K I Bolla

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Polysomnogram changes in marijuana users who report sleep disturbances during prior abstinence
    Karen I Bolla
    Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep Med 11:882-9. 2010
  2. ncbi Prefrontal cortical dysfunction in abstinent cocaine abusers
    Karen Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Neuropsychiatry Clin Neurosci 16:456-64. 2004
  3. ncbi Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 19:1085-94. 2003
  4. ncbi Neural substrates of faulty decision-making in abstinent marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Neuroimage 26:480-92. 2005
  5. ncbi Dose-related neurocognitive effects of marijuana use
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, Baltimore, MD 21224, USA
    Neurology 59:1337-43. 2002
  6. ncbi Sleep disturbance in heavy marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep 31:901-8. 2008
  7. ncbi Sex-related differences in a gambling task and its neurological correlates
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Cereb Cortex 14:1226-32. 2004
  8. ncbi Past adult lead exposure is associated with longitudinal decline in cognitive function
    B S Schwartz
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Neurology 55:1144-50. 2000
  9. ncbi Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers
    B S Schwartz
    Division of Occupational and Environmental Health, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe St, Room 7041, Baltimore, MD 21205, USA
    Am J Epidemiol 153:453-64. 2001
  10. ncbi Environmental lead exposure and cognitive function in community-dwelling older adults
    R A Shih
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 67:1556-62. 2006

Research Grants

  1. Sleep Disturbance in Marijuana Withdrawal
    Karen Bolla; Fiscal Year: 2004

Collaborators

Detail Information

Publications30

  1. ncbi Polysomnogram changes in marijuana users who report sleep disturbances during prior abstinence
    Karen I Bolla
    Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep Med 11:882-9. 2010
    ..Few studies have used polysomnography (PSG) to characterize changes in sleep architecture during abrupt abstinence from heavy MJ use...
  2. ncbi Prefrontal cortical dysfunction in abstinent cocaine abusers
    Karen Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Neuropsychiatry Clin Neurosci 16:456-64. 2004
    ..Since impairment in ECF may be a common feature of various neuropsychiatric disorders, these findings have applicability beyond the neurobiology of addiction...
  3. ncbi Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuroimage 19:1085-94. 2003
    ..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence...
  4. ncbi Neural substrates of faulty decision-making in abstinent marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
    Neuroimage 26:480-92. 2005
    ..Finally, it is unclear if these neurologic findings will become progressively worse with continued heavy MJ use or if they will resolve with abstinence from MJ use...
  5. ncbi Dose-related neurocognitive effects of marijuana use
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Hopkins Bayview Research Campus, Baltimore, MD 21224, USA
    Neurology 59:1337-43. 2002
    ..Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use...
  6. ncbi Sleep disturbance in heavy marijuana users
    Karen I Bolla
    Department of Neurology, Johns Hopkins Medical Institutions, Bayview Medical Center, Baltimore, MD 21224, USA
    Sleep 31:901-8. 2008
    ..To determine if recently abstinent, heavy marijuana (MJ) users show differences in polysomnographic (PSG) measures compared with a drug-free control group...
  7. ncbi Sex-related differences in a gambling task and its neurological correlates
    K I Bolla
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Cereb Cortex 14:1226-32. 2004
    ..These results also provide further evidence of sexual dimorphism in neurocognitive performance and brain function...
  8. ncbi Past adult lead exposure is associated with longitudinal decline in cognitive function
    B S Schwartz
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Neurology 55:1144-50. 2000
    ..To determine whether adults with past exposure to neurotoxicants have progressive declines in cognitive function years after exposure has ceased, and whether tibia lead is a predictor of the magnitude of change...
  9. ncbi Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers
    B S Schwartz
    Division of Occupational and Environmental Health, Johns Hopkins School of Hygiene and Public Health, 615 North Wolfe St, Room 7041, Baltimore, MD 21205, USA
    Am J Epidemiol 153:453-64. 2001
    ..In these currently exposed workers, blood lead was a better predictor of neurobehavioral performance than was tibia or DMSA-chelatable lead, mainly in the domains of executive abilities, manual dexterity, and peripheral motor strength...
  10. ncbi Environmental lead exposure and cognitive function in community-dwelling older adults
    R A Shih
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 67:1556-62. 2006
    ..A portion of age-related decrements in cognitive function in this population may be associated with earlier lead exposure...
  11. ncbi Clinical evaluation of 58 organolead manufacturing workers
    C S Mitchell
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Occup Environ Med 38:372-8. 1996
    ..The clinical presentation and evaluation of workers exposed to organic lead are discussed...
  12. ncbi Simple visual reaction time in organolead manufacturing workers: comparison of different methods of modeling lead exposure and reaction time
    J M Balbus
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA
    Am J Ind Med 32:544-9. 1997
    ..e., blood lead level) than with cumulative measures (i.e., cumulative exposure). Future studies using SVRT should consider parameters of SVRT that have not been commonly used to date, such as the standard deviation of the SVRT...
  13. ncbi Blood mercury levels and neurobehavioral function
    Megan Weil
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    JAMA 293:1875-82. 2005
    ..However, this fast-growing population is at increased risk of cognitive impairment and may be particularly sensitive to methylmercury, a neurotoxicant found in fish...
  14. ncbi Neighborhood psychosocial hazards and the association of cumulative lead dose with cognitive function in older adults
    Thomas A Glass
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 169:683-92. 2009
    ..067; executive functioning, P = 0.025). The joint occurrence of environmental stress and lead exposure across the life span may partially explain persistent racial/ethnic and socioeconomic disparities in cognitive function in late life...
  15. ncbi Are brain volumes based on magnetic resonance imaging mediators of the associations of cumulative lead dose with cognitive function?
    Brian Caffo
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 167:429-37. 2008
    ..The approach to evaluating volumetric mediation may have general applicability in epidemiologic neuroimaging settings...
  16. ncbi Gender differences in neurocognitive functioning among alcohol-dependent Russian patients
    Barbara Flannery
    RTI International, Baltimore, Maryland 21224, USA
    Alcohol Clin Exp Res 31:745-54. 2007
    ....
  17. ncbi Neural substrates of decision making in adults with attention deficit hyperactivity disorder
    Monique Ernst
    Intramural Research Program, NIMH, Natioanl Institute on Drug Abuse, Baltimore, MD, USA
    Am J Psychiatry 160:1061-70. 2003
    ..The study examined reward responsivity in ADHD by comparing the neural correlates of decision making in adults with childhood-onset ADHD and in healthy adults...
  18. ncbi Neurological assessments of marijuana users
    Jean Lud Cadet
    Molecular Neuropsychiatry Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Med 123:255-68. 2006
    ..These neurological approaches have allowed the detection of various neurological and neurovascular deficits that are associated with the abuse of marijuana...
  19. ncbi The differential relationship between cocaine use and marijuana use on decision-making performance over repeat testing with the Iowa Gambling Task
    Antonio Verdejo Garcia
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica, 08003 Barcelona, Spain
    Drug Alcohol Depend 90:2-11. 2007
    ..Differential correlates of cocaine use and MJ use on decision-making learning may have important implications for the development of novel treatment interventions...
  20. ncbi Abnormal brain activity in prefrontal brain regions in abstinent marijuana users
    Dana A Eldreth
    Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Neuroimage 23:914-20. 2004
    ..These differences in brain activity may be a common denominator in the evolution of maladaptive behaviors such as substance abuse and other neuropsychiatric disorders...
  21. ncbi Frontal cortical tissue composition in abstinent cocaine abusers: a magnetic resonance imaging study
    John A Matochik
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuroimage 19:1095-102. 2003
    ..These results extend our previous findings of defective frontal cortical activation (indexed by cerebral blood flow) in cocaine abusers to include abnormalities in gray matter tissue density in the same frontal cortical regions...
  22. ncbi Homocysteine and cognitive function in a population-based study of older adults
    Jyme H Schafer
    Department of Environmental Health Sciences, Division of Occupational and Environmental Health, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Geriatr Soc 53:381-8. 2005
    ..The data suggest that homocysteine may be a potentially important modifiable cause of cognitive dysfunction...
  23. ncbi Altered brain tissue composition in heavy marijuana users
    John A Matochik
    Intramural Research Program, Neuroimaging Research Branch, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 77:23-30. 2005
    ..045). Our preliminary results suggest evidence of possible structural differences in the brain of heavy marijuana users, and localize regions for further investigation of the effects of marijuana in the brain...
  24. ncbi Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adults
    Brian K Lee
    Division of Occupational and Environmental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Psychiatry 165:1456-64. 2008
    ..Background: Elevated cortisol indicates stress and may be a risk factor for cognitive decline in aging. Genetic factors may influence individual vulnerability to the adverse effects of stress on cognitive function in aging...
  25. ncbi Disparities in cognitive functioning by race/ethnicity in the Baltimore Memory Study
    Brian S Schwartz
    Department of Environmental Health Sciences, Division of Occupational and Environmental Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Environ Health Perspect 112:314-20. 2004
    ....
  26. ncbi Associations of salivary cortisol with cognitive function in the Baltimore memory study
    Brian K Lee
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 64:810-8. 2007
    ..Previous studies have concluded that an elevated level of cortisol is a risk factor for cognitive dysfunction and decline in aging but have been limited by sex exclusion, restricted cognitive batteries, and small sample sizes...
  27. ncbi Relations of brain volumes with cognitive function in males 45 years and older with past lead exposure
    Brian S Schwartz
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neuroimage 37:633-41. 2007
    ..In this cohort, an interesting group in which to examine structure-function relations, this finding provides a necessary condition to support the hypothesis that lead may influence cognitive function by its effect on brain volumes...
  28. ncbi Neurocognitive characterizations of Russian heroin addicts without a significant history of other drug use
    Diana H Fishbein
    Transdisciplinary Behavioral Science Program, RTI International, Baltimore, MD 21224, USA
    Drug Alcohol Depend 90:25-38. 2007
    ..Because the nature and degree of recovery from drug abuse are likely a function of the type or pattern of neurocognitive impairment, differential drug effects must be considered...
  29. ncbi Comparison of patella lead with blood lead and tibia lead and their associations with neurobehavioral test scores
    Carrie D Dorsey
    Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Occup Environ Med 48:489-96. 2006
    ..CONCLUSIONS: In this study, measurement of patella lead did not aid causal inference regarding cognitive effects when compared with blood lead and tibia lead...
  30. ncbi Protein kinase C activity and the relations between blood lead and neurobehavioral function in lead workers
    Kyu-Yoon Hwang
    Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Environ Health Perspect 110:133-8. 2002
    ..We hypothesize that subjects with higher PKC activity in the presence of lead may be more susceptible to the health effects of lead...

Research Grants1

  1. Sleep Disturbance in Marijuana Withdrawal
    Karen Bolla; Fiscal Year: 2004
    ..New treatments for alleviating the unpleasant symptoms of marijuana withdrawal would likely increase the number of heavy marijuana users who successfully complete treatment. ..