Research Topics
Species | S BasariaSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Necrobiosis lipoidica diabeticorum: response to pentoxiphyllineS Basaria
Division of Endocrinology and Metabolism, John Hopkins University Bayview Medical Center, Baltimore, MD 21224, USA
J Endocrinol Invest 26:1037-40. 2003..No side effects of treatment were reported. In conclusion, patients with NLD may benefit from treatment with pentoxiphylline. We recommend therapy with 400 mg 3 times daily. The drug should be continued for at least 6 months...
Low testosterone levels and the risk of anemia in older men and womenLuigi Ferrucci
Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
Arch Intern Med 166:1380-8. 2006..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia...- Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancerShehzad Basaria
Arch Intern Med 167:612-3. 2007 - The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult menAndy Menke
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
BMC Public Health 8:72. 2008..Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small... - Andropause: need for concrete guidelines until more evidence becomes availableS Basaria
Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
J Endocrinol Invest 28:667-70. 2005 
Androgen deprivation therapy, insulin resistance, and cardiovascular mortality: an inconvenient truthShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 5200 Eastern Ave, Suite 4300, Baltimore, MD 21224, USA
J Androl 29:534-9. 2008..In the meantime, baseline and serial screening for fasting glucose and other cardiac risk factors in men receiving ADT is prudent. In selected cases, glucose tolerance testing and cardiac evaluation may be required...- Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapyM Braga-Basaria
Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
Int J Impot Res 18:494-8. 2006..Long-term prospective studies are needed to determine the time of onset of changes in these lipoproteins while on ADT and the influence of these changes on cardiovascular mortality... - Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapyMilena Braga-Basaria
Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
J Clin Oncol 24:3979-83. 2006..Because male hypogonadism is a risk factor for metabolic syndrome and men with PCa have high cardiovascular mortality, we evaluated the prevalence of metabolic syndrome in men undergoing long-term ADT... - Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapyShehzad Basaria
Department of Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, and National Institut on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Cancer 106:581-8. 2006.... - Preventing skeletal complications in androgen deprived men with prostate cancer: Time for actionM Braga-Basaria
Division of Endocrinology, Department of Medicine, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
J Endocrinol Invest 29:467-70. 2006 - Hypogonadism and androgen replacement therapy in elderly menS Basaria
Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med 110:563-72. 2001..This review summarizes the trials of testosterone replacement therapy in elderly men and outlines a diagnostic approach to these patients... - Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal womenS Basaria
Department of Internal Medicine, Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Endocrinol Invest 32:150-5. 2009..Isoflavones, a class of plant estrogens, have structural similarities to estradiol. Hence, isoflavones may exert beneficial estrogenic health effects in postmenopausal women with fewer adverse effects... - Androgens and erythropoiesis: past and presentS Shahani
Division of Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX, USA
J Endocrinol Invest 32:704-16. 2009.... - Andropause: to treat or not to treat?S Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore 21224, USA
J Endocrinol Invest 26:693-7. 2003 - Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseasesS Basaria
The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 86:5108-17. 2001.... - The hormonal pathway to frailty in older menM Maggio
Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, USA
J Endocrinol Invest 28:15-9. 2005..Observational and interventional studies will be needed to better define the role of "hormonal dysregulation", alone and in combination with other pathways, in the development of frailty in older men... - Association between hormones and metabolic syndrome in older Italian menMarcello Maggio
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 54:1832-8. 2006.... - Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosisSadeka Shahani
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA
J Clin Endocrinol Metab 93:2042-9. 2008..Recently, metabolic complications like insulin resistance, diabetes, dyslipidemia, and metabolic syndrome have emerged, which may be responsible for the increased cardiovascular mortality in this population... - Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapyMarcello Maggio
Longitudinal Studies Section, Clinical Research Branch and the Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Baltimore, MD, USA
J Androl 27:725-8. 2006..Prospective studies are needed to evaluate for any acute changes in these inflammatory markers that might occur after the initiation of ADT... - The latest options and future agents for treating male hypogonadismDaniel Edelstein
Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, Bayview Medical Center, 5200 Eastern Avenue, Mason F Lord Building, 4th Floor, Suite 4300, Baltimore, Maryland 21224, USA
Expert Opin Pharmacother 8:2991-3008. 2007..This will enhance the effectiveness of available therapies, while mitigating their undesirable effects... - Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI studyMarcello Maggio
National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
Am J Physiol Endocrinol Metab 292:E353-8. 2007..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS... - Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)Elizabeth Selvin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Diabetes Care 30:234-8. 2007..The objective of this study is to test the hypothesis that low normal levels of total, free, and bioavailable testosterone are associated with prevalent diabetes in men... - Clinical review: Controversies regarding transdermal androgen therapy in postmenopausal womenShehzad Basaria
Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 91:4743-52. 2006..Until the patch gets approval, a short trial of oral methyltestosterone in deserving estrogenized women may be justified... - A rare cause of pituitary stalk enlargement and panhypopituitarismShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, B Building, Suite 114, Baltimore, MD 21224, USA
Mt Sinai J Med 70:265-7. 2003..Although infundibular thickening resolved and diabetes insipidus improved after chemotherapy, panhypopituitarism persisted... - Safety and adverse effects of androgens: how to counsel patientsShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 E Monument St, Suite 333, Baltimore, MD 21287, USA
Mayo Clin Proc 79:S25-32. 2004..We believe that long-term studies are necessary to observe the potential effect of androgen replacement on cardiovascular mortality, breast and endometrial tissues, and mood and anger before this therapy can be used routinely in women... - Long-term effects of androgen deprivation therapy in prostate cancer patientsShehzad Basaria
Division of Endocrinolgy and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Clin Endocrinol (Oxf) 56:779-86. 2002..Meanwhile, this information will assist both physicians and patients with prostate cancer to make informed decisions regarding androgen deprivation therapy... - Detection of BRAF mutation on fine needle aspiration biopsy specimens: a new diagnostic tool for papillary thyroid cancerMingzhao Xing
Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 89:2867-72. 2004..Thus, we have demonstrated the usefulness of BRAF mutation detection on FNAB specimens that can help diagnose and identify those PTC patients who may need more aggressive surgical treatment and vigilant clinical monitoring... - New modalities of transdermal testosterone replacementShehzad Basaria
Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Treat Endocrinol 2:1-9. 2003..There are no harmful effects on the prostate and lipids. Acne, polycythemia, and gynecomastia are less common with this form of therapy than with the intramuscular esters... - Anaplastic pseudothyroiditisShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, A 5 E, Suite 503, Baltimore, MD 21224, USA
Clin Endocrinol (Oxf) 56:553-5. 2002..Histopathology showed destruction of the normal thyroid follicles by the invasion of the tumour. As this form of thyrotoxicosis resembles various thyroiditides, we hereby refer this condition as "anaplastic pseudothyroiditis"... - BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancerMingzhao Xing
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 90:6373-9. 2005..Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve risk stratification of this cancer... - A rare form of hypothyroidismShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
South Med J 95:549-51. 2002..The various causes of central hypothyroidism and the role of the thyrotropin-releasing hormone test are briefly described... - Images in cardiovascular medicine. Flash pulmonary edema heralding renal artery stenosisShehzad Basaria
Department of Internal Medicine, The University of Texas Health Science Center at Houston, Tex, USA
Circulation 105:899. 2002 - Testosterone making an entry into the cardiometabolic worldShehzad Basaria
Circulation 116:2658-61. 2007 - Sonographically guided percutaneous ethanol treatment of a symptomatic complex nodule with a large cystic component in a patient with thyroid hemiagenesisMilena Braga-Basaria
, Rua Padre Camargo, 262, Curitiba 80.060, Brazil
J Clin Ultrasound 30:445-9. 2002..We recommend that ethanol injections be considered for treatment of symptomatic cystic or benign solid nodules in patients with thyroid hemiagenesis and in those who have undergone hemithyroidectomy and have symptomatic nodules... - Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) studyMarcello Maggio
National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
Arch Intern Med 167:2249-54. 2007..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders... - Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III)Sabine Rohrmann
Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
Urology 69:708-13. 2007..To evaluate the association of circulating sex steroid hormones and sex hormone binding globulin (SHBG) with lower urinary tract symptoms (LUTS)... - The white butterflyShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Lancet 360:1639. 2002 - Pseudo-central hypothyroidismShehzad Basaria
Division of Endocrinology, Johns Hopkins University Bayview Medical Center, Baltimore, MD 21224, USA
South Med J 96:204-5. 2003..Because patients with isolated triiodothyronine (T3) toxicosis also present with this biochemical pattern, it is important to measure T3 levels in such patients before making a diagnosis of central hypothyroidism... - Amyloidosis: role of fine-needle aspirationShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Thyroid 13:313-4. 2003 - Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancerShuiying Hu
Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 91:98-104. 2006..CONCLUSIONS: We have demonstrated the potential usefulness of serum DNA methylation markers as a novel tool for differential diagnosis of solid thyroid nodules and thyroid cancer recurrence monitoring... - Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study)Marcello Maggio
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
Am J Cardiol 97:1525-9. 2006..This may be 1 of the mechanisms by which ACE inhibitors might slow the decreases in muscle strength and physical function that are often observed in older subjects... - Nebido: a long-acting injectable testosterone for the treatment of male hypogonadismLindsey Harle
University of Texas, Medical Branch at Galveston, TX, USA
Expert Opin Pharmacother 6:1751-9. 2005..In this paper, the structure, pharmacokinetics, efficacy and side-effect profile of testosterone undecanoate will be reviewed and also compared with other existing testosterone esters... - Amiodarone and the thyroidShehzad Basaria
Department of Medicine, Division of Endocrinology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, Maryland, USA
Am J Med 118:706-14. 2005.... - Images in thyroidology. Graves' disease unmasking ectopic thyroid tissueMilena Braga-Basaria
Baltimore, Maryland, USA
Thyroid 14:83-4. 2004 - Effect of methyl testosterone administration on plasma viscosity in postmenopausal womenShehzad Basaria
Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Clin Endocrinol (Oxf) 57:209-14. 2002..The combination regimen did not result in major side-effects. Based on these results, we feel confident in recommending low-dose androgens to postmenopausal women with a history of sexual dysfunction and decreased libido... - Emerging drugs for hypogonadismDaniel Edelstein
Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, Baltimore, MD, USA
Expert Opin Emerg Drugs 11:685-707. 2006.... - Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older menMarcello Maggio
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
J Clin Endocrinol Metab 91:345-7. 2006..05). T was not correlated with any other inflammatory marker. CONCLUSIONS: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association... - Endocrine complications of androgen-deprivation therapy in men with prostate cancerLindsey K Harle
University of Texas Medical Branch, Galveston, TX 77555, USA
Clin Adv Hematol Oncol 4:687-96. 2006..In this article, we provide a detailed review of the endocrine complications of ADT, touching upon management strategies where applicable...