Zaver Bhujwalla

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro
    Z M Bhujwalla
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 41:897-903. 1999
  2. pmc Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer
    Balaji Krishnamachary
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e44078. 2012
  3. pmc Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport
    Samata M Kakkad
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Universität Bremen, Fachbereich 2, Bremen, Germany
    PLoS ONE 8:e81869. 2013
  4. pmc COX-2 in cancer: Gordian knot or Achilles heel?
    Ioannis Stasinopoulos
    Johns Hopkins University In Vivo Cellular And Molecular Imaging Center Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine Baltimore, MD, USA
    Front Pharmacol 4:34. 2013
  5. ncbi request reprint Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470
    Zaver M Bhujwalla
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 9:355-62. 2003
  6. ncbi request reprint Combined vascular and extracellular pH imaging of solid tumors
    Z M Bhujwalla
    MR Oncology Section, Division of MR Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 15:114-9. 2002
  7. pmc Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts
    Z M Bhujwalla
    MR Oncology Section, Division of MR Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 3:143-53. 2001
  8. ncbi request reprint Tumor angiogenesis, vascularization, and contrast-enhanced magnetic resonance imaging
    Z M Bhujwalla
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Top Magn Reson Imaging 10:92-103. 1999
  9. doi request reprint Molecular and functional imaging of cancer
    Zaver M Bhujwalla
    JHU ICMIC Program of the Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:47-9. 2009
  10. ncbi request reprint Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    Yelena Mironchik
    Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 65:10801-9. 2005

Research Grants

  1. Functional Imaging of the Metastatic Phenotype
    Zaver Bhujwalla; Fiscal Year: 2006
  2. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASIS
    Zaver Bhujwalla; Fiscal Year: 2004
  3. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METASTASIS
    Zaver Bhujwalla; Fiscal Year: 2003
  4. Image-Guided Pro-Drug/Enzyme Therapy
    Zaver Bhujwalla; Fiscal Year: 2007
  5. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2002
  6. Image-guided Prodrug and siRNA Targeting of Cancer
    Zaver M Bhujwalla; Fiscal Year: 2010
  7. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METASTASIS
    Zaver Bhujwalla; Fiscal Year: 2000
  8. FUNTIONAL IMAGING OF THE METASTATIC PHENOTYPE
    Zaver Bhujwalla; Fiscal Year: 2000
  9. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2001
  10. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASIS
    Zaver Bhujwalla; Fiscal Year: 2006

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro
    Z M Bhujwalla
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 41:897-903. 1999
    ..These results suggest that nm23 genes may affect suppression of metastasis through phospholipid-mediated signaling and cellular pH regulation...
  2. pmc Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer
    Balaji Krishnamachary
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e44078. 2012
    ..Here we have investigated the effect of hypoxia on CD44 and two of its isoforms in MDA-MB-231 and SUM-149 triple negative human breast cancer cells and MDA-MB-231 tumors using imaging and molecular characterization...
  3. pmc Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport
    Samata M Kakkad
    JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Universität Bremen, Fachbereich 2, Bremen, Germany
    PLoS ONE 8:e81869. 2013
    ..High Col1 fiber density observed around hypoxic regions may facilitate the escape of aggressive cancer cells from hypoxic regions. ..
  4. pmc COX-2 in cancer: Gordian knot or Achilles heel?
    Ioannis Stasinopoulos
    Johns Hopkins University In Vivo Cellular And Molecular Imaging Center Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine Baltimore, MD, USA
    Front Pharmacol 4:34. 2013
    ..We review evidence from our studies and from literature suggesting that cyclooxygenase-2 (COX-2) biology presents a nodal point in cancer biology and an "Achilles heel" of COX-2-dependent tumors...
  5. ncbi request reprint Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470
    Zaver M Bhujwalla
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 9:355-62. 2003
    ..Magnetic resonance imaging (MRI) is one such noninvasive technique that is routinely used clinically...
  6. ncbi request reprint Combined vascular and extracellular pH imaging of solid tumors
    Z M Bhujwalla
    MR Oncology Section, Division of MR Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 15:114-9. 2002
    ..In this study, we have demonstrated the feasibility of such an approach, and presented methods of analyses to detect differences in patterns of combined parameters obtained from spatially co-registered regions in a solid tumor...
  7. pmc Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts
    Z M Bhujwalla
    MR Oncology Section, Division of MR Research, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 3:143-53. 2001
    ..We observed that although invasion was necessary, without adequate vascularization it was not sufficient for metastasis to occur...
  8. ncbi request reprint Tumor angiogenesis, vascularization, and contrast-enhanced magnetic resonance imaging
    Z M Bhujwalla
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Top Magn Reson Imaging 10:92-103. 1999
    ..Contrast-enhanced magnetic resonance imaging techniques that currently are available for basic research and clinical applications to study various aspects of tumor angiogenesis and neovascularization are discussed...
  9. doi request reprint Molecular and functional imaging of cancer
    Zaver M Bhujwalla
    JHU ICMIC Program of the Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:47-9. 2009
    ..Multi-modality and multi-parametric molecular and functional imaging provide unprecedented opportunities for understanding cancer. Some of our recent advances in molecular and functional imaging of cancer are discussed...
  10. ncbi request reprint Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    Yelena Mironchik
    Department of Radiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 65:10801-9. 2005
    ....
  11. ncbi request reprint Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 19:68-75. 2004
    ..To investigate the diagnostic value of proton magnetic resonance spectroscopic imaging (MRSI) in patients with breast lesions...
  12. pmc Extracellular acidification alters lysosomal trafficking in human breast cancer cells
    Kristine Glunde
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 5:533-45. 2003
    ..Filopodia formations, which were observed more frequently in highly metastatic breast cancer cells maintained at acidic pH(e), may also contribute to invasion...
  13. pmc Noninvasive MRI of endothelial cell response to human breast cancer cells
    Barjor Gimi
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Program, Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 8:207-13. 2006
    ....
  14. ncbi request reprint Novel system for determining contrast agent concentration in mouse blood in vivo
    Arvind P Pathak
    Department of Radiology, MR Oncology Section, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 51:612-5. 2004
    ....
  15. ncbi request reprint Diffusion-weighted and macromolecular contrast enhanced MRI of tumor response to antivascular therapy with ZD6126
    Jens Vogel-Claussen
    Johns Hopkins University In Vivo Cellular And Molecular Imaging Center Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 6:1469-75. 2007
    ..Both diffusion and vascular imaging are useful noninvasive techniques to detect response of tumors to antivascular therapy with ZD6126 in the DU-145 human prostate cancer xenograft model...
  16. ncbi request reprint Multimodal image-guided enzyme/prodrug cancer therapy
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Am Chem Soc 128:15072-3. 2006
    ..It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic stability in fresh mouse serum and human breast cancer cell culture...
  17. ncbi request reprint Benign and malignant breast lesions: diagnosis with multiparametric MR imaging
    Michael A Jacobs
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Traylor Bldg, Room 217, 712 Rutland Avenue, Baltimore, MD 21205, USA
    Radiology 229:225-32. 2003
    ..To both develop and use a tissue signature method for the identification and classification of breast lesions and healthy breast tissue with magnetic resonance (MR) imaging...
  18. ncbi request reprint Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype
    Arvind P Pathak
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 66:5151-8. 2006
    ..It is also possible that lymph node metastasis occurred via the cancer cell-bearing tumoral lymphatic vessels. The congestion of these tumoral lymphatics with cancer cells may have restricted the entry and transport of macromolecules...
  19. ncbi request reprint Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imaging
    Arvind P Pathak
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 65:1425-32. 2005
    ....
  20. pmc PAMAM dendrimer-based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach
    Wenlian Zhu
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 59:679-85. 2008
    ..Prolonged and extensive accumulation of both bG4D-Gd and b-G4-Gd-SA in the kidneys was also observed...
  21. ncbi request reprint Choline phospholipid metabolism: a target in cancer cells?
    Ellen Ackerstaff
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biochem 90:525-33. 2003
    ..In this article, we have summarized some of the observations on the choline phospholipid metabolism of cancer cells and tumors, and make a case for targeting the aberrant choline phospholipid metabolism of cancer cells...
  22. ncbi request reprint Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
    Kristine Glunde
    Magnetic Resonance Oncology Section, Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:4270-6. 2004
    ..These observations were consistent with the overexpression of choline kinase and phospholipase C detected in the microarray analyses...
  23. ncbi request reprint Choline metabolism in cancer: implications for diagnosis and therapy
    Kristine Glunde
    The Johns Hopkins University School of Medicine, Russell H Morgan Department of Radiology and Radiological Sciences and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
    Expert Rev Mol Diagn 6:821-9. 2006
    ....
  24. ncbi request reprint Molecular and functional imaging of cancer: advances in MRI and MRS
    Arvind P Pathak
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 386:3-60. 2004
  25. pmc Multiparametric magnetic resonance imaging, spectroscopy and multinuclear (²³Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Acad Radiol 17:1477-85. 2010
    ..The aim of this prospective study was to investigate using multiparametric and multinuclear magnetic resonance imaging during preoperative systemic therapy for locally advanced breast cancer...
  26. pmc Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models
    Yoshinori Kato
    Department of Radiology, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 6:891-7. 2007
    ..The absence of these molecular responses to TMZ treatment in MCF-7 tumors in vivo supports the possibility that the onset of cancer drug resistance is associated with reduced PS, which can decrease delivery of the drug to cancer cells...
  27. pmc Hypoxic tumor microenvironments reduce collagen I fiber density
    Samata M Kakkad
    Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 12:608-17. 2010
    ..These results suggest that hypoxia mediates Col1 fiber restructuring in tumors, which may impact delivery of macromolecular agents as well as dissemination of cells...
  28. pmc Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells
    Tariq Shah
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    NMR Biomed 23:633-42. 2010
    ....
  29. ncbi request reprint Will magnetic resonance imaging (MRI)-based contrast agents for molecular receptor imaging make their way into the clinic?
    Kristine Glunde
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Mol Med 12:187-8. 2008
  30. doi request reprint Image-guided enzyme/prodrug cancer therapy
    Cong Li
    Johns Hopkins University In Vivo Cellular Molecular Imaging Center Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Clin Cancer Res 14:515-22. 2008
    ....
  31. pmc Noninvasive multiparametric imaging of metastasis-permissive microenvironments in a human prostate cancer xenograft
    Marie France Penet
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University In Vivo Cellular And Molecular Imaging Center Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 69:8822-9. 2009
    ..These results also provide the basis for clinically translatable noninvasive imaging markers for predicting metastatic risk in prostate cancer...
  32. ncbi request reprint Visualizing head and neck tumors in vivo using near-infrared fluorescent transferrin conjugate
    Liang Shan
    Department of Radiology, Howard University, Washington, DC 20060, USA
    Mol Imaging 7:42-9. 2008
    ..74, p=.002). Our results indicate that TfR is a promising target and that Tf(NIR)-based optical imaging is potentially useful for noninvasive detection of early HNSCC in the clinic...
  33. pmc Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neoplasia 11:1285-91. 2009
    ..We have demonstrated significant suppression of tumor growth in vivo and subsequent reductions in microvascular density, indicating the potential of these peptides as therapeutic agents for breast cancer...
  34. ncbi request reprint Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Med Chem 51:3572-82. 2008
    ....
  35. ncbi request reprint Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Technol Cancer Res Treat 3:543-50. 2004
    ..A combination of MR, MRSI, and 23Na sodium MR parameters may be examined in a single MR imaging examination, potentially resulting in improved specificity for radiologic evaluation of malignancy...
  36. ncbi request reprint A novel method of imaging lysosomes in living human mammary epithelial cells
    Kristine Glunde
    Johns Hopkins University School of Medicine, 208C Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Mol Imaging 2:24-36. 2003
    ..This novel method of labeling lysosomes biosynthetically was used to image lysosomes in living HMECs perfused in a microscopy-compatible cell perfusion system...
  37. ncbi request reprint Magnetic resonance imaging of cell surface receptors using targeted contrast agents
    Dmitri Artemov
    Johns Hopkins University School of Medicine, JHU ICMIC Program, Department of Radiology, Traylor 217, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Curr Pharm Biotechnol 5:485-94. 2004
    ..In this article we have reviewed current MRI strategies used to visualize receptor expression, the potential advantages and drawbacks of these strategies, and novel areas of focus for the future...
  38. ncbi request reprint Combined dynamic contrast enhanced breast MR and proton spectroscopic imaging: a feasibility study
    Michael A Jacobs
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 21:23-8. 2005
    ..To investigate the feasibility of combined dynamic contrast enhanced (DCE) and magnetic resonance spectroscopy (MRS) in evaluating breast lesions...
  39. ncbi request reprint Synthesis of 6'-O-lissamine-rhodamine B-glucosamine as a novel probe for fluorescence imaging of lysosomes in breast tumors
    Kristine Glunde
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Bioconjug Chem 16:843-51. 2005
    ..We also demonstrated the feasibility of performing in vivo fluorescence imaging of 6'-O-lissamine-rhodamine B-glucosamine to image lysosomes in human breast cancer models...
  40. ncbi request reprint Magnetic resonance molecular imaging of the HER-2/neu receptor
    Dmitri Artemov
    Departments of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 63:2723-7. 2003
    ..Potential applications of this approach may include determination of the HER-2/neu status for prognosis and for selecting tumors for monoclonal antibody therapy...
  41. ncbi request reprint MRI of regular-shaped cell-encapsulating polyhedral microcontainers
    Barjor Gimi
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Magn Reson Med 58:1283-7. 2007
    ..As opposed to the diamagnetic microcontainer, the ferromagnetic microcontainer created a region of MRI contrast several times larger than the microcontainer's dimensions...
  42. ncbi request reprint Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells
    Noriko Mori
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 67:11284-90. 2007
    ..Chk down-regulation with siRNA-chk may provide a novel alternative to enhance the effect of anticancer drugs in malignant cells...
  43. pmc Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism
    Ellen Ackerstaff
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 720 Rutland Ave, Traylor Bldg 217, Baltimore, MD 21205, USA
    Neoplasia 9:1138-51. 2007
    ..Gene expression profiling indicated that hypoxia affects multiple cellular functions and pathways...
  44. pmc Hypoxia increases breast cancer cell-induced lymphatic endothelial cell migration
    Maria Mikhaylova
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 10:380-9. 2008
    ..These data demonstrate the importance of hypoxia in lymphatic endothelial cell invasion and migration through extracellular matrix in the presence of cancer cells...
  45. pmc Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21231, USA
    Neoplasia 11:477-84. 2009
    ....
  46. pmc The malignant phenotype of breast cancer cells is reduced by COX-2 silencing
    Ioannis Stasinopoulos
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 10:1163-9. 2008
    ..Inhibition of human umbilical vein endothelial cell network association in a coculture assay was also observed in COX-2-silenced cells. These data highlight the functional role of COX-2 in pathways that mediate increased malignancy...
  47. ncbi request reprint Choline phospholipid metabolites of human vascular endothelial cells altered by cyclooxygenase inhibition, growth factor depletion, and paracrine factors secreted by cancer cells
    Noriko Mori
    Johns Hopkins University, Baltimore, MD, USA
    Mol Imaging 2:124-30. 2003
    ....
  48. ncbi request reprint RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation
    Kristine Glunde
    John Hopkins University In Vivo Cellular Molecular Imaging Center Program, Russell H Morgan Department of Radiology and Radiological Science, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 65:11034-43. 2005
    ..These results strongly support the targeting of choline kinase in breast cancer cells with RNAi and show the potential ability of noninvasive MRS to detect and evaluate future treatments incorporating such strategies...
  49. ncbi request reprint Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model
    Venu Raman
    The Johns Hopkins University, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 66:9929-36. 2006
    ..These observations are consistent with the possibility that regions of low vascular volumes are hypoxic, which induces increased expression of functionally active vascular endothelial growth factor, a potent vascular permeability factor...
  50. pmc Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells
    Kristine Glunde
    MR Oncology Section, Division of MR Research, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 8:758-71. 2006
    ....
  51. pmc Exposure of human breast cancer cells to the anti-inflammatory agent indomethacin alters choline phospholipid metabolites and Nm23 expression
    Kshama Natarajan
    Department of Radiology, MR Oncology Section, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 4:409-16. 2002
    ..These results suggest that COX-1 expression and its inhibition play a role in the choline phospholipid metabolism of HMECs, and the effect of indomethacin on HMECs may be mediated, in part, through upregulation of nm23...
  52. pmc Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line
    Ellen Ackerstaff
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neoplasia 9:222-35. 2007
    ....
  53. ncbi request reprint Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin
    Kristine Glunde
    MR Oncology Section, Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 48:819-25. 2002
    ..These changes were not related to alterations of intra- or extracellular pH...
  54. ncbi request reprint Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells
    Ioannis Stasinopoulos
    Department of Radiology, The Johns Hopkins University School of Medicine, Room 208C, Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Mol Cancer Res 5:435-42. 2007
    ..These data show that silencing of COX-2 abolishes the metastatic potential of MDA-MB-231 cells in vivo...
  55. ncbi request reprint Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions
    Kristine Glunde
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pharm 3:496-506. 2006
    ..In this contextual review, we have outlined the insight we have gained from these studies and have discussed some of the enzymes and pathways that may present novel targets for pharmaceutical interventions in cancer...
  56. pmc An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer
    Hong Song
    Division of Nuclear Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Clin Cancer Res 14:6116-24. 2008
    ..We have developed and characterized a preclinical model for the evaluation of immune-mediated metastatic breast cancer therapies...
  57. pmc Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft
    Balaji Krishnamachary
    Johns Hopkins University In Vivo Cellular Molecular Imaging Center Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 69:3464-71. 2009
    ..This study shows the use of lentiviral vectors to target chk in a human breast cancer xenograft and noninvasive MRS detection of this targeting...
  58. ncbi request reprint MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles
    Dmitri Artemov
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 49:403-8. 2003
    ..In these experiments, iron oxide nanoparticles were attached to the cell surface and were not internalized into the cells, which is a major advantage for in vivo applications of the method...
  59. pmc Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 70:3935-44. 2010
    ..Our findings show the feasibility of imaging CXCR4 by positron emission tomography using a clinically approved agent as a molecular scaffold...
  60. ncbi request reprint Cell viability and noninvasive in vivo MRI tracking of 3D cell encapsulating self-assembled microcontainers
    Barjor Gimi
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75062, USA
    Cell Transplant 16:403-8. 2007
    ..The microcontainers are characterized by their small size, three dimensionality, controlled porosity, ease of parallel fabrication, chemical and mechanical stability, and noninvasive traceability in vivo...
  61. doi request reprint Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model
    Kristine Glunde
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 68:172-80. 2008
    ..These data suggest that HIF-1 activation of HREs within the putative chk-alpha promoter region can increase Chk-alpha expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments...
  62. doi request reprint MR molecular imaging of tumor vasculature and vascular targets
    Arvind P Pathak
    JHU ICMIC Program, Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Adv Genet 69:1-30. 2010
    ..In this review, we have focused on developments in the characterization of tumor vasculature with functional and molecular MRI...
  63. ncbi request reprint Magnetic resonance imaging and spectroscopy of transgenic models of cancer
    Venu Raman
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    NMR Biomed 20:186-99. 2007
    ....
  64. pmc HIF-dependent antitumorigenic effect of antioxidants in vivo
    Ping Gao
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 12:230-8. 2007
    ..These findings challenge the paradigm that antioxidants diminish tumorigenesis primarily through decreasing DNA damage and mutations and provide significant support for a key antitumorigenic effect of diminishing HIF levels...
  65. ncbi request reprint Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Org Lett 8:3623-6. 2006
    ..In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines...
  66. ncbi request reprint Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline
    Noriko Mori
    Department of Radiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Traylor Building, Baltimore, MD 21205, USA
    Mol Imaging 3:319-23. 2004
    ..These data suggest that the increased malignancy of cancer cells resulting from loss of p53 may be mediated, in part, through the choline phospholipid pathway...
  67. pmc Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2
    Ioannis Stasinopoulos
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 8:31-5. 2009
    ..data suggest that the profound effects of COX-2 silencing on inhibiting invasion, tumor growth and metastasis from MDA-MB-231 cells are dependent on the induction of IL-1beta-dependent COX-2 and HIF-1alpha but are independent of hypoxia..
  68. ncbi request reprint Self-assembled three dimensional radio frequency (RF) shielded containers for cell encapsulation
    Barjor Gimi
    The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biomed Microdevices 7:341-5. 2005
    ..This demonstration is the first step toward the design of 3D, micropatterned, non-invasively trackable, encapsulation devices...
  69. pmc Molecular and functional MRI of the tumor microenvironment
    Marie France Penet
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Nucl Med 49:687-90. 2008
  70. ncbi request reprint Visualizing function in the tumor-associated lymphatic system
    Arvind P Pathak
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Lymphat Res Biol 2:165-72. 2004
    ..This article reviews imaging and other techniques that allow the assessment of lymphatic function, particularly in the tumor microenvironment, and proposes novel solutions for probing the same in vivo...
  71. ncbi request reprint MRI of the tumor microenvironment
    Robert J Gillies
    Department of Biochemistry, Arizona Cancer Center, University of Arizona HSC, Tucson, Arizona 85724 5024, USA
    J Magn Reson Imaging 16:430-50. 2002
    ..Examples are also discussed using electron MR, optical, and radionuclear imaging techniques...
  72. ncbi request reprint Dual probe with fluorescent and magnetic properties for imaging solid tumor xenografts
    Liang Shan
    Department of Radiology and Radiation Oncology, Howard University, Washingron, DC 20060, USA
    Mol Imaging 6:85-95. 2007
    ....
  73. ncbi request reprint Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin
    Hagit Dafni
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100 Israel
    Cancer Res 62:6731-9. 2002
    ..These results revealed a direct link between expression of VEGF165 and peritumor lymphatic drain, thus suggesting a possible role for tumor-derived VEGF in metastatic spread to sentinel lymph nodes...
  74. ncbi request reprint Molecular-functional imaging of cancer: to image and imagine
    Kristine Glunde
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Mol Med 13:287-97. 2007
    ....
  75. ncbi request reprint Choline kinase alpha in cancer prognosis and treatment
    Kristine Glunde
    Lancet Oncol 8:855-7. 2007

Research Grants33

  1. Functional Imaging of the Metastatic Phenotype
    Zaver Bhujwalla; Fiscal Year: 2006
    ..This information is critical for developing strategies to prevent metastasis from prostate cancer. ..
  2. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASIS
    Zaver Bhujwalla; Fiscal Year: 2004
    ..The studies proposed in this application will lead to the potential identification of targets and pathways for the prevention of metastatic disease. ..
  3. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METASTASIS
    Zaver Bhujwalla; Fiscal Year: 2003
    ..Several existing forms of treatment induce hostile environments and it is imperative to determine if these treatments promote subsequent metastasis by promoting invasive behavior of residual cancer cells. ..
  4. Image-Guided Pro-Drug/Enzyme Therapy
    Zaver Bhujwalla; Fiscal Year: 2007
    ..Such a strategy will allow the visualization of the prodrug enzyme to optimize the timing of the prodrug administration to when the enzyme concentration in tumor relative to normal tissue is the highest. ..
  5. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2002
    ..abstract_text> ..
  6. Image-guided Prodrug and siRNA Targeting of Cancer
    Zaver M Bhujwalla; Fiscal Year: 2010
    ....
  7. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METASTASIS
    Zaver Bhujwalla; Fiscal Year: 2000
    ..Several existing forms of treatment induce hostile environments and it is imperative to determine if these treatments promote subsequent metastasis by promoting invasive behavior of residual cancer cells. ..
  8. FUNTIONAL IMAGING OF THE METASTATIC PHENOTYPE
    Zaver Bhujwalla; Fiscal Year: 2000
    ..The aim of the cell studies is to develop a "Metabolic Boyden Chamber" for MR studies of metabolism and invasion of isolated and perfused cells to determine the role of the lactate concentration, pH and oxygen tension in invasion. ..
  9. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2001
    ..abstract_text> ..
  10. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASIS
    Zaver Bhujwalla; Fiscal Year: 2006
    ..The studies proposed in this application will lead to the potential identification of targets and pathways for the prevention of metastatic disease. ..
  11. Functional Imaging of the Metastatic Phenotype
    Zaver Bhujwalla; Fiscal Year: 2005
    ..This information is critical for developing strategies to prevent metastasis from prostate cancer. ..
  12. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..abstract_text> ..
  13. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METASTASIS
    Zaver Bhujwalla; Fiscal Year: 1999
    ..Several existing forms of treatment induce hostile environments and it is imperative to determine if these treatments promote subsequent metastasis by promoting invasive behavior of residual cancer cells. ..
  14. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METASTASIS
    Zaver Bhujwalla; Fiscal Year: 2001
    ..Several existing forms of treatment induce hostile environments and it is imperative to determine if these treatments promote subsequent metastasis by promoting invasive behavior of residual cancer cells. ..
  15. Imaging Hypoxia and Cancer Stem Cells
    Zaver M Bhujwalla; Fiscal Year: 2010
    ..These studies will identify noninvasive surrogate markers for tumor regions containing stem-like breast cancer cells, and create novel treatments to target this lethal subpopulation. ..
  16. JHU ICMIC PROGRAM
    Zaver Bhujwalla; Fiscal Year: 2007
    ..Strong institutional support and the advocacy of the Dean, Vice-Dean and Chairs of Radiology, Oncology and Biomedical Engineering will further ensure the success of the JHU ICMIC and fulfillment of its vision...
  17. Functional Imaging of the Metastatic Phenotype
    Zaver M Bhujwalla; Fiscal Year: 2010
    ....
  18. Image-guided Prodrug and siRNA Targeting of Cancer
    Zaver Bhujwalla; Fiscal Year: 2009
    ....
  19. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASIS
    Zaver Bhujwalla; Fiscal Year: 2005
    ..The studies proposed in this application will lead to the potential identification of targets and pathways for the prevention of metastatic disease. ..
  20. FUNTIONAL IMAGING OF THE METASTATIC PHENOTYPE
    Zaver Bhujwalla; Fiscal Year: 1999
    ..The aim of the cell studies is to develop a "Metabolic Boyden Chamber" for MR studies of metabolism and invasion of isolated and perfused cells to determine the role of the lactate concentration, pH and oxygen tension in invasion. ..
  21. FUNTIONAL IMAGING OF THE METASTATIC PHENOTYPE
    Zaver Bhujwalla; Fiscal Year: 2000
    ..The aim of the cell studies is to develop a "Metabolic Boyden Chamber" for MR studies of metabolism and invasion of isolated and perfused cells to determine the role of the lactate concentration, pH and oxygen tension in invasion. ..
  22. Functional Imaging of the Metastatic Phenotype
    Zaver Bhujwalla; Fiscal Year: 2002
    ..This information is critical for developing strategies to prevent metastasis from prostate cancer. ..
  23. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METASTASIS
    Zaver Bhujwalla; Fiscal Year: 2002
    ..Several existing forms of treatment induce hostile environments and it is imperative to determine if these treatments promote subsequent metastasis by promoting invasive behavior of residual cancer cells. ..
  24. MULTIDICIPLINARY FUNCTIONAL IMAGING OF CANCER
    Zaver Bhujwalla; Fiscal Year: 2002
    ..abstract_text> ..
  25. Functional Imaging of the Metastatic Phenotype
    Zaver Bhujwalla; Fiscal Year: 2003
    ..This information is critical for developing strategies to prevent metastasis from prostate cancer. ..
  26. Functional Imaging of the Metastatic Phenotype
    Zaver Bhujwalla; Fiscal Year: 2004
    ..This information is critical for developing strategies to prevent metastasis from prostate cancer. ..
  27. Functional Imaging of the Metastatic Phenotype
    Zaver M Bhujwalla; Fiscal Year: 2011
    ....
  28. Imaging Hypoxia and Cancer Stem Cells
    Zaver Bhujwalla; Fiscal Year: 2009
    ..These studies will identify noninvasive surrogate markers for tumor regions containing stem-like breast cancer cells, and create novel treatments to target this lethal subpopulation. ..
  29. HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASIS
    Zaver Bhujwalla; Fiscal Year: 2007
    ..The studies proposed in this application will lead to the potential identification of targets and pathways for the prevention of metastatic disease. ..