JEFF BULTE

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging
    Jeff W M Bulte
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 386:275-99. 2004
  2. ncbi request reprint Intracellular endosomal magnetic labeling of cells
    Jeff W M Bulte
    MR Research Division, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Med 124:419-39. 2006
  3. doi request reprint Science to practice: can macrophage infiltration serve as a surrogate marker for stem cell viability?
    Jeff W M Bulte
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor, Baltimore, MD 21205, USA
    Radiology 264:619-20. 2012
  4. ncbi request reprint Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells
    J W Bulte
    Laboratory of Diagnostic Radiology Research CC, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Biotechnol 19:1141-7. 2001
  5. ncbi request reprint MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Magn Reson Med 50:201-5. 2003
  6. doi request reprint Science to practice: can CT be performed for multicolor molecular imaging?
    Jeff W M Bulte
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Radiology 256:675-6. 2010
  7. pmc In vivo MRI cell tracking: clinical studies
    Jeff W M Bulte
    Russell H Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AJR Am J Roentgenol 193:314-25. 2009
  8. ncbi request reprint Monitoring cell therapy using iron oxide MR contrast agents
    Jeff W M Bulte
    Department of Radiology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Pharm Biotechnol 5:567-84. 2004
  9. ncbi request reprint In vivo magnetic resonance tracking of magnetically labeled cells after transplantation
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Cereb Blood Flow Metab 22:899-907. 2002
  10. ncbi request reprint Feridex-labeled mesenchymal stem cells: cellular differentiation and MR assessment in a canine myocardial infarction model
    Jeff W M Bulte
    Dept of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Acad Radiol 12:S2-6. 2005

Detail Information

Publications78

  1. ncbi request reprint Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging
    Jeff W M Bulte
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 386:275-99. 2004
  2. ncbi request reprint Intracellular endosomal magnetic labeling of cells
    Jeff W M Bulte
    MR Research Division, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Med 124:419-39. 2006
    ..With the currently available magnetic labeling methods, it is anticipated that cellular MRI will find broad applications in biology and medicine...
  3. doi request reprint Science to practice: can macrophage infiltration serve as a surrogate marker for stem cell viability?
    Jeff W M Bulte
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor, Baltimore, MD 21205, USA
    Radiology 264:619-20. 2012
    ....
  4. ncbi request reprint Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells
    J W Bulte
    Laboratory of Diagnostic Radiology Research CC, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Biotechnol 19:1141-7. 2001
    ..The availability of magnetodendrimers opens up the possibility of MR tracking of a wide variety of (stem) cell transplants...
  5. ncbi request reprint MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Magn Reson Med 50:201-5. 2003
    ..The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols...
  6. doi request reprint Science to practice: can CT be performed for multicolor molecular imaging?
    Jeff W M Bulte
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Radiology 256:675-6. 2010
    ....
  7. pmc In vivo MRI cell tracking: clinical studies
    Jeff W M Bulte
    Russell H Morgan Department of Radiology, Division of MR Research, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AJR Am J Roentgenol 193:314-25. 2009
    ..The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed...
  8. ncbi request reprint Monitoring cell therapy using iron oxide MR contrast agents
    Jeff W M Bulte
    Department of Radiology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Pharm Biotechnol 5:567-84. 2004
    ..With its excellent spatial resolution and the ability to track labeled cells over prolonged periods of time, MR monitoring of cell therapy is likely to become an important technique in the foreseeable future...
  9. ncbi request reprint In vivo magnetic resonance tracking of magnetically labeled cells after transplantation
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    J Cereb Blood Flow Metab 22:899-907. 2002
    ..Now that MR tracking of magnetically labeled cells appears feasible, it is anticipated that this technique may ultimately become an important tool for monitoring the efficacy of clinical (stem) cell transplantation protocols...
  10. ncbi request reprint Feridex-labeled mesenchymal stem cells: cellular differentiation and MR assessment in a canine myocardial infarction model
    Jeff W M Bulte
    Dept of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Acad Radiol 12:S2-6. 2005
  11. doi request reprint Science to practice: can theranostic fullerenes be used to treat brain tumors?
    Jeff W M Bulte
    Department of Radiology The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Radiology 261:1-2. 2011
    ....
  12. ncbi request reprint Iron oxide MR contrast agents for molecular and cellular imaging
    Jeff W M Bulte
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 17:484-99. 2004
    ....
  13. doi request reprint Optimization of magnetosonoporation for stem cell labeling
    Daohai Xie
    Image Guided Bio Molecular Interventions Section, Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    NMR Biomed 23:480-4. 2010
    ....
  14. ncbi request reprint Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis
    Lisa Kostura
    Osiris Therapeutics Inc, Baltimore, MD, USA
    NMR Biomed 17:513-7. 2004
    ..On the other hand, no detrimental effects of Feridex-labeling are anticipated for MR-guided osteogenic or adipogenic transplantation studies...
  15. ncbi request reprint Monitoring stem cell therapy in vivo using magnetodendrimers as a new class of cellular MR contrast agents
    Jeff W M Bulte
    Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA
    Acad Radiol 9:S332-5. 2002
  16. ncbi request reprint MR evaluation of the glomerular homing of magnetically labeled mesenchymal stem cells in a rat model of nephropathy
    Olivier Hauger
    Department of Radiology and Radiological Sciences, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Radiology 238:200-10. 2006
    ..To assess renal glomerular homing of intravenously injected superparamagnetic iron oxide (SPIO)-labeled mesenchymal stem cells (MSCs) at in vivo and ex vivo magnetic resonance (MR) imaging in an experimental rat model of mesangiolysis...
  17. ncbi request reprint In vivo MR imaging of bone marrow cells trafficking to atherosclerotic plaques
    Bensheng Qiu
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Magn Reson Imaging 26:339-43. 2007
    ..To develop a magnetic resonance imaging (MRI)-based method to monitor in vivo trafficking of bone marrow (BM) cells to atherosclerotic lesions...
  18. ncbi request reprint Magnetic intracellular labeling of mammalian cells by combining (FDA-approved) superparamagnetic iron oxide MR contrast agents and commonly used transfection agents
    Joseph A Frank
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892 1074, USA
    Acad Radiol 9:S484-7. 2002
  19. ncbi request reprint Intracytoplasmic tagging of cells with ferumoxides and transfection agent for cellular magnetic resonance imaging after cell transplantation: methods and techniques
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892, USA
    Transplantation 76:1123-30. 2003
    ..The purpose of this study is to present protocols using SPIO and a polycationic transfection agent for magnetic labeling of cells as a basis for cellular MRI...
  20. ncbi request reprint Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents
    Joseph A Frank
    Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bldg 10, Rm B1N256, 10 Center Dr, MSC 1074, Bethesda, MD 20892 1074, USA
    Radiology 228:480-7. 2003
    ..To label mammalian and stem cells by combining commercially available transfection agents (TAs) with superparamagnetic iron oxide (SPIO) magnetic resonance (MR) imaging contrast agents...
  21. pmc New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI
    Michael T McMahon
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Magn Reson Med 60:803-12. 2008
    ....
  22. ncbi request reprint Magnetoelectroporation: improved labeling of neural stem cells and leukocytes for cellular magnetic resonance imaging using a single FDA-approved agent
    Piotr Walczak
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nanomedicine 2:89-94. 2006
    ..Because magnetoelectroporation allows the use of ferumoxides approved by the US Food and Drug Administration without additional agents, it has excellent potential for clinical translation...
  23. ncbi request reprint Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON)
    Matthias Stuber
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 58:1072-7. 2007
    ..The first successful use of IRON to produce positive contrast in areas of metallic spheres and SPIO-labeled stem cells in vitro and in vivo is presented...
  24. pmc MRI reporter genes
    Assaf A Gilad
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Nucl Med 49:1905-8. 2008
    ..MRI reporter genes have the advantage that the specific signal can be coregistered with soft-tissue anatomy and functional tissue information and have, therefore, become an active and growing area of scientific interest...
  25. pmc Noninvasive MRI of endothelial cell response to human breast cancer cells
    Barjor Gimi
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Program, Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 8:207-13. 2006
    ....
  26. pmc Imaging of stem cells using MRI
    Dara L Kraitchman
    Russell H Morgan Dept of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Basic Res Cardiol 103:105-13. 2008
    ..Several of these approaches have now been applied successfully in preclinical animal models of cardiovascular disease. Once properly implemented, future clinical trials may benefit greatly from imaging stem cells with MRI...
  27. pmc Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes
    Jason M Zhao
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Am Chem Soc 130:5178-84. 2008
    ..These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties...
  28. pmc Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles
    Assaf A Gilad
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Neurosection, Baltimore, Maryland 21231, USA
    Magn Reson Med 61:970-4. 2009
    ..These initial findings are a first step toward using dual CEST/T2 contrast imaging for studying multiple cellular or molecular targets simultaneously in vivo...
  29. pmc In vivo tracking of cellular therapeutics using magnetic resonance imaging
    Christoper M Long
    The Johns Hopkins University, School of Medicine, Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Baltimore, USA
    Expert Opin Biol Ther 9:293-306. 2009
    ..In vivo magnetic resonance (MR) cell tracking provides a means to non-invasively and longitudinally evaluate these parameters for cellular therapy...
  30. pmc Magnetovaccination as a novel method to assess and quantify dendritic cell tumor antigen capture and delivery to lymph nodes
    Christopher M Long
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 69:3180-7. 2009
    ..This study shows the potential of magnetovaccination and MRI cell tracking to systematically evaluate a key parameter relevant to the optimization of vaccine therapies through noninvasive MRI-based quantification of APC numbers...
  31. doi request reprint CEST MRI reporter genes
    Guanshu Liu
    Kennedy Krieger Institute, F M Kirby Research Center for Functional Brain Imaging, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 711:271-80. 2011
    ..Here, we provide a brief summary of recent advances in MRI reporter gene technology, as well as detailed "hands-on" protocols for cloning, expression, and imaging of reporter genes based on chemical exchange saturation transfer (CEST)...
  32. pmc Human glial-restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination
    Piotr Walczak
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Glia 59:499-510. 2011
    ..The latter benefit is likely dependent on trophic support and suggests further exploration of potential of glial progenitors in animal models of chronic inflammatory demyelination...
  33. ncbi request reprint In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
    Dara L Kraitchman
    Johns Hopkins University, School of Medicine, Department of Radiology, 601 N Caroline St, Suite 4231, Baltimore, MD 21287 0845, USA
    Circulation 107:2290-3. 2003
    ..We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model...
  34. pmc MR imaging of transplanted stem cells in myocardial infarction
    Dara L Kraitchman
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 680:141-52. 2011
    ..In this chapter, we will describe several labeling strategies that can be used to label cells with SPIO nanoparticles. This is followed by a discussion of current strategies for using MRI to visualize these cells in myocardial infarct...
  35. ncbi request reprint Magnetically labeled glial cells as cellular MR contrast agents
    Jeff W M Bulte
    Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA
    Acad Radiol 9:S148-50. 2002
  36. pmc Evoked potential and behavioral outcomes for experimental autoimmune encephalomyelitis in Lewis rats
    Angelo H All
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurol Sci 31:595-601. 2010
    ..The results suggest that the SEP measures are more sensitive and reliable markers of focal spinal cord demyelination compared to the behavioral measures like the BBB score...
  37. ncbi request reprint Magnetic resonance imaging of cell surface receptors using targeted contrast agents
    Dmitri Artemov
    Johns Hopkins University School of Medicine, JHU ICMIC Program, Department of Radiology, Traylor 217, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Curr Pharm Biotechnol 5:485-94. 2004
    ..In this article we have reviewed current MRI strategies used to visualize receptor expression, the potential advantages and drawbacks of these strategies, and novel areas of focus for the future...
  38. pmc Effect of MOG sensitization on somatosensory evoked potential in Lewis rats
    Angelo H All
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, United States
    J Neurol Sci 284:81-9. 2009
    ....
  39. pmc In vivo imaging of stem cells and Beta cells using direct cell labeling and reporter gene methods
    Dara L Kraitchman
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 29:1025-30. 2009
    ..In this review article, we will explore some of the state-of-the art methods for stem, progenitor, and beta cell tracking...
  40. pmc Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction
    Dara L Kraitchman
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 112:1451-61. 2005
    ..However, the histological interpretation of postmortem tissue, on which many of these studies are based, has recently been widely debated...
  41. doi request reprint Magnetosonoporation: instant magnetic labeling of stem cells
    Bensheng Qiu
    Image Guided Bio Molecular Interventions Section, Department of Radiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Magn Reson Med 63:1437-41. 2010
    ..The magnetosonoporation technique is expected to be convenient, efficient, and safe for future clinical application of MRI-guided cell therapies...
  42. pmc Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia
    Piotr Walczak
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 217 Traylor, 720 Rutland Ave, Baltimore, MD 21205 2195, USA
    Stroke 39:1569-74. 2008
    ..We assessed the suitability of laser Doppler flow (LDF) signal measurements and magnetic resonance (MR) imaging for noninvasive dual monitoring of targeted IA cell delivery...
  43. ncbi request reprint Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells
    Brad P Barnett
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutes, Blalock 644, 600 North Wolfe Street, Baltimore, Maryland 21212, USA
    Nat Med 13:986-91. 2007
    ..These findings are directly applicable to ongoing improvements in islet cell transplantation for human diabetes, particularly because our magnetocapsules comprise clinically applicable materials...
  44. pmc MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles
    Assaf A Gilad
    Russell H Morgan Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Magn Reson Med 60:1-7. 2008
    ..Simultaneous imaging of both transplants with opposite contrast offers a method for MR "double labeling" of different cell populations...
  45. ncbi request reprint Serial in vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice
    Tamir Ben-Hur
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 57:164-71. 2007
    ..The results are directly relevant for designing and optimizing cell therapies for MS, and achieving a better understanding of in vivo cell dynamics and cell-tissue interactions...
  46. pmc In vivo "hot spot" MR imaging of neural stem cells using fluorinated nanoparticles
    Jesus Ruiz-Cabello
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 60:1506-11. 2008
    ....
  47. pmc Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles
    Dorota A Kedziorek
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 63:1031-43. 2010
    ..These results demonstrate that, although early reactions responsible for iron homeostasis are induced, overall neural stem cell gene expression remains largely unaltered following superparamagnetic iron oxide/PLL labeling...
  48. ncbi request reprint Stem cell profiling by nuclear magnetic resonance spectroscopy
    Jacobus F A Jansen
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, and Department of Radiology, Maastricht University Hospital, The Netherlands
    Magn Reson Med 56:666-70. 2006
    ..The results suggest that NMR spectroscopy in vitro can provide markers to study the effects of differentiation on cell metabolism, and potentially to assess stem cell preparations for differentiation status...
  49. ncbi request reprint Artificial reporter gene providing MRI contrast based on proton exchange
    Assaf A Gilad
    The Russell H Morgan Department of Radiology and Radiological Science, Neurosection, Division of MR Research, Traylor Building Rm 217, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Nat Biotechnol 25:217-9. 2007
    ..This endogenous contrast, based on transfer of radiofrequency labeling from the reporter's amide protons to water protons, can be switched on and off...
  50. ncbi request reprint The role of noninvasive cellular imaging in developing cell-based therapies for neurodegenerative disorders
    Piotr Walczak
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University, Baltimore, MD 21205 2195, USA
    Neurodegener Dis 4:306-13. 2007
    ..In this review, we highlight the current challenges in the field of cell-based therapy for neurodegenerative disorders and outline the role and capabilities of different cellular imaging techniques in addressing those issues...
  51. ncbi request reprint Sensitive CEST agents based on nucleic acid imino proton exchange: detection of poly(rU) and of a dendrimer-poly(rU) model for nucleic acid delivery and pharmacology
    Karim Snoussi
    Johns Hopkins University School of Medicine, Department of Radiology, Baltimore, Maryland 21205, USA
    Magn Reson Med 49:998-1005. 2003
    ..The net charge of the complex was positive, suggesting that the complexed dendrimers would still interact with cell membranes, and that the RNA-dendrimer complex could provide a model for a gene delivery system with good CEST visibility...
  52. pmc Direct saturation MRI: theory and application to imaging brain iron
    Seth A Smith
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Med 62:384-93. 2009
    ..The results show that, contrary to commonly used T(2)*-weighted and absolute R(2) images, the DSR images visualize all GM structures, including cortex. A direct correlation between DSR and iron content was confirmed for these structures...
  53. ncbi request reprint MRI of intravenously injected bone marrow cells homing to the site of injured arteries
    Fabao Gao
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 20:673-81. 2007
    ..01). This study provides initial evidence that may support the potential use of MRI to detect homing of intravenously injected BM cells to injured arteries...
  54. ncbi request reprint Pharmacokinetics of a high-generation dendrimer-Gd-DOTA
    L Henry Bryant
    Laboratory of Diagnostic Radiology Research, Warren Grant Maguson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1074, USA
    Acad Radiol 9:S29-33. 2002
  55. pmc Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly
    Michael T McMahon
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    Magn Reson Med 55:836-47. 2006
    ..9 Hz, ka = 1.21 Hz, kb = 1.92 x 10(9) Hz, and k0 = 106.4 Hz, ka = 25.8 Hz, kb = 5.45 x 10(8) Hz for PLL and SPD-5, respectively, showing the expected predominance of base-catalyzed exchange for these amide protons...
  56. ncbi request reprint Magnetic resonance microscopy of mouse brain development
    Susumu Mori
    Russell H Morgan Department of Radiology and Radiological Science, Kennedy Krieger Institute, Baltimore, MD, USA
    Methods Mol Med 124:129-47. 2006
    ..In this article, the future potential of magnetic resonance (MR) microimaging is discussed, with special emphasis on diffusion tensor microimaging as an effective contrast mechanism for the developing central nervous system...
  57. ncbi request reprint Developing MR reporter genes: promises and pitfalls
    Assaf A Gilad
    Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    NMR Biomed 20:275-90. 2007
    ..Although progress in the use of MR reporter genes has been slow, newer strategies that use metalloproteins or alternative contrast mechanisms, with no need for substrates, promise rapid growth potential for this field...
  58. ncbi request reprint Microscopic R2* mapping of reduced brain iron in the Belgrade rat
    Holly A Zywicke
    Laboratory of Diagnostic Radiology Research, Clinical Center, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 52:102-5. 2002
    ..Therefore, for the clinical monitoring of movement disorders for which normal brain iron homeostasis (either overload or reduction) may be implicated, R2* mapping appears to be well-suited...
  59. ncbi request reprint In vivo magnetic resonance tracking of olfactory ensheathing glia grafted into the rat spinal cord
    I Hui Lee
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Neurol 187:509-16. 2004
    ....
  60. ncbi request reprint Sensitivity of magnetic resonance imaging of dendritic cells for in vivo tracking of cellular cancer vaccines
    Pauline Verdijk
    Department of Tumorimmunology, Nijmegen Centre for Molecular Life Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 120:978-84. 2007
    ....
  61. ncbi request reprint Dy-DTPA derivatives as relaxation agents for very high field MRI: the beneficial effect of slow water exchange on the transverse relaxivities
    Luce Vander Elst
    Department of Organic Chemistry, NMR Laboratory, University of Mons Hainaut, Belgium
    Magn Reson Med 47:1121-30. 2002
    ..This was demonstrated by the spin-echo images of phantoms obtained at 4.7 T on samples containing Dy(DTPA)(2-) and Dy(DTPA-BEA)...
  62. ncbi request reprint In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver
    Clemens Bos
    Laboratoire d Imagerie Moléculaire et Fonctionnelle, Equipes de Recherche Technologique, Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, Case 117, 33076 Bordeaux, France
    Radiology 233:781-9. 2004
    ..To evaluate in vivo magnetic resonance (MR) imaging with a conventional 1.5-T system for depiction and tracking of intravascularly injected superparamagnetic iron oxide (SPIO)-labeled mesenchymal stem cells (MSCs)...
  63. ncbi request reprint Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides
    Jeff W M Bulte
    Blood 104:3410-2; author reply 3412-3. 2004
  64. ncbi request reprint Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells seeded on collagen scaffolds-relevance to tissue engineering
    John V Terrovitis
    Heart Science Centre, Harefield Hospital, Imperial College, London, United Kingdom
    Tissue Eng 12:2765-75. 2006
    ..Ferumoxide labeling of human MSCs seeded on collagen scaffolds is an effective, non-toxic technique for visualization of these cells using MRI. This technique appears promising for cell tracking in future tissue-engineering applications...
  65. ncbi request reprint Hot spot MRI emerges from the background
    Jeff W M Bulte
    Nat Biotechnol 23:945-6. 2005
  66. ncbi request reprint Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
  67. ncbi request reprint Dual-modality in vivo monitoring of subventricular zone stem cell migration and metabolism
    Francesca Cicchetti
    Centre de Recherche en Neurosciences, CHUL, RC 9800, 2705 Boulevard Laurier, Quebec, Canada G1V 4G2
    Contrast Media Mol Imaging 2:130-8. 2007
    ..Thus, combining MRI and PET enables monitoring of cell migration and metabolism non-invasively in vivo for extended periods of time...
  68. ncbi request reprint Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t
    Takayasu Arai
    Division of Cardiovascular Medicine, Stanford University, California 94305 5233, USA
    Magn Reson Med 55:203-9. 2006
    ..Thus, in vivo MRI enables simultaneous detection of transplanted mESC and their therapeutic effect on the injured myocardium...
  69. ncbi request reprint Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain
    Deborah J Watson
    W F Goodman Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Hum Gene Ther 17:693-704. 2006
    ..These variations in pattern of engraftment should be taken into account when designing treatment approaches in nonlesion models of neurologic disease...
  70. doi request reprint Comment on "Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain"
    Jacobus F A Jansen
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 321:640;author reply 640. 2008
    ..A new algorithm was developed to extract the biomarker from noisy in vivo data. We question how this algorithm was validated, because the biomarker overlaps with peaks from nonspecific lipid signals...
  71. ncbi request reprint The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates
    Peter Caravan
    EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
    J Am Chem Soc 124:3152-62. 2002
    ..0 x 10(8) s(-1) bound vs 1.1 x 10(9) s(-1) free) and an increase in the inner-sphere water residency time (tau(m) = 170 +/- 40 ns bound vs 69 +/- 20 ns free)...
  72. ncbi request reprint Improved molecular imaging contrast agent for detection of human thrombus
    Patrick M Winter
    Cardiovascular MR Laboratories, Department of Medicine, Cardiovascular Division, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 50:411-6. 2003
    ..45 +/- 0.02 1/s). These studies demonstrate marked improvement in a fibrin-specific molecular imaging agent that might allow sensitive, early detection of vascular microthrombi, the antecedent to stroke and heart attack...
  73. ncbi request reprint Noninvasive monitoring of stem cell transfer for muscle disorders
    Glenn A Walter
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610, USA
    Magn Reson Med 51:273-7. 2004
    ..We concluded that this technique may be useful for continuous noninvasive readouts of stem cell transfer, replacing sequential muscle biopsies and tissue harvesting...
  74. pmc Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging
    Grigorios Korosoglou
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Am Coll Cardiol 52:483-91. 2008
    ....
  75. ncbi request reprint Brain engraftment and therapeutic potential of stem/progenitor cells derived from mouse skin
    Patrizia Tunici
    Unit of Experimental Neuro Oncology, Istituto Nazionale Neurologico C Besta, Milan, Italy
    J Gene Med 8:506-13. 2006
    ..Thus, prolonged survival, capacity for transgene expression, and lack of uncontrolled proliferation suggest that SKPs warrant further consideration as therapeutic tools for brain tumors and, possibly, other neurological disorders...
  76. ncbi request reprint Paramagnetic viral nanoparticles as potential high-relaxivity magnetic resonance contrast agents
    Mark Allen
    Center for BioInspired Nanomaterials, Montana State University, Bozeman, 59717, USA
    Magn Reson Med 54:807-12. 2005
    ..These preliminary results should encourage further investigations into the use of viral protein cages as a new platform for MR contrast agents...
  77. ncbi request reprint Stem cell therapy for myelin diseases
    Tamir Ben-Hur
    Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Curr Drug Targets 6:3-19. 2005
    ....

Research Grants17

  1. Developing a CEST Reporter Gene (RMI)
    JEFF BULTE; Fiscal Year: 2007
    ..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. ..
  2. MR and BL Tracking of Stem/Progenitor Cells in the CNS
    Jeff W Bulte; Fiscal Year: 2010
    ..The ultimate goal is to develop ways of reporting on successful cell transplantation without removing any tissue, and to provide neurologists with a means to evaluate stem cell treatment in their patients. ..
  3. Developing MPI for Non-Invasive and Quantitative Imaging of Stem Cells
    JEFF BULTE; Fiscal Year: 2009
    ..If this new technique is developed successfully, it will help us to understand much better where the cells exactly go into the brain and elsewhere in the body, which will facilitate introducing these stem cells into patients. ..
  4. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2007
    ..As the MCs are composed of clinical grade and FDA-approved materials, this MR-guided approach will be readily translatable to human diabetic clinical trials for further improvements of islet cell transplantation. ..
  5. MR Tracking of Magnetically Labeled Stem Cells in CNS
    JEFF BULTE; Fiscal Year: 2007
    ..abstract_text> ..
  6. ASN Workshop "In Vivo MR Tracking of Stem Cells in the CNS" (R13)
    JEFF BULTE; Fiscal Year: 2005
    ..The outcome of the workshop will be published in Experimental Neurology and available for the scientific community at large. ..
  7. MR Tracking of Magnetically Labeled Stem Cells in CNS
    JEFF BULTE; Fiscal Year: 2006
    ..abstract_text> ..
  8. MR Tracking of Magnetically Labeled Stem Cells in CNS
    JEFF BULTE; Fiscal Year: 2003
    ..abstract_text> ..
  9. Developing MPI for Non-Invasive and Quantitative Imaging of Stem Cells
    Jeff W Bulte; Fiscal Year: 2010
    ..If this new technique is developed successfully, it will help us to understand much better where the cells exactly go into the brain and elsewhere in the body, which will facilitate introducing these stem cells into patients. ..