Genomes and Genes
Rahul P Bakshi
Affiliation: Johns Hopkins University
- Activity of indenoisoquinolines against African trypanosomesRahul P Bakshi
Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Antimicrob Agents Chemother 53:123-8. 2009..The indenoisoquinolines provide a promising lead for the development of drugs against sleeping sickness...
- Model system to define pharmacokinetic requirements for antimalarial drug efficacyRahul P Bakshi
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
Sci Transl Med 5:205ra135. 2013..The apparatus can also be used to explore the kinetic dependence of other pharmacodynamic endpoints in parasites. ..
- Membrane active chelators as novel anti-African trypanosome and anti-malarial drugsDennis J Grab
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Parasitol Int 62:461-3. 2013..While the exact mechanism of action of MACs against intracellular malaria and extracellular African trypanosome parasites has yet to be determined, their potential as antiparasitic agents warrants further investigation...
- Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmissionEdward J Fuchs
Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
J Infect Dis 195:703-10. 2007..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa...
- RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essentialRahul P Bakshi
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Mol Biochem Parasitol 136:249-55. 2004..These findings underscore the essential nature of type IB topoisomerase activity in Trypanosoma brucei and its suitability as a target for rational drug design...
- Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoitesMyaing M Nyunt
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Trop Med Hyg 80:528-35. 2009..We conclude that a single dose of 100 mg pafuramidine does not adequately protect non-immune individuals against P. falciparum and shows no clinically or statistically significant evidence of causal prophylactic activity...
- Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourseEdward J Fuchs
Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5554, USA
J Infect Dis 207:1389-96. 2013..Microbicide toxicity may reduce the efficacy of topical preexposure prophylaxis for human immunodeficiency virus (HIV) transmission. Noninvasive quantitative measures of microbicide toxicity would usefully inform microbicide development...
- Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patientsRahul P Bakshi
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
AIDS Res Hum Retroviruses 23:1360-5. 2007..Since a significant reduction in dATP was measurable only when ddI was combined with HU, the antiretroviral activity of ddI may be more complex than previously assumed...