Malcolm V Brock

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thorac Cardiovasc Surg 123:466-73; discussion 473-4. 2002
  2. pmc Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
    Anju Singh
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 3:e420. 2006
  3. pmc Cancer as a manifestation of aberrant chromatin structure
    Malcolm V Brock
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205 2196, USA
    Cancer J 13:3-8. 2007
  4. ncbi request reprint Impact of elastic staining on the staging of peripheral lung cancers
    Janis M Taube
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 31:953-6. 2007
  5. ncbi request reprint Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer
    Mingzhou Guo
    Department of Oncology, Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    Int J Cancer 121:1219-26. 2007
  6. doi request reprint DNA methylation markers and early recurrence in stage I lung cancer
    Malcolm V Brock
    Johns Hopkins Hospital, Baltimore, USA
    N Engl J Med 358:1118-28. 2008
  7. ncbi request reprint Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care
    Malcolm V Brock
    Johns Hopkins Hospital, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 43:47-55. 2006
  8. ncbi request reprint Can we improve the cytologic examination of malignant pleural effusions using molecular analysis?
    Malcolm V Brock
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 80:1241-7. 2005
  9. ncbi request reprint Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come
    Malcolm V Brock
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkinds Medical Institutions, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 129:64-72. 2005
  10. ncbi request reprint Hypermethylation of the GATA genes in lung cancer
    Mingzhou Guo
    Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Cancer Res 10:7917-24. 2004

Detail Information

Publications43

  1. ncbi request reprint Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study
    Steven A Ahrendt
    Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Thorac Cardiovasc Surg 123:466-73; discussion 473-4. 2002
    ....
  2. pmc Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
    Anju Singh
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 3:e420. 2006
    ..Increased expression of cellular antioxidants and xenobiotic detoxification enzymes has been implicated in resistance of tumor cells against chemotherapeutic drugs...
  3. pmc Cancer as a manifestation of aberrant chromatin structure
    Malcolm V Brock
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205 2196, USA
    Cancer J 13:3-8. 2007
    ..A more complete understanding of these key, regulatory events is vital in approaching a more rational drug therapy to various malignancies...
  4. ncbi request reprint Impact of elastic staining on the staging of peripheral lung cancers
    Janis M Taube
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 31:953-6. 2007
    ..Our experience suggests that routine elastic tissue staining should be performed as a standard method of assessing pleural involvement for pleural-based nonsmall cell lung carcinomas...
  5. ncbi request reprint Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer
    Mingzhou Guo
    Department of Oncology, Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    Int J Cancer 121:1219-26. 2007
    ..Our results suggest that the inactivation of CDX2 in esophageal cancer associated with DNA methylation may be an important determinant of the squamous or non-adenomatous phenotype...
  6. doi request reprint DNA methylation markers and early recurrence in stage I lung cancer
    Malcolm V Brock
    Johns Hopkins Hospital, Baltimore, USA
    N Engl J Med 358:1118-28. 2008
    ..Despite optimal and early surgical treatment of non-small-cell lung cancer (NSCLC), many patients die of recurrent NSCLC. We investigated the association between gene methylation and recurrence of the tumor...
  7. ncbi request reprint Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care
    Malcolm V Brock
    Johns Hopkins Hospital, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 43:47-55. 2006
    ..Lung cancer is more common in HIV-infected patients than in the general population. We examined how effectively lung cancer was being diagnosed in our HIV-infected patients...
  8. ncbi request reprint Can we improve the cytologic examination of malignant pleural effusions using molecular analysis?
    Malcolm V Brock
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 80:1241-7. 2005
    ..Deoxyribonucleic acid (DNA) methylation is a robust strategy for detecting cancer early in tissue. We hypothesized that DNA methylation would be more sensitive in diagnosing patients with malignant pleural effusions than cytology...
  9. ncbi request reprint Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come
    Malcolm V Brock
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkinds Medical Institutions, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 129:64-72. 2005
    ..Although resection is not the standard of care in treating small cell lung cancer, new platinum drugs and modern staging have allowed the role of surgery to be reevaluated...
  10. ncbi request reprint Hypermethylation of the GATA genes in lung cancer
    Mingzhou Guo
    Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Cancer Res 10:7917-24. 2004
    ..In lung cancer, DNA hypermethylation is known to be a common event...
  11. doi request reprint Neoadjuvant chemoradiation therapy is beneficial for clinical stage T2 N0 esophageal cancer patients due to inaccurate preoperative staging
    Jennifer Q Zhang
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Kimmel Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 93:429-35; discussion 436-7. 2012
    ..It remains unclear if patients with clinical stage T2 N0 (cT2 N0) esophageal cancer should be offered induction therapy vs surgical intervention alone...
  12. pmc Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers
    Robert A Meguid
    Division of Thoracic Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Chest 138:500-9. 2010
    ..Survival outcomes of never smokers with non-small cell lung cancer (NSCLC) who undergo surgery are poorly characterized. This investigation compared surgical outcomes of never and current smokers with NSCLC...
  13. ncbi request reprint Risk of subsequent primary neoplasms developing in lung cancer patients with prior malignancies
    Malcolm V Brock
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 127:1119-25. 2004
    ..This study was performed to test the hypothesis that a history of other primary neoplasms before a lung cancer diagnosis increases the risk of subsequent malignancy...
  14. ncbi request reprint Promoter methylation of HIN-1 in the progression to esophageal squamous cancer
    Mingzhou Guo
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Epigenetics 3:336-41. 2008
    ..These studies demonstrate HIN-1 silencing is associated with dense promoter region hypermethylation in esophageal cancer and suggest that methylation of HIN-1 is an early event in dysplastic transformation...
  15. ncbi request reprint Promoter hypermethylation of resected bronchial margins: a field defect of changes?
    Mingzhou Guo
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 10:5131-6. 2004
    ..We hypothesized that DNA promoter hypermethylation changes at bronchial margins could be detected in patients with no histological evidence of malignancy and that they would reflect epigenetic events in the primary tumor...
  16. ncbi request reprint Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus
    Mingzhou Guo
    Cancer Biology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Clin Cancer Res 12:4515-22. 2006
    ..We examined the changes in promoter region methylation occurring during neoplastic progression...
  17. ncbi request reprint Hypermethylation of the GATA gene family in esophageal cancer
    Mingzhou Guo
    Cancer Biology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    Int J Cancer 119:2078-83. 2006
    ..Our studies demonstrate frequent silencing of GATA-4 and GATA-5, but not GATA-6, in human esophageal neoplasia associated with gene promoter hypermethylation...
  18. pmc Human immunodeficiency virus infection as a prognostic factor in surgical patients with non-small cell lung cancer
    Craig M Hooker
    Department of Oncology, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 93:405-12. 2012
    ..The purpose of this study was to assess the effect of human immunodeficiency virus (HIV) infection on postoperative survival among non-small cell lung cancer (NSCLC) patients...
  19. pmc Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
    Rosalyn A Juergens
    Department of Oncology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Discov 1:598-607. 2011
    ....
  20. pmc Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: does the pattern of recurrence differ for patients with complete response and those with partial or no response?
    Robert A Meguid
    Division of Thoracic Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Thorac Cardiovasc Surg 138:1309-17. 2009
    ..We hypothesized that most relapses in patients with esophageal cancer having neoadjuvant chemoradiation therapy would occur outside of the surgical and radiation fields...
  21. ncbi request reprint Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience
    Malcolm V Brock
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 77:271-7. 2004
    ..The purpose of this study was to determine outcomes in these patients, particularly short- and long-term survival with stage I disease...
  22. ncbi request reprint Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer
    Emi Ota Machida
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 66:6210-8. 2006
    ..Thus, hypermethylation of ASC/TMS1 is a marker for late-stage lung cancer and, in sputum, could predict prognosis in patients resected for early-stage disease...
  23. ncbi request reprint Survival after community diagnosis of early-stage non-small cell lung cancer
    Norma F Kanarek
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Md Electronic address
    Am J Med 127:443-9. 2014
    ..Our objective was to assess the contribution of diagnosis to first surgery interval to survival among patients diagnosed in the community with early-stage non-small cell lung cancer...
  24. ncbi request reprint Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 1000, USA
    J Gastrointest Surg 7:1004-14; discussion 1014. 2003
    ..This study supports the methylation status of E-cadherin as a prognostic marker for early GIST recurrence and survival...
  25. ncbi request reprint Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer
    Brett G Masasyesva
    Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Int J Cancer 113:1022-5. 2005
    ..This methodology may be adaptable to a real-time format for intraoperative use...
  26. pmc A murine xenograft model of spontaneous metastases of human lung adenocarcinoma
    James E Harris
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Surg Res 171:e75-9. 2011
    ..Tail vein injection creates a pattern of metastases, but is artificial. We hypothesized that the liver is a convenient alternative xenograft site and that metastases would gradually proceed spontaneously...
  27. ncbi request reprint Elevated incidence of lung cancer among HIV-infected individuals
    Eric A Engels
    Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 24:1383-8. 2006
    ..We sought to characterize lung cancer incidence among HIV-infected individuals, examine whether cancer risk was related to HIV-induced immunosuppression, and assess whether the high prevalence of smoking explained elevated risk...
  28. pmc Prospective CT Screening for Lung Cancer in a High-Risk Population: HIV-Positive Smokers
    Alicia Hulbert
    Departments of Oncology, Surgery, Medicine, Infectious Diseases, Radiology, Pulmonology, Medicine, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Thorac Oncol 9:752-9. 2014
    ..Epidemiological evidence suggests that HIV-infected individuals are at increased risk of lung cancer, but no data exist because large computed tomography (CT) screening trials routinely exclude HIV-infected participants...
  29. pmc Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer
    Tianyun Jiang
    Departments of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 69:845-54. 2009
    ..Intrinsic tumor cell heterogeneity, including variation in key regulatory factors such as ASCL1, can modulate tumorigenicity in SCLC...
  30. pmc Epigenetic changes associated with neoplasms of the exocrine and endocrine pancreas
    Mingzhou Guo
    Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Discov Med 17:67-73. 2014
    ..Pancreatic adenocarcinomas had patterns of gene methylation that differed from pancreatic endocrine tumors. These differences were most notable for the APC and hMLH1 genes. ..
  31. ncbi request reprint Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma
    Malcolm V Brock
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 9:2912-9. 2003
    ..The association of clinicopathological and biomolecular risk factors to survival and recurrence was performed using the Log-rank test and Cox proportional hazards model for multivariate analysis...
  32. doi request reprint Are surgical outcomes for lung cancer resections improved at teaching hospitals?
    Robert A Meguid
    Division of Thoracic Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Ann Thorac Surg 85:1015-24; discussion 1024-5. 2008
    ..We postulate that short-term outcome after lung cancer resection is better at teaching hospitals (TH) compared with nonteaching hospitals (non-TH), independent of volume...
  33. pmc The effect of volume on esophageal cancer resections: what constitutes acceptable resection volumes for centers of excellence?
    Robert A Meguid
    Division of Thoracic Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Thorac Cardiovasc Surg 137:23-9. 2009
    ..No consensus exists for what constitutes a "high-volume" center. We aim to determine if an objective evidence-based threshold of operative volume associated with improvement in operative outcome for esophageal resections can be defined...
  34. ncbi request reprint Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies
    Oliver Galm
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St, Baltimore, MD 21231, USA
    Oncogene 24:4799-805. 2005
    ..We conclude that promoter hypermethylation of TIMP-2 is a novel epigenetic event in the pathogenesis of lymphoid malignancies and may contribute to a more aggressive NHL phenotype...
  35. pmc Writing a successful NIH Mentored Career Development Grant (K award): hints for the junior faculty surgeon
    Malcolm V Brock
    Department of Surgery, Division of Thoracic Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Ann Surg 251:1013-7. 2010
    ....
  36. ncbi request reprint Epidemiology of lung cancer: looking to the future
    Anthony J Alberg
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, 21205, USA
    J Clin Oncol 23:3175-85. 2005
    ..Unless further reductions in the prevalence of cigarette smoking are achieved over the next decade, lung cancer will remain as an all too common, but avoidable, disease...
  37. ncbi request reprint A case of ectopic parathyroid hormone production by a pulmonary neoplasm
    Eric S Weiss
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Thorac Cardiovasc Surg 131:923-4. 2006
  38. pmc Decoding circulating nucleic acids in human serum using microfluidic single molecule spectroscopy
    Kelvin J Liu
    Biomedical Engineering Department, 3400 North Charles Street, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Am Chem Soc 132:5793-8. 2010
    ..This demonstrates that microfluidic single molecule spectroscopy can be a rapid, facile, and inexpensive alternative to the established PCR-based methods that have been used near exclusively for CNA analysis...
  39. pmc Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
    Charles M Rudin
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 44:1111-6. 2012
    ..These data provide an in-depth view of the spectrum of genomic alterations in SCLC and identify several potential targets for therapeutic intervention...
  40. pmc Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    Hsing Chen Tsai
    The Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Cell 21:430-46. 2012
    ..Low-dose decitabine and azacitidine may have broad applicability for cancer management...
  41. ncbi request reprint Lung cancer: new surgical approaches
    J Timothy Sherwood
    Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Respirology 12:326-32. 2007
    ..In this brave new world, however, complete surgical resection of the lung cancer will continue to be critical...
  42. pmc Defining a gene promoter methylation signature in sputum for lung cancer risk assessment
    Shuguang Leng
    Lung Cancer Program, Lovelace Respiratory Research Institute, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87108, USA
    Clin Cancer Res 18:3387-95. 2012
    ....
  43. pmc The use of "overall accuracy" to evaluate the validity of screening or diagnostic tests
    Anthony J Alberg
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gen Intern Med 19:460-5. 2004
    ..We assessed the value of overall accuracy in studies of test validity, a topic that has not received adequate emphasis in the clinical literature...