R S Blumenthal

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis
    Jon T Giles
    Department of Medicine, The Johns Hopkins University, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Arthritis Res Ther 11:R36. 2009
  2. ncbi request reprint Detecting occult coronary disease in a high-risk asymptomatic population
    Roger S Blumenthal
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 107:702-7. 2003
  3. ncbi request reprint Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality
    Y Cui
    Director, Ciccarone Heart Center, The Johns Hopkins University, 600 W Wolfe St, Carnegie 538, Baltimore, MD 21287, USA
    Arch Intern Med 161:1413-9. 2001
  4. ncbi request reprint Cardiovascular effects of raloxifene: the arterial and venous systems
    Roger S Blumenthal
    The John Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Baltimore, MD 21287, USA
    Am Heart J 147:783-9. 2004
  5. ncbi request reprint Medical therapy versus coronary angioplasty in stable coronary artery disease: a critical review of the literature
    R S Blumenthal
    Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 36:668-73. 2000
  6. ncbi request reprint Statins: effective antiatherosclerotic therapy
    R S Blumenthal
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 139:577-83. 2000
  7. ncbi request reprint Diabetes and progression of coronary calcium under the influence of statin therapy
    Matthew J Budoff
    Division of Cardiology, Harbor UCLA Medical Center Research and Education Institute, Torrance, Calif 90502, USA
    Am Heart J 149:695-700. 2005
  8. ncbi request reprint Hypertension among siblings of persons with premature coronary heart disease
    L R Yanek
    Center for Health Promotion, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Hypertension 32:123-8. 1998
  9. ncbi request reprint Nurse-mediated cholesterol management compared with enhanced primary care in siblings of individuals with premature coronary disease
    D M Becker
    Center for Health Promotion, Johns Hopkins University, Baltimore, MD 21205, USA
    Arch Intern Med 158:1533-9. 1998
  10. pmc The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences
    Venkata Narla
    The Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Vasc Health Risk Manag 5:1033-42. 2009

Detail Information

Publications97

  1. pmc Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis
    Jon T Giles
    Department of Medicine, The Johns Hopkins University, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Arthritis Res Ther 11:R36. 2009
    ..Although cardiovascular morbidity and mortality are increased in rheumatoid arthritis, little is known about the burden of subclinical coronary atherosclerosis in these patients...
  2. ncbi request reprint Detecting occult coronary disease in a high-risk asymptomatic population
    Roger S Blumenthal
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 107:702-7. 2003
    ..In asymptomatic individuals with a family history of premature CAD, it is unclear whether abnormalities on these functional exercise tests represent significant coronary disease...
  3. ncbi request reprint Non-high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality
    Y Cui
    Director, Ciccarone Heart Center, The Johns Hopkins University, 600 W Wolfe St, Carnegie 538, Baltimore, MD 21287, USA
    Arch Intern Med 161:1413-9. 2001
    ..Therefore, non-HDL-C level may be as good a potential predictor of risk for cardiovascular disease (CVD) as low-density lipoprotein cholesterol (LDL-C)...
  4. ncbi request reprint Cardiovascular effects of raloxifene: the arterial and venous systems
    Roger S Blumenthal
    The John Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Baltimore, MD 21287, USA
    Am Heart J 147:783-9. 2004
    ..Cardiovascular disease caused by atherosclerosis is the largest single killer of women. Prior observational data had suggested that hormone therapy may have cardioprotective effects...
  5. ncbi request reprint Medical therapy versus coronary angioplasty in stable coronary artery disease: a critical review of the literature
    R S Blumenthal
    Division of Cardiology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 36:668-73. 2000
    ..Percutaneous revascularization without comprehensive risk factor modification is a suboptimal therapeutic strategy...
  6. ncbi request reprint Statins: effective antiatherosclerotic therapy
    R S Blumenthal
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 139:577-83. 2000
    ..Several large, controlled clinical trials have confirmed significant reductions in rates of coronary heart disease morbidity and death with long-term statin therapy in patients with mild to severe hypercholesterolemia...
  7. ncbi request reprint Diabetes and progression of coronary calcium under the influence of statin therapy
    Matthew J Budoff
    Division of Cardiology, Harbor UCLA Medical Center Research and Education Institute, Torrance, Calif 90502, USA
    Am Heart J 149:695-700. 2005
    ..We sought to evaluate the progression of atherosclerosis in asymptomatic persons with type 2 diabetes and measure the influence of statin therapy on CAC progression...
  8. ncbi request reprint Hypertension among siblings of persons with premature coronary heart disease
    L R Yanek
    Center for Health Promotion, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Hypertension 32:123-8. 1998
    ..These findings demonstrate the intersection of multiple risk factors among hypertensive siblings and emphasize the need for more aggressive screening and treatment in this easily identifiable high-risk population...
  9. ncbi request reprint Nurse-mediated cholesterol management compared with enhanced primary care in siblings of individuals with premature coronary disease
    D M Becker
    Center for Health Promotion, Johns Hopkins University, Baltimore, MD 21205, USA
    Arch Intern Med 158:1533-9. 1998
    ..Siblings of individuals with premature coronary heart disease have a high prevalence of low-density lipoprotein cholesterol (LDL-C) levels requiring treatment...
  10. pmc The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences
    Venkata Narla
    The Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Vasc Health Risk Manag 5:1033-42. 2009
    ..This review outlines the JUPITER and AURORA trials, interprets the data and significance of the results, analyses the drawbacks and impact of both trials and delineates the potential for further clinical trials...
  11. ncbi request reprint Ethnic differences of the presence and severity of coronary atherosclerosis
    Matthew J Budoff
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 W Carson Street, Bldg RB 2, Torrance, CA, USA
    Atherosclerosis 187:343-50. 2006
    ..The objective of the study is to assess the differences in the prevalence and severity of coronary artery calcification, as a measure of atherosclerosis, in these different ethnic groups...
  12. doi request reprint Gender differences in coronary plaque composition by coronary computed tomography angiography
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland, USA
    Coron Artery Dis 20:506-12. 2009
    ..Although males are thought to have a higher prevalence of atherosclerosis for a given age, there are currently few data regarding age-adjusted sex differences in plaque morphology and composition...
  13. ncbi request reprint Underlying risk factors incrementally add to the standard risk estimate in detecting subclinical atherosclerosis in low- and intermediate-risk middle-aged asymptomatic individuals
    Milind Y Desai
    Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am Heart J 148:871-7. 2004
    ..High burden of coronary artery calcification (CAC) on electron beam tomography (EBT) is a CHD risk equivalent...
  14. doi request reprint Association between coronary artery calcification progression and microalbuminuria: the MESA study
    Andrew P DeFilippis
    Division of Cardiology, The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland, USA
    JACC Cardiovasc Imaging 3:595-604. 2010
    ..This study sought to evaluate the relationship between microalbuminuria (MA) and the development and progression of atherosclerosis, as assessed by incident and progression of coronary artery calcification (CAC)...
  15. ncbi request reprint Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects
    Erin D Michos
    Ciccarone Preventative Cardiology Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 95:655-7. 2005
    ..Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of >/=2 metabolic RFs, magnifying the risks for those exposed to both...
  16. ncbi request reprint The metabolic syndrome adds incremental value to the Framingham risk score in identifying asymptomatic individuals with higher degrees of inflammation
    Catherine Y Campbell
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Cardiometab Syndr 3:7-11. 2008
    ..66; 95% CI, 1.39-5.07). The study findings suggest that MS adds value to the FRS in identifying those with higher degrees of inflammation, especially among those classified as low-risk by the FRS...
  17. ncbi request reprint The association of subclinical coronary atherosclerosis with abdominal and total obesity in asymptomatic men
    Khurram Nasir
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Prev Cardiol 8:143-8. 2005
    ..Our results are consistent with evidence that measures of central obesity, compared with body mass index, are more strongly related to clinical as well as subclinical coronary heart disease end points...
  18. ncbi request reprint Relation of degree of physical activity to coronary artery calcium score in asymptomatic individuals with multiple metabolic risk factors
    Milind Y Desai
    Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Cardiol 94:729-32. 2004
    ..Thus, asymptomatic patients who have > or =2 metabolic risk factors and who regularly engage in long-duration PA have a lower prevalence of CAC than do those who are sedentary or participate in moderate-duration PA...
  19. ncbi request reprint Coronary artery calcium volume scores on electron beam tomography in 12,936 asymptomatic adults
    Khurram Nasir
    Ciccarone Preventive Cardiology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Cardiol 93:1146-9. 2004
    ..The 2 scores increased as the number of atherosclerotic risk factors increased. The volume scores were statistically smaller than the Agatston scores at the upper quartile level...
  20. ncbi request reprint Association of body mass index, metabolic syndrome, and leukocyte count
    Milind Y Desai
    Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 97:835-8. 2006
    ..29, p = 0.42) and groups 3 and 4 (coefficient 0.25, p = 0.41). The association between obesity and leukocyte count was highly dependent on the presence of MS...
  21. ncbi request reprint Coronary artery calcification and family history of premature coronary heart disease: sibling history is more strongly associated than parental history
    Khurram Nasir
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circulation 110:2150-6. 2004
    ....
  22. ncbi request reprint Visualizing coronary calcium is associated with improvements in adherence to statin therapy
    Nove K Kalia
    Division of Cardiology, Harbor UCLA Medical Center, Research and Education Institute, Torrance, CA, USA
    Atherosclerosis 185:394-9. 2006
    ..We evaluated whether visualization of coronary calcium would positively affect patients' adherence rates...
  23. ncbi request reprint Reducing global risk for cardiovascular disease: using lifestyle changes and pharmacotherapy
    Alan Cheng
    The Ciccarone Center for Prevention of Heart Disease, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Clin Cardiol 25:205-12. 2002
    ..This review offers an evidence-based strategy toward reducing an individual's global risk for CVD by addressing the modifiable, major independent risk factors...
  24. ncbi request reprint Combined effect of high low-density lipoprotein cholesterol and metabolic syndrome on subclinical coronary atherosclerosis in white men without clinical evidence of myocardial ischemia
    Catherine Y Campbell
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 100:840-3. 2007
    ..In conclusion, these results suggest that the risk of CAC in asymptomatic men with moderate or high LDL cholesterol is magnified in persons with MS...
  25. ncbi request reprint ABCs of cardiovascular disease risk management
    J B Braunstein
    Ciccarone Center for Prevention of Heart Disease, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Carnegie 538, Baltimore, MD 21205, USA
    Cardiol Rev 9:96-105. 2001
    ....
  26. ncbi request reprint Plasma homocysteine predicts progression of atherosclerosis
    M Leila Rasouli
    Division of Cardiology, Harbor UCLA Medical Center Research and Education Institute, Torrance, CA 90502, USA
    Atherosclerosis 181:159-65. 2005
    ..8 mg/L) had a median yearly progression of 22%, compared to 21% for those with CRP value = 0.9-11 mg/L (p = ns). Presence of elevated HCY (>12 micromol/L) strongly and independently predicts progression of coronary plaque burden...
  27. pmc Cardiovascular events with absent or minimal coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Matthew J Budoff
    Division of Cardiology, Los Angeles Biomedical Research Center, Torrance, CA 90502, USA
    Am Heart J 158:554-61. 2009
    ..In this study, we sought to evaluate the characteristics associated with incident CHD events in the setting of minimal (score <or=10) or absent CAC (score of zero)...
  28. doi request reprint Relationship of carotid distensibility and thoracic aorta calcification: multi-ethnic study of atherosclerosis
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
    Hypertension 54:1408-15. 2009
    ..The prognostic significance of these findings requires longitudinal follow-up of the Multi-Ethnic Study of Atherosclerosis cohort...
  29. pmc Coronary calcium predicts events better with absolute calcium scores than age-sex-race/ethnicity percentiles: MESA (Multi-Ethnic Study of Atherosclerosis)
    Matthew J Budoff
    Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 90502, USA
    J Am Coll Cardiol 53:345-52. 2009
    ..In this study, we aimed to establish whether age-sex-specific percentiles of coronary artery calcium (CAC) predict cardiovascular outcomes better than the actual (absolute) CAC score...
  30. ncbi request reprint Comparison of coronary calcium and stress myocardial perfusion imaging in apparently healthy siblings of individuals with premature coronary artery disease
    Roger S Blumenthal
    The Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 97:328-33. 2006
    ..These screening tests may reflect different aspects or stages of coronary disease in an asymptomatic middle-age population...
  31. doi request reprint Association of traditional cardiovascular risk factors with coronary plaque sub-types assessed by 64-slice computed tomography angiography in a large cohort of asymptomatic subjects
    Juan J Rivera
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
    Atherosclerosis 206:451-7. 2009
    ..In this study, we investigate the relationship between traditional CV risk factors and the presence and extent of coronary plaque sub-types in a large group of asymptomatic individuals...
  32. doi request reprint Increased prevalence of carotid artery atherosclerosis in rheumatoid arthritis is artery-specific
    Hitomi Kobayashi
    Divisions of Rheumatology, Cardiology, and Immunogenetics, Department of Medicine, and Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    J Rheumatol 37:730-9. 2010
    ..We compared carotid intima-media thickness (IMT) of both the common carotid (CCA) and proximal internal carotid (bulb-ICA) arteries, and plaque prevalence, between RA and non-RA participants...
  33. doi request reprint Association of combinations of lipid parameters with carotid intima-media thickness and coronary artery calcium in the MESA (Multi-Ethnic Study of Atherosclerosis)
    Pathmaja Paramsothy
    Division of Cardiology, Department of Internal Medicine, University of Washington, Seattle, Washington 98104, USA
    J Am Coll Cardiol 56:1034-41. 2010
    ..The purpose of this study was to determine the association of combinations of lipid parameters with subclinical atherosclerosis...
  34. doi request reprint Coronary artery calcification and inflammation according to various metabolic syndrome definitions
    Venkata Narla
    Johns Hopkins University Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
    J Cardiometab Syndr 4:33-9. 2009
    ..69 (95% CI, 1.04-2.73), 1.84 (95% CI, 1.14-2.95), and 1.66 (95% CI, 1.05-2.62), respectively. MS is associated with increased subclinical atherosclerosis and inflammation irrespective of various definitions...
  35. ncbi request reprint Framingham risk equation underestimates subclinical atherosclerosis risk in asymptomatic women
    Erin D Michos
    Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Atherosclerosis 184:201-6. 2006
    ..However, the adequacy of FRE for identifying asymptomatic women with CAC is unknown...
  36. ncbi request reprint Utility of stress testing and coronary calcification measurement for detection of coronary artery disease in women
    Khurram Nasir
    Divisions of Cardiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Arch Intern Med 164:1610-20. 2004
    ..For high-risk symptomatic women, a more aggressive approach involving coronary angiography appears to be the preferred initial diagnostic strategy...
  37. ncbi request reprint The metabolic syndrome: what to treat, how to treat, what are the goals?
    Parin Parikh
    Johns Hopkins Ciccarone Preventive Cardiology Center, Division of Cardiology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Am Heart Hosp J 2:191-7. 2004
    ..Based on the current evidence, further emphasis should be placed on aggressive management of other metabolic risk factors such as high blood pressure and dyslipidemia...
  38. ncbi request reprint A practical and evidence-based approach to cardiovascular disease risk reduction
    Ty J Gluckman
    Ciccarone Preventive Cardiology Center, Cardiology Division, Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Arch Intern Med 164:1490-500. 2004
    ..We believe that if health care providers and patients use such a format, important lifestyle and pharmacologic options will more likely be addressed...
  39. doi request reprint Adjunctive lipid lowering therapy in the era of surrogate endpoints
    Michael G Silverman
    Division of Cardiology, Department of Medicine, The Johns Hopkins Ciccarone Preventive Cardiology Center, Johns Hopkins University, Baltimore, MD 21287, USA
    Cardiol Rev 19:17-22. 2011
    ..Three ongoing clinical outcomes trials evaluating niacin and ezetimibe in combination with statin will provide more definitive word regarding the safety and efficacy of these agents as adjunctive therapy...
  40. ncbi request reprint Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularization
    Edgar R Miller
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2233, USA
    Coron Artery Dis 14:163-9. 2003
    ..While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent of LDL-c levels remains to be established...
  41. doi request reprint Prevalence of low low-density lipoprotein cholesterol with elevated high sensitivity C-reactive protein in the U.S.: implications of the JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin) st
    Erin D Michos
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Am Coll Cardiol 53:931-5. 2009
    ..S. population...
  42. ncbi request reprint Hypertension care and control in underserved urban African American men: behavioral and physiologic outcomes at 36 months
    Martha N Hill
    Johns Hopkins University School of Nursing, Baltimore, Maryland 21205 2110, USA
    Am J Hypertens 16:906-13. 2003
    ..African American men with hypertension in low socioeconomic urban populations achieve poor rates of hypertension control and suffer early from its complications...
  43. doi request reprint Detection of occult coronary artery disease in asymptomatic individuals with diabetes mellitus using non-invasive cardiac angiography
    Juan J Rivera
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
    Atherosclerosis 203:442-8. 2009
    ....
  44. pmc The use of high-sensitivity assays for C-reactive protein in clinical practice
    Kiran Musunuru
    Johns Hopkins Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Nat Clin Pract Cardiovasc Med 5:621-35. 2008
    ..Data suggests that these high-sensitivity assays should be used in combination with measurements of LDL-cholesterol levels to assist risk stratification of selected patients for prevention of CVD...
  45. doi request reprint Effect of patient visualization of coronary calcium by electron beam computed tomography on changes in beneficial lifestyle behaviors
    Raza H Orakzai
    Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Am J Cardiol 101:999-1002. 2008
    ..In conclusion, in addition to risk stratification of asymptomatic individuals, determination of CAC may also improve utilization of ASA therapy and behavioral modification...
  46. doi request reprint A synergistic relationship of elevated low-density lipoprotein cholesterol levels and systolic blood pressure with coronary artery calcification
    Kiran Musunuru
    The Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Atherosclerosis 200:368-73. 2008
    ..038). The finding of an interaction between SBP and LDL-C relation to CAC in asymptomatic men support the response-to-injury model of atherogenesis...
  47. doi request reprint Relationship of thoracic aortic calcium to coronary calcium and its progression (from the Multi-Ethnic Study of Atherosclerosis [MESA])
    Juan J Rivera
    Division of Cardiology, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Am J Cardiol 103:1562-7. 2009
    ..25 to 30.18). In conclusion, TAC is associated with the incidence and progression of CAC. The detection of TAC may improve risk stratification efforts. Future clinical outcomes studies are needed to support such an approach...
  48. doi request reprint Favorable cardiovascular risk factor profile is associated with reduced prevalence of coronary artery calcification and inflammation in asymptomatic nondiabetic white men
    Erin D Michos
    Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Prev Cardiol 11:189-94. 2008
    ..70; P<.001). Our study supports the notion that a favorable CVD profile is associated with less underlying atherosclerosis and inflammation and further highlights the importance of primary prevention of CVRFs...
  49. ncbi request reprint High prevalence of target organ damage in young, African American inner-city men with hypertension
    Wendy S Post
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Clin Hypertens (Greenwich) 5:24-30. 2003
    ....
  50. pmc Abdominal adiposity in rheumatoid arthritis: association with cardiometabolic risk factors and disease characteristics
    Jon T Giles
    Johns Hopkins University, Baltimore, Maryland 21224, USA
    Arthritis Rheum 62:3173-82. 2010
    ..This study was undertaken to investigate how abdominal fat is distributed in rheumatoid arthritis (RA), and its RA-related determinants...
  51. doi request reprint Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale
    Muhammad Amer
    Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Cardiol Rev 18:204-12. 2010
    ..Until more evidence for safety via randomized trials is available, we recommend caution in prescribing COX-1 and 2 inhibitors for musculoskeletal disorders in patients with existing gastrointestinal or cardiovascular conditions...
  52. doi request reprint Variation in atherosclerotic plaque composition according to increasing coronary artery calcium scores on computed tomography angiography
    Khurram Nasir
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland, USA
    Int J Cardiovasc Imaging 26:923-32. 2010
    ..A higher CACS is more likely to be associated with heterogeneous coronary plaque (combination of calcified, non-calcified, and mixed plaques), and appears to be more strongly associated with a higher burden of mixed plaque...
  53. doi request reprint Coronary artery calcium in relation to initiation and continuation of cardiovascular preventive medications: The Multi-Ethnic Study of Atherosclerosis (MESA)
    Khurram Nasir
    Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Cardiovasc Qual Outcomes 3:228-35. 2010
    ....
  54. doi request reprint Relationship of aortic valve calcification with coronary artery calcium severity: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Khurram Nasir
    Division of Cardiology, Blalock 524 C, Johns Hopkins University, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Cardiovasc Comput Tomogr 4:41-6. 2010
    ..Aortic valve calcification (AVC) and atherosclerosis share causative and pathologic features...
  55. doi request reprint Noninvasive assessment of gender differences in coronary plaque composition with multidetector computed tomographic angiography
    Khurram Nasir
    Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 105:453-8. 2010
    ..Future studies are needed to elucidate whether these underlying differences in plaque composition might explain the reduced risk of cardiac events in women...
  56. pmc Left ventricular structure and function in patients with rheumatoid arthritis, as assessed by cardiac magnetic resonance imaging
    Jon T Giles
    Johns Hopkins University, Baltimore, Maryland 21224, USA
    Arthritis Rheum 62:940-51. 2010
    ..This study was undertaken to assess the factors associated with progression to heart failure in patients with RA...
  57. doi request reprint A practical "ABCDE" approach to the metabolic syndrome
    Michael J Blaha
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Blalock 524C, Division of Cardiology, 600 N Wolfe St, Baltimore, MD 21287, USA
    Mayo Clin Proc 83:932-41. 2008
    ..This ABCDE approach provides a practical and systematic framework for encouraging metabolic syndrome recognition and for implementing a comprehensive, evidence-based management plan for the reduction of cardiovascular risk...
  58. ncbi request reprint Prevalence of significant noncardiac findings on electron-beam computed tomography coronary artery calcium screening examinations
    Karen M Horton
    Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Circulation 106:532-4. 2002
    ..The purpose of this study was to determine the prevalence of significant noncardiac findings in a series of patients undergoing coronary artery calcification screening studies with EBCT scanning...
  59. ncbi request reprint A look at hypertension in young African-American men
    Pamela S Hall
    Johns Hopkins School of Nursing, Baltimore, MD, USA
    Nurse Pract 28:59-60. 2003
  60. ncbi request reprint Nurse case management of hypercholesterolemia in patients with coronary heart disease: results of a randomized clinical trial
    Jerilyn K Allen
    School of Nursing, Johns Hopkins University, Baltimore, MD 21205 2110, USA
    Am Heart J 144:678-86. 2002
    ..This study tested the effectiveness of a nurse case management program to lower blood lipids in patients with CHD...
  61. ncbi request reprint C-reactive protein in cardiovascular risk assessment: a review of the evidence
    Jacob Abraham
    Ciccarone Preventive Cardiology Center, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Cardiometab Syndr 2:119-23. 2007
    ..In the primary prevention setting, CRP can be used to reclassify patients in low or intermediate Framingham risk score groups to a higher risk category, thus making them eligible for more intensive pharmacologic interventions...
  62. ncbi request reprint Low-density lipoprotein cholesterol in high-risk asymptomatic individuals
    Juan J Rivera
    Department of Cardiology, The Johns Hopkins University, Baltimore, MD, USA
    J Cardiometab Syndr 2:49-52. 2007
    ..Recent studies conducted exclusively on individuals with known diabetes have provided an important insight on how to appropriately manage diabetic dyslipidemia...
  63. ncbi request reprint Impact of a community-based multiple risk factor intervention on cardiovascular risk in black families with a history of premature coronary disease
    Diane M Becker
    Division of General Internal Medicine, Johns Hopkins Medical Institutions, 1830 E Monument St, Room 8028, Baltimore, MD 21287, USA
    Circulation 111:1298-304. 2005
    ..We tested a community-based multiple risk factor intervention (community-based care [CBC]) and compared it with "enhanced" primary care (EPC) to reduce CHD risk in high-risk black families...
  64. ncbi request reprint Clinical practice. Low HDL cholesterol levels
    M Dominique Ashen
    Johns Hopkins Hospital, Baltimore, MD 21287, USA
    N Engl J Med 353:1252-60. 2005
  65. ncbi request reprint Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis
    Erin D Michos
    Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am Heart J 150:1276-81. 2005
    ..We postulated that traditional risk factor assessment might fail to identify a sizeable portion of women with a sibling history for premature CHD as having advanced subclinical atherosclerosis...
  66. ncbi request reprint A simplified approach to the management of non-ST-segment elevation acute coronary syndromes
    Ty J Gluckman
    Division of Cardiology, The Johns Hopkins Hospital, Baltimore, MD, USA
    JAMA 293:349-57. 2005
    ..While current practice guidelines provide an evidence-based approach to management of acute coronary syndromes (ACS), application of the evidence by individual physicians has been suboptimal...
  67. ncbi request reprint Therapy Insight: managing cardiovascular risk in patients with rheumatoid arthritis
    Jon T Giles
    Division of Rheumatology, Johns Hopkins University, Baltimore, MD 21224, USA
    Nat Clin Pract Rheumatol 2:320-9. 2006
    ....
  68. ncbi request reprint Electron beam tomography in women. Is it a valuable test?
    Khurram Nasir
    The Ciccarone Preventive Cardiology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Cardiol Rev 13:174-83. 2005
    ..Finally, EBT has the potential to determine the consequences of therapeutic interventions regarding progression, stabilization, or regression of coronary atherosclerotic disease...
  69. ncbi request reprint Spot urinary albumin-creatinine ratio predicts left ventricular hypertrophy in young hypertensive African-American men
    W S Post
    Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Hypertens 13:1168-72. 2000
    ....
  70. ncbi request reprint Lipid disorders: justification of methods and goals of treatment
    J B Braunstein
    Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Department of Internal Medicine, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Chest 120:979-88. 2001
    ..This review considers the challenges and available strategies to optimize lipid management in patients at risk for CHD...
  71. ncbi request reprint Racial differences in low-density lipoprotein particle size in families at high risk for premature coronary heart disease
    B G Kral
    Center for Health Promotion, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Ethn Dis 11:325-37. 2001
    ....
  72. ncbi request reprint Increased level of cardiorespiratory fitness blunts the inflammatory response in metabolic syndrome
    Jamal S Rana
    Department of Medicine, University of Pittsburgh, PA 15213, USA
    Int J Cardiol 110:224-30. 2006
    ..The presence of metabolic syndrome is associated with a higher degree of inflammation. We sought to assess whether the higher levels of cardiorespiratory fitness attenuate the levels of inflammation in people with metabolic syndrome...
  73. ncbi request reprint Opportunity for intervention to achieve American Heart Association guidelines for optimal lipid levels in high-risk women in a managed care setting
    Lori Mosca
    Columbia University, New York, NY, USA
    Circulation 111:488-93. 2005
    ..This study evaluated optimal lipid-level attainment and treatment patterns on the basis of these guidelines in high-risk women in a managed care setting...
  74. ncbi request reprint Statin therapy, cardiovascular events, and total mortality in the Heart and Estrogen/Progestin Replacement Study (HERS)
    David M Herrington
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circulation 105:2962-7. 2002
    ..Although effects of statins on cardiovascular outcomes are well established in men, fewer data exist for women. Furthermore, the effects of statins plus hormone replacement therapy (HRT) on cardiovascular outcomes are uncertain...
  75. ncbi request reprint Difference in atherosclerosis burden in different nations and continents assessed by coronary artery calcium
    Raul D Santos
    Lipid Clinic Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil
    Atherosclerosis 187:378-84. 2006
    ..In this study, significant differences in CACS were detected among three nations in different continents. The CACS differences paralleled the respective cardiovascular mortality rates...
  76. ncbi request reprint Ethnic differences between extra-coronary measures on cardiac computed tomography: multi-ethnic study of atherosclerosis (MESA)
    Khurram Nasir
    Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Atherosclerosis 198:104-14. 2008
    ..The aim of the study is to determine the relative prevalence and quantity of extra-coronary calcifications across ethnic groups in a multi-ethnic population based cohort of asymptomatic individuals...
  77. ncbi request reprint Enhanced risk assessment in asymptomatic individuals with exercise testing and Framingham risk scores
    Samia Mora
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical Schoo, Boston, MA, USA
    Circulation 112:1566-72. 2005
    ..We hypothesized that risk prediction could be improved with 2 non-ECG exercise test measures, exercise capacity (metabolic equivalents, or METs) and heart rate recovery (HRR)...
  78. ncbi request reprint Toward an improved diagnosis of the metabolic syndrome other clues to the presence of insulin resistance
    Gregory S Cohn
    Boca Raton Community Hospital, Boca Raton, FL 33486, USA
    Am J Hypertens 18:1099-103. 2005
    ..By recognizing these "other conditions," appropriate lifestyle changes and medication can be recommended to help prevent cardiovascular disease and diabetes from developing in these high-risk patients...
  79. ncbi request reprint Ethnic differences in the prognostic value of coronary artery calcification for all-cause mortality
    Khurram Nasir
    Cardiac MRI PET CT Program, Massachusetts General Hospital Boston, Harvard School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 50:953-60. 2007
    ....
  80. ncbi request reprint Non-high-density lipoprotein cholesterol: why lower is better
    Rahul Garg
    Johns Hopkins Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Prev Cardiol 8:173-7. 2005
    ..Current evidence indicates that statins not only rapidly and dramatically reduce LDL-C, but also have a similar effect on non-HDL-C, and that the greater the reduction in LDL-C, the greater will be the reduction in non-HDL-C...
  81. ncbi request reprint Predictors of low-density lipoprotein particle size in a high-risk African-American population
    Jeana L Benton
    Division of Cardiology, Medical School, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 95:1320-3. 2005
    ..77. Our data suggest that the standard lipid profile, primarily fasting triglyceride measurement, appears to be a useful surrogate for direct measurement of particle size in a high-risk African-American population...
  82. ncbi request reprint Comprehensive coronary risk determination in primary prevention: an imaging and clinical based definition combining computed tomographic coronary artery calcium score and national cholesterol education program risk score
    Khurram Nasir
    Department of Medicine, University of Pittsburgh, PA, USA
    Int J Cardiol 110:129-36. 2006
    ..The utilization of CAC scores allows the inclusion of sub-clinical disease definition into the context of modifiable risk factors as well as identifies high-risk individuals requiring aggressive treatment...
  83. ncbi request reprint Residual risk in statin-treated patients: future therapeutic options
    Catherine Y Campbell
    Johns Hopkins Ciccarone Preventive Cardiology Center, Blalock 524C, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Curr Cardiol Rep 9:499-505. 2007
    ..For cholesterol management, combination therapy may be required to attain optimal levels of LDL-C, HDL-C, and non-HDL-C...
  84. pmc The impact of obesity on cardiovascular disease risk factors and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis
    Gregory L Burke
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arch Intern Med 168:928-35. 2008
    ..To assess the importance of the obesity epidemic on cardiovascular disease (CVD) risk, we determined the prevalence of obesity and the relationship of obesity to CVD risk factors and subclinical vascular disease...
  85. doi request reprint High prevalence of cardiometabolic risk factors in women considered low risk by traditional risk assessment
    Irene S Pollin
    Sister to Sister, Everyone Has a Heart Foundation, Bethesda, Maryland, USA
    J Womens Health (Larchmt) 17:947-53. 2008
    ....
  86. doi request reprint Placing COURAGE in context: review of the recent literature on managing stable coronary artery disease
    Megan Coylewright
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Mayo Clin Proc 83:799-805. 2008
    ..It is essential that systems are set in place to make the medical management of patients with CAD second nature; this focus could be one of the most powerful results of the COURAGE trial...
  87. doi request reprint Coronary computed tomography angiography as a screening tool for the detection of occult coronary artery disease in asymptomatic individuals
    Eue Keun Choi
    Division of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam si, Gyeonggi Do, South Korea
    J Am Coll Cardiol 52:357-65. 2008
    ....
  88. ncbi request reprint Value of multislice computed tomography coronary angiography in suspected coronary artery disease
    Khurram Nasir
    J Am Coll Cardiol 49:2070-1; author reply 2071. 2007
  89. ncbi request reprint Underserved urban african american men: hypertension trial outcomes and mortality during 5 years
    Cheryl R Dennison
    School of Nursing, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Hypertens 20:164-71. 2007
    ..African American men with hypertension (HTN) in low socioeconomic urban environments continue to achieve poor rates of HTN control...
  90. ncbi request reprint Relation of uric acid levels to presence of coronary artery calcium detected by electron beam tomography in men free of symptomatic myocardial ischemia with versus without the metabolic syndrome
    Raul D Santos
    Lipid Clinic, The Heart Institute InCor University of Sao Paulo Medical School Hospital Sao Paulo, Sao Paulo, Brazil
    Am J Cardiol 99:42-5. 2007
    ..11) or higher levels of CAC (p = 0.16). In conclusion, our study suggests that, among asymptomatic moderate-risk men, high UA levels were independently associated with CAC in subjects with the MS...
  91. ncbi request reprint Treatment of hyperlipidemia in cardiac transplant recipients
    Kenneth C Bilchick
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am Heart J 148:200-10. 2004
    ..A summary algorithm is proposed, including approaches to patients with statin-associated musculoskeletal symptoms and patients with inadequate results after initial statin therapy...
  92. ncbi request reprint Implications of C-reactive protein or coronary artery calcium score as an adjunct to global risk assessment for primary prevention of CHD
    Susan G Lakoski
    Department of Internal Medicine Cardiology, 12 Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Atherosclerosis 193:401-7. 2007
    ..In the Multi-Ethnic Study of Atherosclerosis (MESA), we estimated the proportion of intermediate-risk participants whose risk status might change based on additional testing using CRP and/or CAC score...
  93. ncbi request reprint Primary prevention for patients with intermediate Framingham risk scores
    Jason B Thompson
    Curr Cardiol Rep 8:261-6. 2006
    ..Coronary artery calcium scoring, C-reactive protein measurement, and heart rate recovery and exercise tolerance during exercise stress test may be useful tools for better risk stratification of intermediate-risk patients...
  94. ncbi request reprint Relationship of subclinical coronary atherosclerosis and National Cholesterol Education Panel guidelines in asymptomatic Brazilian men
    Khurram Nasir
    Ciccarone Preventive Cardiology Center, Blalock 524 C Cardiology, Johns Hopkins Hospital, 600 N Wolfe Street Baltimore, MD 21287, United States
    Int J Cardiol 108:68-75. 2006
    ....
  95. ncbi request reprint Gender differences in coronary arteries and thoracic aorta calcification
    Khurram Nasir
    Arterioscler Thromb Vasc Biol 27:1220-2. 2007
  96. ncbi request reprint Reproducibility of CT measurements of aortic valve calcification, mitral annulus calcification, and aortic wall calcification in the multi-ethnic study of atherosclerosis
    Matthew J Budoff
    Harbor UCLA Research and Education Institute, Torrance, CA 90502, USA
    Acad Radiol 13:166-72. 2006
    ..We sought to establish the interscan, interobserver, and intraobserver reproducibility of these measures in all cardiac CT scans in the Multi-Ethnic Study of Atherosclerosis...
  97. ncbi request reprint Hepatic steatosis is associated with a greater prevalence of coronary artery calcification in asymptomatic men
    Raul D Santos
    Atherosclerosis 194:517-9. 2007