Todd Brown

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Approach to the human immunodeficiency virus-infected patient with lipodystrophy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 93:2937-45. 2008
  2. doi request reprint Association between initiation of antiretroviral therapy with efavirenz and decreases in 25-hydroxyvitamin D
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, MD, USA
    Antivir Ther 15:425-9. 2010
  3. pmc Body composition, soluble markers of inflammation, and bone mineral density in antiretroviral therapy-naive HIV-1-infected individuals
    Todd T Brown
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 63:323-30. 2013
  4. doi request reprint Hormonal response to a mixed-meal challenge after reversal of gastric bypass for hypoglycemia
    Clare J Lee
    Division of Endocrinology and Metabolism, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 98:E1208-12. 2013
  5. pmc Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir
    Adriana S A Andrade
    Division of Infectious Diseases, The Johns Hopkins University, Baltimore, MD 21287, USA
    BMC Complement Altern Med 8:50. 2008
  6. pmc Anthropometry in the prediction of sleep disordered breathing in HIV-positive and HIV-negative men
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Antivir Ther 15:651-9. 2010
  7. ncbi request reprint Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 21:1731-8. 2007
  8. pmc Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA
    Diabetes Care 33:2244-9. 2010
  9. pmc Hepatic steatosis associated with increased central body fat by dual-energy X-ray absorptiometry and uncontrolled HIV in HIV/hepatitis C co-infected persons
    Todd T Brown
    Johns Hopkins School of Medicine, USA
    AIDS 24:811-7. 2010
  10. ncbi request reprint Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review
    Todd T Brown
    Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 20:2165-74. 2006

Research Grants

Detail Information

Publications35

  1. pmc Approach to the human immunodeficiency virus-infected patient with lipodystrophy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 93:2937-45. 2008
    ..The contribution of body fat changes and metabolic abnormalities to cardiovascular risk and the changing risk profiles of newer antiretroviral regimens are under intense investigation...
  2. doi request reprint Association between initiation of antiretroviral therapy with efavirenz and decreases in 25-hydroxyvitamin D
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, MD, USA
    Antivir Ther 15:425-9. 2010
    ..We aimed to determine whether antiretroviral therapy (ART) initiation with efavirenz (EFV) is associated with decreases in 25-hydroxyvitamin D (25[OH]D) compared with non-EFV regimens...
  3. pmc Body composition, soluble markers of inflammation, and bone mineral density in antiretroviral therapy-naive HIV-1-infected individuals
    Todd T Brown
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 63:323-30. 2013
    ..To determine the association among bone mineral density (BMD), inflammatory markers, and alterations in fat and lean mass in untreated HIV-infected individuals...
  4. doi request reprint Hormonal response to a mixed-meal challenge after reversal of gastric bypass for hypoglycemia
    Clare J Lee
    Division of Endocrinology and Metabolism, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 98:E1208-12. 2013
    ..Severe hypoglycemia is a rare and challenging complication of Roux-en-Y gastric bypass (RYGB), which is characterized by hypersecretion of insulin and incretin hormones in the postprandial state...
  5. pmc Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir
    Adriana S A Andrade
    Division of Infectious Diseases, The Johns Hopkins University, Baltimore, MD 21287, USA
    BMC Complement Altern Med 8:50. 2008
    ..We evaluated potential pharmacokinetic interactions between IDV and AG, and assessed whether AG improves IDV-induced insulin resistance...
  6. pmc Anthropometry in the prediction of sleep disordered breathing in HIV-positive and HIV-negative men
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Antivir Ther 15:651-9. 2010
    ....
  7. ncbi request reprint Longitudinal increases in waist circumference are associated with HIV-serostatus, independent of antiretroviral therapy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 21:1731-8. 2007
    ..The relative contributions of the different classes of antiretroviral therapy (ART), HIV infection per se, and aging to body shape changes in HIV-infected patients have not been clearly defined in longitudinal studies...
  8. pmc Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA
    Diabetes Care 33:2244-9. 2010
    ..To determine whether systemic inflammation after initiation of HIV-antiretroviral therapy (ART) is associated with the development of diabetes...
  9. pmc Hepatic steatosis associated with increased central body fat by dual-energy X-ray absorptiometry and uncontrolled HIV in HIV/hepatitis C co-infected persons
    Todd T Brown
    Johns Hopkins School of Medicine, USA
    AIDS 24:811-7. 2010
    ..To evaluate the relationship between regional body composition and liver disease (fibrosis or steatosis) in HIV/HCV co-infected individuals...
  10. ncbi request reprint Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review
    Todd T Brown
    Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    AIDS 20:2165-74. 2006
    ..Prevalence estimates of osteopenia and osteoporosis (reduced bone mineral density; BMD) in HIV-infected patients and the role of antiretroviral therapy (ART) varies in the literature...
  11. ncbi request reprint Longitudinal anthropometric changes in HIV-infected and HIV-uninfected men
    Todd Brown
    Johns Hopkins University, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 43:356-62. 2006
    ....
  12. doi request reprint The effects of HIV-1 infection on endocrine organs
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, MD 21287, United States
    Best Pract Res Clin Endocrinol Metab 25:403-13. 2011
    ....
  13. pmc Management of the metabolic effects of HIV and HIV drugs
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA
    Nat Rev Endocrinol 8:11-21. 2012
    ....
  14. ncbi request reprint Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study
    Todd T Brown
    Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    AIDS 19:1375-83. 2005
    ..To estimate insulin resistance and its relationship to antiretroviral therapy (ART) in a cohort of HIV-infected persons with comparison to HIV-seronegative controls...
  15. ncbi request reprint Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study
    Todd T Brown
    Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Arch Intern Med 165:1179-84. 2005
    ..The risk of diabetes mellitus (DM) in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) has not been well defined...
  16. doi request reprint Bone turnover, osteoprotegerin/RANKL and inflammation with antiretroviral initiation: tenofovir versus non-tenofovir regimens
    Todd T Brown
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Antivir Ther 16:1063-72. 2011
    ....
  17. ncbi request reprint Reduced bone mineral density in human immunodeficiency virus-infected patients and its association with increased central adiposity and postload hyperglycemia
    Todd T Brown
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    J Clin Endocrinol Metab 89:1200-6. 2004
    ..Bone resorption is independently associated with female gender and dyslipidemia. HIV-infected patients with metabolic abnormalities may represent a population that would benefit from bone density screening...
  18. pmc Statin therapy and changes in hip circumference among HIV-infected participants in the ALLRT Cohort
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, MD, USA
    Antivir Ther 14:853-8. 2009
    ..We aimed to determine whether statin exposure in antiretroviral-treated individuals is associated with increases in hip circumference compared with HIV treatment without concomitant statin use...
  19. ncbi request reprint Relation of stavudine discontinuation to anthropometric changes among HIV-infected women
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 44:43-8. 2007
    ..To characterize changes in regional anthropometry associated with stavudine exposure and discontinuation...
  20. pmc Effect of highly active antiretroviral therapy on incident AIDS using calendar period as an instrumental variable
    Lauren E Cain
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Epidemiol 169:1124-32. 2009
    ..These methods may help resolve discrepancies between observational and randomized evidence...
  21. ncbi request reprint Body composition, gender, and illicit drug use in an urban cohort
    Joseph Cofrancesco
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Drug Alcohol Abuse 33:467-74. 2007
    ..3 vs.19.9 kg, p = .01) and lower body mass index (21.9 vs. 25.1, p = .01) versus less frequent or nonusers. These data suggest a sex difference in body composition associated with drug use...
  22. ncbi request reprint Opiate drug use: a potential contributor to the endocrine and metabolic complications in human immunodeficiency virus disease
    Odelia B Cooper
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 37:S132-6. 2003
    ..Although much of the evidence should be viewed as preliminary, these potential abnormalities should be kept in mind when treating opiate-dependent patients infected with HIV...
  23. pmc Incidence and risk factors for steatosis progression in adults coinfected with HIV and hepatitis C virus
    Tinsay A Woreta
    The Johns Hopkins Hospital University School of Medicine, Baltimore, Maryland 21287, USA
    Gastroenterology 140:809-17. 2011
    ..We prospectively examined the natural history of steatosis in patients coinfected with HIV and HCV who attended an urban HIV clinic...
  24. ncbi request reprint Metabolic abnormalities in HIV disease and injection drug use
    Adrian Dobs
    The John Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Acquir Immune Defic Syndr 31:S70-7. 2002
    ..The issues covered are current estimations of prevalence, risk factors, underlying pathophysiology, diagnosis, and interventions (prevention and treatment) for metabolic complications of HIV and drug abuse...
  25. ncbi request reprint Management options for facial lipoatrophy
    Joseph Cofrancesco
    Johns Hopkins Lipodystrophy and Metabolic Complications Clinic, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    AIDS Read 14:639-40, 645-50. 2004
    ..Prevention and early recognition of lipoatrophy and proper selection or early modification of antiretroviral treatment remain the best options...
  26. doi request reprint Loss of bone mineral density after antiretroviral therapy initiation, independent of antiretroviral regimen
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins University, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 51:554-61. 2009
    ..Decreased bone mineral density (BMD) has been described in HIV-infected patients initiating antiretroviral therapy (ART), but the contributions of ART and immunologic and/or virologic factors remain unclear...
  27. ncbi request reprint Fish oil supplementation in the treatment of cachexia in pancreatic cancer patients
    Todd T Brown
    Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, Center for Complementary and Alternative Medicine, Baltimore, MD 21287, USA
    Int J Gastrointest Cancer 34:143-50. 2003
    ..Concerns about standardization and quality control should also be considered. With the current available evidence, a recommendation for the use of omega 3 polyunsaturated fatty acids in pancreatic cancer cachexia is premature...
  28. ncbi request reprint Thyroid function abnormalities in HIV-infected patients
    Christopher J Hoffmann
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Infect Dis 45:488-94. 2007
    ....
  29. ncbi request reprint Cortisol levels and depression in men and women using heroin and cocaine
    Amy B Wisniewski
    Department of Biology, Drake University, 328 Olin Hall, 1344 27th Street, Des Moines, IA 50311 4505, USA
    Psychoneuroendocrinology 31:250-5. 2006
    ....
  30. ncbi request reprint Hypothalamic-pituitary-gonadal function in men and women using heroin and cocaine, stratified by HIV status
    Amy B Wisniewski
    Department of Biology, Drake University, Des Moines, Iowa 50311 4505, USA
    Gend Med 4:35-44. 2007
    ..Most studies of hypothalamic-pituitary-gonadal (HPG) function in illicit drug users either focus on men or do not consider the impact of HIV...
  31. ncbi request reprint Response to Berg et al. 'Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review'
    Todd T Brown
    AIDS 21:1830-1. 2007
  32. doi request reprint Management of morphologic changes associated with antiretroviral use in HIV-infected patients
    David Alain Wohl
    AIDS Clinical Trials Unit, University of North Carolina, Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 49:S93-S100. 2008
    ..The potential increase in risk of cardiovascular disease associated with these metabolic disturbances is also discussed...
  33. ncbi request reprint Report from Boston: the 12th Conference on Retroviruses and Opportunistic Infections (CROI). Reduced bone mineral density in HIV-infected patients
    Todd T Brown
    Hopkins HIV Rep 17:12-4, 16. 2005
  34. pmc Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system
    Virginia A Triant
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit Street, Longfellow 207, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 93:3499-504. 2008
    ..Reduced bone mineral density has been demonstrated among HIV-infected patients, but fracture prevalence is unknown...
  35. doi request reprint Prevention strategies for cardiovascular disease in HIV-infected patients
    James H Stein
    Circulation 118:e54-60. 2008

Research Grants1

  1. Fish oil, inflammation, & metabolic complications in HIV
    Todd Brown; Fiscal Year: 2007
    ..This proposal will also help me attain my goal of becoming an independent investigator in the area of CAM and HIV. ..