Research Topics
Species | Dan BerkowitzSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channelsAsif K Mustafa
Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Circ Res 109:1259-68. 2011..Hydrogen sulfide (H(2)S) is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine γ-lyase (CSE), display pronounced hypertension with deficient vasorelaxant responses to acetylcholine...- Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient miceJonathan Jun
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, United States
Atherosclerosis 209:381-6. 2010..This increased risk may be attributable to more extensive or unstable atherosclerotic plaques in subjects with OSA. We studied the effect of chronic IH in atherosclerosis-prone mice... - Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesityShubha V Y Raju
Division of Cardiology and Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 103:4222-7. 2006.... 
Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesityLili A Barouch
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circ Res 98:119-24. 2006..These data offer novel insights into potential mechanisms of myocardial dysfunction and early mortality in obesity...- Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophyKhalid M Minhas
The Johns Hopkins Medical Institutions, Cardiology Division, 720 Rutland Avenue, Ross 1059, Baltimore, MD 21205, USA
J Physiol 565:463-74. 2005..Taken together, these data reveal a novel link between the leptin signalling pathway and normal cardiac function and suggest a mechanism by which leptin deficiency or resistance may lead to cardiac depression... - Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction couplingShakil A Khan
Departments of Medicine Cardiology Division and Anesthesia and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 101:15944-8. 2004.... - Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in miceLili A Barouch
Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, 600 North Wolfe St, Baltimore, MD 21287, USA
Circulation 108:754-9. 2003..Because leptin has cardiovascular bioactivity, we hypothesized that disruption of leptin signaling mediates the development of obesity-associated LVH... - Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in miceAlbert S Jung
Johns Hopkins U Sch Med, Baltimore
Am J Physiol Heart Circ Physiol 289:H600-7. 2005..These findings have important implications for the management of OI in astronauts, the elderly, and individuals subjected to prolonged bed rest... - Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanismJochen Steppan
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 103:4759-64. 2006..These findings have implications for therapy in pathophysiologic states such as aging and heart failure in which myocardial NO signaling is disrupted... - Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthasesShakil A Khan
Department of Medicine, The Johns Hopkins Medical Institution, Baltimore, MD, USA
Circ Res 92:1322-9. 2003.... - Myocyte nitroso-redox imbalance in sepsis: NO simple answerDan E Berkowitz
Circ Res 100:1-4. 2007 - Mitochondrial arginase II constrains endothelial NOS-3 activityHyun Kyo Lim
Department of Anesthesiology, Johns Hopkins Hospital, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287, USA
Am J Physiol Heart Circ Physiol 293:H3317-24. 2007..These data suggest that arginase II is predominantly confined to the mitochondria and that this mitochondrial arginase II regulates NO production, vascular endothelial function, and vascular stiffness by modulating NOS-3 activity... - Estrogen has opposing effects on vascular reactivity in obese, insulin-resistant male Zucker ratsEsther M Brooks-Asplund
Johns Hopkins U, Baltimore, MD
J Appl Physiol 92:2035-44. 2002..These effects are counteracted by adverse factors, such as hyperlipidemia and, potentially, a release of an endothelium-derived contractile agent... - Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoformsLili A Barouch
Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Nature 416:337-9. 2002..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function...
Research Grants
- Arginase and the Aging Cardiovascular SystemDan Berkowitz; Fiscal Year: 2007..abstract_text> ..
- Transglutaminase 2 S-Nitrosylation: Role in Age-Related Vascular StiffnessDan E Berkowitz; Fiscal Year: 2010....