Chetan Bettegowda

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Exomic sequencing of four rare central nervous system tumor types
    Chetan Bettegowda
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 4:572-83. 2013
  2. doi request reprint Sublabial approach for the treatment of symptomatic basilar impression in a patient with Klippel-Feil syndrome
    Chetan Bettegowda
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neurosurgery 69:ons77-82; discussion ons82. 2011
  3. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
  4. pmc Lessons learned from next-generation sequencing in head and neck cancer
    Myriam Loyo
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Head Neck 35:454-63. 2013
  5. pmc Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Science 333:1453-5. 2011
  6. pmc Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
    Nishant Agrawal
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institutions, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Discov 2:899-905. 2012
  7. doi request reprint Detection of circulating tumor DNA in early- and late-stage human malignancies
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Sci Transl Med 6:224ra24. 2014
  8. doi request reprint Intramedullary spinal cord tumor surgery: can we do it without intraoperative neurophysiological monitoring?
    Wesley Hsu
    Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Childs Nerv Syst 26:241-5. 2010
  9. pmc Erlotinib inhibits growth of a patient-derived chordoma xenograft
    I Mei Siu
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e78895. 2013
  10. doi request reprint Spinal cord tumours: advances in genetics and their implications for treatment
    Patricia L Zadnik
    The Johns Hopkins University School of Medicine, Department of Neurosurgery, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Nat Rev Neurol 9:257-66. 2013

Collaborators

Detail Information

Publications21

  1. pmc Exomic sequencing of four rare central nervous system tumor types
    Chetan Bettegowda
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 4:572-83. 2013
    ..Our study supports the hypothesis that pathologically similar tumors arising in different age groups and from different compartments may represent distinct disease processes with varied genetic composition...
  2. doi request reprint Sublabial approach for the treatment of symptomatic basilar impression in a patient with Klippel-Feil syndrome
    Chetan Bettegowda
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neurosurgery 69:ons77-82; discussion ons82. 2011
    ..Symptomatic BI is often difficult to treat surgically secondary to the anatomic variants associated with many of the coinciding congenital syndromes...
  3. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
    ....
  4. pmc Lessons learned from next-generation sequencing in head and neck cancer
    Myriam Loyo
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Head Neck 35:454-63. 2013
    ..Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed...
  5. pmc Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Science 333:1453-5. 2011
    ..These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes...
  6. pmc Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
    Nishant Agrawal
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institutions, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Discov 2:899-905. 2012
    ..Finally, we provide a genetic basis for the evolution of EACs from Barrett esophagus...
  7. doi request reprint Detection of circulating tumor DNA in early- and late-stage human malignancies
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Sci Transl Med 6:224ra24. 2014
    ..Together, these data suggest that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes in patients with multiple different types of cancer. ..
  8. doi request reprint Intramedullary spinal cord tumor surgery: can we do it without intraoperative neurophysiological monitoring?
    Wesley Hsu
    Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Childs Nerv Syst 26:241-5. 2010
    ..The objective of this review is to discuss the utilization of intraoperative neurophysiological monitoring (IONM) during spinal cord tumor surgery...
  9. pmc Erlotinib inhibits growth of a patient-derived chordoma xenograft
    I Mei Siu
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e78895. 2013
    ..This is the first demonstration of antitumor activity in a patient-derived chordoma xenograft model and these findings support further evaluation of EGFR inhibitors in this disease. ..
  10. doi request reprint Spinal cord tumours: advances in genetics and their implications for treatment
    Patricia L Zadnik
    The Johns Hopkins University School of Medicine, Department of Neurosurgery, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Nat Rev Neurol 9:257-66. 2013
    ..We highlight advances in understanding of the biological basis of these lesions, and explain how the latest progress in genetics and beyond are being translated to improve patient care...
  11. doi request reprint Treatment of choroid plexus tumors: a 20-year single institutional experience
    Chetan Bettegowda
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurosurg Pediatr 10:398-405. 2012
    ..The optimal perioperative management and oncological care remain a matter of debate. The authors present the epidemiological and clinical features of CPTs from a 20-year single-institutional experience...
  12. pmc Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS
    Nishant Agrawal
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 98:E364-9. 2013
    ..Objective: To explore the genetic origin of MTC, we sequenced the protein coding exons of approximately 21,000 genes in 17 sporadic MTCs...
  13. pmc Altered telomeres in tumors with ATRX and DAXX mutations
    Christopher M Heaphy
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 333:425. 2011
    ..ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes...
  14. doi request reprint Predictors of surgery-free outcome in adult endoscopic third ventriculostomy
    Graeme F Woodworth
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    World Neurosurg 78:312-7. 2012
    ..We analyze patient, radiographic, and operative factors associated with CSF diversion surgery-free outcomes after ETV...
  15. doi request reprint Subependymoma: clinical features and surgical outcomes
    Amit Jain
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Neurol Res 34:677-84. 2012
    ..Subependymomas are rare, indolent neoplasms that have been described in the brain and the spinal cord. The purpose of this study is to report the clinical and radiolographic features, and surgical outcomes of this entity...
  16. doi request reprint Patients undergoing surgery of intracranial metastases have different outcomes based on their primary pathology
    Kaisorn L Chaichana
    Johns Hopkins University, Baltimore, MD, USA
    Neurol Res 35:1059-69. 2013
    ..Patients who develop intracranial metastases are often grouped into the same study population, and therefore an understanding of outcomes for patients with different primary cancers remain unclear...
  17. pmc Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers
    Isaac Kinde
    The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA
    Sci Transl Med 5:167ra4. 2013
    ..Although improvements need to be made before applying this test in a routine clinical manner, it represents a promising step toward a broadly applicable screening methodology for the early detection of gynecologic malignancies...
  18. doi request reprint Pediatric spinal glioblastoma multiforme: current treatment strategies and possible predictors of survival
    Chiagozie Ononiwu
    Division of Pediatric Neurosurgery, Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Childs Nerv Syst 28:715-20. 2012
    ..Evidence-directed management relies on studies in which such cases are only a subset of a larger group. We reviewed cases of pediatric spinal GBM to assess outcomes and identify prognostic factors related to treatment...
  19. pmc Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    Nishant Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Science 333:1154-7. 2011
    ..Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type...
  20. pmc Pre- and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomas
    Hatim Husain
    Brain Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, 1M 16, Baltimore, MD, 21287, USA
    J Neurooncol 109:123-7. 2012
    ..GFAP remains a potentially informative plasma biomarker for gliomas. Longitudinal studies are required to correlate pGFAP levels with patient outcomes...
  21. doi request reprint Intramedullary tumoral calcinosis
    Vivek A Mehta
    Division of Pediatric Neurosurgery, Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosurg Pediatr 5:630-5. 2010
    ..Additionally, salient features of the TC diagnosis, radiological patterns, histological findings, treatment, and outcomes are discussed...