Research Topics
| Bruce BochnerSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Leukocyte-blood vessel interactionsKelly L Davenpeck
Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Clin Allergy Immunol 16:125-41. 2002- Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosisEsra Nutku
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Blood 101:5014-20. 2003..Siglec-8 activation may provide a useful therapeutic approach to reduce numbers of eosinophils (and perhaps basophils and mast cells) in disease states where these cells are important... - Allergy and asthmaBruce S Bochner
Johns Hopkins University, Baltimore, MD, USA
J Allergy Clin Immunol 115:953-9. 2005..In this review key findings published in 2004 issues of the Journal of Allergy and Clinical Immunology are highlighted to demonstrate recent advances in these areas... - Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injuryEsra Nutku
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Biochem Biophys Res Commun 336:918-24. 2005..These experiments show that Siglec-8-induced apoptosis occurs through the sequential production of ROS, followed by induction of mitochondrial injury and caspase cleavage... 
Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathwaysEsra Nutku-Bilir
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 38:121-4. 2008....- Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD)Bruce S Bochner
Cosner Scholar in Translational Research, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6821, USA
J Allergy Clin Immunol 130:587-96. 2012..The pathophysiologic roles that eosinophils may serve in other human "eosinophil-associated" diseases remain obscure... - What targeting eosinophils has taught us about their role in diseasesBruce S Bochner
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 126:16-25; quiz 26-7. 2010..This review summarizes what has been learned in vivo in both preclinical and clinical studies of eosinophil-directed therapies, with an emphasis on recent advances... - Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis xSherry A Hudson
Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Pharmacol Exp Ther 330:608-12. 2009..These data demonstrate that a soluble, multivalent glycan selectively binds to human eosinophils and induces their apoptosis in vitro and provide proof-of-concept that such a reagent could be used to selectively target eosinophils... - Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptorsB S Bochner
Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 6821, USA
Clin Exp Allergy 39:317-24. 2009.... - Mast cells, basophils, and eosinophils: distinct but overlapping pathways for recruitmentB S Bochner
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Immunol Rev 179:5-15. 2001..Both shared and selective expression of these molecules will be highlighted, as well as differences in their relative levels of expression. Cell type-specific stimuli that alter adhesion and migration responses will also be considered... - Glycan array screening reveals a candidate ligand for Siglec-8Bruce S Bochner
Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Biol Chem 280:4307-12. 2005..We conclude that Siglec-8 binds preferentially to the sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl... - Adhesion molecules as therapeutic targetsBruce S Bochner
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Room 2B71, Baltimore, MD 21224 6801, USA
Immunol Allergy Clin North Am 24:615-30, vi. 2004..Examples of specific adhesion-molecule antagonists are provided, and results of their use in human studies of allergic and other inflammatory conditions are discussed... - Advances in mechanisms of asthma, allergy, and immunology in 2008Joshua A Boyce
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass, USA
J Allergy Clin Immunol 123:569-74. 2009..Articles from other journals have been included to supplement the topics presented... 
Advances in mechanisms of asthma, allergy, and immunology in 2011Joshua A Boyce
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Allergy Clin Immunol 129:335-41. 2012..Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review...- Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagementHidenori Yokoi
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, and the Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 121:499-505.e1. 2008..On eosinophils, Siglec-8 engagement induces apoptosis, but its function on mast cells is unknown... - Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthmaPei Song Gao
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Eur J Hum Genet 18:713-9. 2010..However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma... - Verdict in the case of therapies versus eosinophils: the jury is still outBruce S Bochner
Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 113:3-9; quiz 10. 2004..The known and theoretic benefits and risks of these strategies will also be covered... - Advances in mechanisms of allergyBruce S Bochner
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Room 2B.71, Baltimore, MD 21224-6801, USA
J Allergy Clin Immunol 113:868-75. 2004..When appropriate, articles from other journals have been included to supplement the topics being presented... - Cross-talk between integrins and chemokines that influences eosinophil adhesion and migrationHiroshi Tachimoto
Department of Medicine, Division of Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int Arch Allergy Immunol 128:18-20. 2002 - Advances in mechanisms of allergyBruce S Bochner
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 111:S819-23. 2003..When appropriate, articles from other journals have been included to supplement the topics being presented... - Introduction: anti-IgEBruce Bochner
Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, USA
Clin Rev Allergy Immunol 29:1-2. 2005 - Eotaxin-2 alters eosinophil integrin function via mitogen-activated protein kinasesHiroshi Tachimoto
Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Respir Cell Mol Biol 26:645-9. 2002..These data suggest that eotaxin-2, acting via MAP kinases, may facilitate eosinophil recruitment at sites of allergic inflammation by shifting their adhesion molecule usage away from VCAM-1-dominated to ICAM-1-dominated pathways... - Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G)Hideyuki Aizawa
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
Genomics 82:521-30. 2003.... - Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challengeJohn A Eckman
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Allergy Clin Immunol 125:889-895.e7. 2010..Omalizumab treatment suppresses FcepsilonRI expression faster on blood basophils than skin mast cells... - Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challengeMichael Y Viksman
Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224-6801, USA
Clin Immunol 104:77-85. 2002..The different results obtained with the two challenge methods probably depend on higher local concentrations of allergen in the EB challenge. We suggest that activation of AM occurs following EB challenge with antigen in asthmatics... - Basic and clinical immunology of SiglecsStephan von Gunten
Department of Medicine, Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224 6821, USA
Ann N Y Acad Sci 1143:61-82. 2008..Potential clinical and therapeutic implications of each Siglec will also be covered... - Phorbol esters alter alpha4 and alphad integrin usage during eosinophil adhesion to VCAM-1Matsuo Kikuchi
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Cell Commun Adhes 10:119-28. 2003..Thus, PMA alters eosinophil integrin expression and the relative contributions of alpha4 and alphad integrins during attachment to VCAM-1... - Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flowOwen J T McCarty
Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 2694, USA
Am J Physiol Cell Physiol 284:C1223-34. 2003..These studies provide insights for designing strategies based on blocking of eosinophil-platelet interactions to combat thrombotic disorders in hypereosinophilic patients... - CD8+ T lymphocytes in viral hyperreactivity and M2 muscarinic receptor dysfunctionDarryl J Adamko
Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21224, USA
Am J Respir Crit Care Med 167:550-6. 2003..In contrast, CD8+ T cells are not necessary for virus-induced hyperreactivity and M2R dysfunction in nonsensitized guinea pigs... - Characterization of expression of glycan ligands for Siglec-F in normal mouse lungsJin P Guo
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 44:238-43. 2011..St3gal3, but not St3gal2, is required for constitutive Siglec-F ligand synthesis. The survival of eosinophils entering the lung may be shortened by encountering these Siglec-F sialoside ligands... - Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cellsShin Kurosawa
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
Am J Respir Cell Mol Biol 28:563-73. 2003..These results demonstrate that airway epithelial cells express the costimulatory molecule B7-H2, and suggest the possibility that B7-H2 may participate in antigen presentation by epithelial cells... - E-selectin receptors on human leukocytesLeonardo Nimrichter
Department of Pharmacology and Molecular Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Blood 112:3744-52. 2008.... - Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactionsBruce S Bochner
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Allergy Clin Immunol 112:930-4. 2003..Given the preferential accumulation of TH2 cells at these antigen-challenged sites, the increased production of CCR4-active chemokines might contribute to this response... - Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclassStephan von Gunten
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6821, USA
J Allergy Clin Immunol 123:1268-76.e15. 2009..Specificities for carbohydrate IgG antibodies, thought to be predominantly of the IgG2 subclass, have never been broadly examined in healthy human subjects... - Stimulation of human endothelium with IL-3 induces selective basophil accumulation in vitroLina H K Lim
Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Immunol 176:5346-53. 2006..These data provide novel insights into how IL-3, acting directly on endothelium, can cause basophils to preferentially interact with blood vessels under physiological flow conditions and be selectively recruited to sites of inflammation... - Risk assessment in anaphylaxis: current and future approachesF Estelle R Simons
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada, and Department of Respiratory Medicine, Brighton General Hospital, Belfast, UK
J Allergy Clin Immunol 120:S2-24. 2007.... - Human eosinophils express two Siglec-8 splice variantsHideyuki Aizawa
J Allergy Clin Immunol 109:176. 2002 - Mechanisms of eosinophilia in the pathogenesis of hypereosinophilic disordersSteven J Ackerman
Department of Biochemistry and Molecular Genetics M C 669, Molecular Biology Research Building, Rm 2074, 900 S Ashland Avenue, The University of Illinois at Chicago College of Medicine, Chicago, IL 60607, USA
Immunol Allergy Clin North Am 27:357-75. 2007.... - Induction of apoptosis in human basophils by anti-Fas antibody treatment in vitroKenji Matsumoto
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
Int Arch Allergy Immunol 146:40-6. 2008..In the present study, the expression and function of Fas in human basophils were investigated in vitro... - The effect of etanercept on the human cutaneous allergic responseEd Conner
J Allergy Clin Immunol 121:258-60. 2008
Research Grants
- Adhesion Molecule Biology in Allergic CellsBruce Bochner; Fiscal Year: 2006..abstract_text> ..
- Adhesion Molecule Biology in Allergic CellsBruce Bochner; Fiscal Year: 2007..abstract_text> ..
- Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In VivoBruce Bochner; Fiscal Year: 2007..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..
- Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In VivoBruce Bochner; Fiscal Year: 2009..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..
- Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In VivoBruce S Bochner; Fiscal Year: 2010..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..
- Tissue-Specific Mechanisms of Allergic InflammationBruce Bochner; Fiscal Year: 2004..We expect that the results of these studies will be of great relevance to human disease pathogenesis and the development of new therapeutics. ..
- Adhesion Molecule Biology in Allergic CellsBruce Bochner; Fiscal Year: 2003..Activation via Siglec-8 could potentially be used to inhibit eosinophil, basophil and mast cell function and survival in vivo, providing a novel strategy for reducing or inhibiting these cells in allergic and other diseases. ..
- INTEGRINS AND CHEMOKINES IN ALLERGIC CELL RECRUITMENTBruce Bochner; Fiscal Year: 2002..The investigators believe that the combined use of both in vitro and in vivo models uniquely positions them to assess the relevance of cellular and molecular processes to human allergic diseases of the airways. ..
- GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTESBruce Bochner; Fiscal Year: 2003..Knowledge gained from these studies will advance the design of improved anti-inflammatory drugs, and our understanding of the physiological roles of glycosphingolipids in leukocyte adhesion. ..
- Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In VivoBruce S Bochner; Fiscal Year: 2010..Our proposed work on Siglec-8/Siglec-F should identify new therapeutic approaches for the treatment of diseases characterized by increased numbers of, or mediators from, eosinophils, basophils and mast cells. ..