Affiliation: Johns Hopkins University
Babola T, Li S, Gribizis A, Lee B, Issa J, Wang H, et al
. Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron. 2018;99:511-524.e5 pubmed publisher
Paukert M, Agarwal A, Cha J, Doze V, Kang J, Bergles D. Norepinephrine controls astroglial responsiveness to local circuit activity. Neuron. 2014;82:1263-70 pubmed publisher
..Our findings indicate that norepinephrine shifts the gain of astrocyte networks according to behavioral state, enabling astrocytes to respond to local changes in neuronal activity. ..
Nimmerjahn A, Bergles D. Large-scale recording of astrocyte activity. Curr Opin Neurobiol. 2015;32:95-106 pubmed publisher
..Deciphering how astrocyte network activity is controlled in different physiological and pathological contexts is crucial for defining their roles in the healthy and diseased CNS. ..
Hughes E, Orthmann Murphy J, Langseth A, Bergles D. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci. 2018;21:696-706 pubmed publisher
..This experience-dependent enhancement of myelination in the mature cortex may accelerate information transfer in these circuits and strengthen the ability of axons to sustain activity by providing additional metabolic support. ..
Larson V, Zhang Y, Bergles D. Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles. Brain Res. 2016;1638:138-160 pubmed publisher
..This article is part of a Special Issue entitled SI:NG2-glia(Invited only). ..
Wang H, Lin C, Cheung R, Zhang Hooks Y, Agarwal A, Ellis Davies G, et al
. Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells. Cell. 2015;163:1348-59 pubmed publisher
..These results indicate that supporting cells in the developing cochlea have adapted a pathway used for fluid secretion in other organs to induce periodic excitation of hair cells. ..
Zhang Hooks Y, Agarwal A, Mishina M, Bergles D. NMDA Receptors Enhance Spontaneous Activity and Promote Neuronal Survival in the Developing Cochlea. Neuron. 2016;89:337-50 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al
. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
..By localizing mitochondria to microdomains, astrocytes ensure local metabolic support for energetically demanding processes and enable coupling between metabolic demand and Ca2+ signaling events. ..
Langseth A, Kim J, Ugolino J, Shah Y, Hwang H, Wang J, et al
. Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Sci Rep. 2017;7:5685 pubmed publisher
..These results suggest that cell autonomous changes in both neurons and glia may contribute to C9orf72-mediated disease, as has been shown for mutations in superoxide dismutase-1 (SOD1). ..