Dan Berkowitz

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 109:1259-68. 2011
  2. pmc Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice
    Jonathan Jun
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, United States
    Atherosclerosis 209:381-6. 2010
  3. pmc Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity
    Shubha V Y Raju
    Division of Cardiology and Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:4222-7. 2006
  4. ncbi request reprint Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity
    Lili A Barouch
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 98:119-24. 2006
  5. pmc Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy
    Khalid M Minhas
    The Johns Hopkins Medical Institutions, Cardiology Division, 720 Rutland Avenue, Ross 1059, Baltimore, MD 21205, USA
    J Physiol 565:463-74. 2005
  6. pmc Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling
    Shakil A Khan
    Departments of Medicine Cardiology Division and Anesthesia and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 101:15944-8. 2004
  7. ncbi request reprint Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
    Lili A Barouch
    Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, 600 North Wolfe St, Baltimore, MD 21287, USA
    Circulation 108:754-9. 2003
  8. ncbi request reprint Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice
    Albert S Jung
    Department of Biomedical Engineering, Critical Care Medicine, Johns Hopkins Univ School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 289:H600-7. 2005
  9. pmc Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
    Jochen Steppan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 103:4759-64. 2006
  10. ncbi request reprint Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases
    Shakil A Khan
    Department of Medicine, The Johns Hopkins Medical Institution, Baltimore, MD, USA
    Circ Res 92:1322-9. 2003

Research Grants

Collaborators

  • Solomon H Snyder
  • Rui Wang
  • Lili A Barouch
  • Jonathan Jun
  • A L Burnett
  • Anil Kumar
  • Joshua M Hare
  • Shakil A Khan
  • Shubha V Y Raju
  • Khalid M Minhas
  • Artin A Shoukas
  • Jochen Steppan
  • Daniel Nyhan
  • Asif K Mustafa
  • Kwangho Lee
  • Hyun Kyo Lim
  • Sungwoo Ryoo
  • Karl H Schuleri
  • Alexander C Phan
  • CHRISTOPHER P O'DONNELL
  • Albert S Jung
  • Daniel R Gonzalez
  • Ankit D Tejani
  • Esther M Brooks-Asplund
  • Farah K Gazi
  • L Mario Amzel
  • Viachaslau M Barodka
  • Sung M Jung
  • Anil K Bhunia
  • Roxanne K Barrow
  • Gautam Sikka
  • Sadia K Gazi
  • Alex Benjo
  • Artin Shoukas
  • Andre Camara
  • Karl Shuleri
  • Kevin Soucy
  • Hyun Kyoung Lim
  • Ezra Baraban
  • Victor Miriel
  • Kathleen L Gabrielson
  • Mehnaz Khan
  • Lakshmi Santhanam
  • Roberto M Saraiva
  • Koenraad Vandegaer
  • Lukasz J Bugaj
  • Rani K Hasan
  • Djahida Bedja
  • A Ron White
  • Meizi Zheng
  • Omer Yiginer
  • Chris Gregg
  • Mike W Skaf
  • Anastasios P Saliaris
  • Kwang H Lee
  • E M Brooks-Asplund
  • Anastasies P Saliaris
  • Charles W Emala
  • Jordan Genut
  • Robert Harrison
  • Dechun Li
  • Michel W Skaf
  • Mike Fradley
  • Robert W Harrison
  • Soon Yul Kim
  • Sean A Burke

Detail Information

Publications14

  1. pmc Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 109:1259-68. 2011
    ..Hydrogen sulfide (H(2)S) is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine γ-lyase (CSE), display pronounced hypertension with deficient vasorelaxant responses to acetylcholine...
  2. pmc Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice
    Jonathan Jun
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, United States
    Atherosclerosis 209:381-6. 2010
    ..This increased risk may be attributable to more extensive or unstable atherosclerotic plaques in subjects with OSA. We studied the effect of chronic IH in atherosclerosis-prone mice...
  3. pmc Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity
    Shubha V Y Raju
    Division of Cardiology and Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:4222-7. 2006
    ....
  4. ncbi request reprint Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity
    Lili A Barouch
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 98:119-24. 2006
    ..These data offer novel insights into potential mechanisms of myocardial dysfunction and early mortality in obesity...
  5. pmc Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy
    Khalid M Minhas
    The Johns Hopkins Medical Institutions, Cardiology Division, 720 Rutland Avenue, Ross 1059, Baltimore, MD 21205, USA
    J Physiol 565:463-74. 2005
    ..Taken together, these data reveal a novel link between the leptin signalling pathway and normal cardiac function and suggest a mechanism by which leptin deficiency or resistance may lead to cardiac depression...
  6. pmc Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling
    Shakil A Khan
    Departments of Medicine Cardiology Division and Anesthesia and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 101:15944-8. 2004
    ....
  7. ncbi request reprint Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
    Lili A Barouch
    Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, 600 North Wolfe St, Baltimore, MD 21287, USA
    Circulation 108:754-9. 2003
    ..Because leptin has cardiovascular bioactivity, we hypothesized that disruption of leptin signaling mediates the development of obesity-associated LVH...
  8. ncbi request reprint Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice
    Albert S Jung
    Department of Biomedical Engineering, Critical Care Medicine, Johns Hopkins Univ School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 289:H600-7. 2005
    ..These findings have important implications for the management of OI in astronauts, the elderly, and individuals subjected to prolonged bed rest...
  9. pmc Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
    Jochen Steppan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 103:4759-64. 2006
    ..These findings have implications for therapy in pathophysiologic states such as aging and heart failure in which myocardial NO signaling is disrupted...
  10. ncbi request reprint Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases
    Shakil A Khan
    Department of Medicine, The Johns Hopkins Medical Institution, Baltimore, MD, USA
    Circ Res 92:1322-9. 2003
    ....
  11. ncbi request reprint Myocyte nitroso-redox imbalance in sepsis: NO simple answer
    Dan E Berkowitz
    Circ Res 100:1-4. 2007
  12. ncbi request reprint Mitochondrial arginase II constrains endothelial NOS-3 activity
    Hyun Kyo Lim
    Department of Anesthesiology, Johns Hopkins Hospital, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 293:H3317-24. 2007
    ..These data suggest that arginase II is predominantly confined to the mitochondria and that this mitochondrial arginase II regulates NO production, vascular endothelial function, and vascular stiffness by modulating NOS-3 activity...
  13. ncbi request reprint Estrogen has opposing effects on vascular reactivity in obese, insulin-resistant male Zucker rats
    Esther M Brooks-Asplund
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Appl Physiol 92:2035-44. 2002
    ..These effects are counteracted by adverse factors, such as hyperlipidemia and, potentially, a release of an endothelium-derived contractile agent...
  14. ncbi request reprint Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
    Lili A Barouch
    Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Nature 416:337-9. 2002
    ..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function...

Research Grants6

  1. Arginase and the Aging Cardiovascular System
    Dan Berkowitz; Fiscal Year: 2007
    ..abstract_text> ..
  2. Transglutaminase 2 S-Nitrosylation: Role in Age-Related Vascular Stiffness
    Dan E Berkowitz; Fiscal Year: 2010
    ....