Research Topics
| Michael J BlahaSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Association between obesity, high-sensitivity C-reactive protein ≥2 mg/L, and subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study of AtherosclerosisMichael J Blaha
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
Arterioscler Thromb Vasc Biol 31:1430-8. 2011....- The relationship between insulin resistance and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)Michael J Blaha
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland
Diabetes Care 34:749-51. 2011..We sought to determine whether insulin resistance predicts the incidence and progression of coronary artery calcification (CAC)... - Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort studyMichael J Blaha
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD 21287, USA
Lancet 378:684-92. 2011..In a population eligible for JUPITER, we established whether coronary artery calcium (CAC) might further stratify risk; additionally we compared hsCRP with CAC for risk prediction across the range of low and high hsCRP values... 
A practical "ABCDE" approach to the metabolic syndromeMichael J Blaha
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Blalock 524C, Division of Cardiology, 600 N Wolfe St, Baltimore, MD 21287, USA
Mayo Clin Proc 83:932-41. 2008..This ABCDE approach provides a practical and systematic framework for encouraging metabolic syndrome recognition and for implementing a comprehensive, evidence-based management plan for the reduction of cardiovascular risk...- Impact of coronary computed tomographic angiography results on patient and physician behavior in a low-risk populationJohn W McEvoy
Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, Maryland, USA
Arch Intern Med 171:1260-8. 2011..The impact of screening coronary computed tomographic angiography (CCTA) on physician and patient behavior is unclear... - The relationship of insulin resistance and extracoronary calcification in the multi-ethnic study of atherosclerosisGeoffrey H Tison
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD 21287, USA
Atherosclerosis 218:507-10. 2011..We hypothesized that insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA), is independently associated with prevalent and incident extra-coronary calcification (ECC)... - Coronary artery calcium progression: an important clinical measurement? A review of published reportsJohn W McEvoy
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA
J Am Coll Cardiol 56:1613-22. 2010..First, standards of how CAC progression should be defined and assessed need to be developed. In addition, there remains a need for further studies analyzing the effect of other cardiac therapies on CAC progression and cardiac outcomes... - Association between high-sensitivity C-reactive protein and coronary plaque subtypes assessed by 64-slice coronary computed tomography angiography in an asymptomatic populationJonathan Rubin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Circ Cardiovasc Imaging 4:201-9. 2011..We sought to analyze the relationship between levels of CRP and coronary plaque subtypes as assessed by coronary computed tomography angiography... - Utility of coronary artery calcium scoring in the evaluation of patients with chest painRajesh Tota-Maharaj
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Baltimore, MD 21287, USA
Crit Pathw Cardiol 11:99-106. 2012..Although further research is needed, carefully selected ED patients with a normal electrocardiogram, normal cardiac biomarkers, and CAC = 0 may be considered for early discharge without further testing... - Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetesMichael Gordon Silverman
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA
Diabetes Care 35:624-6. 2012..It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain... - Relationship of carotid distensibility and thoracic aorta calcification: multi-ethnic study of atherosclerosisMichael J Blaha
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, USA
Hypertension 54:1408-15. 2009..The prognostic significance of these findings requires longitudinal follow-up of the Multi-Ethnic Study of Atherosclerosis cohort... - Impact of coronary artery calcification on all-cause mortality in individuals with and without hypertensionGarth Graham
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
Atherosclerosis 225:432-7. 2012..Coronary artery calcium (CAC) has emerged as an important prognostic indicator for coronary heart disease risk. The purpose of this study was to assess the impact of increasing CAC burden among those with and without hypertension (HTN)... - Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: reconciling the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health OuErin D Michos
The Johns Hopkins University School of Medicine, Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland 21287, USA
J Am Coll Cardiol 59:2058-64. 2012..This viewpoint summarizes these imaging trials studying niacin and places them in the context of the failure of AIM-HIGH to support the HDL-C-increasing hypothesis... - Differences in coronary plaque composition with aging measured by coronary computed tomography angiographyRajesh Tota-Maharaj
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, MD, United States
Int J Cardiol 158:240-5. 2012..Little is known about the independent impact of aging on coronary plaque morphology and composition in the era of cardiac computed tomography angiography (CCTA)... - The association of Framingham and Reynolds risk scores with incidence and progression of coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis)Andrew P DeFilippis
Division of Cardiology, University of Louisville, Rudd Heart and Lung Center, Louisville, Kentucky, USA
J Am Coll Cardiol 58:2076-83. 2011..The purpose of this study was to compare the association of the Framingham risk score (FRS) and Reynolds risk score (RRS) with subclinical atherosclerosis, assessed by incidence and progression of coronary artery calcium (CAC)... - Coronary artery calcium for the prediction of mortality in young adults <45 years old and elderly adults >75 years oldRajesh Tota-Maharaj
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
Eur Heart J 33:2955-62. 2012..To determine if coronary artery calcium (CAC) scoring is independently predictive of mortality in young adults and in the elderly population and if a young person with high CAC has a higher mortality risk than an older person with less CAC... - A point-by-point response to recent arguments against the use of statins in primary prevention: this statement is endorsed by the American Society for Preventive CardiologyParag H Joshi
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Clin Cardiol 35:404-9. 2012..Future investigation in prevention should focus on improving our ability to identify these at-risk individuals... - Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcificationJohn W McEvoy
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
JACC Cardiovasc Imaging 5:1037-45. 2012..The aim of this study was to further explore the interplay between smoking status, coronary artery calcium (CAC), and all-cause mortality... - The JUPITER and AURORA clinical trials for rosuvastatin in special primary prevention populations: perspectives, outcomes, and consequencesVenkata Narla
The Ciccarone Preventive Cardiology Center, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Vasc Health Risk Manag 5:1033-42. 2009..This review outlines the JUPITER and AURORA trials, interprets the data and significance of the results, analyses the drawbacks and impact of both trials and delineates the potential for further clinical trials... - Gender differences in coronary plaque composition by coronary computed tomography angiographyMichael J Blaha
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland, USA
Coron Artery Dis 20:506-12. 2009..Although males are thought to have a higher prevalence of atherosclerosis for a given age, there are currently few data regarding age-adjusted sex differences in plaque morphology and composition... - Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderlySydney B Long
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
Clin Interv Aging 6:27-35. 2011..The implications of this JUPITER subanalysis and the broader role of statins among older adults is the subject of this review... - A practical approach to the metabolic syndrome: review of current concepts and managementRajesh Tota-Maharaj
Johns Hopkins Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, USA
Curr Opin Cardiol 25:502-12. 2010..Novel research over the past 2 years has necessitated an update of our 'ABCDE' approach to the metabolic syndrome... - Relation of uric acid to serum levels of high-sensitivity C-reactive protein, triglycerides, and high-density lipoprotein cholesterol and to hepatic steatosisTanya Keenan
Johns Hopkins Ciccarone Preventive Cardiology Center, Baltimore, Maryland, USA
Am J Cardiol 110:1787-92. 2012..In conclusion, high UA levels were associated with increased TG/HDL and hepatic steatosis independently of metabolic syndrome and obesity and with increased hs-CRP independently of metabolic syndrome... - What is the role of calcium scoring in the age of coronary computed tomographic angiography?Parag H Joshi
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Nucl Cardiol 19:1226-35. 2012..Given the strong short-term prognostic value of CAC = 0, studies are needed to further evaluate the role of CAC scanning in low-risk patients with acute chest pain presenting to the emergency room... - Evidence-based use of statins for primary prevention of cardiovascular diseaseC Michael Minder
The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
Am J Med 125:440-6. 2012..When appraised together, these data provide compelling evidence to support the use of statins for primary prevention in patients with risk factors for developing coronary heart disease over the next 10 years... - Effects of physical activity on cardiovascular diseaseHaitham M Ahmed
Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
Am J Cardiol 109:288-95. 2012..Further research is needed to elucidate the effect of physical activity on inflammatory markers and intima-media thickness... - Relation of aortic valve calcium detected by cardiac computed tomography to all-cause mortalityMichael J Blaha
Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 106:1787-91. 2010..03) as well as traditional risk factors plus the presence of CAC (chi-square = 3.58, p = 0.05). In conclusion, AVC was associated with increased all-cause mortality, independent of the traditional risk factors and the presence of CAC... 
Potential use of coronary artery calcium progression to guide the management of patients at risk for coronary artery disease eventsJohn W McEvoy
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Blalock 524C, 600 N Wolfe St, Baltimore, MD, 21287, USA
Curr Treat Options Cardiovasc Med 14:69-80. 2012..In this review we will provide recommendations for repeat CAC testing and discuss when repeat CAC testing may be helpful to assess coronary artery disease progression...- Relation of C-reactive protein to abdominal adiposityGabriel C Brooks
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland, USA
Am J Cardiol 106:56-61. 2010.... - Waiting for the National Cholesterol Education Program Adult Treatment Panel IV Guidelines, and in the Meantime, Some Challenges and RecommendationsSeth S Martin
Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland
Am J Cardiol 110:307-13. 2012.... - Waist circumference, not the metabolic syndrome, predicts glucose deterioration in type 2 diabetesMichael J Blaha
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Obesity (Silver Spring) 16:869-74. 2008..Waist circumference by itself, however, is a strong predictor of future glucose control, and may be a parsimonious tool for risk stratification. BMI may also be a useful predictive tool... - Adjunctive lipid lowering therapy in the era of surrogate endpointsMichael G Silverman
Division of Cardiology, Department of Medicine, The Johns Hopkins Ciccarone Preventive Cardiology Center, Johns Hopkins University, Baltimore, MD 21287, USA
Cardiol Rev 19:17-22. 2011..Three ongoing clinical outcomes trials evaluating niacin and ezetimibe in combination with statin will provide more definitive word regarding the safety and efficacy of these agents as adjunctive therapy... - The importance of non-HDL cholesterol reporting in lipid managementMichael J Blaha
The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA
J Clin Lipidol 2:267-73. 2008..It is our opinion that non-HDL-C should be reported on all routine lipid profiles and used regularly in the management of dyslipidemia for optimal prevention of atherosclerosis and cardiovascular disease... - Adherence to insulin and the risk of glucose deteriorationMichael J Blaha
Diabetes Care 29:1982-3. 2006 - Hypertension prevalence awareness, treatment and control in North NashvilleMichael J Blaha
Department of Medicine, Division of General Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Tenn Med 99:35-7. 2006..This study adds to a growing literature on the racial and geographic disparities in health status in the Unites States and cautions that data from national surveys may not be representative of individual communities...