Terri Beaty

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Fast detection of de novo copy number variants from SNP arrays for case-parent trios
    Robert B Scharpf
    Department of Oncology, Johns Hopkins University, Baltimore, MD, USA
    BMC Bioinformatics 13:330. 2012
  2. pmc Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study
    T H Beaty
    Department of Epidemiology, School of Public Health, Johns Hopkins University, 615N Wolfe St, Baltimore, MD 21205, USA
    Hum Genet 132:771-81. 2013
  3. pmc A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA
    BMC Genet 7:38. 2006
  4. ncbi request reprint Testing candidate genes for non-syndromic oral clefts using a case-parent trio design
    Terri H Beaty
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 22:1-11. 2002
  5. pmc A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
  6. ncbi request reprint Invited commentary: two studies of genetic control of birth weight where large data sets were available
    T H Beaty
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 165:753-5. 2007
  7. pmc Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate
    Terri H Beaty
    School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, Maryland, USA
    Genet Epidemiol 35:469-78. 2011
  8. ncbi request reprint Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations
    T H Beaty
    Johns Hopkins University, Baltimore, MD, USA
    Hum Genet 120:501-18. 2006
  9. pmc Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations
    Ji Wan Park
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA, and Department of Medical Research and Craniofacial Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Genet Med 9:219-27. 2007
  10. pmc Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations
    Jae Woong Sull
    Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 32:505-12. 2008

Detail Information

Publications65

  1. pmc Fast detection of de novo copy number variants from SNP arrays for case-parent trios
    Robert B Scharpf
    Department of Oncology, Johns Hopkins University, Baltimore, MD, USA
    BMC Bioinformatics 13:330. 2012
    ..We evaluate these issues in a study of oral cleft case-parent trios...
  2. pmc Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study
    T H Beaty
    Department of Epidemiology, School of Public Health, Johns Hopkins University, 615N Wolfe St, Baltimore, MD 21205, USA
    Hum Genet 132:771-81. 2013
    ..Formal tests for gene-gene interaction (epistasis) failed to show evidence of statistical interaction in any simple fashion. This study confirms that many different genes influence risk to CL/P...
  3. pmc A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA
    BMC Genet 7:38. 2006
    ..While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals...
  4. ncbi request reprint Testing candidate genes for non-syndromic oral clefts using a case-parent trio design
    Terri H Beaty
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 22:1-11. 2002
    ..03). Using a conditional logistic model to test for gene-gene interaction showed no evidence of interaction between TGFbeta3 and MSX1, with both seeming to contribute independently to risk of isolated, non-syndromic oral clefts...
  5. pmc A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
    Terri H Beaty
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Nat Genet 42:525-9. 2010
    ..Expression studies support a role for MAFB in palatal development...
  6. ncbi request reprint Invited commentary: two studies of genetic control of birth weight where large data sets were available
    T H Beaty
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 165:753-5. 2007
    ..Both of these studies confirm that birth weight is not simply due to the direct effects of the baby's genes but is a complex phenotype reflecting the effects of maternal genes and environments...
  7. pmc Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate
    Terri H Beaty
    School of Public Health, Johns Hopkins University, 615 N Wolfe St, Baltimore, Maryland, USA
    Genet Epidemiol 35:469-78. 2011
    ..8. These results emphasize the need to consider G × E interaction when searching for genes influencing risk to complex and heterogeneous disorders, such as nonsyndromic CP...
  8. ncbi request reprint Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations
    T H Beaty
    Johns Hopkins University, Baltimore, MD, USA
    Hum Genet 120:501-18. 2006
    ....
  9. pmc Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations
    Ji Wan Park
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA, and Department of Medical Research and Craniofacial Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Genet Med 9:219-27. 2007
    ..This study aimed to confirm the contribution of IRF6 to cleft lip with or without palate risk in additional Asian populations...
  10. pmc Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations
    Jae Woong Sull
    Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Genet Epidemiol 32:505-12. 2008
    ..Thus, RUNX2 appears to influence risk of CL/P through a parent-of-origin effect with excess maternal transmission...
  11. pmc Excess maternal transmission of markers in TCOF1 among cleft palate case-parent trios from three populations
    Jae Woong Sull
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Med Genet A 146:2327-31. 2008
    ..136), analysis of haplotypes of rs2255796 and rs15251 suggested excess maternal transmission. Therefore, these data suggest TCOF1 may influence risk of cleft palate through a parent-of-origin effect...
  12. pmc Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations
    Roxann G Ingersoll
    Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, MD 21287, USA
    Eur J Hum Genet 18:726-32. 2010
    ..These two genes plus EVC2 also yielded suggestive evidence for linkage and disequilibrium among cleft palate trios. This analysis suggests that several genes, not just MSX1, in this region may influence risk of oral clefts...
  13. ncbi request reprint Evidence for linkage of nonsyndromic cleft lip with or without cleft palate to a region on chromosome 2
    Joanna S Zeiger
    Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Eur J Hum Genet 11:835-9. 2003
    ..022 and 0.006, respectively). A subset of these 26 families provided additional evidence for a susceptibility gene for CL/P on 2q, suggesting that further studies of genes in this region are warranted...
  14. ncbi request reprint Oral clefts, maternal smoking, and TGFA: a meta-analysis of gene-environment interaction
    Joanna S Zeiger
    Johns Hopkins Bloomberg School of Hygiene and Public Health, Baltimore, Maryland, USA
    Cleft Palate Craniofac J 42:58-63. 2005
    ....
  15. ncbi request reprint Multipoint linkage disequilibrium mapping for complex diseases
    Kung Yee Liang
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Genet Epidemiol 25:285-92. 2003
    ..Furthermore, such discrepancy in preferential transmission was most evident among probands with early onset age (6 years old or younger)...
  16. ncbi request reprint Influence of human leukocyte antigen class II alleles on susceptibility to Entamoeba histolytica infection in Bangladeshi children
    Priya Duggal
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 189:520-6. 2004
    ..To test this hypothesis, we compared the genotype frequencies of human leukocyte antigen (HLA) class II alleles in a cohort of Bangladeshi children intensively monitored for E. histolytica infection for a 3-year period...
  17. pmc Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate
    Tao Wu
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Hum Genet 128:401-10. 2010
    ..These results suggest IRF6 gene may influence risk of CL/P through interaction with multivitamin supplementation and ETS in the Chinese population...
  18. ncbi request reprint Family-based analysis of MSX1 haplotypes for association with oral clefts
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Genet Epidemiol 25:168-75. 2003
    ..This study encourages further focus on the MSX1 gene region to ultimately determine specific variants predisposing to oral clefts...
  19. ncbi request reprint Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 112:382-8. 2003
    ....
  20. ncbi request reprint Genetic and environmental risk factors for sagittal craniosynostosis
    Joanna S Zeiger
    Johns Hopkins Bloomberg School of Hygiene and Public Health, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Craniofac Surg 13:602-6. 2002
    ..Parental education and alcohol consumption were associated with sagittal craniosynostosis in this study...
  21. pmc Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
    Candelaria Vergara
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 178:1017-22. 2008
    ..This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax...
  22. ncbi request reprint Familial aggregation of bothersome benign prostatic hyperplasia symptoms
    Jay D Pearson
    Department of Epidemiology, Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania 19486 0004, USA
    Urology 61:781-5. 2003
    ..To evaluate familial aggregation and the mode of inheritance of bothersome benign prostatic hyperplasia (BPH)...
  23. ncbi request reprint Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 118:70-7. 2006
    ....
  24. pmc Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine
    Ravit Arav-Boger
    Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Hospital, Baltimore, Maryland 21287 4933, USA
    BMC Res Notes 5:140. 2012
    ..A clinical trial of CMV glycoprotein B (gB) vaccine in young women showed promising efficacy. Improved understanding of the basis for prevention of CMV infection is essential for developing improved vaccines...
  25. ncbi request reprint Unified sampling approach for multipoint linkage disequilibrium mapping of qualitative and quantitative traits
    Fang Chi Hsu
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Genet Epidemiol 22:298-312. 2002
    ..84, 43.02) through the 20-cM region framed by markers D12S1052 and D12S1064 on chromosome 12. The test statistic shows strong evidence of linkage and LD (chi-square statistic = 18.39 with 2 df, P-value = 0.0001)...
  26. pmc A genome-wide association study on African-ancestry populations for asthma
    Rasika A Mathias
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    J Allergy Clin Immunol 125:336-346.e4. 2010
    ..Of the limited genetic studies performed on populations of African descent, notable differences in susceptibility allele frequencies have been observed...
  27. ncbi request reprint Evidence for asthma susceptibility genes on chromosome 11 in an African-American population
    Shau Ku Huang
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224 6801, Baltimore, USA
    Hum Genet 113:71-5. 2003
    ..8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families...
  28. doi request reprint Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:507-13, 513.e1-7. 2009
    ..Associations have not been reported in African ancestry populations. Atopic dermatitis eczema herpeticum (ADEH) is a rare but serious complication of AD resulting from disseminated cutaneous herpes simplex virus infections...
  29. ncbi request reprint Family-based linkage disequilibrium tests using general pedigrees
    Yin Yao Shugart
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Methods Mol Biol 376:141-9. 2007
    ..However, when the pedigree structure is more complicated, or when the number of informative families is limited, the pseudo-marker approach is anticipated to outperform FBAT...
  30. ncbi request reprint Comparing whole-genome amplification methods and sources of biological samples for single-nucleotide polymorphism genotyping
    Ji Wan Park
    Department of Epidemiology, Bloomberg School of Public Health, McKusick Nathans Institute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Clin Chem 51:1520-3. 2005
  31. ncbi request reprint Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population
    Peter B Chi
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Genet Epidemiol 30:609-19. 2006
    ..We also found a high degree of consistency between TagSNP and Tagger. Using this set of 713 SNPs on chromosome 12q, our study provides insight towards analytic strategies for future studies of complex traits...
  32. ncbi request reprint Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study
    April Zambelli-Weiner
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 115:1203-9. 2005
    ..Both a functional promoter polymorphism in the gene encoding CD14 (C-260T) and exposure to endotoxin are believed to play key roles in modulating the immune response and expression of atopic disease...
  33. ncbi request reprint Evidence for a major gene influencing risk of pancreatic cancer
    Alison P Klein
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Genet Epidemiol 23:133-49. 2002
    ..This hospital-based segregation analysis of pancreatic cancer found evidence supporting the role of a rare major gene influencing risk of pancreatic cancer...
  34. ncbi request reprint Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma
    Li Gao
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 119:1111-8. 2007
    ..Myosin light chain kinase (MYLK) is a multifunctional protein involved in regulation of airway hyperreactivity and other activities relevant to asthma...
  35. ncbi request reprint Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 115:982-8. 2005
    ..The T-cell immunoglobulin mucin ( TIM ) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases...
  36. ncbi request reprint The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug users
    Priya Duggal
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 38:584-9. 2005
    ..Because RANTES is a critical chemokine and competitively inhibits HIV-1 by binding to its receptor CCR5, treatment to enhance RANTES expression may assist in delaying the progression of AIDS by decreasing the initial viral load...
  37. doi request reprint High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
    Audrey V Grant
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 198:1227-36. 2008
    ....
  38. ncbi request reprint Parent-of-origin effect in the segregation analysis of bipolar affective disorder families
    Tsuo Hung Lan
    Department of Epidemiology, School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Psychiatr Genet 17:93-101. 2007
    ..The purpose of this study is to test for heterogeneity in bipolar families based on the differential parental transmission of disease...
  39. ncbi request reprint Segregation analysis of 389 Icelandic pedigrees with Breast and prostate cancer
    Agnes B Baffoe-Bonnie
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Genet Epidemiol 23:349-63. 2002
    ....
  40. ncbi request reprint Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study
    Xin Liu
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Allergy Clin Immunol 113:489-95. 2004
    ..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors...
  41. ncbi request reprint Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses
    Rasika A Mathias
    Department of Epidemiology, Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Hum Hered 59:228-38. 2005
    ....
  42. pmc Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    PLoS Genet 5:e1000519. 2009
    ....
  43. ncbi request reprint Incorporation of covariates into multipoint linkage disequilibrium mapping in case-control studies
    Yen Feng Chiu
    Division of Biostatistics and Bioinformatics, National Health Research Institutes, Zhunan, Taiwan
    Genet Epidemiol 32:143-51. 2008
    ..Simulation studies and these diabetes data both demonstrate how the efficiency of the estimated location of a disease gene can be improved substantially by incorporating information on covariates...
  44. pmc MSX1 polymorphism associated with risk of oral cleft in Korea: evidence from case-parent trio and case-control studies
    Jungyong Park
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120 752, Korea
    Yonsei Med J 48:101-8. 2007
    ..26, 95% CI=0.10-0.99). These results are consistent with evidence from other studies in the US and Chile and confirm the importance of the MSX1 genotype in determining the risk of CL/P and CP in Koreans...
  45. ncbi request reprint Multipoint linkage disequilibrium mapping approach: incorporating evidence of linkage and linkage disequilibrium from unlinked region
    Fang Chi Hsu
    Section on Biostatistics, Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 21205, USA
    Genet Epidemiol 25:1-13. 2003
    ..67 cM, with a 95% confidence interval of (8.75, 14.59), and the test statistic shows significant evidence of linkage and LD (P-value=0.0198) in this region of chromosome 8...
  46. ncbi request reprint Phenotypic discordance in a family with monozygotic twins and nonsyndromic cleft lip and palate: follow-up
    Diego F Wyszynski
    Am J Med Genet 110:182-3. 2002
  47. ncbi request reprint A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, MMC 434 Mayo, 420 Delaware SE, Minneapolis, MN 55455, USA
    Hum Genet 114:157-64. 2004
    ..65), 8p (D8S1113, lod=1.60), 12p (D12S372, lod=1.54) and 14q (D14S749, lod=1.70). These results suggest that several regions may harbor genes contributing to the risk for atopy and these may interact with one another in a complex manner...
  48. ncbi request reprint A genome-wide scan for loci predisposing to non-syndromic cleft lip with or without cleft palate in two large Syrian families
    Diego F Wyszynski
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Am J Med Genet A 123:140-7. 2003
    ..2 (P < or = 0.01) included 3p21.2, 4q32.1, and 7q34. These data indicate the possible presence of several susceptibility loci for CL/P and identify a strong candidate locus for this common birth defect on chromosome 17p13...
  49. pmc Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35
    Mary L Marazita
    Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Am J Hum Genet 75:161-73. 2004
    ..0004). These are the first genomewide significant linkage results ever reported for CL/P, and they represent an unprecedented demonstration of the power of linkage analysis to detect multiple genes simultaneously for a complex disorder...
  50. ncbi request reprint Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability
    Jing Long Huang
    The Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Hum Mol Genet 13:2691-7. 2004
    ..11q is a strong candidate gene for asthma...
  51. ncbi request reprint Guidelines for the design and analysis of studies on nonsyndromic cleft lip and cleft palate in humans: summary report from a Workshop of the International Consortium for Oral Clefts Genetics
    Laura E Mitchell
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cleft Palate Craniofac J 39:93-100. 2002
    ..This report presents summary statements of the four subcommittees...
  52. ncbi request reprint Model comparison and the likelihood ratio test in segregation analysis
    Rasika A Mathias
    Genet Epidemiol 25:382-3. 2003
  53. pmc Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury
    Li Gao
    Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 34:487-95. 2006
    ..These data strongly implicate MYLK genetic variants to confer increased risk of sepsis and sepsis-associated ALI...
  54. ncbi request reprint Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer families
    Gloria Y F Ho
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cancer 98:938-42. 2002
    ..Our findings do not support the hypothesis that familial clustering of prostate cancer in high-risk families is attributable to these genetic variants...
  55. ncbi request reprint Major gene evidence after MTHFR-segregation analysis of serum homocysteine in families of patients undergoing coronary arteriography
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Health Science and Management, Yonsei University, Seoul 120 752, South Korea
    Hum Genet 111:128-35. 2002
    ..The results of this study also indicated that multifactorial inheritance was supported more strongly than Mendelian inheritance alone. Our findings may have implications for attempts to identify new homocysteine susceptible genes...
  56. ncbi request reprint Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure
    Susan Colilla
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    J Allergy Clin Immunol 111:840-6. 2003
    ..Asthma, a common and chronic disease of the airways, has a multifactorial cause involving both genetic and environmental factors. As a result, mapping genes that influence asthma susceptibility has been challenging...
  57. ncbi request reprint IL6 -174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil
    Lea Castellucci
    Servico de Imunologia, Hospital Universitario Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    J Infect Dis 194:519-27. 2006
    ..Interleukin (IL)-6 down-regulates T helper (Th) cell type 1 differentiation and drives Th2 cell differentiation. The IL6 -174 G/C polymorphism is associated with proinflammatory diseases and IL-6 regulation...
  58. ncbi request reprint Sex differences in heritability of sensitization to Blomia tropicalis in asthma using regression of offspring on midparent (ROMP) methods
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm 8160, Bethesda, MD 20892 7934, USA
    Hum Genet 113:437-46. 2003
    ..Adjustment for covariates had minimal impact. This suggests that future investigations of genetic determinants of IgE levels should include approaches that allow for potential sex differences in their expression...
  59. ncbi request reprint Is there a relationship between risk factors for oral clefts?
    Joanna S Zeiger
    Teratology 66:205-8. 2002
  60. ncbi request reprint Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes
    Steven R Brant
    The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, U S A
    Inflamm Bowel Dis 9:281-9. 2003
    ..Multiple factors, particularly IBD family history, tobacco use, age at diagnosis and recently, NOD2 mutant genotypes may influence Crohn's disease (CD) heterogeneity...
  61. ncbi request reprint Spouse controls in family case-control studies: a methodological consideration
    Bas A J Verhage
    Department of Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Fam Cancer 2:101-8. 2003
    ..Using a simulation study it is illustrated that even strong assortative mating on a factor, which is strongly correlated with a true risk factor under study, will have a negligible effect on the observed extent of familial aggregation...
  62. ncbi request reprint Segregation analysis of 231 Ashkenazi Jewish families for evidence of additional breast cancer susceptibility genes
    David J Kaufman
    Laboratory of Population Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:1045-52. 2003
    ..The study adds support for a major autosomal recessive component to breast cancer susceptibility...
  63. ncbi request reprint Homocysteine levels--before and after methionine loading--in 51 Dutch families
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 13:753-62. 2005
    ..Further studies are needed to identify the genes responsible for the inheritance of postload homocysteine levels...
  64. ncbi request reprint Family history of diabetes and risk of atherosclerotic cardiovascular disease in Korean men and women
    Ji Wan Park
    Department of Molecular and Cellular Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
    Atherosclerosis 197:224-31. 2008
    ....
  65. pmc Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan
    Selma M B Jeronimo
    Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil
    J Infect Dis 196:1261-9. 2007
    ..chagasi may identify proteins essential for immune protection against this parasitic disease and reveal strategies for immunotherapy or prevention...

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