Dwight Bergles

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:1050-2. 2010
  2. pmc Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain
    Ethan G Hughes
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:668-76. 2013
  3. pmc Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
    Shin H Kang
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:571-9. 2013
  4. pmc Neuron-glia synapses in the brain
    Dwight E Bergles
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Brain Res Rev 63:130-7. 2010
  5. ncbi request reprint Synaptic signaling between neurons and glia
    Shih Chun Lin
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Glia 47:290-8. 2004
  6. pmc Photon capture and signalling by melanopsin retinal ganglion cells
    Michael Tri H Do
    Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 457:281-7. 2009
  7. pmc Vesicular release of glutamate from unmyelinated axons in white matter
    Jennifer L Ziskin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe St, WBSB 813, Baltimore, Maryland 21205, USA
    Nat Neurosci 10:321-30. 2007
  8. ncbi request reprint Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis
    Dan Gincel
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Neurol 203:205-12. 2007
  9. ncbi request reprint Synaptic communication between neurons and NG2+ cells
    Martin Paukert
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 16:515-21. 2006
  10. ncbi request reprint Physiological characteristics of NG2-expressing glial cells
    Shih Chun Lin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe St, WBSB 813, Baltimore, MD 21205, USA
    J Neurocytol 31:537-49. 2002

Research Grants

  1. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2006
  2. Neuronal Regulation of NG2 Cells
    Dwight Bergles; Fiscal Year: 2006
  3. Neuronal Regulation of NG2 Cells
    Dwight Bergles; Fiscal Year: 2007
  4. Spontaneous activity in the developing cochlea
    Dwight E Bergles; Fiscal Year: 2010
  5. Spontaneous activity in the developing cochlea
    Dwight Bergles; Fiscal Year: 2009
  6. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2002
  7. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2004
  8. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2003
  9. Neuronal Regulation of NG2 Cells
    Dwight E Bergles; Fiscal Year: 2010
  10. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2005

Collaborators

Detail Information

Publications29

  1. pmc Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:1050-2. 2010
    ..By generating theta-like activity, hair cells may limit the influence of synaptic depression in developing auditory circuits and promote consolidation of synapses...
  2. pmc Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain
    Ethan G Hughes
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:668-76. 2013
    ..Thus, homeostatic control of NG2(+) cell density through a balance of active growth and self-repulsion ensures that these progenitors are available to replace oligodendrocytes and participate in tissue repair...
  3. pmc Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
    Shin H Kang
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:571-9. 2013
    ....
  4. pmc Neuron-glia synapses in the brain
    Dwight E Bergles
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Brain Res Rev 63:130-7. 2010
    ..Future studies using transgenic mice in which expression of receptors can be manipulated selectively in NG2 cells have to define the functions of this enigmatic neuron-glia signaling in the normal and diseased CNS...
  5. ncbi request reprint Synaptic signaling between neurons and glia
    Shih Chun Lin
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Glia 47:290-8. 2004
    ....
  6. pmc Photon capture and signalling by melanopsin retinal ganglion cells
    Michael Tri H Do
    Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 457:281-7. 2009
    ..Notably, like rods, these cells are capable of signalling single-photon absorption. A flash causing a few hundred isomerized melanopsin molecules in a retina is sufficient for reaching threshold for the pupillary light reflex...
  7. pmc Vesicular release of glutamate from unmyelinated axons in white matter
    Jennifer L Ziskin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe St, WBSB 813, Baltimore, Maryland 21205, USA
    Nat Neurosci 10:321-30. 2007
    ..This activity-dependent secretion of glutamate was prevalent in the developing and mature mouse corpus callosum, indicating that axons within white matter both conduct action potentials and engage in rapid neuron-glia communication...
  8. ncbi request reprint Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis
    Dan Gincel
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Neurol 203:205-12. 2007
    ..The correlation of promoter activity to protein expression makes the EAAT4 BAC promoter reporter a valuable tool to study regulation of EAAT4 expression...
  9. ncbi request reprint Synaptic communication between neurons and NG2+ cells
    Martin Paukert
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Opin Neurobiol 16:515-21. 2006
    ..Although the significance of this highly differentiated form of communication remains to be established, these neuro-glia synapses might enable neurons to influence rapidly the behavior of this ubiquitous class of glial progenitors...
  10. ncbi request reprint Physiological characteristics of NG2-expressing glial cells
    Shih Chun Lin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe St, WBSB 813, Baltimore, MD 21205, USA
    J Neurocytol 31:537-49. 2002
    ..This vulnerability to the sustained elevation of glutamate may underlie ischemic induced damage to white matter tracts and contribute to cerebral palsy in premature infants...
  11. ncbi request reprint Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
    Jeffrey D Rothstein
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nature 433:73-7. 2005
    ..Thus these studies provide a class of potential neurotherapeutics that act to modulate the expression of glutamate neurotransmitter transporters via gene activation...
  12. ncbi request reprint Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum
    Shih Chun Lin
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 46:773-85. 2005
    ..This robust activation of Ca2+-permeable AMPA receptors in NG2+ cells expands the influence of the olivocerebellar projection to this abundant class of glial progenitors...
  13. ncbi request reprint Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS
    Melissa R Regan
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 27:6607-19. 2007
    ....
  14. pmc Excitability and synaptic communication within the oligodendrocyte lineage
    Lindsay M De Biase
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 30:3600-11. 2010
    ..These results suggest that NG2(+) cells are uniquely positioned within the oligodendrocyte lineage to monitor the firing patterns of surrounding neurons...
  15. pmc Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum
    Martin Paukert
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 30:7290-9. 2010
    ..The enhanced release of glutamate from CFs in Z(+) zones may alter the threshold for synaptic plasticity and prolong inhibition of cerebellar output neurons in deep cerebellar nuclei...
  16. ncbi request reprint Defining the role of astrocytes in neuromodulation
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, WBSB 813, Baltimore, MD 21205, USA
    Neuron 54:497-500. 2007
    ..In this issue of Neuron, Fiacco et al. use transgenic mice that express a foreign G(q)-coupled receptor in astrocytes to show that selective stimulation of astrocytes is not sufficient to induce the release of glutamate...
  17. ncbi request reprint Glutamate transporters bring competition to the synapse
    Yanhua H Huang
    Department of Neuroscience, Johns Hopkins University, 725 North Wolfe Street, WBSB 813, Baltimore, Maryland 21205, USA
    Curr Opin Neurobiol 14:346-52. 2004
    ..The diversity in synaptic morphology suggests a correspondingly rich diversity of GluT function in excitatory transmission...
  18. ncbi request reprint The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea
    Elisabeth Glowatzki
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 26:7659-64. 2006
    ..These data indicate that GLAST in supporting cells is responsible for transmitter uptake at IHC afferent synapses...
  19. ncbi request reprint Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus
    Shih Chun Lin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB 813, Baltimore, Maryland 21205, USA
    Nat Neurosci 7:24-32. 2004
    ....
  20. ncbi request reprint Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells
    Yanhua H Huang
    Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 24:103-11. 2004
    ..In GluR5 knock-out mice, this current was dramatically reduced, indicating that CF excitation of PCs involves two distinct classes of ionotropic glutamate receptors, AMPA receptors and GluR5-containing kainate receptors...
  21. ncbi request reprint Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons
    Yanhua H Huang
    Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 24:4551-9. 2004
    ....
  22. pmc Developmental regulation of spontaneous activity in the Mammalian cochlea
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience and Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 30:1539-50. 2010
    ..These results suggest that supporting cells in the cochlea provide the primary excitatory stimulus responsible for initiating bursts of action potentials in auditory nerve fibers before the onset of hearing...
  23. ncbi request reprint The origin of spontaneous activity in the developing auditory system
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Nature 450:50-5. 2007
    ....
  24. ncbi request reprint Synthesis and characterization of 4-methoxy-7-nitroindolinyl-D-aspartate, a caged compound for selective activation of glutamate transporters and N-methyl-D-aspartate receptors in brain tissue
    Yanhua H Huang
    Department of Neuroscience, Johns Hopkins University Medical School, 725 North Wolfe Street, WBSB 813, Baltimore, Maryland 21205, USA
    Biochemistry 44:3316-26. 2005
    ..These results indicate that MNI-D-aspartate also may be useful for studying the regulation of NMDA receptors at excitatory synapses...
  25. ncbi request reprint Ncm-D-aspartate: a novel caged D-aspartate suitable for activation of glutamate transporters and N-methyl-D-aspartate (NMDA) receptors in brain tissue
    Yanhua H Huang
    Department of Neuroscience, Johns Hopkins University Medical School, WBSB 813, Baltimore, MD 21205, USA
    Neuropharmacology 49:831-42. 2005
    ..These results indicate that Ncm-D-aspartate can be used to study NMDA receptors at excitatory synapses and interactions between transporters and receptors in brain tissue...
  26. ncbi request reprint NG2 cells generate both oligodendrocytes and gray matter astrocytes
    Xiaoqin Zhu
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269 3156, USA
    Development 135:145-57. 2008
    ..These observations suggest that NG2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in gray matter...
  27. ncbi request reprint 4-Carboxymethoxy-5,7-dinitroindolinyl-Glu: an improved caged glutamate for expeditious ultraviolet and two-photon photolysis in brain slices
    Graham C R Ellis-Davies
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Neurosci 27:6601-4. 2007
  28. ncbi request reprint Shape-shifting at a cerebellar synapse allows submillisecond signaling
    Dwight E Bergles
    Nat Neurosci 8:1279-81. 2005
  29. ncbi request reprint Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters
    Dwight E Bergles
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    J Neurosci 22:10153-62. 2002
    ..The model predicts that in physiological conditions approximately 35% of GLT-1 transporters function as buffers, releasing glutamate back into the extracellular space after binding...

Research Grants14

  1. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2006
    ..Understanding the endogenous mechanisms of transporter regulation may thus provide us with new approaches for treating neurological diseases. ..
  2. Neuronal Regulation of NG2 Cells
    Dwight Bergles; Fiscal Year: 2006
    ....
  3. Neuronal Regulation of NG2 Cells
    Dwight Bergles; Fiscal Year: 2007
    ....
  4. Spontaneous activity in the developing cochlea
    Dwight E Bergles; Fiscal Year: 2010
    ..Furthermore, these studies may reveal one mechanism by which activity can be induced in afferent nerves in the absence of sound, which may have direct relevance to human conditions such as tinnitus. ..
  5. Spontaneous activity in the developing cochlea
    Dwight Bergles; Fiscal Year: 2009
    ..Furthermore, these studies may reveal one mechanism by which activity can be induced in afferent nerves in the absence of sound, which may have direct relevance to human conditions such as tinnitus. ..
  6. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2002
    ..Understanding the endogenous mechanisms of transporter regulation may thus provide us with new approaches for treating neurological diseases. ..
  7. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2004
    ..Understanding the endogenous mechanisms of transporter regulation may thus provide us with new approaches for treating neurological diseases. ..
  8. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2003
    ..Understanding the endogenous mechanisms of transporter regulation may thus provide us with new approaches for treating neurological diseases. ..
  9. Neuronal Regulation of NG2 Cells
    Dwight E Bergles; Fiscal Year: 2010
    ..abstract_text> ..
  10. Synaptic Regulation of Astroglial Glutamate Transporters
    Dwight Bergles; Fiscal Year: 2005
    ..Understanding the endogenous mechanisms of transporter regulation may thus provide us with new approaches for treating neurological diseases. ..
  11. Neuronal Regulation of NG2 Cells
    Dwight Bergles; Fiscal Year: 2009
    ..abstract_text> ..