Amanda M Brown
Affiliation: Johns Hopkins University
- Multiple human immunodeficiency virus type 1 Nef functions contribute to efficient replication in primary human macrophagesAmanda Brown
Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, 7th Floor, New York, NY 10016, USA
J Gen Virol 85:1463-9. 2004..These data suggest that efficient HIV-1 replication is dependent on the ability of Nef to interact with cellular kinases and remove CD4 from the surface of infected macrophages...
- HLA-A2 down-regulation on primary human macrophages infected with an M-tropic EGFP-tagged HIV-1 reporter virusAmanda Brown
Department of Neurology, Meyer 6 181, 600 North Wolfe Street, Baltimore, MD 21287, USA
J Leukoc Biol 78:675-85. 2005..The impact of Nef on HLA-A2 surface expression in MDM was also confirmed by confocal microscopy. These results suggest that the mechanisms of HLA-A2 down-modulation are similar in primary T cells and macrophages...
- In vitro modeling of the HIV-macrophage reservoirAmanda Brown
Johns Hopkins School of Medicine, Department of Neurology, 600 North Wolfe St, Baltimore, MD 21287, USA
J Leukoc Biol 80:1127-35. 2006..A subset of these, were replication competent as shown by their ability to express GFP and/or p24 antigen after reactivation with IL-4...
- Use of a macrophage-tropic GFP-tagged human immunodeficiency virus type 1 (HIV-1) to study viral reservoirsAmanda M Brown
Johns Hopkins University School of Medicine, Neurology, Baltimore, MD 21287, USA
Methods Mol Biol 515:165-75. 2009..The infected cells can be studied at the single-cell level using a variety of fluorescence-based technologies such as flow cytometry, conventional and confocal microscopy, and laser capture microdissection...
- Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individualsAmanda Brown
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7131, USA
J Neurovirol 17:382-92. 2011....