Rahul P Bakshi

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Activity of indenoisoquinolines against African trypanosomes
    Rahul P Bakshi
    Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antimicrob Agents Chemother 53:123-8. 2009
  2. ncbi request reprint Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    J Infect Dis 195:703-10. 2007
  3. ncbi request reprint RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential
    Rahul P Bakshi
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Mol Biochem Parasitol 136:249-55. 2004
  4. pmc Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites
    Myaing M Nyunt
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 80:528-35. 2009
  5. pmc Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourse
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5554, USA
    J Infect Dis 207:1389-96. 2013
  6. doi request reprint Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs
    Dennis J Grab
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Parasitol Int 62:461-3. 2013
  7. ncbi request reprint Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients
    Rahul P Bakshi
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    AIDS Res Hum Retroviruses 23:1360-5. 2007

Collaborators

Detail Information

Publications7

  1. pmc Activity of indenoisoquinolines against African trypanosomes
    Rahul P Bakshi
    Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Antimicrob Agents Chemother 53:123-8. 2009
    ..The indenoisoquinolines provide a promising lead for the development of drugs against sleeping sickness...
  2. ncbi request reprint Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
    J Infect Dis 195:703-10. 2007
    ..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa...
  3. ncbi request reprint RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential
    Rahul P Bakshi
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Mol Biochem Parasitol 136:249-55. 2004
    ..These findings underscore the essential nature of type IB topoisomerase activity in Trypanosoma brucei and its suitability as a target for rational drug design...
  4. pmc Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites
    Myaing M Nyunt
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 80:528-35. 2009
    ..We conclude that a single dose of 100 mg pafuramidine does not adequately protect non-immune individuals against P. falciparum and shows no clinically or statistically significant evidence of causal prophylactic activity...
  5. pmc Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourse
    Edward J Fuchs
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5554, USA
    J Infect Dis 207:1389-96. 2013
    ..Microbicide toxicity may reduce the efficacy of topical preexposure prophylaxis for human immunodeficiency virus (HIV) transmission. Noninvasive quantitative measures of microbicide toxicity would usefully inform microbicide development...
  6. doi request reprint Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs
    Dennis J Grab
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Parasitol Int 62:461-3. 2013
    ..While the exact mechanism of action of MACs against intracellular malaria and extracellular African trypanosome parasites has yet to be determined, their potential as antiparasitic agents warrants further investigation...
  7. ncbi request reprint Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients
    Rahul P Bakshi
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    AIDS Res Hum Retroviruses 23:1360-5. 2007
    ..Since a significant reduction in dATP was measurable only when ddI was combined with HU, the antiretroviral activity of ddI may be more complex than previously assumed...