Konstantin G Birukov

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 26:453-64. 2002
  2. ncbi request reprint Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Univ School of Medicine, 5501 Hopkins Bayview Circle, JHAAC, 5A 42, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 285:L785-97. 2003
  3. ncbi request reprint Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 95:892-901. 2004
  4. ncbi request reprint Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:18-28. 2004
  5. ncbi request reprint Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase
    Steven M Dudek
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:24692-700. 2004
  6. ncbi request reprint Differential regulation of human lung epithelial and endothelial barrier function by thrombin
    Kamon Kawkitinarong
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 31:517-27. 2004
  7. ncbi request reprint Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Cell Physiol 204:934-47. 2005
  8. ncbi request reprint ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FEBS Lett 579:4031-7. 2005
  9. ncbi request reprint Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, 5200 Eastern Avenue, Mason F Lord Building, Center Tower, Room 677, Baltimore, MD 21224, USA
    Exp Cell Res 304:40-9. 2005
  10. ncbi request reprint Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FASEB J 17:2240-9. 2003

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Cell Mol Biol 26:453-64. 2002
    ..Our results suggest a potential role for cortactin in the SS-induced EC cortical cytoskeletal remodeling and demonstrate a novel mechanism of Rac GTPase-dependent regulation of the pulmonary endothelial cytoskeleton by SS...
  2. ncbi request reprint Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Univ School of Medicine, 5501 Hopkins Bayview Circle, JHAAC, 5A 42, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 285:L785-97. 2003
    ..Thus our study demonstrates a critical role for the magnitude of CS in regulation of agonist-mediated pulmonary endothelial cell permeability and strongly suggests phenotypic regulation of HPAEC barrier properties by CS...
  3. ncbi request reprint Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 95:892-901. 2004
    ..Thus, oxidative modification of phospholipids during inflammation leads to the formation of novel regulators that may be critically involved in restoration of vascular barrier function...
  4. ncbi request reprint Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins
    Konstantin G Birukov
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:18-28. 2004
    ....
  5. ncbi request reprint Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase
    Steven M Dudek
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:24692-700. 2004
    ..These data support novel roles for the cytoskeletal proteins cortactin and EC MLCK in mediating lung vascular barrier augmentation evoked by S1P...
  6. ncbi request reprint Differential regulation of human lung epithelial and endothelial barrier function by thrombin
    Kamon Kawkitinarong
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 31:517-27. 2004
    ....
  7. ncbi request reprint Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Cell Physiol 204:934-47. 2005
    ..These results suggest a novel role for MT dynamics in the TGF-beta1-mediated Rho regulation, EC barrier dysfunction, and actin remodeling...
  8. ncbi request reprint ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FEBS Lett 579:4031-7. 2005
    ..Thus, our data demonstrate for the first time direct link between TGF-beta1-mediated activation of ALK5/Smad and EC barrier dysfunction...
  9. ncbi request reprint Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, 5200 Eastern Avenue, Mason F Lord Building, Center Tower, Room 677, Baltimore, MD 21224, USA
    Exp Cell Res 304:40-9. 2005
    ..Thus, our results suggest common signaling and cytoskeletal mechanisms shared by mechanical and chemical factors involved in EC barrier regulation...
  10. ncbi request reprint Involvement of site-specific FAK phosphorylation in sphingosine-1 phosphate- and thrombin-induced focal adhesion remodeling: role of Src and GIT
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    FASEB J 17:2240-9. 2003
    ..These observations highlight the differential mechanisms of focal adhesion protein complex remodeling and FAK activation by S1P and thrombin and link differential FA remodeling to EC barrier regulation...
  11. ncbi request reprint Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Microvasc Res 67:64-77. 2004
    ....
  12. ncbi request reprint MAP kinases in lung endothelial permeability induced by microtubule disassembly
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, MFL Center Tower, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 289:L75-84. 2005
    ..These data suggest a direct link between p38 MAPK activation, remodeling of MT network, and EC barrier regulation...
  13. ncbi request reprint Novel role of microtubules in thrombin-induced endothelial barrier dysfunction
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Ave, MFL Center Tower 660, Baltimore, MD 21224, USA
    FASEB J 18:1879-90. 2004
    ..Collectively, our data demonstrate for the first time a critical involvement of MT disassembly in thrombin-induced EC barrier dysfunction and indicate G-protein-dependent mechanisms of thrombin-induced MT alteration...
  14. ncbi request reprint Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms
    Anna A Birukova
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cell Physiol 201:55-70. 2004
    ....
  15. ncbi request reprint Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin
    Jeffrey R Jacobson
    Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 30:662-70. 2004
    ..These novel observations have broad clinical implications in numerous vascular pathobiologies characterized by alterations in vascular integrity including inflammation, angiogenesis, and acute lung injury...
  16. ncbi request reprint Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction
    Natalia V Bogatcheva
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
    Am J Physiol Lung Cell Mol Physiol 285:L415-26. 2003
    ..Together, these events result in stress fiber destabilization and profound actin rearrangement in bovine endothelium, which may result in the physiological alterations observed in these models...
  17. pmc Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
    Stephanie Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Crit Care 12:R27. 2008
    ....
  18. ncbi request reprint Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
    Raja Elie E Abdulnour
    Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006
    ..We conclude that XOR enzymatic activity is significantly increased by mechanical stress via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with VILI...
  19. pmc EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation
    Srinivas Papaiahgari
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 36:304-12. 2007
    ..Collectively, these novel findings suggest that EGFR-activated signaling and actin remodeling act in concert to regulate the CS-induced Nrf2-ARE transcriptional response and subsequent AOE expression...
  20. ncbi request reprint S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin
    Yasushi Shikata
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Appl Physiol 94:1193-203. 2003
    ..These results suggest a role of FA rearrangement in S1P-mediated barrier enhancement via Rac- and GIT-mediated processes...
  21. pmc Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury
    Stephanie Nonas
    Division of Pulmonary and Critical Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Respir Crit Care Med 173:1130-8. 2006
    ....
  22. ncbi request reprint Focal adhesions: paradigm for a signaling nexus
    Lewis H Romer
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4904, USA
    Circ Res 98:606-16. 2006
    ....
  23. ncbi request reprint Novel interaction of cortactin with endothelial cell myosin light chain kinase
    Steven M Dudek
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Biochem Biophys Res Commun 298:511-9. 2002
    ..These data suggest that cortactin-EC MLCK interaction may be a novel determinant of endothelial cortical actin-based cytoskeletal rearrangement...
  24. ncbi request reprint Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids
    Anna A Birukova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 293:L199-211. 2007
    ..In turn, paxillin knockdown by specific siRNA attenuated AJ enhancement in response to OxPAPC. These results show for the first time the novel interactions between FA and AJ protein complexes critical for EC barrier regulation by OxPAPC...
  25. pmc Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection
    Anna A Birukova
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Physiol 215:715-24. 2008
    ..These results suggest a novel mechanism of ANP protective effects against agonist-induced pulmonary EC barrier dysfunction via inhibition of Rho signaling by Epac/Rap1-Rac and PKA signaling cascades...
  26. pmc Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin
    Fernando Teran Arce
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Biophys J 95:886-94. 2008
    ....
  27. pmc Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids
    Anna A Birukova
    Dept of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 295:L593-602. 2008
    ....
  28. pmc Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
    Anna A Birukova
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, Chicago, IL 60637, USA
    Exp Cell Res 313:2504-20. 2007
    ..These mechanisms may mediate protective effects of PGs against agonist-induced lung vascular barrier dysfunction in vitro and against mechanical stress-induced lung injury in vivo...
  29. ncbi request reprint HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, University of Chicago, 929 East 57th St, CIS Bldg, W410, Chicago, IL 60637, USA
    FASEB J 21:2776-86. 2007
    ....
  30. pmc Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th Street, CIS Bldg, W410, Chicago, IL 60637, USA
    Microvasc Res 73:173-81. 2007
    ....
  31. ncbi request reprint Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids
    Anna A Birukova
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Physiol 211:608-17. 2007
    ..These results show for the first time that Tiam1 and betaPIX mediate OxPAPC-induced Rac activation, cytoskeletal remodeling, and barrier protective response in pulmonary endothelium...
  32. ncbi request reprint Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium
    Anna A Birukova
    Section of Pulmonary and Critical Medicine, Department of Medicine, Division of Biomedical Sciences, University of Chicago, 929 East 57th St, CIS Bldg, W410, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 292:L924-35. 2007
    ....
  33. pmc Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch
    Anna A Birukova
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Pathol 168:1749-61. 2006
    ..These results suggest a critical role for the CS amplitude and the balance between Rac and Rho in mechanochemical regulation of lung EC barrier...
  34. ncbi request reprint GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction
    Anna A Birukova
    Sect of Pulmonary and Critical Care, Dept of Medicine, Biological Sciences Div, Univ of Chicago, 929 E 57th St, W410, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 290:L540-8. 2006
    ....
  35. pmc Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation
    Anna A Birukova
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 295:L612-23. 2008
    ..These results support the importance of HGF-VEGF balance in control of acute lung injury/acute respiratory distress syndrome severity via small GTPase-dependent regulation of lung endothelial permeability...
  36. ncbi request reprint Oxidized lipids: the two faces of vascular inflammation
    Konstantin G Birukov
    Department of Medicine, University of Chicago, 929 East 57th Street, W410, Chicago, IL 60637, USA
    Curr Atheroscler Rep 8:223-31. 2006
    ....