Michael J Blaha

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint The new "intermediate risk" group: A comparative analysis of the new 2013 ACC/AHA risk assessment guidelines versus prior guidelines in men
    Michael J Blaha
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA Electronic address
    Atherosclerosis 237:1-4. 2014
  2. pmc Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review
    Lara L Roberson
    Center for Prevention and Wellness Research, Baptist Health Medical Group, Michigan Ave Suite 500, Miami Beach, Florida
    BMC Public Health 14:14. 2014
  3. pmc Association between obesity, high-sensitivity C-reactive protein ≥2 mg/L, and subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study of Atherosclerosis
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 31:1430-8. 2011
  4. pmc Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD 21287, USA
    Lancet 378:684-92. 2011
  5. pmc The relationship between insulin resistance and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland
    Diabetes Care 34:749-51. 2011
  6. doi request reprint A practical "ABCDE" approach to the metabolic syndrome
    Michael J Blaha
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Blalock 524C, Division of Cardiology, 600 N Wolfe St, Baltimore, MD 21287, USA
    Mayo Clin Proc 83:932-41. 2008
  7. pmc Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Md Department of Cardiology, Danbury Hospital, Danbury, CT
    Mayo Clin Proc 89:493-503. 2014
  8. pmc Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: results from MESA
    Haitham M Ahmed
    Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Epidemiol 178:12-21. 2013
  9. doi request reprint Impact of coronary computed tomographic angiography results on patient and physician behavior in a low-risk population
    John W McEvoy
    Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, Maryland, USA
    Arch Intern Med 171:1260-8. 2011
  10. pmc Impact of fitness versus obesity on routinely measured cardiometabolic risk in young, healthy adults
    Michael N Vranian
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Am J Cardiol 111:991-5. 2013

Detail Information

Publications82

  1. doi request reprint The new "intermediate risk" group: A comparative analysis of the new 2013 ACC/AHA risk assessment guidelines versus prior guidelines in men
    Michael J Blaha
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA Electronic address
    Atherosclerosis 237:1-4. 2014
    ..The 2013 ACC/AHA Report on the Assessment of Cardiovascular (CVD) Risk redefined "intermediate risk". We sought to critically compare the intermediate risk groups identified by prior guidelines and the new ACC/AHA guidelines...
  2. pmc Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review
    Lara L Roberson
    Center for Prevention and Wellness Research, Baptist Health Medical Group, Michigan Ave Suite 500, Miami Beach, Florida
    BMC Public Health 14:14. 2014
    ..The purpose of this review was to analyze the literature which has examined the burden of cardiovascular disease (CVD) and all-cause mortality in the metabolically healthy obese (MHO) population...
  3. pmc Association between obesity, high-sensitivity C-reactive protein ≥2 mg/L, and subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study of Atherosclerosis
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
    Arterioscler Thromb Vasc Biol 31:1430-8. 2011
    ....
  4. pmc Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD 21287, USA
    Lancet 378:684-92. 2011
    ..In a population eligible for JUPITER, we established whether coronary artery calcium (CAC) might further stratify risk; additionally we compared hsCRP with CAC for risk prediction across the range of low and high hsCRP values...
  5. pmc The relationship between insulin resistance and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland
    Diabetes Care 34:749-51. 2011
    ..We sought to determine whether insulin resistance predicts the incidence and progression of coronary artery calcification (CAC)...
  6. doi request reprint A practical "ABCDE" approach to the metabolic syndrome
    Michael J Blaha
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Blalock 524C, Division of Cardiology, 600 N Wolfe St, Baltimore, MD 21287, USA
    Mayo Clin Proc 83:932-41. 2008
    ..This ABCDE approach provides a practical and systematic framework for encouraging metabolic syndrome recognition and for implementing a comprehensive, evidence-based management plan for the reduction of cardiovascular risk...
  7. pmc Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Md Department of Cardiology, Danbury Hospital, Danbury, CT
    Mayo Clin Proc 89:493-503. 2014
    ..To describe ethnic and sex differences in the prevalence and determinants of fatty liver in a multiethnic cohort...
  8. pmc Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: results from MESA
    Haitham M Ahmed
    Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Epidemiol 178:12-21. 2013
    ..In conclusion, a combination of regular exercise, healthy diet, smoking avoidance, and weight maintenance was associated with lower coronary calcium incidence, slower calcium progression, and lower all-cause mortality over 7.6 years. ..
  9. doi request reprint Impact of coronary computed tomographic angiography results on patient and physician behavior in a low-risk population
    John W McEvoy
    Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, Maryland, USA
    Arch Intern Med 171:1260-8. 2011
    ..The impact of screening coronary computed tomographic angiography (CCTA) on physician and patient behavior is unclear...
  10. pmc Impact of fitness versus obesity on routinely measured cardiometabolic risk in young, healthy adults
    Michael N Vranian
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Am J Cardiol 111:991-5. 2013
    ..These findings underscore the need for weight loss in obese patients and suggest an unmeasured benefit of fitness...
  11. doi request reprint Impact of coronary artery calcification on all-cause mortality in individuals with and without hypertension
    Garth Graham
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Atherosclerosis 225:432-7. 2012
    ..Coronary artery calcium (CAC) has emerged as an important prognostic indicator for coronary heart disease risk. The purpose of this study was to assess the impact of increasing CAC burden among those with and without hypertension (HTN)...
  12. doi request reprint Relation between self-reported physical activity level, fitness, and cardiometabolic risk
    Camille Michael Minder
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland
    Am J Cardiol 113:637-43. 2014
    ..In conclusion, self-reported physical activity level and directly measured fitness are moderately correlated, and the latter is more strongly associated with a protective cardiovascular risk profile...
  13. doi request reprint High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link?
    Omair Yousuf
    Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 62:397-408. 2013
    ..Furthermore, we highlight recommendations from societies and important considerations when using hsCRP to guide treatment decisions in the primary prevention setting...
  14. pmc Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcification
    John W McEvoy
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    JACC Cardiovasc Imaging 5:1037-45. 2012
    ..The aim of this study was to further explore the interplay between smoking status, coronary artery calcium (CAC), and all-cause mortality...
  15. doi request reprint Gender differences in coronary plaque composition and burden detected in symptomatic patients referred for coronary computed tomographic angiography
    Waqas Qureshi
    Division of Cardiology, Department of Internal Medicine, Henry Ford Hospital Wayne State University, Detroit, MI, USA
    Int J Cardiovasc Imaging 29:463-9. 2013
    ..Future studies are needed to determine the prognostic implications of these findings...
  16. pmc The relationship of insulin resistance and extracoronary calcification in the multi-ethnic study of atherosclerosis
    Geoffrey H Tison
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD 21287, USA
    Atherosclerosis 218:507-10. 2011
    ..We hypothesized that insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA), is independently associated with prevalent and incident extra-coronary calcification (ECC)...
  17. pmc Association between resting heart rate and inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin-6, and fibrinogen) (from the Multi-Ethnic Study of Atherosclerosis)
    Seamus P Whelton
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland Electronic address
    Am J Cardiol 113:644-9. 2014
    ..In conclusion, an increased HR at rest was associated with a higher level of inflammation among an ethnically diverse group of subjects without known cardiovascular disease...
  18. doi request reprint Risk and the physics of clinical prediction
    John W McEvoy
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland Electronic address
    Am J Cardiol 113:1429-35. 2014
    ..We also discuss innovative future strategies for risk estimation and treatment allocation in preventive cardiology. ..
  19. pmc Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD S S M, M J B, P O, S R J, R S B, K N Noninvasive Cardiovascular Imaging Program, Department of Medicine Cardiovascular Division and Radiology, Brigham and Women s Hospital, Boston, MA R B South Beach Preventive Cardiology Center, University of Miami, Miami, FL A A Columbia University Division of Cardiology at Mount Sinai Medical Center, Miami Beach, FL J J R Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX S S V Division of Cardiology, Harbor University of California Los Angeles Medical Center, Los Angeles, CA M J B Center for Prevention and Wellness Research, Baptist Health Medical Group, Miami, FL K N Baptist Cardiovascular Institute, Baptist Health South Florida, Miami, FL K N Department of Epidemiology, Robert Stempel College of Public Health, Florida International University, Miami, FL K N and Department of Medicine, Herbert Wertheim College of Medicine, Miami, FL K N
    Circulation 129:77-86. 2014
    ..Worldwide clinical practice guidelines for dyslipidemia emphasize allocating statin therapy to those at the highest absolute atherosclerotic cardiovascular disease (CVD) risk...
  20. doi request reprint Absolute coronary artery calcium score is the best predictor of non-calcified plaque involvement in patients with low calcium scores (1-100)
    Lori M Tam
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD 21287, USA
    Atherosclerosis 230:76-9. 2013
    ..We sought to identify the predictors of non-calcified plaque (NCP) burden in patients with low coronary artery calcium (CAC) scores of 1-100...
  21. doi request reprint What is the role of calcium scoring in the age of coronary computed tomographic angiography?
    Parag H Joshi
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Nucl Cardiol 19:1226-35. 2012
    ..Given the strong short-term prognostic value of CAC = 0, studies are needed to further evaluate the role of CAC scanning in low-risk patients with acute chest pain presenting to the emergency room...
  22. pmc Relation of uric acid to serum levels of high-sensitivity C-reactive protein, triglycerides, and high-density lipoprotein cholesterol and to hepatic steatosis
    Tanya Keenan
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland, USA
    Am J Cardiol 110:1787-92. 2012
    ..In conclusion, high UA levels were associated with increased TG/HDL and hepatic steatosis independently of metabolic syndrome and obesity and with increased hs-CRP independently of metabolic syndrome...
  23. doi request reprint Association between high-sensitivity C-reactive protein and coronary plaque subtypes assessed by 64-slice coronary computed tomography angiography in an asymptomatic population
    Jonathan Rubin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Circ Cardiovasc Imaging 4:201-9. 2011
    ..We sought to analyze the relationship between levels of CRP and coronary plaque subtypes as assessed by coronary computed tomography angiography...
  24. doi request reprint Coronary artery calcium progression: an important clinical measurement? A review of published reports
    John W McEvoy
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA
    J Am Coll Cardiol 56:1613-22. 2010
    ..First, standards of how CAC progression should be defined and assessed need to be developed. In addition, there remains a need for further studies analyzing the effect of other cardiac therapies on CAC progression and cardiac outcomes...
  25. pmc The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
    Evan D Muse
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA, USA Electronic address
    Atherosclerosis 239:101-8. 2015
    ..To describe the relationship between circulating resistin levels and cardiovascular diseases (CVD) and all-cause death in a multi-ethnic cohort...
  26. doi request reprint Very large database of lipids: rationale and design
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medicine, Baltimore, Maryland
    Clin Cardiol 36:641-8. 2013
    ..0) is underway. Overall, the Very Large Database of Lipids database provides an opportunity for collaboration and new knowledge generation through careful examination of granular lipid data on a large scale. ..
  27. doi request reprint Landmark lipid-lowering trials in the primary prevention of cardiovascular disease
    Jonathan Chrispin
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, Maryland
    Clin Cardiol 36:516-23. 2013
    ..This review will highlight several key clinical trials encompassing several classes of lipid-lowering medications that have provided clinicians with an evidence-based framework for managing their patients' cardiovascular risk. ..
  28. pmc Association of resting heart rate with carotid and aortic arterial stiffness: multi-ethnic study of atherosclerosis
    Seamus P Whelton
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Hypertension 62:477-84. 2013
    ....
  29. pmc Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland
    JAMA 310:2061-8. 2013
    ....
  30. doi request reprint Family history of coronary heart disease and markers of subclinical cardiovascular disease: where do we stand?
    Arvind K Pandey
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Atherosclerosis 228:285-94. 2013
    ....
  31. pmc Relationship of carotid distensibility and thoracic aorta calcification: multi-ethnic study of atherosclerosis
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
    Hypertension 54:1408-15. 2009
    ..The prognostic significance of these findings requires longitudinal follow-up of the Multi-Ethnic Study of Atherosclerosis cohort...
  32. doi request reprint Differences in coronary plaque composition with aging measured by coronary computed tomography angiography
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, United States
    Int J Cardiol 158:240-5. 2012
    ..Little is known about the independent impact of aging on coronary plaque morphology and composition in the era of cardiac computed tomography angiography (CCTA)...
  33. doi request reprint Utility of coronary artery calcium scoring in the evaluation of patients with chest pain
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Baltimore, MD 21287, USA
    Crit Pathw Cardiol 11:99-106. 2012
    ..Although further research is needed, carefully selected ED patients with a normal electrocardiogram, normal cardiac biomarkers, and CAC = 0 may be considered for early discharge without further testing...
  34. pmc Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes
    Michael Gordon Silverman
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA
    Diabetes Care 35:624-6. 2012
    ..It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain...
  35. doi request reprint Usefulness of regional distribution of coronary artery calcium to improve the prediction of all-cause mortality
    Rajesh Tota-Maharaj
    Department of Cardiology, Danbury Hospital, Danbury, Connecticut Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, Maryland
    Am J Cardiol 115:1229-34. 2015
    ..In conclusion, increasing number of vessels with CAC and left main CAC predict increased all-cause mortality and improve the prognostic power of the traditional Agatston CAC score. ..
  36. doi request reprint Maximal exercise testing variables and 10-year survival: fitness risk score derivation from the FIT Project
    Haitham M Ahmed
    Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, Baltimore, MD
    Mayo Clin Proc 90:346-55. 2015
    ..To determine which routinely collected exercise test variables most strongly correlate with survival and to derive a fitness risk score that can be used to predict 10-year survival...
  37. doi request reprint 2013 ACC/AHA cholesterol treatment guideline: what was done well and what could be done better
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland
    J Am Coll Cardiol 63:2674-8. 2014
    ..Overall, we aim to continue discussions about the important contributions and shortfalls of the guideline and create momentum for effective implementation and timely updates. ..
  38. pmc Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the multi-ethnic study of atherosclerosis: a secondary analysis of a prospective, population-based cohort
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD Danbury Hospital, Danbury, CT
    Mayo Clin Proc 89:1350-9. 2014
    ..To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals...
  39. doi request reprint Is there a role for coronary artery calcium scoring for management of asymptomatic patients at risk for coronary artery disease?: Clinical risk scores are not sufficient to define primary prevention treatment strategies among asymptomatic patients
    Michael J Blaha
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD
    Circ Cardiovasc Imaging 7:398-408; discussion 408. 2014
    ....
  40. doi request reprint A clinician's guide to the ABCs of cardiovascular disease prevention: the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease and American College of Cardiology Cardiosource Approach to the Million Hearts Initiative
    Steven Hsu
    Ciccarone Center for the Prevention of Heart Disease, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cardiol 36:383-93. 2013
    ..We believe that the ABCDE approach will be the core framework for addressing CV risk in our effort to prevent CVD. ..
  41. doi request reprint Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: reconciling the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Ou
    Erin D Michos
    The Johns Hopkins University School of Medicine, Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 59:2058-64. 2012
    ..This viewpoint summarizes these imaging trials studying niacin and places them in the context of the failure of AIM-HIGH to support the HDL-C-increasing hypothesis...
  42. pmc The association of Framingham and Reynolds risk scores with incidence and progression of coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis)
    Andrew P DeFilippis
    Division of Cardiology, University of Louisville, Rudd Heart and Lung Center, Louisville, Kentucky, USA
    J Am Coll Cardiol 58:2076-83. 2011
    ..The purpose of this study was to compare the association of the Framingham risk score (FRS) and Reynolds risk score (RRS) with subclinical atherosclerosis, assessed by incidence and progression of coronary artery calcium (CAC)...
  43. doi request reprint Relationship of cigarette smoking with inflammation and subclinical vascular disease: the multi-ethnic study of atherosclerosis
    John W McEvoy
    From the Ciccarone Center for the Prevention of Heart Disease J W M, K N, A P D, R S B, M J Blaha and Division of Cardiology J A C L, W S P, Johns Hopkins University, Baltimore, MD Center for Wellness and Prevention, Baptist Health South Florida, Miami Beach K N Division of Cardiology, University of Louisville, Rudd Heart and Lung Center, KY A P D Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD D A B Division of Cardiology, Wake Forest University Health Center, Winston Salem, NC W G H Division of General Medicine, Division of Pulmonary, Allergy and Critical Care, Department of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, NY R G B Los Angeles Biomedical Research Institute at Harbor UCLA, Los Angeles, CA M J Budoff Bloomberg School of Public Health, John Hopkins University, Baltimore, MD M S, A N A, W S P, M J B and Department of Radiology, Tufts University School of Medicine, Boston, MA J F P
    Arterioscler Thromb Vasc Biol 35:1002-10. 2015
    ....
  44. pmc The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA)
    Mahmoud Al Rifai
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Atherosclerosis 239:629-33. 2015
    ..We characterized the association of 3 metabolic conditions - obesity, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) - with increased inflammation and subclinical atherosclerosis...
  45. pmc Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis
    Michael G Silverman
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA Brigham and Women s Hospital, Cardiovascular Division, Boston, MA, USA
    Eur Heart J 35:2232-41. 2014
    ..We sought to evaluate the impact of coronary artery calcium (CAC) in individuals at the extremes of risk factor (RF) burden...
  46. pmc Narrowing sex differences in lipoprotein cholesterol subclasses following mid-life: the very large database of lipids (VLDL-10B)
    Kristopher J Swiger
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD
    J Am Heart Assoc 3:e000851. 2014
    ..We hypothesized that the average lipid profile of women undergoes unfavorable changes compared with men after midlife...
  47. doi request reprint Coronary artery calcium for the prediction of mortality in young adults <45 years old and elderly adults >75 years old
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Eur Heart J 33:2955-62. 2012
    ..To determine if coronary artery calcium (CAC) scoring is independently predictive of mortality in young adults and in the elderly population and if a young person with high CAC has a higher mortality risk than an older person with less CAC...
  48. doi request reprint A point-by-point response to recent arguments against the use of statins in primary prevention: this statement is endorsed by the American Society for Preventive Cardiology
    Parag H Joshi
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Cardiol 35:404-9. 2012
    ..Future investigation in prevention should focus on improving our ability to identify these at-risk individuals...
  49. doi request reprint Gender differences in coronary plaque composition by coronary computed tomography angiography
    Michael J Blaha
    Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland, USA
    Coron Artery Dis 20:506-12. 2009
    ..Although males are thought to have a higher prevalence of atherosclerosis for a given age, there are currently few data regarding age-adjusted sex differences in plaque morphology and composition...
  50. pmc The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequences
    Venkata Narla
    The Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Vasc Health Risk Manag 5:1033-42. 2009
    ..This review outlines the JUPITER and AURORA trials, interprets the data and significance of the results, analyses the drawbacks and impact of both trials and delineates the potential for further clinical trials...
  51. doi request reprint Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk
    Ehimen C Aneni
    aCenter for Prevention and Wellness Research, Baptist Health South Florida, Miami, Florida bJohns Hopkins Ciccarone Center for Prevention of Cardiovascular Disease, Baltimore, Maryland cRobert Stempel College of Public Health, Florida International University, Miami, Florida dSchool of Medicine, Department of Medicine, Emory University, Atlanta, Georgia, USA eHospital Israelita Albert Einstein fHeart Institute InCor, University of Sao Paolo Medical School Hospital, Sao Paolo, Brazil gHerbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA
    J Hypertens 33:1207-14. 2015
    ..To determine the relationship between clinically relevant blood pressure (BP) groups and nonalcoholic fatty liver disease (NAFLD) presence and severity especially in the milieu of other metabolic risk factors...
  52. pmc Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA Electronic address
    Atherosclerosis 239:67-72. 2015
    ..We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort...
  53. pmc Cost-effectiveness of coronary artery calcium testing for coronary heart and cardiovascular disease risk prediction to guide statin allocation: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Eric T Roberts
    Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management, Baltimore, Maryland, United States of America
    PLoS ONE 10:e0116377. 2015
    ..However, the cost-effectiveness of incorporating CAC into treatment decision rules has yet to be clearly delineated...
  54. doi request reprint Friedewald-estimated versus directly measured low-density lipoprotein cholesterol and treatment implications
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 62:732-9. 2013
    ..The aim of this study was to compare Friedewald-estimated and directly measured low-density lipoprotein cholesterol (LDL-C) values...
  55. doi request reprint All-cause mortality in asymptomatic persons with extensive Agatston scores above 1000
    Jaideep Patel
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA Division of Internal Medicine, Virginia Commonwealth University Medical Center Medical College of Virginia, 1200 E Broad Street, Richmond, VA 23298, USA Electronic address
    J Cardiovasc Comput Tomogr 8:26-32. 2014
    ..Risk assessment in the extensive calcified plaque phenotype has been limited by small sample size...
  56. doi request reprint A practical approach to the metabolic syndrome: review of current concepts and management
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, USA
    Curr Opin Cardiol 25:502-12. 2010
    ..Novel research over the past 2 years has necessitated an update of our 'ABCDE' approach to the metabolic syndrome...
  57. pmc Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderly
    Sydney B Long
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Clin Interv Aging 6:27-35. 2011
    ..The implications of this JUPITER subanalysis and the broader role of statins among older adults is the subject of this review...
  58. doi request reprint Prognostic value of exercise capacity in patients with coronary artery disease: the FIT (Henry Ford ExercIse Testing) project
    Rupert K Hung
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD
    Mayo Clin Proc 89:1644-54. 2014
    ..To examine the prognostic value of exercise capacity in patients with nonrevascularized and revascularized coronary artery disease (CAD) seen in routine clinical practice...
  59. doi request reprint Recommendations for the management of patients with familial hypercholesterolemia
    David I Feldman
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Curr Atheroscler Rep 17:473. 2015
    ..Our objective herein is to provide concise overviews of how to screen for and diagnose FH and summarize international consensus recommendations for managing adults and children with available treatments. ..
  60. pmc Baseline subclinical atherosclerosis burden and distribution are associated with frequency and mode of future coronary revascularization: multi-ethnic study of atherosclerosis
    Michael G Silverman
    Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, Maryland
    JACC Cardiovasc Imaging 7:476-86. 2014
    ....
  61. pmc HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the Lipoprotein Investigators Collaborative
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, 600 N Wolfe St, Carnegie 565 G, Baltimore, 21287 MD, USA
    Eur Heart J 36:22-30. 2015
    ..High-density lipoprotein (HDL) is highly heterogeneous and the link of its subclasses to prognosis remains controversial. We aimed to rigorously examine the associations of HDL subclasses with prognosis in secondary prevention...
  62. pmc Headed in the right direction but at risk for miscalculation: a critical appraisal of the 2013 ACC/AHA risk assessment guidelines
    Nivee P Amin
    Ciccarone Center for the Prevention of Cardiovascular Diseases, Johns Hopkins University, Baltimore, Maryland
    J Am Coll Cardiol 63:2789-94. 2014
    ....
  63. doi request reprint Relation of resting heart rate to risk for all-cause mortality by gender after considering exercise capacity (the Henry Ford exercise testing project)
    Amer I Aladin
    Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, Maryland
    Am J Cardiol 114:1701-6. 2014
    ..In conclusion, after adjustment for fitness, elevated RHR was an independent risk factor for all-cause mortality in men but not women, suggesting gender differences in the utility of RHR for risk stratification...
  64. doi request reprint Improving the relationship between coronary artery calcium score and coronary plaque burden: addition of regional measures of coronary artery calcium distribution
    Rajesh Tota-Maharaj
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Carnegie 565A, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA Danbury Hospital, 24 Hospital Avenue, Danbury, CT 06810, USA
    Atherosclerosis 238:126-31. 2015
    ..It is unclear whether adding regional measures of CAC distribution to the Agatston score improves this association...
  65. pmc Statins, mood, sleep, and physical function: a systematic review
    Kristopher J Swiger
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, 1800 Orleans Street, Zayed 7125, Baltimore, MD, 21287, USA
    Eur J Clin Pharmacol 70:1413-22. 2014
    ..We aimed to evaluate the effects of statins on mood, sleep, and physical function...
  66. pmc Current guidelines for high-density lipoprotein cholesterol in therapy and future directions
    Bishnu H Subedi
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA Greater Baltimore Medical Center, Baltimore, MD, USA
    Vasc Health Risk Manag 10:205-16. 2014
    ..This review will outline current therapies and describe future directions for HDL therapeutics. ..
  67. doi request reprint Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA)
    Arvind K Pandey
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA
    Atherosclerosis 232:369-76. 2014
    ..We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA)...
  68. doi request reprint Comparing the new European cardiovascular disease prevention guideline with prior American Heart Association guidelines: an editorial review
    Van Khue Ton
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA
    Clin Cardiol 36:E1-6. 2013
    ....
  69. doi request reprint Evidence-based use of statins for primary prevention of cardiovascular disease
    C Michael Minder
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    Am J Med 125:440-6. 2012
    ..When appraised together, these data provide compelling evidence to support the use of statins for primary prevention in patients with risk factors for developing coronary heart disease over the next 10 years...
  70. doi request reprint Effects of physical activity on cardiovascular disease
    Haitham M Ahmed
    Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Am J Cardiol 109:288-95. 2012
    ..Further research is needed to elucidate the effect of physical activity on inflammatory markers and intima-media thickness...
  71. doi request reprint Relation of aortic valve calcium detected by cardiac computed tomography to all-cause mortality
    Michael J Blaha
    Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 106:1787-91. 2010
    ..03) as well as traditional risk factors plus the presence of CAC (chi-square = 3.58, p = 0.05). In conclusion, AVC was associated with increased all-cause mortality, independent of the traditional risk factors and the presence of CAC...
  72. ncbi request reprint Potential use of coronary artery calcium progression to guide the management of patients at risk for coronary artery disease events
    John W McEvoy
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Blalock 524C, 600 N Wolfe St, Baltimore, MD, 21287, USA
    Curr Treat Options Cardiovasc Med 14:69-80. 2012
    ..In this review we will provide recommendations for repeat CAC testing and discuss when repeat CAC testing may be helpful to assess coronary artery disease progression...
  73. doi request reprint Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects
    Kristopher J Swiger
    Department of Medicine, Division of Cardiology, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD
    Mayo Clin Proc 88:1213-21. 2013
    ..To evaluate the effect of statins on short-term cognitive function and the long-term incidence of dementia...
  74. doi request reprint Relation of C-reactive protein to abdominal adiposity
    Gabriel C Brooks
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA
    Am J Cardiol 106:56-61. 2010
    ....
  75. doi request reprint Statins for primary prevention of cardiovascular disease: the benefits outweigh the risks
    C Michael Minder
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Maryland 21287, USA
    Curr Opin Cardiol 28:554-60. 2013
    ..Here, we review the evidence for statins in primary prevention and offer guidance for their appropriate use...
  76. ncbi request reprint Waiting for the National Cholesterol Education Program Adult Treatment Panel IV Guidelines, and in the Meantime, Some Challenges and Recommendations
    Seth S Martin
    Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland
    Am J Cardiol 110:307-13. 2012
    ....
  77. pmc Waist circumference, not the metabolic syndrome, predicts glucose deterioration in type 2 diabetes
    Michael J Blaha
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:869-74. 2008
    ..Waist circumference by itself, however, is a strong predictor of future glucose control, and may be a parsimonious tool for risk stratification. BMI may also be a useful predictive tool...
  78. doi request reprint Adjunctive lipid lowering therapy in the era of surrogate endpoints
    Michael G Silverman
    Division of Cardiology, Department of Medicine, The Johns Hopkins Ciccarone Preventive Cardiology Center, Johns Hopkins University, Baltimore, MD 21287, USA
    Cardiol Rev 19:17-22. 2011
    ..Three ongoing clinical outcomes trials evaluating niacin and ezetimibe in combination with statin will provide more definitive word regarding the safety and efficacy of these agents as adjunctive therapy...
  79. doi request reprint Risk factors: new risk-assessment guidelines-more or less personalized?
    Michael J Blaha
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Carnegie 565A, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Nat Rev Cardiol 11:136-7. 2014
    ..However, the equations rely on the same traditional risk factors as previous versions, are driven predominantly by age, and curtail the intermediate-risk group, in which personalized risk assessment is recommended...
  80. ncbi request reprint The importance of non-HDL cholesterol reporting in lipid management
    Michael J Blaha
    The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
    J Clin Lipidol 2:267-73. 2008
    ..It is our opinion that non-HDL-C should be reported on all routine lipid profiles and used regularly in the management of dyslipidemia for optimal prevention of atherosclerosis and cardiovascular disease...
  81. ncbi request reprint Adherence to insulin and the risk of glucose deterioration
    Michael J Blaha
    Diabetes Care 29:1982-3. 2006
  82. ncbi request reprint Hypertension prevalence awareness, treatment and control in North Nashville
    Michael J Blaha
    Department of Medicine, Division of General Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Tenn Med 99:35-7. 2006
    ..This study adds to a growing literature on the racial and geographic disparities in health status in the Unites States and cautions that data from national surveys may not be representative of individual communities...