Joel Blankson

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint The challenge of viral reservoirs in HIV-1 infection
    Joel N Blankson
    Departments of Medicine and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 e mail
    Annu Rev Med 53:557-93. 2002
  2. pmc Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations
    Justin R Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Exp Med 203:1357-69. 2006
  3. pmc Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs
    Robert W Buckheit
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 880, Baltimore, Maryland 21205, USA
    Nat Commun 3:716. 2012
  4. pmc CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants
    Christopher W Pohlmeyer
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, BRB 880, Baltimore, MD 21205, USA
    Retrovirology 10:152. 2013
  5. pmc Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells
    Robert W Buckheit
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 10:68. 2013
  6. pmc Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients
    Kenneth W Witwer
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21025, USA
    Retrovirology 9:5. 2012
  7. pmc Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Retrovirology 8:97. 2011
  8. pmc Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
  9. pmc Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
  10. pmc Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors
    Justin R Bailey
    Broadway Research Bldg, Rm 880, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    J Virol 83:88-97. 2009

Collaborators

Detail Information

Publications41

  1. ncbi request reprint The challenge of viral reservoirs in HIV-1 infection
    Joel N Blankson
    Departments of Medicine and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 e mail
    Annu Rev Med 53:557-93. 2002
    ..The clinical implications of this and other HIV-1 reservoirs are discussed...
  2. pmc Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations
    Justin R Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Exp Med 203:1357-69. 2006
    ..Continued viral suppression probably reflects CTL responses against unmutated epitopes and residual or de novo responses against epitopes with escape mutations...
  3. pmc Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs
    Robert W Buckheit
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 880, Baltimore, Maryland 21205, USA
    Nat Commun 3:716. 2012
    ..These data suggest that host factors have a dominant role in the control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination...
  4. pmc CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants
    Christopher W Pohlmeyer
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, BRB 880, Baltimore, MD 21205, USA
    Retrovirology 10:152. 2013
    ..Surprisingly, viruses amplified from the plasma of ES have been shown to contain multiple escape mutations, and it is not clear how immunologic control is maintained in the face of virologic escape...
  5. pmc Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells
    Robert W Buckheit
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 10:68. 2013
    ..While it is unclear how this reduced seeding of the reservoir is achieved, it is possible that effective CTL responses play an in important role in limiting the size of the latent reservoir...
  6. pmc Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients
    Kenneth W Witwer
    Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland 21025, USA
    Retrovirology 9:5. 2012
    ..Using samples from a well-characterized ES cohort, untreated viremic patients, and uninfected controls, we explored the PBMC miRNA profile and probed the relationships of miRNA expression, CD4+ T-cell counts, and viral load...
  7. pmc Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Retrovirology 8:97. 2011
    ....
  8. pmc Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressor
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Retrovirology 8:63. 2011
    ..These responses, in combination with low viral fitness of each variant, may contribute to sustained elite control in this ES...
  9. pmc Evolution of the HIV-1 nef gene in HLA-B*57 positive elite suppressors
    Maria Salgado
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N, Broadway, Baltimore, MD 21205, USA
    Retrovirology 7:94. 2010
    ..The results provide further evidence of ongoing viral replication in ES and suggest that the nef and gag genes in these patients respond similarly to selective pressure from the host...
  10. pmc Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors
    Justin R Bailey
    Broadway Research Bldg, Rm 880, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    J Virol 83:88-97. 2009
    ..The results provide further evidence of CD8(+) T-cell-mediated selective pressure on plasma virus in ES and suggest that there must be ongoing HIV-1 replication in spite of the very low viral loads seen for these patients...
  11. doi request reprint Low frequency of GB virus C viremia in a cohort of HIV-1-infected elite suppressors
    Joel N Blankson
    Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    AIDS 22:2398-400. 2008
    ..Thus, GB virus C does not appear to explain the nonprogressive course seen in this cohort of elite suppressors...
  12. pmc A case of seronegative HIV-1 infection
    Adam M Spivak
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 201:341-5. 2010
    ..Lack of an antibody response to HIV-1 is rare and appears to be due to a defect in HIV-1-specific immunity rather than infection with attenuated virus...
  13. ncbi request reprint Control of HIV-1 replication in elite suppressors
    Joel N Blankson
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21210, USA
    Discov Med 9:261-6. 2010
    ..The mechanisms responsible for this remarkable control may lead to the design of effective HIV-1 vaccines...
  14. pmc Effector mechanisms in HIV-1 infected elite controllers: highly active immune responses?
    Joel N Blankson
    Broadway Research Bldg, Rm 880, Johns Hopkins University School of Medicine, 722 N Broadway, Baltimore, MD 21205, United States
    Antiviral Res 85:295-302. 2010
    ..This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010...
  15. pmc Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors
    Joel N Blankson
    Department of Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    J Virol 81:2508-18. 2007
    ..The results suggest that some ES are infected with HIV-1 isolates that are fully replication competent and that long-term immunologic control of replication-competent HIV-1 is possible...
  16. pmc Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor
    Justin R Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 82:7395-410. 2008
    ..The results strongly suggest that through direct and indirect mechanisms, CD8(+) T cells in some ES control HIV-1 isolates are capable of causing profound immunosuppression...
  17. pmc Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus
    Karen A O'Connell
    Broadway Research Bldg, Rm 880, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    J Virol 84:7018-28. 2010
    ..Interestingly, there was little continual evolution in CTL epitopes, and we detected de novo CTL responses to autologous viral mutants. Thus, some ES control viremia despite ongoing replication and evolution...
  18. ncbi request reprint Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape
    Justin R Bailey
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 196:50-5. 2007
    ..The present study suggests that control of viral replication in elite suppressors may be due to HIV-1-specific CD8(+) T cells and, in some cases, mutations that have subtle effects on viral fitness...
  19. ncbi request reprint Elucidating the elite: mechanisms of control in HIV-1 infection
    Karen A O'Connell
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 30:631-7. 2009
    ..This review will discuss differences between ECs and progressors while emphasizing recent findings on the immunological response of ECs to HIV-1...
  20. pmc HIV-1 evolution following transmission to an HLA-B*5801-positive patient
    Karen A O'Connell
    Department of Medicine, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Infect Dis 200:1820-4. 2009
    ..Thus, relative control of viral replication can be maintained in spite of the rapid development of multiple escape mutations within cytotoxic T lymphocyte epitopes...
  21. pmc Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation
    Amanda J Chase
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 82:8307-15. 2008
    ..Furthermore, the maintenance of Tregs may be one mechanism associated with the nonprogressive nature of HIV-1 infection in ES...
  22. pmc CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load
    Adriana Andrade
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 46:e78-82. 2008
    ..Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors...
  23. doi request reprint Elite suppression of HIV-1 replication
    Joel N Blankson
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Immunity 29:845-7. 2008
    ..In this issue of Immunity, Migueles et al. (2008) show that HIV-1-specific CD8+ T cells from these individuals effectively suppress viral replication by granzyme B-mediated killing of target cells...
  24. pmc Role of natural killer cells in a cohort of elite suppressors: low frequency of the protective KIR3DS1 allele and limited inhibition of human immunodeficiency virus type 1 replication in vitro
    Karen A O'Connell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 83:5028-34. 2009
    ..Thus, the strong NK cell-mediated inhibition of viral replication is not necessary for the immunological control of HIV-1 in all ES...
  25. pmc Effective downregulation of HLA-A*2 and HLA-B*57 by primary human immunodeficiency virus type 1 isolates cultured from elite suppressors
    Eric Nou
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 83:6941-6. 2009
    ..Thus, a diminished ability of viral isolates from ES to evade HIV-specific immune responses probably does not contribute to the control of viral replication in these patients...
  26. ncbi request reprint Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs
    Justin Bailey
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21204, USA
    Curr Opin Immunol 16:470-6. 2004
    ....
  27. ncbi request reprint An atypical case of fatal zygomycosis: simultaneous cutaneous and laryngeal infection in a patient with a non-neutropenic solid prostatic tumor
    Kristine E Johnson
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2100, USA
    Ear Nose Throat J 87:152-5. 2008
    ....
  28. pmc Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapy
    Justin R Bailey
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 80:4758-70. 2006
    ..Both drug-mediated and natural suppression of HIV-1 replication to levels below 50 copies/ml may limit the stimulation and maintenance of effective NAb responses...
  29. pmc T cell dynamics and the response to HAART in a cohort of HIV-1-infected elite suppressors
    Ahmad R Sedaghat
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 49:1763-6. 2009
    ..Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation...
  30. pmc A comparison of viral loads between HIV-1-infected elite suppressors and individuals who receive suppressive highly active antiretroviral therapy
    Jason B Dinoso
    1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Infect Dis 47:102-4. 2008
    ....
  31. ncbi request reprint The role of protective HCP5 and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors
    Yefei Han
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    AIDS 22:541-4. 2008
    ..These results suggest that some ES control viremia by mechanisms independent of the newly-identified genetic factors...
  32. pmc Role of APOBEC3G/F-mediated hypermutation in the control of human immunodeficiency virus type 1 in elite suppressors
    Shiv K Gandhi
    Broadway Research Bldg, Rm 880, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    J Virol 82:3125-30. 2008
    ..Thus, enhanced APOBEC3 activity alone cannot explain the ability of elite suppressors to control viremia...
  33. ncbi request reprint Primary HIV-1 infection: to treat or not to treat?
    Joel N Blankson
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    AIDS Read 15:245-6, 249-51. 2005
    ..This article will examine the risks and benefits of starting HAART during acute HIV-1 disease...
  34. pmc A simian immunodeficiency virus-infected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy
    Jason B Dinoso
    Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 83:9247-57. 2009
    ....
  35. pmc Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors
    Adam M Spivak
    Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD 21205, USA
    J Virol 85:10399-403. 2011
    ..Thus, monocytes do not appear to be a major reservoir of HIV-1 in ES...
  36. pmc Unstimulated primary CD4+ T cells from HIV-1-positive elite suppressors are fully susceptible to HIV-1 entry and productive infection
    S Alireza Rabi
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 85:979-86. 2011
    ..The results of this physiological study strongly suggest that differences in HIV-1 entry and infection of CD4(+) T cells alone cannot explain the elite control of viral replication...
  37. ncbi request reprint Crosscurrents in HIV-1 evolution
    Joel N Blankson
    Nat Immunol 7:121-2. 2006
  38. ncbi request reprint Loss of HIV-1-specific immunity during treatment interruption in 2 chronically infected patients
    Joel N Blankson
    JAMA 288:162-4. 2002
  39. ncbi request reprint Early treatment of HIV
    Joel N Blankson
    Hopkins HIV Rep 16:14. 2004
  40. ncbi request reprint The Effect of early treatment on the latent reservoir of HIV-1
    Joel N Blankson
    J Infect Dis 191:1394-6. 2005
  41. ncbi request reprint Report from Los Angeles: the 14th Conference on Retroviruses and Opportunistic Infections (CROI). CD4 lymphocyte depletion: where have all the cells gone?
    Scott Kim
    Hopkins HIV Rep 19:10-2. 2007

Research Grants4

  1. Latent virus and HIV-1 specific immunity in LTNPs
    Joel Blankson; Fiscal Year: 2006
    ..Siliciano, and the supportive environment of the Johns Hopkins University will provide Dr. Blankson with the skills he needs to develop into an independent clinician and basic scientist researcher in HIV-1 pathogenesis. ..
  2. Characterization of HIV excape mutants and T cell responses in elite suppressors
    Joel Blankson; Fiscal Year: 2007
    ..This may allow some patients to control the virus without antiretroviral therapy for prolonged periods of time. ..
  3. CD8+ T cell mediated inhibition of HIV-1 replication in Elite Suppressors
    Joel Blankson; Fiscal Year: 2009
    ..This project plans to determine how CD8+ T cells from ES control the virus; the results may be applicable to the development of an effective HIV-1 vaccine. ..
  4. CD8+ T cell mediated inhibition of HIV-1 replication in Elite Suppressors
    Joel N Blankson; Fiscal Year: 2010
    ..This project plans to determine how CD8+ T cells from ES control the virus;the results may be applicable to the development of an effective HIV-1 vaccine. ..