S Bi

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance
    Liang Yang
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:179-90. 2009
  2. ncbi Dorsomedial hypothalamic NPY and energy balance control
    Sheng Bi
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropeptides 46:309-14. 2012
  3. ncbi Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 293:R55-63. 2007
  4. ncbi Role of dorsomedial hypothalamic neuropeptide Y in energy homeostasis
    Sheng Bi
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Peptides 28:352-6. 2007
  5. ncbi A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats
    S Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 281:R254-60. 2001
  6. ncbi Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland 21205, USA
    Endocrinology 146:1676-85. 2005
  7. ncbi Differential roles for cholecystokinin a receptors in energy balance in rats and mice
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 145:3873-80. 2004
  8. ncbi Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat
    Sheng Bi
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropeptides 36:171-81. 2002
  9. ncbi Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    Sheng Bi
    Dept of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, Ross 618, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1030-6. 2003
  10. ncbi Response to acute food deprivation in OLETF rats lacking CCK-A receptors
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Physiol Behav 79:655-61. 2003

Research Grants

  1. Dorsomedial Hypothalamic Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2005
  2. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
  3. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
  4. Exercise and energy balance: role of hypothalamic transthyretin
    Sheng Bi; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. ncbi Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance
    Liang Yang
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:179-90. 2009
    ..Together, these results indicate that DMH NPY plays an important role in modulating food intake and energy balance and its dysregulation causes disordered energy balance leading to obesity...
  2. ncbi Dorsomedial hypothalamic NPY and energy balance control
    Sheng Bi
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropeptides 46:309-14. 2012
    ..Overall, the recent findings provide clear evidence demonstrating critical roles for DMH NPY in energy balance control, and also imply a potential role for DMH NPY in maintaining glucose homeostasis...
  3. ncbi Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 293:R55-63. 2007
    ..Together, these data provide further evidence for differential roles of CCK1 receptors in the controls of food intake and body weight in rats and mice...
  4. ncbi Role of dorsomedial hypothalamic neuropeptide Y in energy homeostasis
    Sheng Bi
    Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Peptides 28:352-6. 2007
    ..Moreover, access to running wheels normalizes body weight and prevents altered DMH NPY expression of OLETF rats. Together, these data suggest that DMH NPY plays an important role in feeding and body weight control...
  5. ncbi A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats
    S Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 281:R254-60. 2001
    ..A similar DMH NPY overexpression was evident in 5-wk-old preobese OLETF rats. These findings suggest a role for DMH NPY upregulation in the etiology of OLETF hyperphagia and obesity...
  6. ncbi Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland 21205, USA
    Endocrinology 146:1676-85. 2005
    ....
  7. ncbi Differential roles for cholecystokinin a receptors in energy balance in rats and mice
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 145:3873-80. 2004
    ..The deficit in CCK's action in the control of DMH NPY gene expression may play a major role in the obese phenotype in OLETF rats...
  8. ncbi Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat
    Sheng Bi
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuropeptides 36:171-81. 2002
    ..Thus, the obesity in the OLETF rats may be the outcome of two regulatory disruptions, one depending upon a peripheral within meal satiety pathway and the other depending upon a central pathway critical to overall energy balance...
  9. ncbi Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    Sheng Bi
    Dept of Psychiatry and Behavioral Sciences, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, Ross 618, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1030-6. 2003
    ..Together, these data suggest that arcuate and DMH NPY gene expression are differentially regulated. DMH NPY-expressing neurons do not appear to be under the direct control of leptin signaling...
  10. ncbi Response to acute food deprivation in OLETF rats lacking CCK-A receptors
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Physiol Behav 79:655-61. 2003
    ....
  11. ncbi A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice
    X Li
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Int J Obes (Lond) 36:1215-21. 2012
    ..Synphilin-1, a cytoplasmic protein, was initially identified as an interaction partner of alpha-synuclein, and has implications in Parkinson's disease pathogenesis related to protein aggregation...
  12. ncbi Lateral ventricular ghrelin and fourth ventricular ghrelin induce similar increases in food intake and patterns of hypothalamic gene expression
    Kimberly P Kinzig
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1565-9. 2006
    ..These data demonstrate that ghrelin can affect food intake and hypothalamic gene expression through interactions at multiple brain sites...
  13. ncbi Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia
    Maiko Kawaguchi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 618, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1800-5. 2005
    ..Central CRF antagonist injection further increased DMH CRF mRNA expression in exercised rats. Together, these data suggest that DMH CRF play a critical role in the anorexia resulting from increased voluntary exercise...
  14. ncbi Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration
    J Chen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Neuroscience 152:178-88. 2008
    ..Together, these data suggest that DMH CCK plays an important role in the control of food intake, and does so by activating different pathways from those activated by peripheral CCK...
  15. ncbi Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet
    Kimberly P Kinzig
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
    Obes Res 13:1672-82. 2005
    ..To model how consuming a low-carbohydrate (LC) diet influences food intake and body weight...
  16. ncbi Intensive blood-pressure control in hypertensive chronic kidney disease
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    N Engl J Med 363:918-29. 2010
    ..Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients...
  17. ncbi Long-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Institutions, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    Arch Intern Med 168:832-9. 2008
    ..A low blood pressure (BP) goal (BP, <130/80 mm Hg) is also recommended. The objective of this study was to determine the long-term effects of currently recommended BP therapy in 1094 African Americans with hypertensive CKD...
  18. ncbi Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation
    Ellen E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Endocrinology 150:672-8. 2009
    ....
  19. ncbi Factors contributing to obesity in bombesin receptor subtype-3-deficient mice
    Ellen E Ladenheim
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland 21205, USA
    Endocrinology 149:971-8. 2008
    ..However, our finding that pair-feeding did not completely normalize fat distribution and plasma leptin levels suggests there is also a metabolic dysregulation that may contribute to, or sustain, their obese phenotype...
  20. ncbi Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Psychobiol 48:360-7. 2006
    ..These lasting metabolic effects of exercise may be secondary to an exercise induced reduction in DMH NPY mRNA expression...
  21. ncbi Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats
    Susan Aja
    Department of Psychiatry and Behavioural Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 291:R148-54. 2006
    ..Overall, the data suggest that gene expression changes leading to altered melanocortin signaling are important for the hypophagic response to intracerebroventricular C75...
  22. ncbi Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Philos Trans R Soc Lond B Biol Sci 361:1211-8. 2006
    ..The OLETF rat is a valuable model for characterizing actions of CCK in energy balance and has provided novel insights into interactions between exercise and food intake...
  23. ncbi High-fat diet offsets the long-lasting effects of running-wheel access on food intake and body weight in OLETF rats
    Pei Ting Chao
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1459-67. 2011
    ..Together, these results demonstrate that high-fat diet modulates the long-lasting effects of exercise on food intake and body weight in OLETF rats...

Research Grants8

  1. Dorsomedial Hypothalamic Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2005
    ..Together, these neurochemical and functional demonstrations will provide a clear view of the role of the DMH in energy balance ..
  2. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
    ..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
  3. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
    ..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
  4. Exercise and energy balance: role of hypothalamic transthyretin
    Sheng Bi; Fiscal Year: 2010
    ..Such identification will provide a potential target for the prevention and treatment of obesity. ..