Research Topics
Genomes and Genes | DAVID MONTY BERMANSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Publications
Medulloblastoma growth inhibition by hedgehog pathway blockadeDavid M Berman
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 297:1559-61. 2002....- Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumoursDavid M Berman
Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 425:846-51. 2003..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression... 
Investigative pathology: leading the post-genomic revolutionDavid M Berman
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Lab Invest 92:4-8. 2012..This review calls for changes aimed at rectifying these troubling trends to ensure that pathology continues to guide patient care in a post-genomic era...
Pre-processing Agilent microarray dataMarianna Zahurak
Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA
BMC Bioinformatics 8:142. 2007..The larger goal is to define best study design and pre-processing practices for Agilent arrays, and we offer some suggestions...- Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesisDavid M Berman
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Biol 267:387-98. 2004..Taken together, our studies indicate that the initial organogenesis of the prostate proceeds independently of Shh, but that Shh or other Hh ligands may play a role in subsequent events that pattern the prostate... - Hedgehog signalling in prostate regeneration, neoplasia and metastasisSunil S Karhadkar
Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 431:707-12. 2004..Monitoring and manipulating Hh pathway activity may thus offer significant improvements in diagnosis and treatment of prostate cancers with metastatic potential... - Tissue repair and stem cell renewal in carcinogenesisPhilip A Beachy
Department of Molecular Biology and Genetics, The Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
Nature 432:324-31. 2004.... - Hedgehog signaling: progenitor phenotype in small-cell lung cancerD Neil Watkins
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 572, Baltimore, MD 21231, USA
Cell Cycle 2:196-8. 2003..How Hh signaling works to promote the malignant phenotype promises to be as important biologically as the promise of Hh pathway inhibitors are clinically... - Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancerD Neil Watkins
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 422:313-7. 2003..This requirement for Hh pathway activation identifies a common lethal malignancy that may respond to pharmacological blockade of the Hh signalling pathway... - Mending and malignancyPhilip A Beachy
Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, at The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 431:402. 2004 - Urothelial carcinoma: stem cells on the edgeWilliam D Brandt
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Cancer Metastasis Rev 28:291-304. 2009..In this review, we discuss the implications of these findings in understanding CSCs and in better understanding how UroCas form, progress, and should be treated... - Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasisWolfram Kleeberger
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 67:9199-206. 2007..Further dissection of this novel Nestin migration pathway may lead to strategies to prevent and neutralize metastatic spread... - Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cellsJoyce E Ohm
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 70:7662-73. 2010..Our findings suggest that by studying the process of induced reprogramming, we may gain significant insight into the origins of epigenetic gene silencing associated with human tumorigenesis, and add to means of assessing iPS for safety... - Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinomaZeshaan A Rasheed
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Natl Cancer Inst 102:340-51. 2010..Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma... - Molecular genetic analysis of ovarian serous cystadenomasEric J Cheng
Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231, USA
Lab Invest 84:778-84. 2004..Accordingly, it appears that serous cystadenomas develop as a hyperplastic expansion from epithelial inclusions with a clonal/neoplastic transformation occurring in a subset of them... - A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencingJoyce E Ohm
Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center
Nat Genet 39:237-42. 2007.... - A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican AmericansJian Gu
Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Cancer 106:2716-24. 2006..Recently, the authors reported that 3 single-nucleotide polymorphisms (SNPs) in 2 members of the RGS family were associated with significant reductions in the risk of cancer... - Measuring tissue-based biomarkers by immunochromatography coupled with reverse-phase lysate microarrayMartin J Romeo
Laboratory of Pathology, Surgery Branch, and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
Clin Cancer Res 12:2463-7. 2006..41-0.64). CONCLUSION: I-RPM is a promising technology for quantitative grading of tissue biomarkers; however, antigen-dependent correlations are noted...
Research Grants
- Hedgehog Pathway in Urogenital Sinus DevelopmentDavid Berman; Fiscal Year: 2005..The aim of the mentored training period is to acquire the necessary intellectual and technical skills to transition into independent investigation of urogenital development and its relationships to urologic disease. ..
- Hedgehog signaling links bladder injury and cancerDavid Berman; Fiscal Year: 2006..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
- Hedgehog signaling links bladder injury and cancerDavid Berman; Fiscal Year: 2009..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
- Hedgehog signaling links bladder injury and cancerDavid Berman; Fiscal Year: 2009..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
- Hedgehog signaling links bladder injury and cancerDAVID MONTY BERMAN; Fiscal Year: 2010..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..