NANCY ATOR

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Behavioral Effects and Pharmacokinetics of ({+/-})-3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) after Intragastric Administration to Baboons
    Amy K Goodwin
    Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224 6823
    J Pharmacol Exp Ther 345:342-53. 2013
  2. pmc Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes
    Nancy A Ator
    Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 332:4-16. 2010
  3. ncbi request reprint Relation between discriminative and reinforcing effects of midazolam, pentobarbital, chlordiazepoxide, zolpidem, and imidazenil in baboons
    Nancy A Ator
    Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 163:477-87. 2002
  4. ncbi request reprint Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons
    Nancy A Ator
    Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
    Drug Alcohol Depend 78:113-23. 2005
  5. ncbi request reprint Contributions of GABAA receptor subtype selectivity to abuse liability and dependence potential of pharmacological treatments for anxiety and sleep disorders
    Nancy A Ator
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Hopkins Bayview Campus, Baltimore, MD 21224 6823, USA
    CNS Spectr 10:31-9. 2005
  6. ncbi request reprint Selectivity in generalization to GABAergic drugs in midazolam-trained baboons
    Nancy A Ator
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, Johns Hopkins Bayview Campus, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 75:435-45. 2003
  7. ncbi request reprint Principles of drug abuse liability assessment in laboratory animals
    Nancy A Ator
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins School of Medicine, Hopkins Bayview Campus, 5510 Nathan Shock Drive, Ste 3000, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 70:S55-72. 2003
  8. pmc Novel discriminative stimulus effects of TPA023B, subtype-selective gamma-aminobutyric-acid(A)/benzodiazepine modulator: comparisons with zolpidem, lorazepam, and TPA023
    Stephen J Kohut
    Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, Johns Hopkins School of Medicine, Baltimore, MD, United States
    Pharmacol Biochem Behav 90:65-73. 2008
  9. ncbi request reprint Morphine withdrawal dramatically reduces lymphocytes in morphine-dependent macaques
    Michael R Weed
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, BBRC Suite 3000, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Neuroimmune Pharmacol 1:250-9. 2006
  10. doi request reprint Consistent, high-level ethanol consumption in pig-tailed macaques via a multiple-session, limited-intake, oral self-dosing procedure
    Michael R Weed
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
    Alcohol Clin Exp Res 32:942-51. 2008

Detail Information

Publications12

  1. pmc Behavioral Effects and Pharmacokinetics of ({+/-})-3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) after Intragastric Administration to Baboons
    Amy K Goodwin
    Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224 6823
    J Pharmacol Exp Ther 345:342-53. 2013
    ..Similar to humans, blood levels of MDMA after oral administration may not be predictive of the behavioral effects of MDMA. Metabolites, particularly HHMA, may play a significant role in the behavioral effects of MDMA...
  2. pmc Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes
    Nancy A Ator
    Division of Behavioral Biology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 332:4-16. 2010
    ..In the context of other data, elimination of efficacy at the alpha(1) subtype of the GABA/benzodiazepine receptor is not sufficient to eliminate abuse liability but may do so when coupled with reduced alpha(2/3) subtype efficacy...
  3. ncbi request reprint Relation between discriminative and reinforcing effects of midazolam, pentobarbital, chlordiazepoxide, zolpidem, and imidazenil in baboons
    Nancy A Ator
    Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 163:477-87. 2002
    ..This presumed predictive relationship has not been studied directly, however...
  4. ncbi request reprint Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboons
    Nancy A Ator
    Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
    Drug Alcohol Depend 78:113-23. 2005
    ..Lower doses maintained higher self-injection during and shortly after methadone maintenance. Further research should explore the duration of higher self-injection rates following methadone maintenance...
  5. ncbi request reprint Contributions of GABAA receptor subtype selectivity to abuse liability and dependence potential of pharmacological treatments for anxiety and sleep disorders
    Nancy A Ator
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Hopkins Bayview Campus, Baltimore, MD 21224 6823, USA
    CNS Spectr 10:31-9. 2005
    ....
  6. ncbi request reprint Selectivity in generalization to GABAergic drugs in midazolam-trained baboons
    Nancy A Ator
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Suite 3000, Johns Hopkins Bayview Campus, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 75:435-45. 2003
    ..However, to date, positive modulation of GABA through the barbiturate site is not generally sufficient for this effect in nonhuman primates and pigeons although it is in rodents...
  7. ncbi request reprint Principles of drug abuse liability assessment in laboratory animals
    Nancy A Ator
    Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins School of Medicine, Hopkins Bayview Campus, 5510 Nathan Shock Drive, Ste 3000, Baltimore, MD 21224 6823, USA
    Drug Alcohol Depend 70:S55-72. 2003
    ..A key consideration for cross-cutting and specific methodological issues is that choices made enable confident interpretation of both positive and negative results...
  8. pmc Novel discriminative stimulus effects of TPA023B, subtype-selective gamma-aminobutyric-acid(A)/benzodiazepine modulator: comparisons with zolpidem, lorazepam, and TPA023
    Stephen J Kohut
    Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, Johns Hopkins School of Medicine, Baltimore, MD, United States
    Pharmacol Biochem Behav 90:65-73. 2008
    ..Together with previous data, the present results suggest that elimination of alpha(1) efficacy plus reductions in alpha(2/3) efficacy permits anxiolysis but decreases BZ-like interoceptive stimulus effects...
  9. ncbi request reprint Morphine withdrawal dramatically reduces lymphocytes in morphine-dependent macaques
    Michael R Weed
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, BBRC Suite 3000, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Neuroimmune Pharmacol 1:250-9. 2006
    ....
  10. doi request reprint Consistent, high-level ethanol consumption in pig-tailed macaques via a multiple-session, limited-intake, oral self-dosing procedure
    Michael R Weed
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
    Alcohol Clin Exp Res 32:942-51. 2008
    ..A small percentage of macaques will spontaneously consume large quantities of ethanol; however, most nonhuman primate models of "voluntary" ethanol intake produce relatively low daily ethanol intake in the majority of monkeys...
  11. ncbi request reprint Principles of initial experimental drug abuse liability assessment in humans
    Roland R Griffiths
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drug Alcohol Depend 70:S41-54. 2003
    ..g. behavioral performance, observer-rated assessments, physiological measures)...
  12. ncbi request reprint Comparison of the behavioral effects of bretazenil and flumazenil in triazolam-dependent and non-dependent baboons
    Elise M Weerts
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, MD 21224, USA
    Eur J Pharmacol 519:103-13. 2005
    ..Thus, bretazenil can function as an antagonist under conditions of benzodiazepine physical dependence...

Research Grants27

  1. FUNCTIONAL ANALYSIS OF GABAERGIC SEDATIVE/ANXIOLYTICS
    NANCY ATOR; Fiscal Year: 2001
    ..This research should inform current thinking over the ways in which stimulus control processes operate in determining chronic drug-taking. ..
  2. Functional Analysis of GABAerglc Sedative/Anxiolytics
    NANCY ATOR; Fiscal Year: 2007
    ..abstract_text> ..
  3. The reinforcing and discriminative stimulus effects of orally administered MDMA
    Nancy A Ator; Fiscal Year: 2010
    ..Our proposal will generate data fundamental to the future development of pharmacotherapies for MDMA abuse, thereby contributing to our long-term goal of facilitating treatment of MDMA intoxication, overdose, and use/abuse. ..
  4. ANALYSIS OF ANXIOLYTICS AS DISCRIMINATIVE STIMULI
    NANCY ATOR; Fiscal Year: 1993
    ....
  5. ANALYSIS OF ANXIOLYTICS AS DISCRIMINATIVE STIMULI
    NANCY ATOR; Fiscal Year: 1991
    ....
  6. GABA-A alpha5 cognitive enhancers: pharmacology and neuropsychology in macaques
    Nancy A Ator; Fiscal Year: 2010
    ....