DAVID MONTY BERMAN

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Medulloblastoma growth inhibition by hedgehog pathway blockade
    David M Berman
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 297:1559-61. 2002
  2. ncbi request reprint Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
  3. doi request reprint Investigative pathology: leading the post-genomic revolution
    David M Berman
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Lab Invest 92:4-8. 2012
  4. pmc Pre-processing Agilent microarray data
    Marianna Zahurak
    Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA
    BMC Bioinformatics 8:142. 2007
  5. ncbi request reprint Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis
    David M Berman
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 267:387-98. 2004
  6. ncbi request reprint Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    Sunil S Karhadkar
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:707-12. 2004
  7. ncbi request reprint Tissue repair and stem cell renewal in carcinogenesis
    Philip A Beachy
    Department of Molecular Biology and Genetics, The Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Nature 432:324-31. 2004
  8. ncbi request reprint Hedgehog signaling: progenitor phenotype in small-cell lung cancer
    D Neil Watkins
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 572, Baltimore, MD 21231, USA
    Cell Cycle 2:196-8. 2003
  9. ncbi request reprint Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    D Neil Watkins
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 422:313-7. 2003
  10. ncbi request reprint Mending and malignancy
    Philip A Beachy
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, at The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:402. 2004

Research Grants

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Medulloblastoma growth inhibition by hedgehog pathway blockade
    David M Berman
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 297:1559-61. 2002
    ....
  2. ncbi request reprint Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
    ..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression...
  3. doi request reprint Investigative pathology: leading the post-genomic revolution
    David M Berman
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Lab Invest 92:4-8. 2012
    ..This review calls for changes aimed at rectifying these troubling trends to ensure that pathology continues to guide patient care in a post-genomic era...
  4. pmc Pre-processing Agilent microarray data
    Marianna Zahurak
    Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA
    BMC Bioinformatics 8:142. 2007
    ..The larger goal is to define best study design and pre-processing practices for Agilent arrays, and we offer some suggestions...
  5. ncbi request reprint Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis
    David M Berman
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 267:387-98. 2004
    ..Taken together, our studies indicate that the initial organogenesis of the prostate proceeds independently of Shh, but that Shh or other Hh ligands may play a role in subsequent events that pattern the prostate...
  6. ncbi request reprint Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    Sunil S Karhadkar
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:707-12. 2004
    ..Monitoring and manipulating Hh pathway activity may thus offer significant improvements in diagnosis and treatment of prostate cancers with metastatic potential...
  7. ncbi request reprint Tissue repair and stem cell renewal in carcinogenesis
    Philip A Beachy
    Department of Molecular Biology and Genetics, The Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Nature 432:324-31. 2004
    ....
  8. ncbi request reprint Hedgehog signaling: progenitor phenotype in small-cell lung cancer
    D Neil Watkins
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Room 572, Baltimore, MD 21231, USA
    Cell Cycle 2:196-8. 2003
    ..How Hh signaling works to promote the malignant phenotype promises to be as important biologically as the promise of Hh pathway inhibitors are clinically...
  9. ncbi request reprint Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    D Neil Watkins
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 422:313-7. 2003
    ..This requirement for Hh pathway activation identifies a common lethal malignancy that may respond to pharmacological blockade of the Hh signalling pathway...
  10. ncbi request reprint Mending and malignancy
    Philip A Beachy
    Department of Molecular Biology and Genetics and the Howard Hughes Medical Institute, at The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 431:402. 2004
  11. pmc Urothelial carcinoma: stem cells on the edge
    William D Brandt
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Metastasis Rev 28:291-304. 2009
    ..In this review, we discuss the implications of these findings in understanding CSCs and in better understanding how UroCas form, progress, and should be treated...
  12. pmc Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis
    Wolfram Kleeberger
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 67:9199-206. 2007
    ..Further dissection of this novel Nestin migration pathway may lead to strategies to prevent and neutralize metastatic spread...
  13. pmc Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells
    Joyce E Ohm
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 70:7662-73. 2010
    ..Our findings suggest that by studying the process of induced reprogramming, we may gain significant insight into the origins of epigenetic gene silencing associated with human tumorigenesis, and add to means of assessing iPS for safety...
  14. pmc Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    Zeshaan A Rasheed
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Natl Cancer Inst 102:340-51. 2010
    ..Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma...
  15. ncbi request reprint Molecular genetic analysis of ovarian serous cystadenomas
    Eric J Cheng
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231, USA
    Lab Invest 84:778-84. 2004
    ..Accordingly, it appears that serous cystadenomas develop as a hyperplastic expansion from epithelial inclusions with a clonal/neoplastic transformation occurring in a subset of them...
  16. pmc A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    Joyce E Ohm
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center
    Nat Genet 39:237-42. 2007
    ....
  17. ncbi request reprint A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans
    Jian Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 106:2716-24. 2006
    ..Recently, the authors reported that 3 single-nucleotide polymorphisms (SNPs) in 2 members of the RGS family were associated with significant reductions in the risk of cancer...
  18. pmc Measuring tissue-based biomarkers by immunochromatography coupled with reverse-phase lysate microarray
    Martin J Romeo
    Laboratory of Pathology, Surgery Branch, and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Clin Cancer Res 12:2463-7. 2006
    ..Furthermore, RPM is currently limited by time-consuming microdissection and low amounts of evaluable protein lysates...

Research Grants7

  1. Hedgehog signaling links bladder injury and cancer
    DAVID MONTY BERMAN; Fiscal Year: 2010
    ..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
  2. Hedgehog Pathway in Urogenital Sinus Development
    David Berman; Fiscal Year: 2005
    ..The aim of the mentored training period is to acquire the necessary intellectual and technical skills to transition into independent investigation of urogenital development and its relationships to urologic disease. ..
  3. Hedgehog signaling links bladder injury and cancer
    David Berman; Fiscal Year: 2006
    ..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
  4. Hedgehog signaling links bladder injury and cancer
    David Berman; Fiscal Year: 2009
    ..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..
  5. Hedgehog signaling links bladder injury and cancer
    David Berman; Fiscal Year: 2009
    ..4) To test whether continuously enforced Hh signaling is sufficient to induce urothelial carcinogenesis. ..