Mary Y Armanios

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita
    Erin M Parry
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans St, CRB 186, Baltimore, MD 21287, USA
    J Med Genet 48:327-33. 2011
  2. pmc Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis
    Jonathan K Alder
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Genet 7:e1001352. 2011
  3. pmc Short telomeres compromise β-cell signaling and survival
    Nini Guo
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17858. 2011
  4. pmc Telomeres and age-related disease: how telomere biology informs clinical paradigms
    Mary Armanios
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Invest 123:996-1002. 2013
  5. pmc The telomere syndromes
    Mary Armanios
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Rev Genet 13:693-704. 2012
  6. pmc Telomerase and idiopathic pulmonary fibrosis
    Mary Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mutat Res 730:52-8. 2012
  7. pmc Short telomeres are sufficient to cause the degenerative defects associated with aging
    Mary Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Hum Genet 85:823-32. 2009
  8. pmc Syndromes of telomere shortening
    Mary Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21285, USA
    Annu Rev Genomics Hum Genet 10:45-61. 2009
  9. ncbi request reprint Telomerase mutations in families with idiopathic pulmonary fibrosis
    Mary Y Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    N Engl J Med 356:1317-26. 2007
  10. ncbi request reprint Adjuvant chemotherapy for resected adenocarcinoma of the esophagus, gastro-esophageal junction, and cardia: phase II trial (E8296) of the Eastern Cooperative Oncology Group
    Mary Armanios
    Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Oncol 22:4495-9. 2004

Research Grants

  1. Telomere Shortening and Stem Cell Maintenance
    Mary Armanios; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. pmc Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita
    Erin M Parry
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans St, CRB 186, Baltimore, MD 21287, USA
    J Med Genet 48:327-33. 2011
    ..These data identify decreased dyskerin levels as a novel mechanism of DC, and indicate that intact dyskerin levels, in the absence of coding mutations, are critical for telomerase RNA stability and for in vivo telomere maintenance...
  2. pmc Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis
    Jonathan K Alder
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS Genet 7:e1001352. 2011
    ..Our data identify an ancestral mutation in telomerase with a novel loss-of-function mechanism. They indicate that telomere repeat addition processivity is a critical determinant of telomere length and telomere-mediated disease...
  3. pmc Short telomeres compromise β-cell signaling and survival
    Nini Guo
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e17858. 2011
    ..They implicate telomere length as a determinant of β-cell function and diabetes pathogenesis...
  4. pmc Telomeres and age-related disease: how telomere biology informs clinical paradigms
    Mary Armanios
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, and McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Invest 123:996-1002. 2013
    ..I also critically examine nuances of interpreting telomere length measurement in clinical studies...
  5. pmc The telomere syndromes
    Mary Armanios
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Nat Rev Genet 13:693-704. 2012
    ..Here we review the manifestations and unique genetics of telomere syndromes. We also discuss their underlying molecular mechanisms and significance for understanding common age-related disease processes...
  6. pmc Telomerase and idiopathic pulmonary fibrosis
    Mary Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mutat Res 730:52-8. 2012
    ..Here I review the significance of telomere defects for understanding the genetics, disease patterns and pathophysiology of IPF. The importance of this diagnosis for patient care decisions will also be discussed...
  7. pmc Short telomeres are sufficient to cause the degenerative defects associated with aging
    Mary Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Hum Genet 85:823-32. 2009
    ..Our findings implicate telomere length as a unique heritable trait that, when short, is sufficient to mediate the degenerative defects of aging, even when telomerase is wild-type...
  8. pmc Syndromes of telomere shortening
    Mary Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21285, USA
    Annu Rev Genomics Hum Genet 10:45-61. 2009
    ..I also propose broader clinical criteria for defining telomere-mediated syndromes outside of dyskeratosis congenita, with the goal of facilitating their diagnosis and highlighting their pathophysiology...
  9. ncbi request reprint Telomerase mutations in families with idiopathic pulmonary fibrosis
    Mary Y Armanios
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    N Engl J Med 356:1317-26. 2007
    ....
  10. ncbi request reprint Adjuvant chemotherapy for resected adenocarcinoma of the esophagus, gastro-esophageal junction, and cardia: phase II trial (E8296) of the Eastern Cooperative Oncology Group
    Mary Armanios
    Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Oncol 22:4495-9. 2004
    ..To evaluate the effect of postoperative paclitaxel and cisplatin on 2-year survival in patients with completely resected adenocarcinoma of the distal esophagus, gastro-esophageal (GE) junction, and cardia...
  11. pmc Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: case study and review of the literature
    Mary Y Armanios
    Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Neuro Oncol 6:259-63. 2004
    ..The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission...
  12. pmc Short telomeres are a risk factor for idiopathic pulmonary fibrosis
    Jonathan K Alder
    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 105:13051-6. 2008
    ..The clustering of cryptogenic liver cirrhosis with IPF suggests that the telomere shortening we identify has consequences and can contribute to what appears clinically as idiopathic progressive organ failure in the lung and the liver...
  13. ncbi request reprint Short telomeres, even in the presence of telomerase, limit tissue renewal capacity
    Ling Yang Hao
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 123:1121-31. 2005
    ..We propose that short telomeres in mice that have normal telomerase levels can cause an occult form of genetic disease...
  14. ncbi request reprint Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis
    Ling Qi
    Departments of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 63:8188-96. 2003
    ..We propose that Atm protects short telomeres and that Atm deficiency cooperates with short telomeres, leading to increased cell death, decreased tumorigenesis, and increased overall survival...
  15. pmc Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita
    Mary Armanios
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:15960-4. 2005
    ..This finding emphasizes the importance of telomere maintenance and telomerase dosage for maintaining tissue proliferative capacity and has relevance for understanding mechanisms of age-related changes...

Research Grants2

  1. Telomere Shortening and Stem Cell Maintenance
    Mary Armanios; Fiscal Year: 2007
    ..These effects are particularly relevant as telomerase inhibitors are actively pursued as anti-cancer therapies. ..