Kathleen Barnes

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Genetic determinants and ethnic disparities in sepsis-associated acute lung injury
    Kathleen C Barnes
    Division of Johns Hopkins Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 2:195-201. 2005
  2. pmc Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease
    Nadia N Hansel
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 5:e14226. 2010
  3. pmc Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum
    Pei Song Gao
    Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Invest Dermatol 132:650-7. 2012
  4. pmc Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study
    Seunghye Han
    Critical Care Medicine Department, National Institute of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Crit Care 15:R262. 2011
  5. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
  6. ncbi request reprint Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 118:70-7. 2006
  7. ncbi request reprint A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma: common variants for common phenotypes?
    Kathleen C Barnes
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Curr Opin Allergy Clin Immunol 5:379-85. 2005
  8. ncbi request reprint Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families
    K C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Genes Immun 7:27-35. 2006
  9. ncbi request reprint Genetic epidemiology of health disparities in allergy and clinical immunology
    Kathleen C Barnes
    The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 117:243-54; quiz 255-6. 2006
  10. pmc African Americans with asthma: genetic insights
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Proc Am Thorac Soc 4:58-68. 2007

Detail Information

Publications54

  1. pmc Genetic determinants and ethnic disparities in sepsis-associated acute lung injury
    Kathleen C Barnes
    Division of Johns Hopkins Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 2:195-201. 2005
    ..In trying to understand the basis for contemporary differences in allelic frequency, which may lead to differences in susceptibility, the potential role of positive selection for genetic variants in ancestral populations is considered...
  2. pmc Aquaporin 5 polymorphisms and rate of lung function decline in chronic obstructive pulmonary disease
    Nadia N Hansel
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 5:e14226. 2010
    ..Aquaporin-5 (AQP5) can cause mucus overproduction and lower lung function. Genetic variants in the AQP5 gene might be associated with rate of lung function decline in chronic obstructive pulmonary disease (COPD)...
  3. pmc Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum
    Pei Song Gao
    Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Invest Dermatol 132:650-7. 2012
    ..008). Our findings suggest that distinct markers in IRF2 may be associated with AD and ADEH, which may depend upon ethnic ancestry, and genetic variants in IRF2 may contribute to an abnormal immune response to HSV...
  4. pmc Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study
    Seunghye Han
    Critical Care Medicine Department, National Institute of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Crit Care 15:R262. 2011
    ..Mortality of ALI may vary by gender, which could result from treatment variability. Whether gender is associated with the use of LPV is not known...
  5. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  6. ncbi request reprint Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 118:70-7. 2006
    ....
  7. ncbi request reprint A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma: common variants for common phenotypes?
    Kathleen C Barnes
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Curr Opin Allergy Clin Immunol 5:379-85. 2005
    ....
  8. ncbi request reprint Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families
    K C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Genes Immun 7:27-35. 2006
    ..003, 0.007, 0.018, respectively) considering haplotype-specific tests. Taken together, these results implicate the C3 gene as a priority candidate controlling risk for asthma and allergic disease in this population of African descent...
  9. ncbi request reprint Genetic epidemiology of health disparities in allergy and clinical immunology
    Kathleen C Barnes
    The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 117:243-54; quiz 255-6. 2006
    ..Herein is a discussion of how genetic variants might explain, at least in part, the marked disparities observed in risk to allergic asthma...
  10. pmc African Americans with asthma: genetic insights
    Kathleen C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Proc Am Thorac Soc 4:58-68. 2007
    ..Cutting-edge approaches, such as genomewide association studies, admixture mapping, and phylogenetic analyses, offer new opportunities for dissecting the genetic basis for asthma in populations of African descent...
  11. ncbi request reprint Testing for gene-gene interaction controlling total IgE in families from Barbados: evidence of sensitivity regarding linkage heterogeneity among families
    K C Barnes
    Division of Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genomics 71:246-51. 2001
    ....
  12. ncbi request reprint A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations
    K C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21224, USA
    Clin Exp Allergy 34:736-44. 2004
    ..A susceptibility locus for murine allergen-induced airway hyper-responsiveness was identified in a region syntenic to human chromosome 19q13, where linkage to asthma has been demonstrated and where the gene encoding C5R1 is localized...
  13. pmc An update on the genetics of atopic dermatitis: scratching the surface in 2009
    Kathleen C Barnes
    Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Room 3A 62, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 125:16-29.e1-11; quiz 30-1. 2010
    ..Current challenges and the potential effect of new technologies are discussed...
  14. pmc Genomewide association studies in allergy and the influence of ethnicity
    Kathleen C Barnes
    Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Curr Opin Allergy Clin Immunol 10:427-33. 2010
    ....
  15. pmc Genetic studies of the etiology of asthma
    Kathleen C Barnes
    The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Proc Am Thorac Soc 8:143-8. 2011
    ....
  16. pmc The Peru Urban versus Rural Asthma (PURA) Study: methods and baseline quality control data from a cross-sectional investigation into the prevalence, severity, genetics, immunology and environmental factors affecting asthma in adolescence in Peru
    Colin L Robinson
    Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    BMJ Open 2:e000421. 2012
    ..The authors sought to characterise the epidemiology of asthma in Peru in two regions with disparate degrees of urbanisation. In this manuscript, the authors summarise the study design and implementation...
  17. pmc Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations
    Li Gao
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Transl Res 150:18-29. 2007
    ..These data, generated via functional genomic and genetic approaches, suggest that MIF is a relevant molecular target in ALI...
  18. ncbi request reprint A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, MMC 434 Mayo, 420 Delaware SE, Minneapolis, MN 55455, USA
    Hum Genet 114:157-64. 2004
    ..65), 8p (D8S1113, lod=1.60), 12p (D12S372, lod=1.54) and 14q (D14S749, lod=1.70). These results suggest that several regions may harbor genes contributing to the risk for atopy and these may interact with one another in a complex manner...
  19. pmc Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury
    Li Gao
    Department of Medicine, University of Chicago Pritzker School of Medicine, 5841 S Maryland Avenue, W604, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 34:487-95. 2006
    ..These data strongly implicate MYLK genetic variants to confer increased risk of sepsis and sepsis-associated ALI...
  20. pmc Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations
    Candelaria Vergara
    Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 178:1017-22. 2008
    ..This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax...
  21. doi request reprint Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:507-13, 513.e1-7. 2009
    ..Associations have not been reported in African ancestry populations. Atopic dermatitis eczema herpeticum (ADEH) is a rare but serious complication of AD resulting from disseminated cutaneous herpes simplex virus infections...
  22. ncbi request reprint Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma
    Li Gao
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 119:1111-8. 2007
    ..Myosin light chain kinase (MYLK) is a multifunctional protein involved in regulation of airway hyperreactivity and other activities relevant to asthma...
  23. pmc A genome-wide association study on African-ancestry populations for asthma
    Rasika A Mathias
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    J Allergy Clin Immunol 125:336-346.e4. 2010
    ..Of the limited genetic studies performed on populations of African descent, notable differences in susceptibility allele frequencies have been observed...
  24. ncbi request reprint Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study
    April Zambelli-Weiner
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 115:1203-9. 2005
    ..Both a functional promoter polymorphism in the gene encoding CD14 (C-260T) and exposure to endotoxin are believed to play key roles in modulating the immune response and expression of atopic disease...
  25. pmc Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis
    Mark M Wurfel
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Respir Crit Care Med 178:710-20. 2008
    ..Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis...
  26. ncbi request reprint Host defense genes in asthma and sepsis and the role of the environment
    Li Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Curr Opin Allergy Clin Immunol 7:459-67. 2007
    ..Variants in genes associated with classic innate immunity-related disorders, such as sepsis, may be unique candidates for asthma susceptibility...
  27. ncbi request reprint Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury
    Shui Q Ye
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL Building Center Tower 664, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 171:361-70. 2005
    ..Together, these results strongly indicate that PBEF is a potential novel biomarker in ALI and demonstrate the successful application of robust genomic technologies in the identification of candidate genes in complex lung disease...
  28. ncbi request reprint Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population
    Pei Song Gao
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 115:982-8. 2005
    ..The T-cell immunoglobulin mucin ( TIM ) proteins and their genetic variants have been suggested to play a role in regulating allergic diseases...
  29. pmc Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma
    Pei Song Gao
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Eur J Hum Genet 18:713-9. 2010
    ..However, our association results suggest that the Siglec8 gene may be a susceptibility locus for asthma...
  30. ncbi request reprint A rapid method for microarray cross platform comparisons using gene expression signatures
    Chris Cheadle
    Genomics Core, Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Mason Lord Bldg, Center Tower, Rm 664, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Mol Cell Probes 21:35-46. 2007
    ....
  31. ncbi request reprint Evidence for asthma susceptibility genes on chromosome 11 in an African-American population
    Shau Ku Huang
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, MD 21224 6801, Baltimore, USA
    Hum Genet 113:71-5. 2003
    ..8 cM with a confidence interval spanning the linkage peak. Evidence from both linkage and association analyses suggest that this region of chromosome 11 contains one or more susceptibility genes for asthma in these AA families...
  32. ncbi request reprint Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population
    Peter B Chi
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Genet Epidemiol 30:609-19. 2006
    ..We also found a high degree of consistency between TagSNP and Tagger. Using this set of 713 SNPs on chromosome 12q, our study provides insight towards analytic strategies for future studies of complex traits...
  33. pmc Vaccinia virus-specific molecular signature in atopic dermatitis skin
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD, USA
    J Allergy Clin Immunol 125:153-159.e28. 2010
    ..However, the precise mechanism or mechanisms and key factor or factors of EV are unknown...
  34. pmc Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru
    Lauren M Baumann
    Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD 21205, USA
    J Allergy Clin Immunol 127:875-82. 2011
    ....
  35. pmc Recent advances in genetic predisposition to clinical acute lung injury
    Li Gao
    The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 296:L713-25. 2009
    ....
  36. ncbi request reprint Unified sampling approach for multipoint linkage disequilibrium mapping of qualitative and quantitative traits
    Fang Chi Hsu
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Genet Epidemiol 22:298-312. 2002
    ..84, 43.02) through the 20-cM region framed by markers D12S1052 and D12S1064 on chromosome 12. The test statistic shows strong evidence of linkage and LD (chi-square statistic = 18.39 with 2 df, P-value = 0.0001)...
  37. pmc Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis
    Michelle L Harris
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 58:1958-67. 2008
    ..This study was undertaken to investigate whether anti-PAD-4 antibodies are specific to RA, are associated with disease phenotype or severity, and whether PAD-4 polymorphisms influence the anti-PAD-4 autoantibody response...
  38. pmc Identification of candidate genes in scleroderma-related pulmonary arterial hypertension
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
    Transl Res 151:197-207. 2008
    ..Deciphering the role of genes involved in vascular remodeling and PAH development may reveal new treatment targets for this devastating disorder...
  39. doi request reprint Effects of anti-adhesive therapy on kidney biomarkers of ischemia reperfusion injury in human deceased donor kidney allografts
    Chris Cheadle
    Lowe Family Genomics Core, Johns Hopkins University, Baltimore, MD, USA
    Clin Transplant 25:766-75. 2011
    ..Molecular biomarkers validated previously in animal models are increasingly being studied in conjunction with traditional clinical endpoints in therapeutic trials...
  40. pmc Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis
    Chris Cheadle
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 62:1744-54. 2010
    ..The aim of this study was to understand the biology underlying WG and to discover markers of disease activity that would be useful for prognosis and treatment guidance...
  41. doi request reprint High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population
    Audrey V Grant
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 198:1227-36. 2008
    ....
  42. ncbi request reprint A genome-wide search for quantitative trait loci contributing to variation in seasonal pollen reactivity
    Malcolm N Blumenthal
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    J Allergy Clin Immunol 117:79-85. 2006
    ..Asthma and atopy represent complex traits for which genetic predisposition has been demonstrated. Pollen sensitivity, whether seasonal or chronic, appears to be a major contributor to the asthmatic phenotype...
  43. ncbi request reprint Inheritance of total serum IgE in the isolated Tangier Island population from Virginia: complexities associated with genealogical depth of pedigrees in segregation analyses
    Rasika A Mathias
    Department of Epidemiology, Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21224, USA
    Hum Hered 59:228-38. 2005
    ....
  44. pmc The local and systemic inflammatory transcriptome after acute kidney injury
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, 5501 Hopkins Bayview Circle, JHAAC 3A 62, Baltimore, Maryland, 21224, USA
    J Am Soc Nephrol 19:547-58. 2008
    ..Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development...
  45. ncbi request reprint Genetics and epidemiology
    Kathleen C Barnes
    Curr Opin Allergy Clin Immunol 2:375-8. 2002
  46. ncbi request reprint Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7934, USA
    Int Arch Allergy Immunol 131:119-26. 2003
    ..The main objective of this study was to determine prevalence and correlates of sensitivity to these mites in families with asthma and characteristics of persons sensitized to both...
  47. ncbi request reprint Quantitative linkage genome scan for atopy in a large collection of Caucasian families
    Bradley T Webb
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    Hum Genet 121:83-92. 2007
    ..This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders...
  48. ncbi request reprint A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p
    Sreekumar G Pillai
    Genetics Research Glaxo SmithKline, Research Triangle Park, NC 27709, USA Stevenage, UK Sreekumar
    Eur J Hum Genet 14:307-16. 2006
    ..The refined locus covers a region with a physical size of 12.2 Mb. Taken together, these results provide evidence for a major asthma susceptibility locus on chromosome 2p...
  49. ncbi request reprint Sex differences in heritability of sensitization to Blomia tropicalis in asthma using regression of offspring on midparent (ROMP) methods
    Teri A Manolio
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Rm 8160, Bethesda, MD 20892 7934, USA
    Hum Genet 113:437-46. 2003
    ..Adjustment for covariates had minimal impact. This suggests that future investigations of genetic determinants of IgE levels should include approaches that allow for potential sex differences in their expression...
  50. ncbi request reprint Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation
    Julia H White
    Molecular Discovery Research, GlaxoSmithKline Research and Development, RTP, NC, USA Stevenage, UK
    Hum Mol Genet 17:1890-903. 2008
    ..Collectively, these data suggest that OPN3 is an asthma susceptibility gene on 1qter, which unexpectedly may play a role in immune modulation...
  51. pmc A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
    Rasika A Mathias
    Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Balitmore, USA
    BMC Genet 7:38. 2006
    ..While efficient in screening a region of dense genotyping, this approach does create some problems: high numbers of tests, assimilating thousands of results, and questions about setting priorities on regions with association signals...
  52. ncbi request reprint Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability
    Jing Long Huang
    The Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Hum Mol Genet 13:2691-7. 2004
    ..11q is a strong candidate gene for asthma...
  53. ncbi request reprint The genetic association database
    Kevin G Becker
    Nat Genet 36:431-2. 2004
  54. pmc Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:150-5. 2007
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD...

Research Grants14

  1. Genomics/Genotyping
    Kathleen Barnes; Fiscal Year: 2007
    ..abstract_text> ..
  2. Genetic Studies of Immune Responsiveness to Cockroach
    Kathleen Barnes; Fiscal Year: 2003
    ..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..
  3. Genome-Wide Association Studies of Asthma in Populations of African Descent
    Kathleen Barnes; Fiscal Year: 2007
    ..Findings from this study will provide a better understanding of the complex pathways related to risk of asthma and associated phenotypes. ..
  4. Genome-Wide Association Studies of Asthma in Populations of African Descent
    Kathleen Barnes; Fiscal Year: 2006
    ..Findings from this study will provide a better understanding of the complex pathways related to risk of asthma and associated phenotypes. ..
  5. AIRWAY DISEASE AND COCKROACH EXPOSURE IN PUBLIC HOUSING
    Kathleen Barnes; Fiscal Year: 2007
    ..We hope that with the data to be generated, we will positively impact the health of urban US populations who are disproportionally suffering from asthma morbidity and mortality. ..
  6. Genetic Studies of Immune Responsiveness to Cockroach
    Kathleen Barnes; Fiscal Year: 2007
    ..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..
  7. Genetic Studies of Immune Responsiveness to Cockroach
    Kathleen Barnes; Fiscal Year: 2006
    ..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..