maneuver: corporoglanular shunt surgical modification for ischemic priapismArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
J Sex Med 6:1171-6. 2009..Current surgical shunting procedures for major ischemic priapism do not always effectively resolve acute presentations of this disorder... - Nitric oxide regulation of penile erection: biology and therapeutic implicationsArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Androl 23:S20-6. 2002 - Intraoperative assessment of an implantable electrode array for cavernous nerve stimulationArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
J Sex Med 5:1949-54. 2008..Conclusions. A chronic implantable nerve stimulation system for cavernous nerve stimulation having possible neuromodulatory effects on the recovery of penile erections after radical prostatectomy is feasible... - Environmental erectile dysfunction: can the environment really be hazardous to your erectile health?Arthur L Burnett
Department of Urology, The Johns Hopkins Hospital, 600 N Wolfe Street, Marburg 407, Baltimore, MD 21287 2411, USA
J Androl 29:229-36. 2008..More scientific work is needed to identify specific environmental agents that may harm erectile function and define their exact mechanisms of action in this regard... - Priapism: current principles and practiceArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Instituitions, Baltimore, MD, USA
Urol Clin North Am 34:631-42, viii. 2007..All health care professionals should appreciate the importance of the disorder and be prepared to follow current principles of diagnosis and treatment to reduce or avert its complications... - Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism?Arthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Sex Med 5:237-40. 2008..Efforts to identify the health risk associations for priapism may reveal pathophysiologic mechanisms for the disorder and suggest a scientifically rational approach for correcting it... - Priapism: new concepts in medical and surgical managementArthur L Burnett
Division of Sexual Medicine, Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Johns Hopkins Hospital, Marburg 407, 600 North Wolfe Street, Baltimore, MD 21287, USA
Urol Clin North Am 38:185-94. 2011..All successes in these arenas ensure that afflicted individuals avoid the health burdens of priapism and preserve sexual function... - Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2A L Burnett
Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Med 4:84-7. 1998..Reflex activity of the bulbospongiosus muscle, which mediates ejaculation and ejaculatory behavior, is markedly diminished in mice with targeted deletion of the gene for HO2 (HO2-)... - Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humansA L Burnett
Department of Urology, College of Arts and Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Med 3:571-4. 1997..The mice possess hypertrophic dilated bladders and dysfunctional urinary outlets which do not relax in response to electrical field stimulation or L-arginine. The mice also display increased urinary frequency... - FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanismsGwen Lagoda
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 N Wolfe Street Marburg 407, Baltimore, MD 21287, USA
J Sex Med 4:908-16. 2007..Immunophilin ligands and phosphodiesterase type 5 (PDE5) inhibitors are touted to promote erectile function recovery after cavernous nerve (CN) injury. However, the mechanisms for their effects remain unclear... 
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erectionK Joseph Hurt
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 99:4061-6. 2002..Our findings support a model in which rapid, brief activation of neuronal NOS initiates the erectile process, whereas PI3-kinase/Akt-dependent phosphorylation and activation of eNOS leads to sustained NO production and maximal erection...- Reproductive function in female mice lacking the gene for endothelial nitric oxide synthaseD L Drazen
Departments of Psychology and Neuroscience, The Johns Hopkins University, Baltimore, Maryland, 21218, USA
Nitric Oxide 3:366-74. 1999..These data suggest that NO from endothelial sources might play a role in mediating rodent ovulation and may be involved in regulation of the timing of the estrous cycle... - Impaired ovulation in mice with targeted deletion of the neuronal isoform of nitric oxide synthaseS L Klein
Department of Psychology, Johns Hopkins University, Baltimore, Maryland, USA
Mol Med 4:658-64. 1998..The purpose of this study was to determine the specific role of neuronal NOS (nNOS) in the regulation of ovulation in female mice lacking the gene that encodes for nNOS (nNOS-/-)... - Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: new experimental paradigmsHeather Valentine
Department of Research, Guilford Pharmaceuticals Inc now MGI Pharma, Baltimore, Maryland 21287, United States
Eur Urol 51:1724-31. 2007.... - Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapismTrinity J Bivalacqua
The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Sex Med 6:2494-504. 2009..Priapism is a poorly understood disease process with little information on the etiology and pathophysiology of this erectile disorder. One group of patients with a high prevalence of priapism is men with sickle-cell disease... - Rationale for cavernous nerve restorative therapy to preserve erectile function after radical prostatectomyArthur L Burnett
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-2411, USA
Urology 61:491-7. 2003 - Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nervesN F Gonzalez-Cadavid
Department of Urology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
Biol Reprod 63:704-14. 2000.... - Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunctionLiming Jin
Department of Urology, Johns Hopkins University, Baltimore, Maryland 21287, USA
FASEB J 20:536-8. 2006..05). Taken together, these data suggest that impaired erectile function during the aging process involves increased RhoA/Rho-kinase signaling, and this pathway may be exploited for the treatment of age-associated ED... - Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-)L J Kriegsfeld
Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
Physiol Behav 67:561-6. 1999..003) and intromissions (p < 0.001) to ejaculate compared to WT mice. Taken together, these results suggest that NO synthesized by eNOS may be involved in ejaculatory physiology, but not sexual motivation... - eNOS function and dysfunction in the penisBiljana Musicki
Johns Hopkins Hospital, Department of Urology, 600 North Wolfe Street, Baltimore, MD 21287, USA
Exp Biol Med (Maywood) 231:154-65. 2006.... - A castrated mouse model of erectile dysfunctionMichael A Palese
Department of Surgery Division of Urology, University of Maryland Medical System, Baltimore, Maryland, USA
J Androl 24:699-703. 2003..This study defines an androgen-dependent mechanism of veno-occlusive erectile function in the mouse. The castrated mouse model can be applied in future studies of veno-occlusive erectile dysfunction... - Endothelial nitric oxide synthase keeps erection regulatory function balance in the penisTrinity J Bivalacqua
The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Hospital, Baltimore, MD 21287, United States
Eur Urol 51:1732-40. 2007.... - FK506-binding protein localizations in human penile innervationGwen Lagoda
Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
BJU Int 101:604-9. 2008.... - Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapismHunter C Champion
Department of Cardiology, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 102:1661-6. 2005..Coupled with the observation that sickle cell disease mice (which show a priapism phenotype) evince dysregulated PDE5A expression/activity, these data suggest that PDE5A dysregulation is a fundamental mechanism for priapism... - Increased expression of nestin in the major pelvic ganglion following cavernous nerve injuryO Kutlu
The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Int J Impot Res 24:84-90. 2012..In conclusion, CNI induces nestin in the MPG. These data suggest that nestin may be involved in the regenerative process of the cavernous nerve following crush injury... - eNOS-uncoupling in age-related erectile dysfunctionJ M Johnson
Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
Int J Impot Res 23:43-8. 2011..These findings suggest that aging induces eNOS uncoupling in the penis, resulting in increased oxidative stress and ED... - Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthaseA L Burnett
Department of Urology, Johns Hopkins Hospital, Baltimore, Maryland, USA
Mol Med 2:288-96. 1996..To clarify the source of NO in penile function, we have examined mice with targeted deletion of the nNOS gene (nNOS- mice)... - Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginaseTrinity J Bivalacqua
Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
Am J Physiol Heart Circ Physiol 292:H1340-51. 2007..Inhibition of the arginase pathway improves endothelial function in the aging penile circulation, suggesting that the arginase pathway may be exploited to improve erectile dysfunction associated with aging... - Serum biomarker measurements of endothelial function and oxidative stress after daily dosing of sildenafil in type 2 diabetic men with erectile dysfunctionArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Urol 181:245-51. 2009..We investigated changes in serum biomarkers of vascular function after short-term, continuous sildenafil dosing in men with type 2 diabetes with erectile dysfunction... - Neuroprotection and nerve grafts in the treatment of neurogenic erectile dysfunctionArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287-2411, USA
J Urol 170:S31-4; discussion S34. 2003..Medical and surgical innovations for preserving and reconstituting the functional nerve supply of the penis offer great promise in the management of erectile dysfunction... - FK506 and rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injuryGwen Lagoda
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 2411, USA
J Sex Med 6:1914-23. 2009..Immunophilin ligands function by binding to receptor proteins such as FK506 binding proteins (FKBPs). FKBPs are studied for their roles in neuroprotection... - Protein inhibitor of nitric oxide synthase (NOS) and the N-methyl-D-aspartate receptor are expressed in the rat and mouse penile nerves and colocalize with penile neuronal NOST R Magee
Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
Biol Reprod 68:478-88. 2003..In conclusion, PIN and NMDAR colocalize with PnNOS in penile nerves, but the functional significance of these protein interactions for penile erection remains to be elucidated... - Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanismK K Meldrum
Departments of Urology and Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
Am J Physiol Regul Integr Comp Physiol 281:R359-64. 2001..These data demonstrate that thermal stress protects renal tubular cells from simulated ischemia-induced apoptosis through a PKC-dependent mechanism... - Imaging the cavernous nerves in the rat prostate using optical coherence tomographyNathaniel M Fried
Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Lasers Surg Med 39:36-41. 2007..The rat prostate serves as an excellent model for studying the use of OCT for imaging the CNs, as the rat CN is a large, visible, and distinct bundle allowing for easy identification with OCT in addition to histologic confirmation... - Erythropoietin receptor expression in the human urogenital tract: immunolocalization in the prostate, neurovascular bundle and penisTongyun Liu
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
BJU Int 100:1103-6. 2007.... - Alternatively spliced neuronal nitric oxide synthase mediates penile erectionK Joseph Hurt
Department of Urology, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 103:3440-3. 2006..Thus, alternatively spliced forms of nNOS are major mediators of penile erection and so may be targets for therapeutic intervention... - Stem and endothelial progenitor cells in erection biologyT D Strong
Department of Urology, The Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Int J Impot Res 20:243-54. 2008..In this paper, erection physiology and stem cell biology is reviewed, and the potential application of novel cell-based therapies for the treatment of ED is discussed... - Role of immunophilins in recovery of erectile function after cavernous nerve injurySena F Sezen
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Department of Urology, Baltimore, MD 21287, USA
J Sex Med 6:340-6. 2009..Immunophilin ligands provide potentially new alternatives for the treatment of erectile dysfunction (ED), which occurs after injury of the cavernous nerves (CNs)... - Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoformsLili A Barouch
Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Nature 416:337-9. 2002..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function... - In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: no tachyphylaxis effectBiljana Musicki
Department of Urology and Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Urol 174:1493-6. 2005.... - Time from dosing to sexual intercourse attempts in men taking tadalafil in clinical trialsRidwan Shabsigh
Department of Urology, Columbia University, New York, NY 10032, USA
BJU Int 96:857-63. 2005.... - Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivoTrinity J Bivalacqua
Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 72:1169-73. 2008..To evaluate the effect of the fibrin sealant, Evicel, on the neuroregulatory control of penile erections in an experimental rat model... - Erythropoietin promotes the recovery of erectile function following cavernous nerve injuryMohamad E Allaf
The James Buchanan Brady Urological Institute, Baltimore, Maryland, USA
J Urol 174:2060-4. 2005..We investigated the effects of recombinant human (rh) erythropoietin (EPO) on erectile function recovery in a rat model of cavernous nerve (CN) injury... - Endothelial nitric oxide synthase regulation in female genital tract structuresBiljana Musicki
Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
J Sex Med 6:247-53. 2009..However, the role of endothelial NO synthase (eNOS) and the mechanisms that regulate eNOS in female genital tract structures are largely unknown... - Erection capability is potentiated by long-term sildenafil treatment: role of blood flow-induced endothelial nitric-oxide synthase phosphorylationBiljana Musicki
Department of Urology, Johns Hopkins Hospital, Marburg 405, 600 North Wolfe St, Baltimore, MD 21287, USA
Mol Pharmacol 68:226-32. 2005.... - Post-translational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vaginaBiljana Musicki
Department of Urology, The Johns Hopkins University, Baltimore, MD 21287, USA
J Sex Med 7:1768-77. 2010..Although vascular effects of estrogens are attributed to an increase in endothelial NO production, the mechanisms of endothelial NO synthase (eNOS) regulation by estrogens in the vagina are largely unknown... - RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insightsLiming Jin
Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
Clin Sci (Lond) 110:153-65. 2006..Understanding the RhoA/Rho-kinase signalling pathway in the regulation of erection is important for the development of therapeutic interventions for erectile dysfunction... - Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidaseBiljana Musicki
Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
J Sex Med 7:3023-32. 2010.... - Penile rehabilitation and neuromodulationFernando Facio
Department of Urology, The Johns Hopkins Hospital, Baltimore, MD, USA
ScientificWorldJournal 9:652-64. 2009.... - The effect of 5 alpha-reductase inhibitors on erectile functionOnder Canguven
The Johns Hopkins Hospital, The James Buchanan Brady Urological Institute, Department of Urology, Marburg 414, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Androl 29:514-23. 2008..We conclude that 5 alpha-reductase inhibitors do not lead to erectile dysfunction to a significant degree, and we support the position that dihydrotestosterone is less relevant than testosterone in erectile function... - Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell miceTrinity J Bivalacqua
James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Urology 76:510.e7-12. 2010..Therefore, the objective of the present study was to evaluate the molecular changes in RhoA and ROCK in an established transgenic sickle cell mouse model of priapism... - Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunctionBiljana Musicki
Department of Urology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 102:11870-5. 2005..In vivo penile erection paradigm supports the physiologic relevance of O-GlcNAc modification in vascular disorders associated with diabetes... - Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunctionTrinity J Bivalacqua
Department of Urology, The Johns Hopkins Medical Institution, The James Buchanan Brady Urological Institute, Baltimore, Maryland 21287, USA
J Urol 181:899-906. 2009.... - Phosphorylated endothelial nitric oxide synthase mediates vascular endothelial growth factor-induced penile erectionBiljana Musicki
Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Biol Reprod 70:282-9. 2004..The data provide a molecular explanation for VEGF stimulatory effect on penile erection, which involves phosphorylated eNOS (Serine 1177) mediation... - Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penisBiljana Musicki
Johns Hopkins Hospital, Brady Urological Institute, Baltimore, MD 21287, USA
J Sex Med 2:347-55; discussion 355-7. 2005.... - Erectile dysfunction management for the futureArthur L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2411, USA
J Androl 30:391-6. 2009..The purpose of this review is to present the foundations for future therapies in ED management... - Low-fat diet and exercise preserve eNOS regulation and endothelial function in the penis of early atherosclerotic pigs: a molecular analysisBiljana Musicki
Johns Hopkins Hospital Urology, Baltimore, MD 21287, USA
J Sex Med 5:552-61. 2008..Diet and exercise affect endothelial function in the penis, but the molecular mechanisms underlying their effects are not understood... - Endothelial dysfunction in diabetic erectile dysfunctionB Musicki
Department of Urology, Johns Hopkins University, SOM, Baltimore, MD 21287, USA
Int J Impot Res 19:129-38. 2007..Considering recent advances in the field of vascular biology and diabetes, the emphasis in this review is placed on the mechanisms of hyperglycemia-induced endothelial dysfunction in the pathophysiology of diabetes-associated ED... - FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injuryS F Sezen
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
Int J Impot Res 14:506-12. 2002..Whether FK506 affords neuroprotection that preserves penile erection through FKBP 12 upregulation is unclear... - Corporoplasty using pericardium allograft (tutoplast) with complex penile prosthesis surgeryM A Palese
Department of Surgery, Division of Urology, University of Maryland Medical System, Baltimore, Maryland, USA
Urology 58:1049-52. 2001..We offer a new role for Tutoplast processed pericardial allograft for complex corporoplasty during penile prosthesis surgery... - Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic ratA G Akingba
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-2411, USA
Mol Urol 5:189-97. 2001..These eNOS effects apparently preceded nNOS effects. Full elucidation of the possible mechanisms affecting eNOS function in the diabetic rat penis requires further investigation... - General use of animal models for investigation of the physiology of erectionA L Burnett
Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and The Johns Hopkins University School of Medicine, Baltimore, MD 21287-2411, USA
Int J Impot Res 13:135-9. 2001..The promise of advancing therapies in this field indicates the additional prominent role for animals for the purposes of drug development... - Avanafil for the treatment of erectile dysfunctionR Segal
Department of Urology, The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Drugs Today (Barc) 48:7-15. 2012..It was recently approved and launched in Korea, and is currently under review by the U.S. Food and Drug Administration. Its efficacy and purported role in the treatment for erectile dysfunction are reviewed here... - Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablationPhillip M Pierorazio
James Buchanan Brady Urological Institute, Johns Hopkins Hospital, 600 N Wolfe Ave, Marburg 407, Baltimore, MD 21287, USA
J Androl 32:371-4. 2011..Our treatment of recurrent priapism implicates androgens and both biochemical and neurovascular control mechanisms in the penis... - Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference)John B Kostis
University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Am J Cardiol 96:313-21. 2005..Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended... - Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscleLan Zhou
Department of Medicine, Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, USA
Biochem Biophys Res Commun 294:1030-5. 2002.... - The efficacy of sildenafil citrate (Viagra) in clinical populations: an updateCulley C Carson
Department of Surgery, Division of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7235, USA
Urology 60:12-27. 2002..Findings from published accounts of sildenafil use in the clinical practice setting further demonstrated that sildenafil is an effective treatment for a wide range of patients with ED... - A consumer's guide to impotence drugsArthur L Burnett
Johns Hopkins Med Lett Health After 50 17:6. 2004
Research Grants
- NITRIC OXIDE REGULATORY SYSTEM IN THE PENISArthur Burnett; Fiscal Year: 2002....