Bruce Bochner

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Leukocyte-blood vessel interactions
    Kelly L Davenpeck
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Allergy Immunol 16:125-41. 2002
  2. ncbi Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis
    Esra Nutku
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Blood 101:5014-20. 2003
  3. ncbi Allergy and asthma
    Bruce S Bochner
    Johns Hopkins University, Baltimore, MD, USA
    J Allergy Clin Immunol 115:953-9. 2005
  4. ncbi Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury
    Esra Nutku
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biochem Biophys Res Commun 336:918-24. 2005
  5. pmc Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways
    Esra Nutku-Bilir
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:121-4. 2008
  6. pmc Glycomic analysis of human mast cells, eosinophils and basophils
    Simon J North
    Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK
    Glycobiology 22:12-22. 2012
  7. pmc Eosinophil survival and apoptosis in health and disease
    Yong Mean Park
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Allergy Asthma Immunol Res 2:87-101. 2010
  8. pmc Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen
    Hui Mao
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e68143. 2013
  9. doi Advances in mechanisms of allergy and clinical immunology in 2012
    Bruce S Bochner
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 131:661-7. 2013
  10. pmc Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD)
    Bruce S Bochner
    Cosner Scholar in Translational Research, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6821, USA
    J Allergy Clin Immunol 130:587-96. 2012

Collaborators

Detail Information

Publications45

  1. ncbi Leukocyte-blood vessel interactions
    Kelly L Davenpeck
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Allergy Immunol 16:125-41. 2002
  2. ncbi Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis
    Esra Nutku
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Blood 101:5014-20. 2003
    ..Siglec-8 activation may provide a useful therapeutic approach to reduce numbers of eosinophils (and perhaps basophils and mast cells) in disease states where these cells are important...
  3. ncbi Allergy and asthma
    Bruce S Bochner
    Johns Hopkins University, Baltimore, MD, USA
    J Allergy Clin Immunol 115:953-9. 2005
    ..In this review key findings published in 2004 issues of the Journal of Allergy and Clinical Immunology are highlighted to demonstrate recent advances in these areas...
  4. ncbi Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury
    Esra Nutku
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biochem Biophys Res Commun 336:918-24. 2005
    ..These experiments show that Siglec-8-induced apoptosis occurs through the sequential production of ROS, followed by induction of mitochondrial injury and caspase cleavage...
  5. pmc Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways
    Esra Nutku-Bilir
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:121-4. 2008
    ....
  6. pmc Glycomic analysis of human mast cells, eosinophils and basophils
    Simon J North
    Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK
    Glycobiology 22:12-22. 2012
    ..g. lectins) have the possibility to dictate cellular functions, and might thus have important implications for the pathogenesis of inflammatory and allergic diseases...
  7. pmc Eosinophil survival and apoptosis in health and disease
    Yong Mean Park
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Allergy Asthma Immunol Res 2:87-101. 2010
    ..Ultimately, the control of eosinophil apoptosis may someday become another therapeutic strategy for treating allergic diseases and other eosinophil-associated disorders...
  8. pmc Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen
    Hui Mao
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e68143. 2013
    ..Given that Siglec-F-induced apoptosis is much less robust than Siglec-8-induced apoptosis, we hypothesized that mechanisms involved in cell death via these receptors would differ...
  9. doi Advances in mechanisms of allergy and clinical immunology in 2012
    Bruce S Bochner
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 131:661-7. 2013
    ..The highlights of these studies and their potential clinical implications are summarized in this review...
  10. pmc Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD)
    Bruce S Bochner
    Cosner Scholar in Translational Research, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6821, USA
    J Allergy Clin Immunol 130:587-96. 2012
    ..The pathophysiologic roles that eosinophils may serve in other human "eosinophil-associated" diseases remain obscure...
  11. ncbi Adhesion molecules as therapeutic targets
    Bruce S Bochner
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Room 2B71, Baltimore, MD 21224 6801, USA
    Immunol Allergy Clin North Am 24:615-30, vi. 2004
    ..Examples of specific adhesion-molecule antagonists are provided, and results of their use in human studies of allergic and other inflammatory conditions are discussed...
  12. ncbi Glycan array screening reveals a candidate ligand for Siglec-8
    Bruce S Bochner
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 280:4307-12. 2005
    ..We conclude that Siglec-8 binds preferentially to the sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl...
  13. pmc What targeting eosinophils has taught us about their role in diseases
    Bruce S Bochner
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 126:16-25; quiz 26-7. 2010
    ..This review summarizes what has been learned in vivo in both preclinical and clinical studies of eosinophil-directed therapies, with an emphasis on recent advances...
  14. ncbi Mast cells, basophils, and eosinophils: distinct but overlapping pathways for recruitment
    B S Bochner
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Immunol Rev 179:5-15. 2001
    ..Both shared and selective expression of these molecules will be highlighted, as well as differences in their relative levels of expression. Cell type-specific stimuli that alter adhesion and migration responses will also be considered...
  15. pmc Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x
    Sherry A Hudson
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 330:608-12. 2009
    ..These data demonstrate that a soluble, multivalent glycan selectively binds to human eosinophils and induces their apoptosis in vitro and provide proof-of-concept that such a reagent could be used to selectively target eosinophils...
  16. pmc Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors
    B S Bochner
    Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6821, USA
    Clin Exp Allergy 39:317-24. 2009
    ....
  17. doi Advances in mechanisms of asthma, allergy, and immunology in 2011
    Joshua A Boyce
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 129:335-41. 2012
    ..Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review...
  18. pmc Advances in mechanisms of asthma, allergy, and immunology in 2008
    Joshua A Boyce
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass, USA
    J Allergy Clin Immunol 123:569-74. 2009
    ..Articles from other journals have been included to supplement the topics presented...
  19. ncbi Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement
    Hidenori Yokoi
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, and the Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 121:499-505.e1. 2008
    ..On eosinophils, Siglec-8 engagement induces apoptosis, but its function on mast cells is unknown...
  20. pmc Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
    Pei Song Gao
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Eur J Hum Genet 18:713-9. 2010
    ..However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma...
  21. ncbi Advances in mechanisms of allergy
    Bruce S Bochner
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Room 2B 71, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 113:868-75. 2004
    ..When appropriate, articles from other journals have been included to supplement the topics being presented...
  22. ncbi Verdict in the case of therapies versus eosinophils: the jury is still out
    Bruce S Bochner
    Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 113:3-9; quiz 10. 2004
    ..The known and theoretic benefits and risks of these strategies will also be covered...
  23. ncbi Advances in mechanisms of allergy
    Bruce S Bochner
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 111:S819-23. 2003
    ..When appropriate, articles from other journals have been included to supplement the topics being presented...
  24. ncbi Cross-talk between integrins and chemokines that influences eosinophil adhesion and migration
    Hiroshi Tachimoto
    Department of Medicine, Division of Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int Arch Allergy Immunol 128:18-20. 2002
  25. ncbi Introduction: anti-IgE
    Bruce Bochner
    Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, USA
    Clin Rev Allergy Immunol 29:1-2. 2005
  26. ncbi Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G)
    Hideyuki Aizawa
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Genomics 82:521-30. 2003
    ....
  27. ncbi Eotaxin-2 alters eosinophil integrin function via mitogen-activated protein kinases
    Hiroshi Tachimoto
    Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 26:645-9. 2002
    ..These data suggest that eotaxin-2, acting via MAP kinases, may facilitate eosinophil recruitment at sites of allergic inflammation by shifting their adhesion molecule usage away from VCAM-1-dominated to ICAM-1-dominated pathways...
  28. pmc Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge
    John A Eckman
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 125:889-895.e7. 2010
    ..Omalizumab treatment suppresses FcepsilonRI expression faster on blood basophils than skin mast cells...
  29. ncbi Basic and clinical immunology of Siglecs
    Stephan von Gunten
    Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224 6821, USA
    Ann N Y Acad Sci 1143:61-82. 2008
    ..Potential clinical and therapeutic implications of each Siglec will also be covered...
  30. ncbi CD8+ T lymphocytes in viral hyperreactivity and M2 muscarinic receptor dysfunction
    Darryl J Adamko
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 167:550-6. 2003
    ..In contrast, CD8+ T cells are not necessary for virus-induced hyperreactivity and M2R dysfunction in nonsensitized guinea pigs...
  31. ncbi Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow
    Owen J T McCarty
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 2694, USA
    Am J Physiol Cell Physiol 284:C1223-34. 2003
    ..These studies provide insights for designing strategies based on blocking of eosinophil-platelet interactions to combat thrombotic disorders in hypereosinophilic patients...
  32. ncbi Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge
    Michael Y Viksman
    Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6801, USA
    Clin Immunol 104:77-85. 2002
    ..The different results obtained with the two challenge methods probably depend on higher local concentrations of allergen in the EB challenge. We suggest that activation of AM occurs following EB challenge with antigen in asthmatics...
  33. ncbi Phorbol esters alter alpha4 and alphad integrin usage during eosinophil adhesion to VCAM-1
    Matsuo Kikuchi
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Cell Commun Adhes 10:119-28. 2003
    ..Thus, PMA alters eosinophil integrin expression and the relative contributions of alpha4 and alphad integrins during attachment to VCAM-1...
  34. pmc Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs
    Jin P Guo
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 44:238-43. 2011
    ..St3gal3, but not St3gal2, is required for constitutive Siglec-F ligand synthesis. The survival of eosinophils entering the lung may be shortened by encountering these Siglec-F sialoside ligands...
  35. ncbi Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells
    Shin Kurosawa
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 28:563-73. 2003
    ..These results demonstrate that airway epithelial cells express the costimulatory molecule B7-H2, and suggest the possibility that B7-H2 may participate in antigen presentation by epithelial cells...
  36. ncbi Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions
    Bruce S Bochner
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 112:930-4. 2003
    ..The mechanisms responsible for their selective recruitment remain unknown, but T(H)(2) cells preferentially express the chemokine receptors CCR4 and CCR8...
  37. pmc E-selectin receptors on human leukocytes
    Leonardo Nimrichter
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Blood 112:3744-52. 2008
    ....
  38. ncbi Stimulation of human endothelium with IL-3 induces selective basophil accumulation in vitro
    Lina H K Lim
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Immunol 176:5346-53. 2006
    ..These data provide novel insights into how IL-3, acting directly on endothelium, can cause basophils to preferentially interact with blood vessels under physiological flow conditions and be selectively recruited to sites of inflammation...
  39. pmc Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass
    Stephan von Gunten
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6821, USA
    J Allergy Clin Immunol 123:1268-76.e15. 2009
    ..Specificities for carbohydrate IgG antibodies, thought to be predominantly of the IgG2 subclass, have never been broadly examined in healthy human subjects...
  40. pmc Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disorders
    Steven J Ackerman
    Department of Biochemistry and Molecular Genetics M C 669, Molecular Biology Research Building, Rm 2074, 900 S Ashland Avenue, The University of Illinois at Chicago College of Medicine, Chicago, IL 60607, USA
    Immunol Allergy Clin North Am 27:357-75. 2007
    ....
  41. ncbi Risk assessment in anaphylaxis: current and future approaches
    F Estelle R Simons
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada, and Department of Respiratory Medicine, Brighton General Hospital, Belfast, UK
    J Allergy Clin Immunol 120:S2-24. 2007
    ....
  42. doi The effect of etanercept on the human cutaneous allergic response
    Ed Conner
    J Allergy Clin Immunol 121:258-60. 2008
  43. doi Induction of apoptosis in human basophils by anti-Fas antibody treatment in vitro
    Kenji Matsumoto
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Arch Allergy Immunol 146:40-6. 2008
    ..In the present study, the expression and function of Fas in human basophils were investigated in vitro...
  44. ncbi Human eosinophils express two Siglec-8 splice variants
    Hideyuki Aizawa
    J Allergy Clin Immunol 109:176. 2002

Research Grants21

  1. Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In Vivo
    Bruce S Bochner; Fiscal Year: 2010
    ..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..
  2. Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In Vivo
    Bruce S Bochner; Fiscal Year: 2010
    ..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..
  3. Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In Vivo
    Bruce Bochner; Fiscal Year: 2009
    ..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..
  4. Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In Vivo
    Bruce Bochner; Fiscal Year: 2007
    ..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..
  5. Adhesion Molecule Biology in Allergic Cells
    Bruce Bochner; Fiscal Year: 2007
    ..abstract_text> ..
  6. Adhesion Molecule Biology in Allergic Cells
    Bruce Bochner; Fiscal Year: 2006
    ..abstract_text> ..
  7. Tissue-Specific Mechanisms of Allergic Inflammation
    Bruce Bochner; Fiscal Year: 2004
    ..We expect that the results of these studies will be of great relevance to human disease pathogenesis and the development of new therapeutics. ..
  8. Adhesion Molecule Biology in Allergic Cells
    Bruce Bochner; Fiscal Year: 2003
    ..Activation via Siglec-8 could potentially be used to inhibit eosinophil, basophil and mast cell function and survival in vivo, providing a novel strategy for reducing or inhibiting these cells in allergic and other diseases. ..
  9. GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTES
    Bruce Bochner; Fiscal Year: 2003
    ..Knowledge gained from these studies will advance the design of improved anti-inflammatory drugs, and our understanding of the physiological roles of glycosphingolipids in leukocyte adhesion. ..
  10. INTEGRINS AND CHEMOKINES IN ALLERGIC CELL RECRUITMENT
    Bruce Bochner; Fiscal Year: 2002
    ..The investigators believe that the combined use of both in vitro and in vivo models uniquely positions them to assess the relevance of cellular and molecular processes to human allergic diseases of the airways. ..
  11. INTEGRINS AND CHEMOKINES IN ALLERGIC CELL RECRUITMENT
    Bruce Bochner; Fiscal Year: 1999
    ..The investigators believe that the combined use of both in vitro and in vivo models uniquely positions them to assess the relevance of cellular and molecular processes to human allergic diseases of the airways. ..
  12. GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTES
    Bruce Bochner; Fiscal Year: 2002
    ..Knowledge gained from these studies will advance the design of improved anti-inflammatory drugs, and our understanding of the physiological roles of glycosphingolipids in leukocyte adhesion. ..
  13. INTEGRINS AND CHEMOKINES IN ALLERGIC CELL RECRUITMENT
    Bruce Bochner; Fiscal Year: 2001
    ..The investigators believe that the combined use of both in vitro and in vivo models uniquely positions them to assess the relevance of cellular and molecular processes to human allergic diseases of the airways. ..
  14. GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTES
    Bruce Bochner; Fiscal Year: 2000
    ..Knowledge gained from these studies will advance the design of improved anti-inflammatory drugs, and our understanding of the physiological roles of glycosphingolipids in leukocyte adhesion. ..
  15. INTEGRINS AND CHEMOKINES IN ALLERGIC CELL RECRUITMENT
    Bruce Bochner; Fiscal Year: 2000
    ..The investigators believe that the combined use of both in vitro and in vivo models uniquely positions them to assess the relevance of cellular and molecular processes to human allergic diseases of the airways. ..
  16. GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTES
    Bruce Bochner; Fiscal Year: 2001
    ..Knowledge gained from these studies will advance the design of improved anti-inflammatory drugs, and our understanding of the physiological roles of glycosphingolipids in leukocyte adhesion. ..