Research Topics
Genomes and GenesSpecies | Malcolm V BrockSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective studySteven A Ahrendt
Department of Surgery, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Thorac Cardiovasc Surg 123:466-73; discussion 473-4. 2002....
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancerAnju Singh
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS Med 3:e420. 2006..Increased expression of cellular antioxidants and xenobiotic detoxification enzymes has been implicated in resistance of tumor cells against chemotherapeutic drugs...- Cancer as a manifestation of aberrant chromatin structureMalcolm V Brock
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205 2196, USA
Cancer J 13:3-8. 2007..A more complete understanding of these key, regulatory events is vital in approaching a more rational drug therapy to various malignancies... - Impact of elastic staining on the staging of peripheral lung cancersJanis M Taube
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 31:953-6. 2007..Our experience suggests that routine elastic tissue staining should be performed as a standard method of assessing pleural involvement for pleural-based nonsmall cell lung carcinomas... - Epigenetic silencing of CDX2 is a feature of squamous esophageal cancerMingzhou Guo
Department of Oncology, Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
Int J Cancer 121:1219-26. 2007..Our results suggest that the inactivation of CDX2 in esophageal cancer associated with DNA methylation may be an important determinant of the squamous or non-adenomatous phenotype... 
DNA methylation markers and early recurrence in stage I lung cancerMalcolm V Brock
Johns Hopkins Hospital, Baltimore, USA
N Engl J Med 358:1118-28. 2008..Despite optimal and early surgical treatment of non-small-cell lung cancer (NSCLC), many patients die of recurrent NSCLC. We investigated the association between gene methylation and recurrence of the tumor...- Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient careMalcolm V Brock
Johns Hopkins Hospital, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
J Acquir Immune Defic Syndr 43:47-55. 2006..Lung cancer is more common in HIV-infected patients than in the general population. We examined how effectively lung cancer was being diagnosed in our HIV-infected patients... - Can we improve the cytologic examination of malignant pleural effusions using molecular analysis?Malcolm V Brock
Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Ann Thorac Surg 80:1241-7. 2005..Deoxyribonucleic acid (DNA) methylation is a robust strategy for detecting cancer early in tissue. We hypothesized that DNA methylation would be more sensitive in diagnosing patients with malignant pleural effusions than cytology... - Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has comeMalcolm V Brock
Division of Thoracic Surgery, Department of Surgery, The Johns Hopkinds Medical Institutions, Baltimore, MD, USA
J Thorac Cardiovasc Surg 129:64-72. 2005..Although resection is not the standard of care in treating small cell lung cancer, new platinum drugs and modern staging have allowed the role of surgery to be reevaluated... - Hypermethylation of the GATA genes in lung cancerMingzhou Guo
Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
Clin Cancer Res 10:7917-24. 2004..In lung cancer, DNA hypermethylation is known to be a common event... - Neoadjuvant chemoradiation therapy is beneficial for clinical stage T2 N0 esophageal cancer patients due to inaccurate preoperative stagingJennifer Q Zhang
Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Kimmel Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Ann Thorac Surg 93:429-35; discussion 436-7. 2012..It remains unclear if patients with clinical stage T2 N0 (cT2 N0) esophageal cancer should be offered induction therapy vs surgical intervention alone... 
Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokersRobert A Meguid
Division of Thoracic Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Chest 138:500-9. 2010..Survival outcomes of never smokers with non-small cell lung cancer (NSCLC) who undergo surgery are poorly characterized. This investigation compared surgical outcomes of never and current smokers with NSCLC...- Risk of subsequent primary neoplasms developing in lung cancer patients with prior malignanciesMalcolm V Brock
Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Thorac Cardiovasc Surg 127:1119-25. 2004..CONCLUSIONS: The risk of developing a subsequent malignancy is very high in lung cancer patients with prior primary malignancies, but it is not markedly different from the risks experienced by patients with no prior malignancies... - Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagusMingzhou Guo
Cancer Biology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Clin Cancer Res 12:4515-22. 2006..CONCLUSIONS: These findings suggest that epigenetic progression parallels the histologic changes observed in the progression of squamous carcinoma of the esophagus... - Promoter methylation of HIN-1 in the progression to esophageal squamous cancerMingzhou Guo
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
Epigenetics 3:336-41. 2008..These studies demonstrate HIN-1 silencing is associated with dense promoter region hypermethylation in esophageal cancer and suggest that methylation of HIN-1 is an early event in dysplastic transformation... - Promoter hypermethylation of resected bronchial margins: a field defect of changes?Mingzhou Guo
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Clin Cancer Res 10:5131-6. 2004..We hypothesized that DNA promoter hypermethylation changes at bronchial margins could be detected in patients with no histological evidence of malignancy and that they would reflect epigenetic events in the primary tumor... - Hypermethylation of the GATA gene family in esophageal cancerMingzhou Guo
Cancer Biology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
Int J Cancer 119:2078-83. 2006..Our studies demonstrate frequent silencing of GATA-4 and GATA-5, but not GATA-6, in human esophageal neoplasia associated with gene promoter hypermethylation... - Human immunodeficiency virus infection as a prognostic factor in surgical patients with non-small cell lung cancerCraig M Hooker
Department of Oncology, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Ann Thorac Surg 93:405-12. 2012..The purpose of this study was to assess the effect of human immunodeficiency virus (HIV) infection on postoperative survival among non-small cell lung cancer (NSCLC) patients... - Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancerRosalyn A Juergens
Department of Oncology, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cancer Discov 1:598-607. 2011.... - Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: does the pattern of recurrence differ for patients with complete response and those with partial or no response?Robert A Meguid
Division of Thoracic Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Thorac Cardiovasc Surg 138:1309-17. 2009..We hypothesized that most relapses in patients with esophageal cancer having neoadjuvant chemoradiation therapy would occur outside of the surgical and radiation fields... - Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experienceMalcolm V Brock
The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Ann Thorac Surg 77:271-7. 2004..CONCLUSIONS: The 5-year survival, particularly in patients with stage Ia tumors with favorable ASA and FEV(1), supports the notion that health status and tumor stage outweigh chronologic age in determining surgical candidates... - Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancerEmi Ota Machida
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Cancer Res 66:6210-8. 2006..Thus, hypermethylation of ASC/TMS1 is a marker for late-stage lung cancer and, in sputum, could predict prognosis in patients resected for early-stage disease... - Molecular margin analysis predicts local recurrence after sublobar resection of lung cancerBrett G Masasyesva
Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Int J Cancer 113:1022-5. 2005..This methodology may be adaptable to a real-time format for intraoperative use... - Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behaviorMichael G House
Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 1000, USA
J Gastrointest Surg 7:1004-14; discussion 1014. 2003..This study supports the methylation status of E-cadherin as a prognostic marker for early GIST recurrence and survival... - A murine xenograft model of spontaneous metastases of human lung adenocarcinomaJames E Harris
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Surg Res 171:e75-9. 2011..Tail vein injection creates a pattern of metastases, but is artificial. We hypothesized that the liver is a convenient alternative xenograft site and that metastases would gradually proceed spontaneously... - Elevated incidence of lung cancer among HIV-infected individualsEric A Engels
Johns Hopkins Hospital, Baltimore, MD, USA
J Clin Oncol 24:1383-8. 2006..We sought to characterize lung cancer incidence among HIV-infected individuals, examine whether cancer risk was related to HIV-induced immunosuppression, and assess whether the high prevalence of smoking explained elevated risk... - Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancerTianyun Jiang
Departments of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 69:845-54. 2009..Intrinsic tumor cell heterogeneity, including variation in key regulatory factors such as ASCL1, can modulate tumorigenicity in SCLC... - Are surgical outcomes for lung cancer resections improved at teaching hospitals?Robert A Meguid
Division of Thoracic Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
Ann Thorac Surg 85:1015-24; discussion 1024-5. 2008..We postulate that short-term outcome after lung cancer resection is better at teaching hospitals (TH) compared with nonteaching hospitals (non-TH), independent of volume... - The effect of volume on esophageal cancer resections: what constitutes acceptable resection volumes for centers of excellence?Robert A Meguid
Division of Thoracic Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
J Thorac Cardiovasc Surg 137:23-9. 2009..We aim to determine if an objective evidence-based threshold of operative volume associated with improvement in operative outcome for esophageal resections can be defined... - Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignanciesOliver Galm
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St, Baltimore, MD 21231, USA
Oncogene 24:4799-805. 2005..We conclude that promoter hypermethylation of TIMP-2 is a novel epigenetic event in the pathogenesis of lymphoid malignancies and may contribute to a more aggressive NHL phenotype... - Writing a successful NIH Mentored Career Development Grant (K award): hints for the junior faculty surgeonMalcolm V Brock
Department of Surgery, Division of Thoracic Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Ann Surg 251:1013-7. 2010.... - Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinomaMalcolm V Brock
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Clin Cancer Res 9:2912-9. 2003..The association of clinicopathological and biomolecular risk factors to survival and recurrence was performed using the Log-rank test and Cox proportional hazards model for multivariate analysis... - Epidemiology of lung cancer: looking to the futureAnthony J Alberg
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, 21205, USA
J Clin Oncol 23:3175-85. 2005..Unless further reductions in the prevalence of cigarette smoking are achieved over the next decade, lung cancer will remain as an all too common, but avoidable, disease... - A case of ectopic parathyroid hormone production by a pulmonary neoplasmEric S Weiss
Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Thorac Cardiovasc Surg 131:923-4. 2006 - Decoding circulating nucleic acids in human serum using microfluidic single molecule spectroscopyKelvin J Liu
Biomedical Engineering Department, 3400 North Charles Street, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Am Chem Soc 132:5793-8. 2010..This demonstrates that microfluidic single molecule spectroscopy can be a rapid, facile, and inexpensive alternative to the established PCR-based methods that have been used near exclusively for CNA analysis... - Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancerCharles M Rudin
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 44:1111-6. 2012..These data provide an in-depth view of the spectrum of genomic alterations in SCLC and identify several potential targets for therapeutic intervention... - Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cellsHsing Chen Tsai
The Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Cancer Cell 21:430-46. 2012..Low-dose decitabine and azacitidine may have broad applicability for cancer management... - Lung cancer: new surgical approachesJ Timothy Sherwood
Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Respirology 12:326-32. 2007..In this brave new world, however, complete surgical resection of the lung cancer will continue to be critical... - Defining a gene promoter methylation signature in sputum for lung cancer risk assessmentShuguang Leng
Lung Cancer Program, Lovelace Respiratory Research Institute, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87108, USA
Clin Cancer Res 18:3387-95. 2012.... - The use of "overall accuracy" to evaluate the validity of screening or diagnostic testsAnthony J Alberg
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Gen Intern Med 19:460-5. 2004..We assessed the value of overall accuracy in studies of test validity, a topic that has not received adequate emphasis in the clinical literature...