R H Brown

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint The effects of systemic lidocaine on airway tone and pulmonary function in asthmatic subjects
    Herng Yu Sucie Chang
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Anesth Analg 104:1109-15, tables of contents. 2007
  2. ncbi request reprint Airway response to deep inspiration: role of nitric oxide
    R H Brown
    Dept of Anaesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Eur Respir J 22:57-61. 2003
  3. ncbi request reprint Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 102:496-502. 2005
  4. ncbi request reprint How health care organizations can establish and conduct a program for a latex-safe environment
    Robert H Brown
    Johns Hopkins Medical Institutions, Baltimore, USA
    Jt Comm J Qual Saf 29:113-23. 2003
  5. ncbi request reprint Different latex aeroallergen size distributions between powdered surgical and examination gloves: significance for environmental avoidance
    Robert H Brown
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Allergy Clin Immunol 114:358-63. 2004
  6. ncbi request reprint Functional imaging of airway narrowing
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, School of Medicine, The Johns Hopkins University, 620 North Wolfe Street, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 137:327-37. 2003
  7. ncbi request reprint Airway narrowing in healthy humans inhaling methacholine without deep inspirations demonstrated by HRCT
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 161:1256-63. 2000
  8. ncbi request reprint Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive
    H Groeben
    Department of Environmental Health Sciences Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Br J Anaesth 92:697-703. 2004
  9. ncbi request reprint Airway response to deep inspiration: role of inflation pressure
    R H Brown
    Physiology, Rm 7006, Johns Hopkins School of Public Health, 615 North Wolfe St, Baltimore, MD 21205, USA
    J Appl Physiol (1985) 91:2574-8. 2001
  10. ncbi request reprint Delayed distension of contracted airways with lung inflation in vivo
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 162:2113-6. 2000

Research Grants

  1. IMAGING CORE
    Robert Brown; Fiscal Year: 2007

Collaborators

Detail Information

Publications61

  1. ncbi request reprint The effects of systemic lidocaine on airway tone and pulmonary function in asthmatic subjects
    Herng Yu Sucie Chang
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Anesth Analg 104:1109-15, tables of contents. 2007
    ..Therefore we examined the effects of IV lidocaine on baseline airway tone in asthmatic subjects...
  2. ncbi request reprint Airway response to deep inspiration: role of nitric oxide
    R H Brown
    Dept of Anaesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Eur Respir J 22:57-61. 2003
    ..These results support the idea that nitric oxide may be a potential bronchoprotective agent in the airways...
  3. ncbi request reprint Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 102:496-502. 2005
    ..The current study tests the hypothesis that known functional polymorphisms in genes encoding interleukin 4, interleukin 13, and interleukin 18 occur in a higher frequency in healthcare workers with natural rubber latex allergy...
  4. ncbi request reprint How health care organizations can establish and conduct a program for a latex-safe environment
    Robert H Brown
    Johns Hopkins Medical Institutions, Baltimore, USA
    Jt Comm J Qual Saf 29:113-23. 2003
    ..In 1997 the Johns Hopkins Hospital created the interdisciplinary Latex Task Force to address the issue of creating, implementing, and evaluating a latex-safe environment...
  5. ncbi request reprint Different latex aeroallergen size distributions between powdered surgical and examination gloves: significance for environmental avoidance
    Robert H Brown
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Allergy Clin Immunol 114:358-63. 2004
    ....
  6. ncbi request reprint Functional imaging of airway narrowing
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, School of Medicine, The Johns Hopkins University, 620 North Wolfe Street, Baltimore, MD 21205, USA
    Respir Physiol Neurobiol 137:327-37. 2003
    ....
  7. ncbi request reprint Airway narrowing in healthy humans inhaling methacholine without deep inspirations demonstrated by HRCT
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 161:1256-63. 2000
    ..01), and taup (r(2) = 0.51, p = 0.0004). We conclude that in normal subjects who are prevented from taking a deep breath, the spirometric changes occurring with aerosol MCh challenge are associated with conducting airway narrowing...
  8. ncbi request reprint Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive
    H Groeben
    Department of Environmental Health Sciences Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Br J Anaesth 92:697-703. 2004
    ....
  9. ncbi request reprint Airway response to deep inspiration: role of inflation pressure
    R H Brown
    Physiology, Rm 7006, Johns Hopkins School of Public Health, 615 North Wolfe St, Baltimore, MD 21205, USA
    J Appl Physiol (1985) 91:2574-8. 2001
    ..The precise mechanism underlying these observations is uncertain, but it seems to be related to an interaction between intrinsic properties of the contracted airway smooth muscle and the response to mild stretch...
  10. ncbi request reprint Delayed distension of contracted airways with lung inflation in vivo
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 162:2113-6. 2000
    ..This effect may play a role in the unique response of asthmatic subjects to deep inspiration. The mechanism of this dynamic slowness of contracted airways probably involves intrinsic properties of the smooth-muscle contractile processes...
  11. ncbi request reprint Airway closure with high PEEP in vivo
    R H Brown
    The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 89:956-60. 2000
    ..Our results show that increased lung volume shifted the airway methacholine dose-response curve to the right, but, in many airways in most animals, airway closure still occurred even at the highest levels of PEEP...
  12. ncbi request reprint Potential mechanism of hyperresponsive airways
    W Mitzner
    Departments of Environmental Medicine, and Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 161:1619-23. 2000
    ..Altered sensitivity of airway smooth muscle to normal tidal stresses thus may be operative in the development of the asthmatic pathology...
  13. ncbi request reprint Interaction between airway edema and lung inflation on responsiveness of individual airways in vivo
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 83:366-70. 1997
    ..At high lung volume, bradykinin increased wall thickness but had no effect on the MCh-induced airway constriction. We conclude that inflammatory fluid leakage in the airways cannot be a primary cause of airway hyperresponsiveness...
  14. ncbi request reprint High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 163:994-1001. 2001
    ..Therefore, the mechanism for reduced bronchodilation after DIs in subjects with mild asthma could be intrinsic to the airway smooth muscle...
  15. ncbi request reprint High-resolution computed tomography--physiologic correlation
    E A Zerhouni
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD 21205
    J Thorac Imaging 8:265-72. 1993
    ..In this article, the rationale for and present status of physiologic HRCT is presented...
  16. ncbi request reprint Effect of lung inflation and airway muscle tone on airway diameter in vivo
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 80:1581-8. 1996
    ..Thus a transient deep inspiration in vivo would be expected to have only a small effect on contracted airways...
  17. ncbi request reprint The structural basis of airways hyperresponsiveness in asthma
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Appl Physiol (1985) 101:30-9. 2006
    ..These findings suggest that dynamic hyperinflation caused by narrowing of large airways is a major determinant of AHR in asthma...
  18. ncbi request reprint HRCT imaging of airway responsiveness: effects of anesthetics
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, Environmental Health Sciences Division of Physiology, and Radiology, Johns Hopkins University, Baltimore, MD, USA
    J Clin Monit Comput 16:443-55. 2000
    ..This ability of HRCT to measure airway caliber and response heterogeneity in vivo noninvasively will dramatically improve our understanding of pulmonary physiology in general and the effects of anesthetics on the airways specifically...
  19. ncbi request reprint Mechanisms of bronchoprotection by anesthetic induction agents: propofol versus ketamine
    R H Brown
    Environmental Health Sciences Division of Physiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Anesthesiology 90:822-8. 1999
    ..We compared propofol and ketamine to attenuate the direct activation of airway smooth muscle by methacholine and limit neurally mediated bronchoconstriction (vagal nerve stimulation)...
  20. pmc Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
    S S An
    Division of Physiology, Dept of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Eur Respir J 29:834-60. 2007
    ..In the present study, a central role for airway smooth muscle in the pathogenesis of airway hyperresponsiveness in asthma is explored...
  21. ncbi request reprint A method of endotracheal intubation and pulmonary functional assessment for repeated studies in mice
    R H Brown
    Department of Anesthesiology, Environmental Health Sciences Division of Physiology, and Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 87:2362-5. 1999
    ..Brief infusions of acetylcholine through a needle into the jugular vein are used to assess the responsiveness of the airway smooth muscle...
  22. ncbi request reprint Effect of bronchial thermoplasty on airway distensibility
    R H Brown
    Johns Hopkins University Environmental Health Sciences, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Eur Respir J 26:277-82. 2005
    ..In conclusion, these results show that reducing that amount of functional smooth muscle with bronchial thermoplasty leads to increased airway size in both relaxed and contracted states over a normal range of inflation pressures...
  23. ncbi request reprint Ipratropium decreases airway size in dogs by preferential M2 muscarinic receptor blockade in vivo
    H Groeben
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesthesiology 85:867-73. 1996
    ....
  24. ncbi request reprint Administering pharmaceuticals to latex-allergic patients from vials containing natural rubber latex closures
    Robert G Hamilton
    Johns Hopkins University Dermatology, Allergy and Clinical Immunology Reference Laboratory, Division of Allergy and Clinical Immunology, Department of Medicine, Baltimore, MD 21224, USA
    Am J Health Syst Pharm 62:1822-7. 2005
  25. pmc Assessment of heterogeneous airway constriction in dogs: a structure-function analysis
    David W Kaczka
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Appl Physiol (1985) 106:520-30. 2009
    ..These data demonstrate that increases in airway heterogeneity as assessed with forced oscillations and inverse modeling can be linked to specific structural alterations in airway diameters...
  26. pmc Recirculation of inhaled xenon does not alter lung CT density
    Jeffrey B Hoag
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Tower 711, The Johns Hopkins University, 600 N Wolfe Street, Baltimore, MD 21287 8711, USA
    Acad Radiol 14:81-4. 2007
    ..Because Xe is moderately soluble, vascular uptake and redistribution has been proposed as a confounding phenomenon. We propose that the redistribution of Xe via the circulation is negligible, and correction is unwarranted...
  27. doi request reprint Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients
    Constance L Monitto
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Anesth Analg 110:1310-7. 2010
    ..In this study, we tested the hypothesis that single-nucleotide polymorphisms in genes encoding IL13 and IL18 occur at an increased frequency in NRL allergic patients with spina bifida (SB) or bladder exstrophy (BE)...
  28. ncbi request reprint Duration of deep inspiration and subsequent airway constriction in vivo
    Robert H Brown
    Department of Anesthesiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Asthma 40:119-24. 2003
    ..The precise mechanism underlying these observations is uncertain but seems to be related to intrinsic properties within the contracted airway smooth muscle...
  29. pmc Temporal variability in the responses of individual canine airways to methacholine
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    J Appl Physiol (1985) 104:1381-6. 2008
    ..If we consider that increased heterogeneity may potentiate clinical symptoms, then airway response variability may play an important role in the manifestation of airway disease...
  30. ncbi request reprint Blood flow distribution within the airway wall
    Elizabeth M Wagner
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Appl Physiol (1985) 92:1964-9. 2002
    ..During challenge, there was greater MCh delivery to larger airways during increased flow and less delivery to smaller airways during control flow. The results demonstrate the effects of axial perfusion distribution on Raw...
  31. ncbi request reprint Prevalence of latex allergy among anesthesiologists: identification of sensitized but asymptomatic individuals
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, and Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Anesthesiology 89:292-9. 1998
    ..The objectives of the current study were to determine the prevalence of and risk factors for latex sensitization among a cohort of highly exposed health-care workers...
  32. ncbi request reprint Bronchial reactivity of healthy subjects: 18-20 h postexposure to ozone
    W M Foster
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 89:1804-10. 2000
    ..These results suggest that bronchial reactivity is significantly altered approximately 1 day after O(3); this injury may contribute to the respiratory morbidity that is observed 1-2 days after an episode of ambient air pollution...
  33. ncbi request reprint In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography
    Robert H Brown
    Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Appl Physiol 98:1603-6. 2005
    ..The work in this study thus supports the underlying concept that impairing the smooth muscle may be an effective treatment for asthma...
  34. ncbi request reprint Efficacy of propofol to prevent bronchoconstriction: effects of preservative
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Anesthesiology 94:851-5; discussion 6A. 2001
    ..The authors used a sheep model in which anesthetic agents could be directly administered to the airways via the bronchial artery...
  35. pmc Decreased pulmonary vascular permeability in aquaporin-1-null humans
    Landon S King
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 99:1059-63. 2002
    ..These studies indicate that AQP1 is a determinant of vascular permeability in the lung, and demonstrate a role for aquaporins in human pulmonary physiology...
  36. ncbi request reprint Understanding airway pathophysiology with computed tomograpy
    Robert H Brown
    Department od Environmental Health Science, Bloomberg School of Public Health and School of Health, The John Hopkins University, Baltimore, MD 21205, USA
    J Appl Physiol 95:854-62. 2003
    ..In this mini-review, we focus on these capabilities of HRCT by briefly reviewing highlights of experimental results from several canine and human studies...
  37. ncbi request reprint Mechanisms of limited airway dimension with lung inflation
    Robert H Brown
    Departments of Anesthesiology and Critical Care Medicine Pulmonary and Critical Care Medicine, Radiology and Environmental Health Sciences Division of Physiology, Johns Hopkins University, Baltimore, USA
    Pulm Pharmacol Ther 20:118-25. 2007
    ....
  38. ncbi request reprint Heritable differences in respiratory drive and breathing pattern in mice during anaesthesia and emergence
    H Groeben
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Br J Anaesth 91:541-5. 2003
    ..We studied the effect of isoflurane anaesthesia in two inbred mouse strains known for phenotypic differences in breathing pattern and respiratory drive during carbon dioxide challenge and their first-generation offspring (F(1))...
  39. doi request reprint Different mechanisms of atelectasis formation require different treatment strategies
    Harald Groeben
    Department of Environmental Health Sciences Division of Physiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Exp Lung Res 34:115-24. 2008
    ..Passive atelectasis was easily resolved by deep inspirations. In contrast, active airway constriction that leads to atelectasis could not be overcome with recruitment maneuvers...
  40. ncbi request reprint The final steps in converting a health care organization to a latex-safe environment
    Robert H Brown
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, USA
    Jt Comm J Qual Patient Saf 35:224-8. 2009
    ..Before the complete conversion to nonlatex sterile gloves, operating room use had increased to approximately one-third of our total sterile glove use during the preceding four years...
  41. ncbi request reprint The effect of leptin on the ventilatory responseto hyperoxia
    Harald Groeben
    Department of Anesthesiology and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Exp Lung Res 30:559-70. 2004
    ..Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function...
  42. ncbi request reprint Heritable and pharmacological influences on pauses and apneas in inbred mice during anesthesia and emergence
    Harald Groeben
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Exp Lung Res 31:839-53. 2005
    ..This response seems to be independent from the inherited response to hypercapnia...
  43. pmc The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana, Univ of Palermo, 90146 Palermo, Italy
    J Appl Physiol (1985) 105:832-8. 2008
    ....
  44. ncbi request reprint Variants in candidate ALS modifier genes linked to Cu/Zn superoxide dismutase do not explain divergent survival phenotypes
    Wendy J Broom
    Day Neuromuscular Research Laboratory, Massachusetts General Hospital, 114 16th Street, Navy Yard, Charlestown, 02129, USA
    Neurosci Lett 392:52-7. 2006
    ..We conclude that mutations within coding regions of genes around the SOD1 locus are not responsible for the more aggressive and more benign natures of the SOD1(A4V) and SOD1(D90A/D90A) mutations, respectively...
  45. ncbi request reprint Airway distension with lung inflation measured by HRCT
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine
    Acad Radiol 10:1097-103. 2003
  46. ncbi request reprint Effects of the alpha2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs
    Harald Groeben
    Department of Anesthesiology and Critical Care Medicine, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Anesthesiology 100:359-63. 2004
    ..Dexmedetomidine is a selective alpha2-adrenoceptor agonist approved for sedation in the intensive care unit. Whether dexmedetomidine can affect reflex bronchoconstriction is unknown...
  47. doi request reprint An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology
    Robert H Brown
    Proc Am Thorac Soc 5:591-600. 2008
  48. pmc A common haplotype within the PON1 promoter region is associated with sporadic ALS
    John E Landers
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital East, Charlestown, MA, USA
    Amyotroph Lateral Scler 9:306-14. 2008
    ..75E-05). We conclude that a common haplotype within the PON1 promoter region is associated with susceptibility to sporadic ALS...
  49. doi request reprint 50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis
    Wendy J Broom
    Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Amyotroph Lateral Scler 9:229-37. 2008
    ..Our findings suggest the hypothesis that this deletion reduces expression of the SOD1 gene and that levels of the SOD1 protein may modify the phenotype of SALS within selected populations...
  50. pmc A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q
    Collette K Hand
    Centre for Research in Neuroscience, McGill University and The Montreal General Hospital Research Institute, Montreal, Canada
    Am J Hum Genet 70:251-6. 2002
    ..The maximum LOD score is 4.5 at recombination fraction 0.0, for polymorphism D18S39. Haplotype analysis has identified a 7.5-cM, 8-Mb region of chromosome 18q21, flanked by markers D18S846 and D18S1109, as a novel FALS locus...
  51. ncbi request reprint Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis
    Yi Ju Li
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurogenetics 5:209-13. 2004
    ..Similar to our previous report, we did not find APOE associated with ALS risk. Our findings suggest that APOE may express its strongest effect through age at onset rather than on risk...
  52. ncbi request reprint Birth order and the genetics of amyotrophic lateral sclerosis
    Umesh Vivekananda
    MRC Centre for Neurodegeneration, Research, P043, King s College London, Dept of Neurology, Institute of Psychiatry, London, SE5 8AF, UK
    J Neurol 255:99-102. 2008
    ..This is encouraging for the prospect of finding sporadic ALS susceptibility genes using genome-wide association mapping...
  53. ncbi request reprint Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis
    Michael L Garcia
    Ludwig Institute for Cancer Research and Department of Neurosciences, University of California at San Diego, 9500 Gilman Drive, CMM E Room 3072, La Jolla, CA 92093 0670, USA
    Neurobiol Dis 21:102-9. 2006
    ..Thus, mutations in neurofilaments are possible risk factors that may contribute to pathogenesis in ALS in conjunction with one or more additional genetic or environmental factors, but are not significant primary causes of ALS...
  54. ncbi request reprint Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
    Shinji Hadano
    Department of Molecular Neuroscience, The Institute of Medical Sciences, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Hum Mol Genet 15:233-50. 2006
    ....
  55. ncbi request reprint No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach
    Paresh R Shah
    Department of Neurodegenerative Disease, Institute of Neurology, London, UK
    Amyotroph Lateral Scler 7:46-56. 2006
    ....
  56. ncbi request reprint Molecular biology of amyotrophic lateral sclerosis: insights from genetics
    Piera Pasinelli
    Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Room 3125, Building 114, 16th Street, Navy Yard, Charlestown, Massachusetts 02429, USA
    Nat Rev Neurosci 7:710-23. 2006
    ..Here, we present an overview of the mechanisms for motor neuron death and of the role of non-neuronal cells in ALS...
  57. ncbi request reprint A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice
    Kristin E Larsen
    Columbia University, Department of Neurology, New York, NY 10032, and Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
    Brain Res 1120:1-12. 2006
    ..These results indicate that TTC can serve as a non-viral vehicle to substantially improve the delivery of functionally active growth factors to motor neurons in the mammalian CNS...
  58. ncbi request reprint Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis
    Ammar Al-Chalabi
    Department of Neurology, Academic Neuroscience Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    Ann Neurol 54:130-4. 2003
    ..There was no difference in age of onset, clinical presentation, rate of progression, or disease duration for those with one or two copies of the null allele, excluding CNTF as a major disease modifier in ALS...
  59. ncbi request reprint Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains
    Martin Ingelsson
    Harvard Medical School, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Acta Neuropathol 114:471-9. 2007
    ..In conclusion, we demonstrated increased but largely variable 4R tau/3R tau mRNA ratios in FTLD and PSP cases, suggesting heterogeneous pathophysiological processes within these disorders...
  60. pmc Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery
    Katrina Gwinn
    National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e1254. 2007
    ..This resource should facilitate genetic discoveries which we anticipate will ultimately provide a better understanding of the biological mechanisms of neurodegeneration in ALS...
  61. doi request reprint Evaluation of the Golgi trafficking protein VPS54 (wobbler) as a candidate for ALS
    Miriam H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan48109 0618, USA
    Amyotroph Lateral Scler 9:141-8. 2008
    ..Several polymorphic non-synonymous SNPs were also observed in patients and controls. These initial data suggest that mutations in VPS54 are not a major cause of ALS...

Research Grants1

  1. IMAGING CORE
    Robert Brown; Fiscal Year: 2007
    ..The Core will support Projects 2 and 5 and will interact with Core C. ..