Dimitrios Avramopoulos

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Orientation, distance, regulation and function of neighbouring genes
    Adrian Gherman
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Hum Genomics 3:143-56. 2009
  2. pmc Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients
    A Hatzimanolis
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transl Psychiatry 3:e264. 2013
  3. pmc Genetics of Alzheimer's disease: recent advances
    Dimitrios Avramopoulos
    McKusick Nathans Institute of Genetic Medicine and Department of Psychiatry, Johns Hopkins University School of Medicine, Broadway Research Building Room 509, 733 N Broadway, Baltimore, MD 21205, USA
    Genome Med 1:34. 2009
  4. pmc Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level
    Nicholas C Stefanis
    University Mental Health Research Institute, Athens, Greece
    Behav Brain Funct 4:46. 2008
  5. pmc Testing groups of genomic locations for enrichment in disease loci using linkage scan data: a method for hypothesis testing
    Dimitrios Avramopoulos
    Department of Psychiatry, The Johns Hopkins University, School of Medicine, Broadway Research Building 509, 733 North Broadway, Baltimore, MD 21205, USA
    Hum Genomics 2:345-52. 2006
  6. ncbi A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease
    Dimitrios Avramopoulos
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurogenetics 8:111-20. 2007
  7. pmc Genetics of psychiatric disorders methods: molecular approaches
    Dimitrios Avramopoulos
    Department of Psychiatry, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Clin North Am 33:1-13. 2010
  8. doi Genetics of psychiatric disorders methods: molecular approaches
    Dimitrios Avramopoulos
    Department of Psychiatry, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, BRB 509, 733 North Broadway, Baltimore, MD 21205, USA
    Clin Lab Med 30:815-27. 2010
  9. ncbi Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms
    Dimitrios Avramopoulos
    The Johns Hopkins University, Department of Psychiatry, School of Medicine, Meyer 4 Room 139, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 132:9-13. 2005
  10. ncbi Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis
    D Avramopoulos
    Department of Psychiatry, Johns Hopkins University, School of Medicine, North Wolfe Street, Baltimore, MD 21287, USA
    Mol Psychiatry 9:191-6. 2004

Research Grants

  1. Identification of genetic determinants of schizophrenia related phenotypes
    Dimitrios Avramopoulos; Fiscal Year: 2010
  2. Gene detection in regions linked to Alzheimer's disease
    Dimitrios Avramopoulos; Fiscal Year: 2006
  3. Gene detection in regions linked to Alzheimer's disease
    Dimitrios Avramopoulos; Fiscal Year: 2007
  4. Gene detection in regions linked to Alzheimer's disease
    Dimitrios Avramopoulos; Fiscal Year: 2009
  5. 1/2 Schizophrenia Heterogeneity and Toxoplasma Exposure
    Dimitrios Avramopoulos; Fiscal Year: 2011

Detail Information

Publications49

  1. pmc Orientation, distance, regulation and function of neighbouring genes
    Adrian Gherman
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Hum Genomics 3:143-56. 2009
    ..Further, we provide extensive graphical representations of the genome-wide data to allow for observations and comparisons beyond what we address...
  2. pmc Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients
    A Hatzimanolis
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Transl Psychiatry 3:e264. 2013
    ..On the basis of this, we propose a general model of pathway heterogeneity in SZ, which, in part, may explain its phenotypic variability and genetic complexity...
  3. pmc Genetics of Alzheimer's disease: recent advances
    Dimitrios Avramopoulos
    McKusick Nathans Institute of Genetic Medicine and Department of Psychiatry, Johns Hopkins University School of Medicine, Broadway Research Building Room 509, 733 N Broadway, Baltimore, MD 21205, USA
    Genome Med 1:34. 2009
    ....
  4. pmc Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level
    Nicholas C Stefanis
    University Mental Health Research Institute, Athens, Greece
    Behav Brain Funct 4:46. 2008
    ..abstract:..
  5. pmc Testing groups of genomic locations for enrichment in disease loci using linkage scan data: a method for hypothesis testing
    Dimitrios Avramopoulos
    Department of Psychiatry, The Johns Hopkins University, School of Medicine, Broadway Research Building 509, 733 North Broadway, Baltimore, MD 21205, USA
    Hum Genomics 2:345-52. 2006
    ..We present an application of the method to real data from a late-onset Alzheimer's disease linkage scan as a proof of principle...
  6. ncbi A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease
    Dimitrios Avramopoulos
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurogenetics 8:111-20. 2007
    ..Comparison of primate and other mammal genomes suggests that ASAH2L is human specific. Further research would be necessary to determine the function of the ASAH2L transcript and explore any possible involvement in neurodegeneration...
  7. pmc Genetics of psychiatric disorders methods: molecular approaches
    Dimitrios Avramopoulos
    Department of Psychiatry, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Clin North Am 33:1-13. 2010
    ....
  8. doi Genetics of psychiatric disorders methods: molecular approaches
    Dimitrios Avramopoulos
    Department of Psychiatry, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, BRB 509, 733 North Broadway, Baltimore, MD 21205, USA
    Clin Lab Med 30:815-27. 2010
    ....
  9. ncbi Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms
    Dimitrios Avramopoulos
    The Johns Hopkins University, Department of Psychiatry, School of Medicine, Meyer 4 Room 139, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 132:9-13. 2005
    ..This region requires further study to replicate the finding and identify the genetic variant responsible for the linkage...
  10. ncbi Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis
    D Avramopoulos
    Department of Psychiatry, Johns Hopkins University, School of Medicine, North Wolfe Street, Baltimore, MD 21287, USA
    Mol Psychiatry 9:191-6. 2004
    ..Biologically, plausible candidate genes in this region include thyroglobulin, KCNQ3 coding for a voltage-gated potassium channel and the gene for brain adenyl-cyclase (ADCY8)...
  11. doi Linkage and association on 8p21.2-p21.1 in schizophrenia
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Med Genet B Neuropsychiatr Genet 156:188-97. 2011
    ..2007. Proteomics 7(7):1131–1139; Paulson et al. 2004. Proteomics 4(3):819–825]. Taken together, this work further supports DPYSL2 and the surrounding genomic region as a susceptibility locus for SZ...
  12. ncbi SNP fine mapping of chromosome 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 144:625-30. 2007
    ..Several other interesting candidate genes are also located nearby. The congruence of findings across methods and samples suggests further investigation is warranted in these two targeted regions...
  13. doi Familiality of novel factorial dimensions of schizophrenia
    John A McGrath
    Department of Psychiatry, The Johns Hopkins University School of Medicine, 1820 Lancaster St, Ste 300, Baltimore, MD 21231, USA
    Arch Gen Psychiatry 66:591-600. 2009
    ..Examination of familiality of factor scores can demonstrate whether they are likely to be of use in genetic research...
  14. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
    ..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms...
  15. pmc Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia
    Pei Lung Chen
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Hum Genet 84:21-34. 2009
    ..These biological properties together with our linkage and association results strongly support NRG3 as a gene involved in SZ...
  16. pmc Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women
    Yaping Liu
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Psychiatr Genet 20:184-6. 2010
    ..Furthermore, we explore the effects of this polymorphism through quantitative trait loci analysis of nine SZ related factors providing information on sex-specific genotype--phenotype correlations...
  17. ncbi Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene
    Dimitrios Avramopoulos
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Genet Med 9:745-51. 2007
    ..This study is a second stage follow-up focusing on regions that showed positive linkage scores in our previous scan but were not fine-mapped at that time...
  18. ncbi Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  19. pmc Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's disease
    Susan Spear Bassett
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 141:537-40. 2006
    ....
  20. ncbi Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1
    James B Potash
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008
    ..Further work is needed to confirm these results and uncover the functional variation underlying the association signal...
  21. pmc SynaptomeDB: an ontology-based knowledgebase for synaptic genes
    Mehdi Pirooznia
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA
    Bioinformatics 28:897-9. 2012
    ..However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking...
  22. doi Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  23. pmc Fine mapping of the chromosome 10q11-q21 linkage region in Alzheimer's disease cases and controls
    Margaret Daniele Fallin
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurogenetics 11:335-48. 2010
    ..Acquiring additional support and clarifying the mechanisms of such involvement is important for AD and other complex disorder genetics research...
  24. pmc Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Am J Hum Genet 77:918-36. 2005
    ..They provide further support for shared genetic susceptibility between these two disorders that involve glutamate-signaling pathways...
  25. pmc Neuroglobin and Alzheimer's dementia: genetic association and gene expression changes
    Megan Szymanski
    McKusick Nathans Institute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neurobiol Aging 31:1835-42. 2010
    ..We speculate that a compromised response due to DNA variation might increase the risk for AD. Our and others' data strongly support the involvement of NGB in AD...
  26. ncbi Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
    Am J Psychiatry 160:680-6. 2003
    ....
  27. pmc Family-based SNP association study on 8q24 in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 147:612-8. 2008
    ..These findings with ADCY8 and ST3GAL1 warrant further investigation in order to confirm the observed associations and their functional significance for BP susceptibility...
  28. pmc Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 156:370-8. 2011
    ..8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles...
  29. ncbi Evidence for parent of origin effect in late-onset Alzheimer disease
    Susan Spear Bassett
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet 114:679-86. 2002
    ....
  30. pmc Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene
    Nara L M Sobreira
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Genet 6:e1000991. 2010
    ..This combination of a new technology and a classical genetic approach provides a powerful strategy to discover the genes responsible for unexplained Mendelian disorders...
  31. pmc Gene expression reveals overlap between normal aging and Alzheimer's disease genes
    Dimitrios Avramopoulos
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, 733 N Broadway, Baltimore, MD, USA
    Neurobiol Aging 32:2319.e27-34. 2011
    ..This result supports an overlap between the biological processes of normal aging and susceptibility to AD and suggests that age related genes expression changes might increase the risk of developing AD...
  32. pmc Exonic DNA sequencing of ERBB4 in bipolar disorder
    Fernando S Goes
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20242. 2011
    ..However, the modest sample size in this study cannot definitively rule out a role for rare variants in bipolar disorder and studies with larger sample sizes are needed to confirm the observed association...
  33. pmc Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene
    Sarah M Hartz
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Psychiatr Genet 21:77-84. 2011
    ....
  34. pmc Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N Broadway, Baltimore, MD 21205, USA
    Arch Womens Ment Health 12:27-34. 2009
    ..Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use...
  35. pmc Brain activation in offspring of AD cases corresponds to 10q linkage
    Susan Spear Bassett
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 58:142-6. 2005
    ..These results suggest the possibility that activation patterns may prove useful as a preclinical quantitative trait related to the putative familial late-onset AD gene in this chromosome 10 region...
  36. ncbi Rh and ABO maternal-fetal incompatibility and risk of autism
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Med Genet B Neuropsychiatr Genet 141:643-7. 2006
    ..Furthermore, we did not find any evidence for the presence of a high-risk susceptibility allele at or near these two loci operating either through the mother or child...
  37. pmc Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia
    Eunchai Kang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 72:559-71. 2011
    ..Our findings support a model in which DISC1 regulates distinct aspects of neuronal development through its interaction with different intracellular partners and such epistasis may contribute to increased risk for schizophrenia...
  38. pmc Glutathione pathway gene variation and risk of autism spectrum disorders
    Katherine Bowers
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St room W6509, Baltimore, MD, 21205, USA
    J Neurodev Disord 3:132-43. 2011
    ..These results suggest that variation in genes involved in counterbalancing oxidative stress may contribute to autism, though replication is necessary...
  39. pmc Do treatment effects vary among differing baseline depression criteria in depression in Alzheimer's disease study ± 2 (DIADS-2)?
    Lea T Drye
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Geriatr Psychiatry 26:573-83. 2011
    ..To determine if the effect of sertraline in the depression in Alzheimer's disease study - 2 (DIADS-2) differed in subgroups of patients defined by baseline depression criteria...
  40. ncbi Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  41. ncbi Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level
    Nicholas C Stefanis
    University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece
    Biol Psychiatry 62:784-92. 2007
    ..It is unknown whether the expression of these endophenotypes at the population level is modulated by the genetic variability of candidate susceptibility genes for schizophrenia...
  42. ncbi COMT Val158Met moderation of stress-induced psychosis
    Nicholas C Stefanis
    Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychol Med 37:1651-6. 2007
    ..This study aimed to investigate whether a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderates the psychosis-inducing effects of stress...
  43. ncbi Results of a high-resolution genome screen of 437 Alzheimer's disease families
    Deborah Blacker
    Massachusetts General Hospital, Charlestown, MA, USA
    Hum Mol Genet 12:23-32. 2003
    ..Although some of these will surely prove to be false positives, these linkage signals should provide a valuable framework for future studies aimed at identifying additional susceptibility genes for late-onset AD...
  44. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  45. ncbi Variation in catechol-o-methyltransferase val158 met genotype associated with schizotypy but not cognition: a population study in 543 young men
    Nicholas C Stefanis
    Department of Psychiatry, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece
    Biol Psychiatry 56:510-5. 2004
    ....
  46. ncbi Effect of schizotypy on cognitive performance and its tuning by COMT val158 met genotype variations in a large population of young men
    Nikolaos Smyrnis
    University Mental Health Research Institute, Psychiatry Department, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece
    Biol Psychiatry 61:845-53. 2007
    ..The relation of schizotypy and state psychopathology to cognitive performance and its link to catechol-O-methyltransferase (COMT) val(158) met genotype variations was studied in a large sample of young men...
  47. ncbi Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control study
    George N Papadimitriou
    Athens University Medical School, Department of Psychiatry, Eginition Hospital, Athens, Greece
    Psychiatr Genet 13:211-20. 2003
    ..02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder...
  48. ncbi Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance
    Nicholas C Stefanis
    Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 74 Vas Sofias Ave, Athens 11528, Greece
    Am J Psychiatry 162:1752-4. 2005
    ..The authors' goal was to determine whether, in confirmation of this prediction, performance on a measure of cognitive stability would be associated with Met loading...

Research Grants6

  1. Identification of genetic determinants of schizophrenia related phenotypes
    Dimitrios Avramopoulos; Fiscal Year: 2010
    ....
  2. Gene detection in regions linked to Alzheimer's disease
    Dimitrios Avramopoulos; Fiscal Year: 2006
    ..abstract_text> ..
  3. Gene detection in regions linked to Alzheimer's disease
    Dimitrios Avramopoulos; Fiscal Year: 2007
    ..abstract_text> ..
  4. Gene detection in regions linked to Alzheimer's disease
    Dimitrios Avramopoulos; Fiscal Year: 2009
    ..abstract_text> ..
  5. 1/2 Schizophrenia Heterogeneity and Toxoplasma Exposure
    Dimitrios Avramopoulos; Fiscal Year: 2011
    ....